The project will reduce trans-boundary animal diseases (TAD), food safety and zoonotic disease risks and strengthen livestock value chains and COVID-19 responses through investments in infrastructure, capacity building and policy support. The project will have the following outcome: health, value chains, and formal trade of livestock and livestock products improved. The project will be aligned with the following impact: GMS vision as a leading supplier of safe and environmentally friendly agriculture products realized.

Microwaves in homes, offices and laboratories have been found to host diverse microbiomes, highlighting the importance of regular cleaning

Forget videos by gamers or influencers. For a real online thrill, watch the world's biggest flower emerging in a former web designer's greenhouse, says Annalee Newitz

The veteran presenter adds authority to Secret Lives of Orangutans, a film about a family of endangered orangutans in Sumatra. File this new entry in his vast oeuvre under lovable but lightweight

From migrating sauropods and semi-aquatic predators to doting parents, palaeontologists are finally uncovering the mysteries of the lifestyles of dinosaurs

From migrating sauropods and semi-aquatic predators to doting parents, palaeontologists are finally uncovering the mysteries of the lifestyles of dinosaurs

Recent research shows that anti-inflammatory diets are not as faddish as they might sound, with the power to reduce the risk of heart attacks and some cancers

The Kīlauea volcano in Hawaii has begun erupting, spewing volcanic gas and ash across the island

Iceland’s Fagradalsfjall volcano, located on the country’s south-west Reykjanes peninsula, has erupted after weeks of earthquake activity

Recent research shows that anti-inflammatory diets are not as faddish as they might sound, with the power to reduce the risk of heart attacks and some cancers

Underground tunnels created by lava flows provided humans with shelter for thousands of years beneath the hot desert landscape of Saudi Arabia

A young boy who lived towards the end of the last glacial period had dark skin, blue eyes and a congenital heart condition, a study of his genome reveals

Title: PFAS 'Forever Chemicals' Linked With Liver Cancer
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Title: Study: Diet Sodas May Raise Risk of Preterm Delivery
Category: Health News
Created: 8/23/2010 10:47:00 AM
Last Editorial Review: 8/23/2010 10:47:52 AM

Title: Bottled Teas May Not Deliver on Antioxidants
Category: Health News
Created: 8/23/2010 12:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM

Title: Low-Cal Diets Kept Monkeys Healthier, But Didn't Lengthen Lives
Category: Health News
Created: 8/29/2012 4:05:00 PM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: Donated Livers Not Harmed by Travel Distances, Study Finds
Category: Health News
Created: 8/28/2014 2:36:00 PM
Last Editorial Review: 8/29/2014 12:00:00 AM

Title: Sex Lives Best When Couples Share Child Care Duties, Survey Shows
Category: Health News
Created: 8/23/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: Weight Loss Fights Liver Condition, No Matter How It's Done
Category: Health News
Created: 8/21/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Title: Liver Damage From Hepatitis C More Widespread Than Thought
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM

Title: Family Trumps Friends in Extending Seniors' Lives
Category: Health News
Created: 8/21/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: Drink Coffee, Live Longer?
Category: Health News
Created: 8/28/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM

Title: Could an Estrogen Patch Boost Women's Sex Lives in Menopause?
Category: Health News
Created: 8/28/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM

Title: FDA Warns of Liver Problems for Some Taking Hep C Drugs
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: Flu, Pneumonia Vaccines Save Lives of Heart Failure Patients: Study
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: AHA News: She Had a 20% Chance to Live First From a Stroke, Then From COVID-19
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Wildfire Smoke Could Raise Odds for Preterm Delivery
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Title: Want to Live Longer? Exercise More, Study Confirms
Category: Health News
Created: 7/26/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM

Title: Heat Waves That Threaten Lives Will Be Common by 2100
Category: Health News
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Many Older Women Have Active Sex Lives, But Menopause Can Interfere
Category: Health News
Created: 5/18/2022 12:00:00 AM
Last Editorial Review: 5/19/2022 12:00:00 AM

Title: You Could Live 9 Years Longer in Hawaii Than in Mississippi, New Data Shows
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM

Title: Organ From Live Donor Best When Child Needs New Kidney
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM

The rising obesity epidemic is a phenomenon that has gained increasing attention from health providers and health policy makers. This led to recognition of nonalcoholic fatty liver disease (MASLD). The standard for its assessment has been histologic, which is neither practical nor acceptable by patients. Subsequently, a number of noninvasive assessment methods have been developed. However, despite ease of implementation, their confounding variables do hinder their accuracy. Nonetheless, the development of the liver stiffness measurement (LSM) and incorporation of other biological parameters has minimized but not eliminated the need for liver biopsy. Imaging methods are useful in evaluation, estimation, and following the progression of steatosis and fibrosis with particular attention to controlled attenuation parameter (CAP) and MRI–Proton Density Fat Fraction (MRI-PDFF). The choices for the family physician are broad and rely on tests’ availability, cost, and patient acceptance. Great efforts have been undertaken to produce more robust and novel noninvasive markers that indicate fibrinogenesis directly in an implementable and cost-effective way.

BACKGROUND:Beneficial effects of breathing at FIO2 < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of breathing hypoxic gas for 5 d have not been established. In this study, we examined the physiologic effects of breathing a gas mixture with FIO2 as low as 0.11 in 5 healthy volunteers.METHODS:All 5 subjects completed the study, spending 5 consecutive days in a hypoxic tent, where the ambient oxygen level was lowered in a stepwise manner over 5 d, from FIO2 of 0.16 on the first day to FIO2 of 0.11 on the fifth day of the study. All the subjects returned to an environment at room air on the sixth day. The subjects' SpO2, heart rate, and breathing frequency were continuously recorded, along with daily blood sampling, neurologic evaluations, transthoracic echocardiography, and mental status assessments.RESULTS:Breathing hypoxia concentration dependently caused profound physiologic changes, including decreased SpO2 and increased heart rate. At FIO2 of 0.14, the mean SpO2 was 92%; at FIO2 of 0.13, the mean SpO2 was 93%; at FIO2 of 0.12, the mean SpO2 was 88%; at FIO2 of 0.11, the mean SpO2 was 85%; and, finally, at an FIO2 of 0.21, the mean SpO2 was 98%. These changes were accompanied by increased erythropoietin levels and reticulocyte counts in blood. All 5 subjects concluded the study with no adverse events. No subjects exhibited signs of mental status changes or pulmonary hypertension.CONCLUSIONS:Results of the current physiologic study suggests that, within a hospital setting, delivering FIO2 as low as 0.11 is feasible and safe in healthy subjects, and provides the foundation for future studies in which therapeutic effects of hypoxia breathing are tested.

Hepatocyte nuclear factor 4 alpha antisense 1 (HNF4A-AS1) is a long noncoding RNA (lncRNA) gene physically located next to the transcription factor HNF4A gene in the human genome. Its transcription products have been reported to inhibit the progression of hepatocellular carcinoma (HCC) and negatively regulate the expression of cytochrome P450s (CYPs), including CYP1A2, 2B6, 2C9, 2C19, 2E1, and 3A4. By altering CYP expression, lncRNA HNF4A-AS1 also contributes to the susceptibility of drug-induced liver injury. Thus, HNF4A-AS1 lncRNA is a promising target for controlling HCC and modulating drug metabolism. However, HNF4A-AS1 has four annotated alternative transcripts in the human genome browsers, and it is unclear which transcripts the small interfering RNAs or small hairpin RNAs used in the previous studies are silenced and which transcripts should be used as the target. In this study, four annotated and two newly identified transcripts were confirmed. These six transcripts showed different expression levels in different liver disease conditions, including metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, and obesity. The expression patterns of all HNF4A-AS1 transcripts were further investigated in liver cell growth from human embryonic stem cells to matured hepatocyte-like cells, HepaRG differentiation, and exposure to rifampicin treatment. Several HNF4A-AS1 transcripts highly displayed correlations with these situations. In addition, some of the HNF4A-AS1 transcripts also showed a strong correlation with CYP3A4 during HepaRG maturation and rifampicin exposure. Our findings provide valuable insights into the specific roles of HNF4A-AS1 transcripts, paving the way for more targeted therapeutic strategies for liver diseases and drug metabolism.

A STING (stimulator of interferon genes) agonist GSK3996915 under investigation in early discovery for hepatitis B was orally dosed to a mouse model for understanding the parent drug distribution in liver, the target organ. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to quantify the distribution of GSK3996915 in liver collected from mice administered a single oral dose at 90 mg/kg. GSK3996915 was detected with a zonal distribution localized in the portal triad and highly concentrated in the main bile ducts, indicating clearance through biliary excretion. High spatial resolution imaging showed the distribution of the parent drug localized to the cellular populations in the sinusoids, including the Kupffer cells. Additionally, a series of drug-related metabolites were observed to be localized in the central zones of the liver. These results exemplify the potential of utilizing MALDI IMS for measuring not only quantitative drug distribution and target exposure but also drug metabolism and elimination in a single suite of experiments.

ABSTRACTIntroduction:Emergency contraceptive pills (ECPs) are effective and can be used safely at any age repeatedly within the same cycle. They are often favored by youth yet are underutilized. Private facilities can increase ECP access but present barriers including cost. Identifying effective public-sector ECP distribution models can help ensure equitable access. The Malawi Ministry of Health developed a strategy to improve ECP access in 2020. We documented ECP provision through select public, youth-serving channels recommended by the strategy: general and youth-specific outreach, paid and unpaid community health workers (CHWs), and youth clubs.Methods:We conducted this mixed methods study from November 2022–March 2023 in 2 rural districts (Mchinji and Phalombe) implementing the strategy. We conducted qualitative interviews with 10 national stakeholders, 46 providers, and 24 clients aged 15–24 years about ECP service delivery. Additionally, 25 providers collected quantitative tally data about clients seeking ECPs. We analyzed qualitative data using grounded theory and quantitative data descriptively.Results:Stakeholders and providers reported ECP uptake increased in geographies where the strategy was implemented, especially among youth. Providers documented 3,988 client visits for ECPs over 3 months. Of these visits, 26% were from male clients, 36% were from clients aged younger than 20 years, and 64% received ECPs for the first time. Across channels, youth club leaders and unpaid CHWs reported the most client visits per provider and served the youngest clients. However, no ECPs were dispensed during 29% of visits due to stock-outs. While many providers were supportive of youth accessing ECPs, most held unfavorable attitudes toward repeat use.Conclusion:ECP access should be expanded through provision in the studied channels, especially youth clubs and CHWs. However, to meet demand, the supply chain must be strengthened. We recommend addressing providers’ attitudes about repeat use to ensure informed method choice.

ABSTRACTIntroduction:Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality. A new clinical intervention (E-MOTIVE) holds the potential to improve early PPH detection and management. We aimed to develop and pilot implementation strategies to support uptake of this intervention in Kenya, Nigeria, South Africa, and Tanzania.Methods:Implementation strategy development: We triangulated findings from qualitative interviews, surveys and a qualitative evidence synthesis to identify current PPH care practices and influences on future intervention implementation. We mapped influences using implementation science frameworks to identify candidate implementation strategies before presenting these at stakeholder consultation and design workshops to discuss feasibility, acceptability, and local adaptations. Piloting: The intervention and implementation strategies were piloted in 12 health facilities (3 per country) over 3 months. Interviews (n=58), case report forms (n=1,269), and direct observations (18 vaginal births, 7 PPHs) were used to assess feasibility, acceptability, and fidelity.Results:Implementation strategy development: Key influences included shortages of drugs, supplies, and staff, limited in-service training, and perceived benefits of the intervention (e.g., more accurate PPH detection and reduced PPH mortality). Proposed implementation strategies included a PPH trolley, on-site simulation-based training, champions, and audit and feedback. Country-specific adaptations included merging the E-MOTIVE intervention with national maternal health trainings, adapting local PPH protocols, and PPH trollies depending on staff needs. Piloting: Intervention and implementation strategy fidelity differed within and across countries. Calibrated drapes resulted in earlier and more accurate PPH detection but were not consistently used at the start. Implementation strategies were feasible to deliver; however, some instances of limited use were observed (e.g., PPH trolley and skills practice after training).Conclusion:Systematic intervention development, piloting, and process evaluation helped identify initial challenges related to intervention fidelity, which were addressed ahead of a larger-scale effectiveness evaluation. This has helped maximize the internal validity of the trial.

Historically, the intestinal lymphatics were considered passive conduits for fluids, immune cells, dietary lipids, lipid soluble vitamins, and lipophilic drugs. Studies of intestinal lymphatic drug delivery in the late 20th century focused primarily on the drugs’ physicochemical properties, especially high lipophilicity, that resulted in intestinal lymphatic transport. More recent discoveries have changed our traditional view by demonstrating that the lymphatics are active, plastic, and tissue-specific players in a range of biological and pathological processes, including within the intestine. These findings have, in turn, inspired exploration of lymph-specific therapies for a range of diseases, as well as the development of more sophisticated strategies to actively deliver drugs or vaccines to the intestinal lymph, including a range of nanotechnologies, lipid prodrugs, and lipid-conjugated materials that "hitchhike" onto lymphatic transport pathways. With the increasing development of novel therapeutics such as biologics, there has been interest in whether these therapeutics are absorbed and transported through intestinal lymph after oral administration. Here we review the current state of understanding of the anatomy and physiology of the gastrointestinal lymphatic system in health and disease, with a focus on aspects relevant to drug delivery. We summarize the current state-of-the-art approaches to deliver drugs and quantify their uptake into the intestinal lymphatic system. Finally, and excitingly, we discuss recent examples of significant pharmacokinetic and therapeutic benefits achieved via intestinal lymphatic drug delivery. We also propose approaches to advance the development and clinical application of intestinal lymphatic delivery strategies in the future.

PURPOSE

Currently, 40% of counties in the United States do not have an obstetrician or midwife, and in rural areas the likelihood of childbirth being attended to by a family medicine (FM) physician is increasing. We sought to characterize the effect of the FM presence on unit culture and a key perinatal quality metric in Iowa hospital intrapartum units.

The respiratory literature, both written and in online formats, is growing exponentially. Capturing quality content, to meet the learning needs of those working in all fields of respiratory medicine and delivering it in a palatable, accessible format is challenging but paramount. In this article we discuss ways to determine the information content and review different methods of delivering this content to those who need it.

So far, the Israeli leadership seems unmoved by U.S. President Biden’s quiet suggestions for a pause in hostilities in Gaza.

The post Saving Palestinian lives will save Israeli lives appeared first on rabble.ca.

Stroll on down to Uncle Capcom's garage, girls and boys, because it's time to meddle with a cat's voicebox, ride a combat peacock and meticulously injure a vast, blubbery teddybear. By which I mean, the Monster Hunter Wilds beta is now live on Steam through to 4th November at 2.59am GMT. That's 2.59am sharp. If you're hurrying along at 3am on Monday absolutely desperate to polish the aesthetics of a small enslaved catperson, you can sod off and play Dragon Age: The Veilguard instead.

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Finance guru Laura Pomfret explained how changes to inheritance tax in the budget may hit people in a way they hadn't realised

PGMOL chief Howard Webb has responded after referee David Coote was suspended for comments he appeared to make in a video.

Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ICRA@40: 23–26 September 2024, ROTTERDAM, NETHERLANDS

IROS 2024: 14–18 October 2024, ABU DHABI, UAE

ICSR 2024: 23–26 October 2024, ODENSE, DENMARK

Cybathlon 2024: 25–27 October 2024, ZURICH

Enjoy today’s videos!

Zipline has (finally) posted some real live footage of its new Platform 2 drone, and while it’s just as weird looking as before, it seems to actually work really well.

[ Zipline ]

I appreciate Disney Research’s insistence on always eventually asking, “okay, but can we get this to work on a real robot in the real world?”

[ Paper from ETH Zurich and Disney Research [PDF] ]

In this video, we showcase our humanoid robot, Nadia, being remotely controlled for boxing training using a simple VR motion capture setup. A remote user takes charge of Nadia’s movements, demonstrating the power of our advanced teleoperation system. Watch as Nadia performs precise boxing moves, highlighting the potential for humanoid robots in dynamic, real-world tasks.

[ IHMC ]

Guide dogs are expensive to train and maintain—if available at all. Because of these limiting factors, relatively few blind people use them. Computer science assistant professor Donghyun Kim and Ph.D candidate Hochul Hwang are hoping to change that with the help of UMass database analyst Gail Gunn and her guide dog, Brawny.

[ University of Massachusetts, Amherst ]

Thanks Julia!

The current paradigm for motion planning generates solutions from scratch for every new problem, which consumes significant amounts of time and computational resources. Our approach builds a large number of complex scenes in simulation, collects expert data from a motion planner, then distills it into a reactive generalist policy. We then combine this with lightweight optimization to obtain a safe path for real world deployment.

[ Neural MP ]

A nice mix of NAO and AI for embodied teaching.

[ Aldebaran ]

When retail and logistics giant Otto Group set out to strengthen its operational efficiency and safety, it turned to robotics and automation. The Otto Group has become the first company in Europe to deploy the mobile case handling robot Stretch, which unloads floor-loaded trailers and containers.

[ Boston Dynamics ]

From groceries to last-minute treats, Wing is here to make sure deliveries arrive quickly and safely. Our latest aircraft design features a larger, more standardized box and can carry a higher payload which came directly from customer and partner feedback.

[ Wing ]

It’s the jacket that gets me.

[ Devanthro ]

In this video, we introduce Rotograb, a robotic hand that merges the dexterity of human hands with the strength and efficiency of industrial grippers. Rotograb features a new rotating thumb mechanism, allowing for precision in-hand manipulation and power grasps while being adaptable. The robotic hand was developed by students during “Real World Robotics”, a master course by the Soft Robotics Lab at ETH Zurich.

[ ETH Zurich ]

A small scene where Rémi, our distinguished professor, is teaching chess to the person remotely operating Reachy! The grippers allow for easy and precise handling of chess pieces, even the small ones! The robot shown in this video is the Beta version of Reachy 2, our new robot coming very soon!

[ Pollen ]

Enhancing the adaptability and versatility of unmanned micro aerial vehicles (MAVs) is crucial for expanding their application range. In this article, we present a bimodal reconfigurable robot capable of operating in both regular quadcopter flight mode and a unique revolving flight mode, which allows independent control of the vehicle’s position and roll-pitch attitude.

[ City University Hong Kong ]

The Parallel Continuum Manipulator (PACOMA) is an advanced robotic system designed to replace traditional robotic arms in space missions, such as exploration, in-orbit servicing, and docking. Its design emphasizes robustness against misalignments and impacts, high precision and payload capacity, and sufficient mechanical damping for stable, controlled movements.

[ DFKI Robotics Innovation Center ]

Even the FPV pros from Team BlackSheep do, very occasionally, crash.

[ Team BlackSheep ]

This is a one-hour uninterrupted video of a robot cleaning bathrooms in real time. I’m not sure if it’s practical, but I am sure that it’s impressive, honestly.

[ Somatic ]

The Pokemon Company is teaming up with content creators to stage a 24-hour unboxing live stream for its new Scarlet & Violet - Surging Sparks card set as you Gotta Catch 'Em All

Researchers calculated that if 30 per cent of vehicles in Chicago currently running on combustion engines were converted to electric, the reduction in pollution would save billions in health care costs every year. 

LIVERPOOL midfielder Georginio Wijnaldum will be pivotal for Jurgen Klopp at Manchester City..