Although opioid pain relievers are commonly prescribed in pregnancy, their association with neonatal outcomes is not well described. Further, factors associated with development of neonatal abstinence syndrome, a neonatal opioid withdrawal syndrome is inadequately understood.

Prescription opioid use in pregnancy is common and strongly associated with neonatal complications. Antenatal cumulative prescription opioid exposure, opioid type, tobacco use, and selective serotonin reuptake inhibitor use increase the risk of neonatal abstinence syndrome. (Read the full article)

Treatment of idiopathic steroid-resistant nephrotic syndrome is challenging, and therapeutic options are limited. In spite of good initial response with rituximab, responders always remain prone to further relapse, necessitating either repeat course of rituximab or addition of another steroid-sparing immunosuppressant.

Mycophenolate mofetil may be an effective maintenance therapy to consider as an additive immunosuppressant after induction with rituximab in maintaining remission among children with refractory steroid-resistant nephrotic syndrome. (Read the full article)

Legitimate opioid is a risk factor for subsequent misuse of opioids among adults. This study provides the first population-based estimate of the risk of future opioid misuse associated with legitimate opioid use among adolescents.

Use of prescribed opioids before the 12th grade is independently associated with future opioid misuse among patients with little drug experience and who disapprove of illegal drug use. (Read the full article)

A richer chat experience was rolled out by Valve last year on PC, but now it's being joined by a 'modernized chat experience' for iOS and Android devices.

A health expert discusses what late joiner penalties are and how to avoid them.

Alors qu’une tentative de coup d’Etat contre Pierre Nkurunziza, émanant de l’ex-chef d’état-major, Godefroid Niyombaré, est en cours au Burundi, Thierry Vircoulon chercheur à l'International Crisis Group, explique qui est le général putschiste et analyse, plus généralement, l'appareil sécuritaire du Burundi.

Ibrexafungerp (formerly SCY-078) is a semisynthetic triterpenoid and potent (1->3)-β-D-glucan synthase inhibitor. We investigated the in vitro activity, pharmacokinetics, and in vivo efficacy of ibrexafungerp (SCY) alone and in combination with anti-mould triazole isavuconazole (ISA) against invasive pulmonary aspergillosis (IPA). The combination of ibrexafungerp and isavuconazole in in vitro studies resulted in an additive and synergistic interactions against Aspergillus spp. Plasma concentration-time curves of ibrexafungerp were compatible with linear dose proportional profile. In vivo efficacy was studied in a well established persistently neutropenic NZW rabbit model of experimental IPA. Treatment groups included untreated rabbits (UC) and rabbits receiving ibrexafungerp at 2.5(SCY2.5) and 7.5(SCY7.5) mg/kg/day, isavuconazole at 40(ISA40) mg/kg/day, or combinations of SCY2.5+ISA40 and SCY7.5+ISA40. The combination of SCY+ISA produced in vitro synergistic interaction. There was significant in vivo reduction of residual fungal burden, lung weights, and pulmonary infarct scores in SCY2.5+ISA40, SCY7.5+ISA40, and ISA40-treatment groups vs that of SCY2.5-treated, SCY7.5-treated and UC (p<0.01). Rabbits treated with SCY2.5+ISA40 and SCY7.5+ISA40 had prolonged survival in comparison to that of SCY2.5-, SCY7.5-, ISA40-treated or UC (p<0.05). Serum GMI and (1->3)-β-D-glucan levels significantly declined in animals treated with the combination of SCY7.5+ISA40 in comparison to those treated with SCY7.5 or ISA40 (p<0.05). Ibrexafungerp and isavuconazole combination demonstrated prolonged survival, decreased pulmonary injury, reduced residual fungal burden, lower GMI and (1->3)-β-D-glucan levels in comparison to those of single therapy for treatment of IPA. These findings provide an experimental foundation for clinical evaluation of the combination of ibrexafungerp and an anti-mould triazole for treatment of IPA.

Antimicrobial peptides and proteins play critical roles in the host defense against invading pathogens. We recently discovered that recombinantly expressed human and mouse serum amyloid A1 (rhSAA1 and rmSAA1) proteins have potent antifungal activities against the major human fungal pathogen Candida albicans. At high concentrations, rhSAA1 disrupts C. albicans membrane integrity and induces rapid fungal cell death. In the current study, we find that rhSAA1 promotes cell aggregation and targets the C. albicans cell wall adhesin Als3. Inactivation of ALS3 in C. albicans leads to a striking decrease in cell aggregation and cell death upon rhSAA1 treatment, suggesting that Als3 plays a critical role in SAA1 sensing. We further demonstrate that deletion of the transcriptional regulators controlling the expression of ALS3, such as AHR1, BCR1, and EFG1 in C. albicans results in similar effects to that of the als3/als3 mutant upon rhSAA1 treatment. Global gene expression profiling indicates that rhSAA1 has a discernible impact on the expression of cell wall- and metabolism-related genes, suggesting that rhSAA1 treatment could lead to a nutrient starvation effect on C. albicans cells.

Clostridioides difficile, the leading cause of nosocomial infections, is an urgent health threat worldwide. The increased incidence and severity of disease, the high recurrence rates, and the dearth of effective anticlostridial drugs have created an urgent need for new therapeutic agents. In an effort to discover new drugs for treatment of Clostridioides difficile infections (CDIs), we investigated a panel of FDA-approved antiparasitic drugs against C. difficile and identified diiodohydroxyquinoline (DIHQ), an FDA-approved oral antiamoebic drug. DIHQ exhibited potent activity against 39 C. difficile isolates, inhibiting growth of 50% and 90% of these isolates at the concentrations of 0.5 μg/mL and 2 μg/mL, respectively. In a time-kill assay, DIHQ was superior to vancomycin and metronidazole, reducing a high bacterial inoculum by 3-log₁₀ within six hours. Furthermore, DIHQ reacted synergistically with vancomycin and metronidazole against C. difficile in vitro. Moreover, at subinhibitory concentrations, DIHQ was superior to vancomycin and metronidazole in inhibiting two key virulence factors of C. difficile, toxin production and spore formation. Additionally, DIHQ did not inhibit growth of key species that compose the host intestinal microbiota, such as Bacteroides, Bifidobacterium and Lactobacillus spp. Collectively, our results indicate that DIHQ is a promising anticlostridial drug that warrants further investigation as a new therapeutic for CDIs.

While we wait for Apple Arcade to launch for iOS devices, Google is preparing its own app/game subscription service for Android called Play Pass.

Android may be leaving dessert names behind with Android 10, but its OS market share is still a buffet of Pie, Oreos, Nougat, Marshmallows, Lollipops, and even a couple of KitKats.

The latest version of Google's Android mobile operating system brings a batch of security and privacy improvements and a new Dark Theme, too.

Don't settle for the default settings on your Android device. With the right launcher, you can customize the screens and layouts of your phone.

Google removes the free WireGuard app from the Play Store for having a donation button, reigniting a debate over whether its policy hurts the open-source community.

Free apps are cool, but a few bucks can get you so much more. If you are looking to buy in the Google Play store, here are the best paid Android apps to put on your phone.

Not all of the Google Play store's 2.9 million apps are worth downloading. Our picks of the best Android apps in 14 categories deserve a place on your phone.

Have an important phone call coming up and want to save it to reference later? You can record both incoming and outgoing calls on your Android phone with the right app.

G. C. Liggins
Oct 1, 1972; 50:515-525
ARTICLES

Businesses can avoid workplace disputes and CCMA hearings by taking a number of precautions, labour experts say.

Sars' online system has made tax submissions simpler, but business owners need to take care when filing returns online.

Complaint accuses family behind Purdue Pharma of consumer fraud, negligence, and nuisance  Attorney General Kathy Jennings Monday sued seven members of the Sackler family for their role in creating and sustaining the opioid crisis in Delaware. The individuals named in the Delaware Superior Court complaint controlled and directed opioid manufacturer Purdue Pharma’s two-decade course of falsely and deceptively marketing opioids, sowing the seeds […]

Statistics from the Division of Professional Regulation, which licenses controlled substance prescribers, show a 12-percent drop in opioid prescriptions statewide compared to the first quarter of 2017. The number of Delaware patients being treated with opioid medications has also declined by 8 percent over the same time period, the division reports.

"Big love with my little love," wrote Mira

An Indian-origin psychiatrist in the US has to pay USD 1,45,000 as settlement to resolve allegations that he overprescribed opioids to his patients outside the usual course of his professional...

The number of prescriptions for opioid medications in Delaware, as well as the total quantity of opioids dispensed, have dropped significantly in the 12 months since the Department of State enacted stricter prescribing regulations to help combat the opioid crisis statewide.

The Division of Public Health (DPH) is announcing the state’s second human case of West Nile Virus (WNV) in 2018. WNV, a mosquito-borne illness, can become serious, and DPH reminds people to take precautions to avoid mosquito bites.

The Division of Public Health launched a new smartphone app that provides lifesaving step-by-step instructions on how to use naloxone during an opioid overdose.

The Delaware Division of Public Health (DPH) is engaging dental providers in the launch of a statewide campaign directed at increasing awareness about the addictive nature of opioid medications used after dental procedures.

Recommendations focus on systemic changes and expanding treatment options   New Castle, Del. – On Thursday, Lt. Governor Hall-Long joined members of Delaware’s Behavioral Health Consortium, community advocates, and elected officials to accept recommendations from The Pew Charitable Trusts aimed at reforming Delaware’s addiction treatment system. Pew Charitable Trusts has been working in partnership with […]

The Delaware Division of Public Health (DPH) is reminding Delawareans to avoid consuming raw dairy products as it announces a confirmed case of brucellosis caused by Brucella melitensis in a 46-year-old Sussex County woman.

NEW CASTLE (July 11, 2019) – As a new support for individuals and families impacted by the effects of mental health and substance use issues, the Division of Substance Abuse and Mental Health (DSAMH) officially will open the Sussex County Bridge Clinic on July 15 at the Promise Access Center in Georgetown, providing screening and […]

Sony's Xperia 10 and 10 Plus were the midrange counterparts to last year's flagship Xperia 1. Sony did promise an update to Android 10 in "early 2020" but the two midrangers had to wait a bit longer to finally get the latest Google firmware update. With the COVID-19 outbreak disrupting most companies' regular operations the delay is understandable and the good thing is the latest Android version is finally hitting the duo. For the time being, the rollout is limited to select regions and carriers. It bears the 53.1.A.2.2 build number and also adds the March security...

Samsung rolled out the Android 10 update with One UI 2.0 for the Galaxy A20 and Galaxy A20e last month, and now it's the Galaxy A20s that's receiving the latest version of Android with One UI 2.0. The new build requires a download of around 1.3GB and comes with the usual set of Android 10 and One UI 2.0 goodies along with the March 2020 Android security patch. The Android 10 update is rolling out over the air for units with model code SM-A207F and SM-A207M. If you own a Galaxy A20s with either of these model numbers, you'll receive the update in a few days. You can also head over...

I was recently honored to share the stage with government and medical leaders to discuss ways to impact the nation’s opioid epidemic. Hosted by The Washington Post, this event included often spirited conversations on ways to solve this national crisis. As the medical director for SAS US Government, I have [...]

The post Washington Post, new SAS user group, highlight need to collaborate on opioid epidemic appeared first on Government Data Connection.

No patient was discharged on Thursday and the number of cured people stood at 109, leaving 93 active cases in the district, the officials said.

Gautam Buddh Nagar recorded 202 positive cases of coronavirus till Thursday evening, and official figures for Friday were awaited.

  Big internet bills can be a pain, especially when it comes to Android (which has tons of applications that keep using web services in the background). You cannot stop these applications from doing so...

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  If you own an Android device, then you probably owned something else sometime before. If you owned any other device, your biggest regret could be the fact that you couldn’t transfer all your dat...

  My name is Antonio De Falco, and I am the creator of the game Planet Conqueror. Having graduated from University as a Game-Designer, I found myself inclined to develop games that are easy to get into...

   Introduction Playing with small civilian drones is fun. Building them is even better! For those of you who are interested in developing your own “smart” drone, this article provides...