It serves multiple purposes as it acts as a hedge against inflation and provides stability during economic downturns

Abstract: UNESCO Biosphere Reserves were first established under the Man and Biosphere Programme of UNESCO in the 1970s. Their mandate has expanded beyond conservation to include sustainable development and local capacity enhancement. As institutions under UNESCO, they also work on “building peace” by seeking to reconcile relations between peoples, and between people and the

The post Biosphere Reserves appeared first on Berkshire Publishing.

Cambridge, MA. : National Bureau of Economic Research, 2023

Prof Geim addressed the 15th Convocation of Hindustan Institute of Technology and Science (HITS).

Hi.
@brandonmcconnell
A few years ago now but any chance you could elucidate how to implement your solution on a WordPress site to someone in the self-taught hack category? e.g. where would you put that code: function.php, style.php etc?
Can’t believe this problem existed the first place!
Many thanks

Users will be able to customise the time on the lock screen with Indian numerals from 12 languages

Lugduni : apud Hugonem à Porta, M. D. X L VI. [1546]

Google has new widgets for Gmail and Google News app on iOS 16 

6 steps to download iOS 16 updates

Settings has an option to remove the Apple iOS ‘security response’

A few changes have showed up with the iOS 16 update on iMessage

Apple iOS 16.2 brings end-to-end encryption for iCloud data, advanced data protection, and others

There are still more AI features to come, like the ChatGPT-powered Siri, Genmoji, and Visual Intelligence, which will mostly be a part of the iOS 19 update

Next week, the hardware company is set to release iOS 18.1 which will include the first set of Apple Intelligence features

The iOS 18.1 beta 1 update added ChatGPT integration with Siri, the iOS 18.2 beta 2 update will let developers subscribe to ChatGPT Plus directly from Settings

Users will also be able to use Gemini Live through the app which can’t be done through the Google app

The drug company will pay $1.6 billion to gain Armo’s IL-10 program

Bioluminscent bacteria pair with electronics to detect blood in the gut

Company: Indscope
Experience: 2 to 4
Salary: 3.00 to 4.20
location: Bengaluru / Bangalore
Ref: 24828923
Summary: 2-3 years of iOS application development, with extensive use of Obj-C (or Swift) IO, collections, algorithms, and well-known application frameworks

1. Jackie Trad resigns as Queensland's Deputy Premier and Treasurer, Steven Miles and Cameron Dick to take on portfolios  ABC News
2. Poster girl’s fall a shock for the left of politics  The Australian
3. Corruption investigation into Queensland Deputy Premier Jackie Trad has potential to unravel Labor Government's five-year reign  ABC News
4. Editorial: Premier, Queensland needs a new treasurer now  Courier Mail
5. Analysis: Latest investigation not a good look for Jackie Trad  Courier Mail
6. View Full coverage on Google News

Brooding bad ass, Kane Fox is absolute fire as he drowns in twink superstar, Hayden Lee’s hot kisses. He envelops the boy’s body while tasting every inch of his tight, twink torso while massaging his piece over his pants. Once he’s teased Lee to the limit, the boy turns the tables, unzipping the jock’s jeans... View Article

The post HelixStudios: Hayden Lee and Kane Fox appeared first on QueerClick.

Electronic Arts Drops Prices on iOS and Android Games

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, influences various signaling pathways in endothelial cells by binding to VEGFR2. In this study, we discovered that soluble endorepellin activates the canonical stress signaling pathway consisting of PERK, eIF2α, ATF4, and GADD45α. Specifically, endorepellin evoked transient activation of VEGFR2, which, in turn, phosphorylated PERK at Thr980. Subsequently, PERK phosphorylated eIF2α at Ser51, upregulating its downstream effector proteins ATF4 and GADD45α. RNAi-mediated knockdown of PERK or eIF2α abrogated the endorepellin-mediated up-regulation of GADD45α, the ultimate effector protein of this stress signaling cascade. To functionally validate these findings, we utilized an ex vivo model of angiogenesis. Exposure of the aortic rings embedded in 3D fibrillar collagen to recombinant endorepellin for 2–4 h activated PERK and induced GADD45α vis à vis vehicle-treated counterparts. Similar effects were obtained with the established cellular stress inducer tunicamycin. Notably, chronic exposure of aortic rings to endorepellin for 7–9 days markedly suppressed vessel sprouting, an angiostatic effect that was rescued by blocking PERK kinase activity. Our findings unravel a mechanism by which an extracellular matrix protein evokes stress signaling in endothelial cells, which leads to angiostasis.