Wall Street firms are expected to pay heftier bonuses for this year, the first increase since a bumper year in 2021, according to a report by compensation consultancy Johnson Associates. Payouts will probably rise after financiers benefited from several factors in recent months: a recovery in dealmaking, the Federal Reserve cutting interest rates and equity […]

Foreign Minister Constantinos Kombos met his Azeri counterpart on the sidelines of COP29, the first such contact from the state. Kombos had a bilateral meeting with Azeri Foreign Minister Jeyhun Bayramov, in Baku, Government Spokesman Konstantinos Letymbiotis posted on X. Letymbiotis said the two ministers had discussed issues of mutual interest in a frank exchange […]

to write the first sentence of a research paper

The first generation of stars changed the course of cosmic history. Now, thanks to the James Webb Space Telescope, we have a real chance of spotting them

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

A well in Nebraska is the first in the world to have been drilled in search of naturally occurring geologic hydrogen, but tests to determine how much of the gas it might supply are on hold because of a broken pump

In Iceland, scientists are planning to drill two boreholes to a reservoir of liquid rock. One will give us our first direct measurements of magma – the other could supercharge geothermal power

Long feted by fossil hunters and geologists, if UNESCO recognises the extraordinary rock formation at Madygen in Kyrgyzstan, it will soon be a player on the world stage

This year’s average global temperature is almost certain to exceed 1.5°C above pre-industrial times – a milestone that should spur urgent action, say climate scientists

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Korolevo, a site in Ukraine where early humans made stone tools, has been dated to 1.4 million years ago, suggesting early humans moved from Ukraine into the rest of Europe

The use of cocaine only took off in Europe during the 19th century, after the drug was chemically isolated from coca leaves, but new evidence suggests much earlier use

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Title: First Biosynthetic Corneas Implanted
Category: Health News
Created: 8/26/2010 10:54:00 AM
Last Editorial Review: 8/26/2010 10:54:57 AM

Title: Drinking Before First Pregnancy Raises Risk of Breast Cancer: Study
Category: Health News
Created: 8/28/2013 4:35:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM

Title: When It Comes to a Growing Child, the Brain Comes First
Category: Health News
Created: 8/26/2014 9:36:00 AM
Last Editorial Review: 8/26/2014 12:00:00 AM

Title: Health Tip: Preparing for the First Day of School
Category: Health News
Created: 8/27/2014 7:35:00 AM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: First Gene Therapy Approved in U.S.
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM

Title: Weight-Loss Drug Belviq Is First to Show No Harm to Heart
Category: Health News
Created: 8/27/2018 12:00:00 AM
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Title: First Death Tied to Lung Injury From Vaping Reported in Illinois
Category: Health News
Created: 8/23/2019 12:00:00 AM
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Title: Health Tip: Dislocation First Aid
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: AHA News: She Had a 20% Chance to Live First From a Stroke, Then From COVID-19
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Little Change in Number of Uninsured in Pandemic's First Year
Category: Health News
Created: 8/23/2021 12:00:00 AM
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Title: First Lady Jill Biden Leaves Isolation After Testing Negative for COVID Twice
Category: Health News
Created: 8/22/2022 12:00:00 AM
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Title: First Lady Jill Biden Tests Positive for COVID Again
Category: Health News
Created: 8/24/2022 12:00:00 AM
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Title: What Baby Food Should I Introduce First?
Category: Health and Living
Created: 6/16/2021 12:00:00 AM
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Background:

Nested within a growing body of evidence of a gender pay gap in medicine are more alarming recent findings from family medicine: a gender pay gap of 16% can be detected at a very early career stage. This article explores qualitative evidence of women’s experiences negotiating for their first job out of residency to ascertain women’s engagement with and approach to the negotiation process.

ABSTRACTToxicological emergencies present a significant health challenge in Nepal. Despite the high burden, the country has inadequate formal toxicology training, medical toxicology expertise, and adequate poison control infrastructure. In recognition of this need, the Nepal Poison Information Center (PIC) was established as a collaborative effort involving local and international partners. Through a comprehensive partnership framework, the Nepal PIC provides 24 hours a day, 7 days a week expert guidance to health care workers, conducts educational webinars, and engages in research. Initial data from the pilot phase indicate successful consultation delivery. Challenges include bureaucratic hurdles and the need for sustainable funding. Despite these challenges, the Nepal PIC demonstrates early feasibility and potential for expansion into a comprehensive toxicology center, contributing to the advancement of clinical toxicology in Nepal. Long-term sustainability relies on governmental support and continued advocacy efforts.

Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS), with a putative autoimmune origin and complex pathogenesis. Modification of the natural history of MS by reducing relapses and slowing disability accumulation was first attained in the 1990 s with the development of the first-generation disease-modifying therapies. Glatiramer acetate (GA), a copolymer of L-alanine, L-lysine, L-glutamic acid, and L-tyrosine, was discovered due to its ability to suppress the animal model of MS, experimental autoimmune encephalomyelitis. Extensive clinical trials and long-term assessments established the efficacy and the safety of GA. Furthermore, studies of the therapeutic processes induced by GA in animal models and in MS patients indicate that GA affects various levels of the innate and the adaptive immune response, generating deviation from proinflammatory to anti-inflammatory pathways. This includes competition for binding to antigen presenting cells; driving dendritic cells, monocytes, and B-cells toward anti-inflammatory responses; and stimulating T-helper 2 and T-regulatory cells. The immune cells stimulated by GA reach the CNS and secrete in situ anti-inflammatory cytokines alleviating the pathological processes. Furthermore, cumulative findings reveal that in addition to its immunomodulatory effect, GA promotes neuroprotective repair processes such as neurotrophic factors secretion, remyelination, and neurogenesis. This review aims to provide an overview of MS pathology diagnosis and treatment as well as the diverse mechanism of action of GA.

A nudibranch from the midnight zone has fingers on its tail, collects food with a hood, and glows.

WASHINGTON — Secretary of State Rex Tillerson says diplomatic efforts aimed at resolving the North Korean crisis “will continue until the first bomb drops.”

That statement comes despite President Donald Trump’s tweets a couple of weeks ago that his chief envoy was “wasting his time” trying to negotiate with “Little Rocket Man,” a mocking nickname Trump has given the nuclear-armed nation’s leader, Kim Jong Un.

“I think he does want to be clear with Kim Jong Un and that regime in North Korea that he has military preparations ready to go and he has those military options on the table. And we have spent substantial time actually perfecting those,” Tillerson told CNN’s “State of the Union” on Sunday. “But be clear: The president has also made clear to me that he wants this solved diplomatically. He’s not seeking to go to war.”

Recent mixed messaging from the top of the U.S. government has raised concerns about the potential for miscalculation amid the increasingly bellicose exchange of words by Trump and the North Korean leader.

Trump told the U.N. General Assembly last month that if the U.S. is “forced to defend itself or its allies, we will have no choice but to totally destroy North Korea.” Trump also tweeted that Korea’s leadership “won’t be around much longer” if it continued its provocations, a declaration that led the North’s foreign minister to assert that Trump had “declared war on our country.”

Tillerson acknowledged during a recent trip to Beijing that the Trump administration was keeping open direct channels of communications with North Korea and probing the North’s willingness to talk. He provided no elaboration about those channels or the substance of any discussions.

Soon after, Trump took to Twitter, saying he had told “our wonderful Secretary of State, that he is wasting his time trying to negotiate with Little Rocket Man … Save your energy Rex, we’ll do what has to be done!” Trump offered no further explanation, but he said all military options are on the table for dealing with North Korea’s nuclear and missile programs.

Analysts have speculated about whether the president and his top diplomat were playing “good cop, bad cop” with North Korea, and how China might interpret the confusing signals from Washington. Beijing is the North’s main trading partner, and the U.S. is counting on China to enforce U.N. sanctions.

“Rest assured that the Chinese are not confused in any way what the American policy towards North Korea (is) or what our actions and efforts are directed at,” Tillerson said.

Asked if Trump’s tweets undermined Tillerson, the secretary said: “I think what the president is doing is he’s trying to motivate action on a number of people’s part, in particular the regime in North Korea. I think he does want to be clear with Kim Jong Un and that regime in North Korea that he has military preparations ready to go and he has those military options on the table and we have spent substantial time perfecting those.”

He added that Trump “has made it clear to me to continue my diplomatic efforts, which we are, and I’ve told others those diplomatic efforts will continue until the first bomb drops.”

North Korea has launched missiles that potentially can strike the U.S. mainland and recently conducted its largest ever underground nuclear explosion. It has threatened to explode another nuclear bomb above the Pacific.

The post Rex Tillerson says continue diplomacy with North Korea ‘until first bomb drops’ appeared first on PBS NewsHour.

The flats are described as the first new homes on the Scottish town's High Street 'in living memory'

The plane is hailed as 'one of the most advanced aircraft available on the market'

A rail service linking Scotland, Wales and England with one train journey is to start running for the first time. 

A baroque fiddle believed to have been played by Robert Burns will be performed live on stage in the United States for the first time.

A new digital-first Gaelic language production will be launched in Scotland after a joint agreement between BBC Alba and BBC Scotland.

It’s a tiny cast with just Chris, Anna Marie, and Kelley. PS5 blood money is being thrown around, while Kelley curses the asthma tax. Chris is simulating his real life job in a game that simulates his job. Anna Marie re-discovers she doesn’t like SMT. And everyone agrees cutscenes need both pause and skip options.

The post RPG Cast – Episode 592: “First World Donut Problems” appeared first on RPGamer.

It’s tempting to frame Straftat as a throwback to an older, better time for the multiplayer FPS, when the lingo was coded in frags and gibs and sucking it down, when satisfaction was drawn entirely from performance rather than some convoluted, artificial system of progression. Not only would this be inaccurate, but it would also do a disservice to what Straftat truly is, namely a wild overcorrection in response to the direction of modern multiplayer gunfests, one that careens straight through retro stations to arrive somewhere new and exciting.

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Call Of Duty: Black Ops 6 has been out for a little while already, what with me giving its multiplayer largely a thumbs up. Still, it's an ever-evolving thing and Activision have announced the game's first seasonal drop. It's a hefty one with a lot of additions, so I'll try my best to break down the good stuff. TLDR: there's some new maps for multiplayer and zombies, new modes, and a few extra bits. I'm mildly excited for more. More in this case is good.

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The first generation of stars changed the course of cosmic history. Now, thanks to the James Webb Space Telescope, we have a real chance of spotting them

Four private astronauts are riding a SpaceX Crew Dragon capsule further from Earth than any human since 1972, where they will attempt the first ever civilian spacewalk

If you were standing on Mars as it was hit by charged particles from the sun, you might be able to see an aurora just like on Earth

The Euclid space telescope's massive “cosmic atlas” promises to shed light on fundamental questions in physics and cosmology

The first “failed star” ever discovered has been a weird outlier since it was found nearly 30 years ago. New observations show that it is unusually massive because it isn’t a single star after all

Complex carbon-based molecules crucial to life on Earth originated somewhere in space, but we didn't know where. Now, huge amounts of them have been spotted in a huge, cold cloud of gas

Scientists are using machine learning to decode and eventually translate how sperm whales communicate with Morse code-like clicks and pauses.

Senate Republicans on Wednesday will elect a new party leader for the first time in nearly two decades.

Marin Cilic has experienced many great moments on court in recent years, but the 18-time tour-level titlist announced that he will enjoy a milestone moment off the court in 2020. Speaking to his 170,000 followers on Twitter, the Croat shared the news that he will become a father next year. The news comes just 18 months after Cilic married Kristina Milkovic in Dubrovnik. Cilic’s announcement was accompanied by a photo of the 31-year-old shopping for a pushchair. New ride ?? ?? Excited to share with you all that #teamCilic will be growing. New member joining us in 2020 ???????? pic.twitter.com/m0Qxn6AdQB — Marin Cilic (@cilic_marin) 7 October 2019 Cilic will compete at next week’s VTB Kremlin Cup in Moscow, where he will be aiming to achieve his 500th tour-level victory. If Cilic achieves the feat, he would become the 10th active player on the ATP Tour to reach that mark..