By visiting a local park in Catalonia regularly, to get to know the youth, and handing out little bags of toasted corn, the OM team are able to make friendships and share seeds of faith

THERE is a new altar to worship at: all hail the mighty god of DIY. If you're not sitting down to a Zoom call on Monday morning with plaster-streaked hair, singed eyebrows and muscles aching from hard graft, what on earth have you been doing with your weekend?

Does the Hyundai Grand i10 Nios get what it takes to take the fight to the Swift and what are its pros and cons? Read on to find out.

In the wake of Franklin Templeton wounding up six of its debt mutual fund schemes, India’s largest mutual fund distributors body has urged the Reserve Bank of India to set up a SPV to buy portfolios from troubled fund houses and pay off investors.

NEW CASTLE (5 de mayo de 2020) – El 1 de mayo, la División de Servicios Sociales fue aprobada por el Departamento de Agricultura de los Estados Unidos (USDA, por sus siglas en inglés) para operar la Transferencia Electrónica de Beneficios Debido a la Pandemia (P-EBT, por sus siglas en inglés), un programa nuevo autorizado […]

Europe’s utilities are re-evaluating their business models due to the energy transition. Members of POWER-GEN Europe’s Advisory Board consider how a reliance on fossil fuels is no longer politically desirable, forcing utilities to transform their portfolios to adapt to radical change.

Dermer set to stay in Washington til US election, taking away plum post in crowded Likud

Apex Legends might finally be getting a mobile version, at least that's what EA's latest financial briefing seems to suggest

With no fanfare, Hollywood studios and leaders of the Writers Guild of America have moved back the start of masters contract negotiations a week to May 18. Representatives of the Alliance of Motion Picture and Television Producers were not immediately available for comment about the change, which was revealed Saturday. A WGA spokesman said, “It’s […]

In 2015 the Lithuanian government launched an ambitious Social Model reform agenda aimed at balancing flexibility of the labour market and security provided through the system of social protection.

In 2015 the Lithuanian government launched an ambitious Social Model reform agenda aimed at balancing flexibility of the labour market and security provided through the system of social protection.

Micro-organisms play a fundamental role in the environment. Yet their role is the result of complex biogeochemical processes by consortia of micro-organisms and the function of individual species is not clear in many cases. This publication provides an overview of the current situation and relevant developments in environmental microbiology.

The Chemical Safety and Biosafety Progress Report is released every eight months. Its purpose is to provide an update on the projects, events and activities. Information on new publications as well as dates and venues of upcoming events and meetings are given.

Several user reports and news websites mentioned that after the installation process the handset showed an error prompting users to plug it to iTunes on a PC. On connecting, another error cropped up which read, “There is a problem with the iPhone 'iPhone' that requires it to be updated or restored.”

Apple's latest mobile operating system -- iOS 10 -- is rolling our to users globally starting today.

iOS 10 reached 14.45% of eligible devices in the first 24 hours of its release. In comparison, iOS 9 was on 12.60% of eligible device within 24 hours of it being released for all users.

हुंडई ग्रैंड आई10 नियोस को बीएस6 पेट्रोल व डीजल दोनों अवतार में लाया जा चुका है। हाल ही में हमने इसके डीजल इंजन के माइलेज की जानकारी दी थी अब इसके पेट्रोल बीएस6 के माइलेज की जानकारी का खुलासा हो गया है।

The Hyundai Grand i10 NIOS BS6 petrol variant mileage figures have been revealed. The company had updated the petrol engine to achieve BS6 compliance earlier this year, and also added a new turbo-engine to the Grand i10 NIOS BS6.

The four-wheeler space in India has received new models at the higher and lower end of the pricing scale. The demand for performance variants of normal SUVs and hatchback have increased substantially. As a result, more manufacturers are either developing or

As of today, the total number of confirmed COVID-19 cases in India is 27892 with 6185 recovered cases and 872 deaths. Early diagnosis of COVID-19 is crucial to slow down the spread of the infection. COVID-19 spread at a

Archives, Room Use Only - HE6935.H93 1889

The kiosks, modelled after those used in South Korea, have built-in gloves which can be used by health workers as protective shield while collecting samples of suspected patients.

As you may have heard, the upcoming iOS 4.3 will support AirPlay streaming in Mobile Safari. Previously video streaming was only available in Apple-controlled iOS applications like the YouTube and iPod/Video apps, but the new iOS 4.3 beta opens up AirPlay support to both third party App Store applications, as well as embedded web videos using either the Quicktime plugin () or the

Autor:
Erschienen
BSB-Signatur Clm 18565

URN: urn:nbn:de:bvb:12-bsb00131315-7
URL: http://daten.digitale-sammlungen.de/~db/0013/bsb00131315/images/

Being able to visualize biology at the molecular level is essential for our understanding of the world. A structural biology approach reveals the molecular basis of disease processes and can guide the design of new drugs as well as aid in the optimization of existing medicines. However, due to the lack of a synchrotron light source, adequate infrastructure, skilled persons and incentives for scientists in addition to limited financial support, the majority of countries across the African continent do not conduct structural biology research. Nevertheless, with technological advances such as robotic protein crystallization and remote data collection capabilities offered by many synchrotron light sources, X-ray crystallography is now potentially accessible to Africa-based scientists. This leap in technology led to the establishment in 2017 of BioStruct-Africa, a non-profit organization (Swedish corporate ID: 802509-6689) whose core aim is capacity building for African students and researchers in the field of structural biology with a focus on prevalent diseases in the African continent. The team is mainly composed of, but not limited to, a group of structural biologists from the African diaspora. The members of BioStruct-Africa have taken up the mantle to serve as a catalyst in order to facilitate the information and technology transfer to those with the greatest desire and need within Africa. BioStruct-Africa achieves this by organizing workshops onsite at our partner universities and institutions based in Africa, followed by post-hoc online mentoring of participants to ensure sustainable capacity building. The workshops provide a theoretical background on protein crystallography, hands-on practical experience in protein crystallization, crystal harvesting and cryo-cooling, live remote data collection on a synchrotron beamline, but most importantly the links to drive further collaboration through research. Capacity building for Africa-based researchers in structural biology is crucial to win the fight against the neglected tropical diseases, e.g. ascariasis, hookworm, trichuriasis, lymphatic filariasis, active trachoma, loiasis, yellow fever, leprosy, rabies, sleeping sickness, onchocerciasis, schistosomiasis, etc., that constitute significant health, social and economic burdens to the continent. BioStruct-Africa aims to build local and national expertise that will have direct benefits for healthcare within the continent.

The crystal structure of the c-type cytochrome NirC from Pseudomonas aeruginosa has been determined and reveals the simultaneous presence of monomers and 3D domain-swapped dimers in the same asymmetric unit.

The title complex, [Os3(C2H4N)H(CO)10] or [Os3(CO)10(μ-H)(μ-HN=C—CH3-1κN:2κC)], was synthesized in 41.6% yield by reactions between Os3(CO)11(CH3CN) and 2,4,6-tri­methyl­hexa­hydro-1,3,5-triazine. The central osmium triangle has two OsI atoms bridged by a hydride ligand and a μ-HN= C—CH3-1κN:2κC triazine fragment. Three CO ligands complete the coordination sphere around each OsI atom, while the remaining Os0 atom has four CO ligands. Each Os atom exhibits a pseudo-octa­hedral coordination environment, discounting the bridging Os—Os bond.

In the title hydrated hybrid compound C14H14N2OS2·H2O, the planar imidazo[1,2-a]pyridine ring system is linked to the 1,3-di­thiol­ane moiety by an enone bridge. The atoms of the C—C bond in the 1,3-di­thiol­ane ring are disordered over two positions with occupancies of 0.579 (14) and 0.421 (14) and both disordered rings adopt a half-chair conformation. The oxygen atom of the enone bridge is involved in a weak intra­molecular C—H⋯O hydrogen bond, which generates an S(6) graph-set motif. In the crystal, the hybrid mol­ecules are associated in R22(14) dimeric units by weak C—H⋯O inter­actions. O—H⋯O hydrogen bonds link the water mol­ecules, forming infinite self-assembled chains along the b-axis direction to which the dimers are connected via O—H⋯N hydrogen bonding. Analysis of inter­molecular contacts using Hirshfeld surface analysis and contact enrichment ratio descriptors indicate that hydrogen bonds induced by water mol­ecules are the main driving force in the crystal packing formation.

Monoheme c-type cytochromes are important electron transporters in all domains of life. They possess a common fold hallmarked by three α-helices that surround a covalently attached heme. An intriguing feature of many monoheme c-type cytochromes is their capacity to form oligomers by exchanging at least one of their α-helices, which is often referred to as 3D domain swapping. Here, the crystal structure of NirC, a c-type cytochrome co-encoded with other proteins involved in nitrite reduction by the opportunistic pathogen Pseudomonas aeruginosa, has been determined. The crystals diffracted anisotropically to a maximum resolution of 2.12 Å (spherical resolution of 2.83 Å) and initial phases were obtained by Fe-SAD phasing, revealing the presence of 11 NirC chains in the asymmetric unit. Surprisingly, these protomers arrange into one monomer and two different types of 3D domain-swapped dimers, one of which shows pronounced asymmetry. While the simultaneous observation of monomers and dimers probably reflects the interplay between the high protein concentration required for crystallization and the structural plasticity of monoheme c-type cytochromes, the identification of conserved structural motifs in the monomer together with a comparison with similar proteins may offer new leads to unravel the unknown function of NirC.

Digitonin has long been used as a mild detergent for extracting proteins from membranes for structure and function studies. As supplied commercially, digitonin is inhomogeneous and requires lengthy pre-treatment for reliable downstream use. Glyco-diosgenin (GDN) is a recently introduced synthetic surfactant with features that mimic digitonin. It is available in homogeneously pure form. GDN is proving to be a useful detergent, particularly in the area of single-particle cryo-electron microscopic studies of membrane integral proteins. With a view to using it as a detergent for crystallization trials by the in meso or lipid cubic phase method, it was important to establish the carrying capacity of the cubic mesophase for GDN. This was quantified in the current study using small-angle X-ray scattering for mesophase identification and phase microstructure characterization as a function of temperature and GDN concentration. The data show that the lipid cubic phase formed by hydrated monoolein tolerates GDN to concentrations orders of magnitude in excess of those used for membrane protein studies. Thus, having GDN in a typical membrane protein preparation should not deter use of the in meso method for crystallogenesis.

A new report from the National Academies of Sciences, Engineering, and Medicine examines policies and practices governing dual-use research in the life sciences – research that could potentially be misused to cause harm – and its findings identify multiple shortcomings.

The National Institute for Occupational Safety and Health (NIOSH) should lead a collaborative effort with the U.S. Bureau of Labor Statistics (BLS), Occupational Safety and Health Administration (OSHA), and the states to establish and strengthen regional occupational safety and health surveillance programs, says a new report by the National Academies of Sciences, Engineering, and Medicine.

Flowbird Group has announced recent developments that limit...

Pedestrians walk by the Castro Theatre that has a marquee announcing that they are closed due to a statewide ordinance banning gatherings of more than 250 people in San Francisco, California. ; Credit: Justin Sullivan/Getty Images

Hollywood has come to a stand still. The film and entertainment industry has been hit hard by the coronavirus outbreak as theaters close, film releases and events are being postponed, and studios are putting a pause on film production.

The gravity of the coronavirus is being felt all throughout the country and Hollywood is not coming out of the outbreak unscathed. Social distancing measures being enforced to help control the outbreak has studios and theatres taking a huge hit. It’s predicted that about 170,000 people in the film industry will lose their jobs. Many of the lowest-paid positions and freelance jobs have been the first to go. From events to films, the industry is trying to strategize around the outbreak with no clear picture on how long these conditions could last. Hollywood unions, activist groups and nonprofits are coming together to help provide some kind of emergency relief for workers who are getting hit the hardest. It’s been a period of economic shock for the entertainment industry and it’s still too early to see what Hollywood could look like after the outbreak is over.

Today on AirTalk, we check-in with people in the entertainment industry who have been impacted by the outbreak and where might Hollywood go from here. If you work in entertainment, we'd like to hear from you! How are you coping as most productions are shut down? Join the live conversation by calling 866-893-5722.

Guest:

Andrew Wallenstein, co-editor-in-chief at Variety; he tweets @awallenstein

This content is from Southern California Public Radio. View the original story at SCPR.org.

Apple Senior Vice President of Worldwide Marketing Phil Schiller announces the new iPhone 6 during an Apple special event at the Flint Center for the Performing Arts on September 9, 2014 in Cupertino, California. Apple unveiled the two new iPhones the iPhone 6 and iPhone 6 Plus.; Credit: Justin Sullivan/Getty Images

Apple's latest mobile operating system — iOS 8 — is now available, and with it, a new technical hurdle for law enforcement. The company says it will be technologically impossible to access data on phones and iPads running iOS 8, because it won't allow user passcodes to be bypassed.

Our phones, of course, contain troves of information — contacts, messages, recordings — which can be helpful for investigative or prosecutorial purposes. The Supreme Court earlier this year ruled law enforcement cannot access that kind of data without a warrant. Prosecutors had already feared the warrant hurdle would be too much — Rockland County, N.Y., District Attorney Thomas Zugibe told the Wall Street Journal in June that technology "is making it easier and easier for criminals to do their trade," while the court "is making it harder for law enforcement to do theirs."

Now, even with a warrant, data from Apple devices running iOS 8 will be tough — and, Apple says, impossible — for law enforcement to get its hands on.

As The Washington Post reports, the move "amounts to an engineering solution to a legal quandary: Rather than comply with binding court orders, Apple has reworked its latest encryption in a way that prevents the company — or anyone but the device's owner — from gaining access to the vast troves of user data typically stored on smartphones or tablet computers."

Not so fast, writes an iOS forensics expert, Jonathan Zdziarski. Just because Apple will no longer help police doesn't mean police can't find ways to use existing commercial forensics tools to extract the data themselves. Wired Magazine describes how Zdziarski proved his own point:

Zdziarski confirmed with his own forensics software that he was still able to pull from a device running iOS 8 practically all of its third-party application data — that means sensitive content from Twitter, Facebook, Instagram, web browsers, and more — as well as photos and video. The attack he used impersonates a trusted computer to which a user has previously connected the phone; it takes advantage of the same mechanisms that allow users to siphon data off a device with programs like iTunes and iPhoto without entering the gadget's passcode.

"I can do it. I'm sure the guys in suits in the governments can do it," says Zdziarski.

And, Apple will still be able to turn over user data stored outside its phones, for example, on its iCloud service, The Washington Post notes. Users often back up photos, videos, emails and more to iCloud, as the recent nude photo theft reminded us.

Apple, in creating plausible deniability for itself, is also using its strongly worded new privacy stance as a marketing opportunity. It's reinforcing what it says is a commitment to privacy and transparency when it comes to government data requests. Apple says so far this year, it has received fewer than 250 government requests for data, including requests to unlock encrypted iPhones.

A pair of vulnerabilities in the default email app on iOS devices is believed to have been exploited against high-profile targets

The post iOS Mail app flaws may have left iPhone users vulnerable for years appeared first on WeLiveSecurity

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

A recent study has assessed the sustainability of different nuclear cycle scenarios in Europe, and suggests trade-offs are required between reducing the amount of uranium fuel needed, costs and proliferation risks.

A new study has explored how cities can create a low carbon future by presenting an approach to stakeholder engagement that develops scenarios of an ideal city. Rather than projecting towards a low carbon target for the future, the study suggests that ‘backcasting’ to the present day from these scenarios may provide a useful goal-orientated approach to environmental planning in cities.