Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

BACKGROUND The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1.METHODS We performed multiple assays to dissect the immune responses induced in humans (n = 12) receiving BPZE1, with particular emphasis on the magnitude and characteristics of the antibody responses. Such responses were benchmarked to adolescents (n = 12) receiving the complete vaccination program of the currently used acellular pertussis vaccine (aPV). Using immunoproteomics analysis, potentially novel immunogenic B. pertussis antigens were identified.RESULTS All BPZE1 vaccinees showed robust B. pertussis–specific antibody responses with regard to significant increase in 1 or more of the following parameters: IgG, IgA, and memory B cells to B. pertussis antigens. BPZE1–specific T cells showed a Th1 phenotype, and the IgG exclusively consisted of IgG1 and IgG3. In contrast, all aPV vaccines showed a Th2-biased response. Immunoproteomics profiling revealed that BPZE1 elicited broader and different antibody specificities to B. pertussis antigens as compared with the aPV that primarily induced antibodies to the vaccine antigens. Moreover, BPZE1 was superior at inducing opsonizing antibodies that stimulated ROS production in neutrophils and enhanced bactericidal function, which was in line with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSION The breadth of the antibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects of improving vaccine efficacy and protection against B. pertussis transmission.TRIAL REGISTRATION ClinicalTrials.gov NCT02453048, NCT00870350.FUNDING ILiAD Biotechnologies, Swedish Research Council (Vetenskapsrådet), Swedish Heart-Lung Foundation.

You read that right. Joanne and I visited a Masonic Cemetary. Alone. It was one of the most calming experiences of my life. We were kind of invited, by the town, and when we arrived, we were definitely welcomed by the residents. This all started when, in the brochure listing the “town attractions” that we received in St. Helens, were two cemeteries. The addresses as well as short descriptions were listed, as well as a short missive asking us to please be respectful and not make loud noises. It sounded really creepy and really interesting, so both of us jumped at the chance to drive out there right before sunset. They weren’t what I expected at all… Well, the first one was actually roped off with a “no trespassing” sign hanging from it, so we didn’t go inside. It was right alongside the highway in Oregon, across some old train tracks, visible from the road, and named and marked on a tourist map, yet they didn’t want visitors. I wonder what happened there. In any case, we headed for the other cemetery. This one was removed from the main road, and rumored to be a lot larger. It was also known to be haunted, but visitors were welcome as long as they were respectful. Off the map it was, but when we arrived, it was also gated off. A sad Joanne looks through the gate at the second destination that was cut off from us. Ah, but unlike the other cemetery, this one didn’t have a “no tresspassing” sign. There was a clear path around the sides of the gate, the ground bare of grass and obviously well-traversed. Apparently a lot of people walked around the gate. Maybe they just didn’t want us to drive. We decided to walk. There was even a sign. And a long, winding, steep road through the forest.  It was quite a hike to reach the top of the large hill where the cemetery was supposedly located, but the view was breathtaking. It took us a good ten or fifteen minutes to reach the top, and the road was quite steep. For some reason, to the immediate right of the trail, someone had been excavating land for quite some time, and there was a deep quarry. Why someone would dig a quarry next to a burial ground is beside me. I don’t doubt that the residents were unhappy about it. I wondered if maybe I would feel some spirits, but I didn’t expect what really happened to me. As soon as I stepped off of the road and onto the grass, a calm unlike anything I’ve ever felt descended upon me. It enveloped me in a warm cocoon, and Joanne and I immediately separated and wandered quietly alone between the gravestones. I know, 100%, that not only was I welcomed, but that the residents were happy to have me there. I talked a bit with some of the gravestones, but mostly wandered about, amazed at how much serenity I felt. We must have spent around a half hour wandering quietly alone, together, before we left in order to return to the festivities in town. But I’ll never forget the experience. It was something really, really special. I took some video footage too, but I’m not sure yet whether I want to use it. We’ll see! Someday, I’ll set up a tripod and get a shot of me walking like this. But for now, have Joanne instead. ???? <3

Amazon is taking up to $100 off the Apple Watch Series 5 this week, with prices starting at $299.99 for the 40mm GPS models. Only the Gold Aluminum Case with Pink Sport Band is available at this price. If you order today, the Apple Watch should arrive sometime next week.

Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.

The Apple Watch Series 5 was released in September 2019 with a new OLED screen that supports an always-on feature, which represents the biggest change to the Series 5 models. The newest Apple Watch is available in 40mm and 44mm sizes, and it has the overall same design as the Series 4 models.

$100 OFF

Apple Watch S5 (40mm, GPS) for $299.99

If you're shopping for a cellular model, there are also a few solid discounts on Amazon for these devices. You can get the Gold Aluminum Case with Pink Sport Band (40mm) for $399.00, down from $499.00. Likewise, the Silver Aluminum Case with White Sport Band (40mm) is $399.00 right now.

For the 44mm cellular models, a solid deal is the Space Gray Aluminum Case with Black Sport Band at $429.00, down from $529.00. You'll find the same price on the Silver Aluminum Case with White Sport Band and the Gold Aluminum Case with Pink Sport Band.

Across the board, these sales are either new low prices on the Apple Watch Series 5, or they're matching previous low prices seen on these models on Amazon. There are a few other deals going on for different Series 5 models as well, including numerous 44mm cellular devices that are about $50 off Apple's original prices. Be sure to head to Amazon to check out the full sale before these prices expire, or the retailer runs out of stock.

Keep up with all of this week's best discounts on Apple products and related accessories in our dedicated Apple Deals roundup.
This article, "Deals: Apple Watch Series 5 Models Discounted by Up to $100 on Amazon" first appeared on MacRumors.com

Discuss this article in our forums

Apple's plan to release an updated version of AirPods later this year has been delayed due to the global health crisis, according to the Nikkei Asian Review.


This lines up with a recent report from analyst Ming-Chi Kuo, who said that mass production of third-generation AirPods will begin in the first half of 2021, followed by mass production of second-generation AirPods Pro between the fourth quarter of 2021 and the first quarter of 2022. Kuo also expects Apple's rumored high-end over-ear headphones to enter mass production at some point in mid-2020.

Kuo did acknowledge rumors of new AirPods coming in the second half of 2020, but he said they are "more likely to be the new Beats model." Last month, leaker Jon Prosser claimed that Apple was planning to release so-called "AirPods X" around September or October with a BeatsX-like design for sports and running.

Apple's second-generation AirPods launched in March 2019, while the AirPods Pro were released at the end of October.

This article, "Apple's Plan to Introduce New AirPods Later This Year Reportedly Delayed" first appeared on MacRumors.com

Discuss this article in our forums

A great many people only experience science fiction by what my mother and millions of others referred to as "monster movies". From Frankenstein to Aliens and beyond, the unknown and the unexplored are often our undoing. Bleak Horizons, edited by Tarl Hoch, is a wonderful collection of 15 stories that mix SF and Horror with various levels of anthropomorphic settings and characters. And, full disclosure, one of those stories is mine. Happily, the mix includes more than just blood thirsty monsters and end of the universe scenarios.

Overall my favorite stories in this anthology are Hardwire, Pentangle, and The Ouroboros Plate. My least favorites are 4/13/2060 and Not Like Us. Below is a short review of all the pieces. I think you should snag a copy, if only to read my favorites and have a taste for this genre. However, I also really enjoyed Carmen Miranda's Ghost Is Haunting Space Station 3 so you have every right to question my taste.

read more

The Senate considered H.R. 1314, the legislative vehicle for trade promotion authority reauthorization.?It would give the president broad fast-track authority when negotiating trade agreements and require Congress to consider treaties without an amendment process. Senator Bernie Sanders speaks out against this bill before the Senate on May 12, 2015. Continue reading →

Read the text of Senator Bernie Sanders bill to make college tuition free for students and to be financed by a tax on Wall Street speculation. WASHINGTON, May 19 – Sen. Bernie Sanders (I-Vt.) today introduced legislation to make 4-year public colleges and universities tuition free. “We live in a highly competitive global economy. If our economy is to be strong, we need the best educated work force in the world. That will not happen if every year hundreds of thousands of bright young people cannot afford to go to college and if millions more leave school deeply in debt,” Sanders said. Under the legislation, $70 billion a year in assistance – two-thirds from the federal government and one-third from states – would replace what public colleges and universities now charge in tuition and fees. The federal share of the cost would be offset by imposing a tax on Wall Street transactions by investment houses, hedge funds and other speculators. The legislation also would overhaul student loan programs so students and their parents could reduce crushing debt loads which now exceed Americans’ credit card debt. Federal profits on loans would be eliminated, work-study programs expanded and incentives offered for colleges and universities to keep costs down. “We once led the world in the percentage of our people with a college degree, now we are in 12th place.” Sanders said. “Countries like Germany, Denmark, Sweden and many more are providing free or inexpensive higher education for their young people. They understand how important it is to be investing in their youth. We should be doing the same,” he added. Tuition at 4-year public colleges and universities rose by 50 percent in the United States during the past decade. As state governments have cut support for higher education, the burden has shifted to students and their parents. With this spring’s college commencement season underway, the class of 2015 is the most indebted class in American history, according to Mark Kantrowitz, publisher of Edvisors, a website on college costs and financial aid. Continue reading →

Even though Corporate America has anointed Hillary Clinton as its next President, Senator Bernie Sanders' populist message is already in a week's time raising individual contributions totaling millions of dollars from hundreds of thousands of people! Continue reading →

Video and transcript of Farron Cousins' discussion of Hillary Clinton's fake populism on Ring of Fire TV, May 18, 2015. Continue reading →

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading →

When longtime independent Senator Bernie Sanders lost his bid for the Democratic presidential nomination, he concluded his campaign by endorsing Hillary Clinton instead of a third-party candidate. "This huge, wonderful effort that he launched is now aborted," says our guest, four-time former presidential candidate Ralph Nader. "Sanders hasn’t returned a call from me in 18 years. He is a lone ranger. He doesn’t like to be pushed into more progressive action than he is willing to adhere to. As a result, millions of his voters now are in disarray. They don’t know where to go." Nader has a new book titled "Breaking Through Power: It’s Easier Than We Think." Continue reading →

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading →

The sweetheart deal that Governor Malloy and his fellow Democrats in the General Assembly cut with state employee unions, the so-called SEBAC agreement, is protected by contract for a full decade —leaving meaningful reforms waaay down the road. The contract is the mother of all can-kicks. Continue reading →

TED NUGENT в рамках разговора с "The Joe Pags Show" подверг критике губернатора Мичигана Гретхен Уитмер за жёсткие требования находиться дома из-за пандемии COVID-19.

Губернатор-демократ в прошлом месяце продлила одно из самых жёстких в стране предписаний по нахождению по домам в целях предотвращения распространения коронавируса. Согласно этому предписанию, запрещаются все виды работ, кроме жизненно важных. Уитмер сказала, что введение одних из самых жёстких ограничений в стране необходимо из-за того, что стремительно растёт число случаев и смертей, которые грозят перегрузкой больниц.

Nugent, который переехал в Техас из Мичигана в 2005 году, прокомментировл агрессивный приказ Уитмер «оставаться по домам»:

«Есть все доказательства — нельзя отрицать неопровержимые доказательства того, что у либералов аллергия на здравый смысл, логику, Конституцию, понимание того, что мы, люди, наняли их на основании их клятвы Конституции, которая ограничивает их власть; но это вовсе не ограничивает нашу власть.

Я каждый день благодарю Бога за Нэнси Пелосис и Гретхен Уитмерс, потому что они настолько оскорбительны, настолько прогнили до глубины души, настолько нечестны и не сколько злоупотребляют властью, сколько навязывают власть другим людям.

Гретхен Уитмер — это позор для хороших, порядочных, трудолюбивых американских семей, особенно в моём любимом штате Мичиган, откуда я родом.

Это не её вина. Это апатия консерваторов, которые не голосовали...

Если бы мы с тобой говорили 20 лет назад, то это было бы моим первым осуждением Американской Мечты — апатия привела к тиранам у власти и преступникам вроде [бывшего директора ФБР] Джеймса Коми и [бывшего директора ЦРУ] Джона Бреннана и Гретхен Уитмер».

Nugent также защищал сотни демонстрантов, протестовавших против чрезвычайных мер в Мичигане в связи с коронавирусом. Во вторник Уитмер утверждала, что некоторые из людей, устроивших демонстрацию в здании Капитолия штата, «несли петли, флаги Конфедерации и свастики».

Nugent продолжил:

«Гретхен Уитмер не только противная, но вдобавок и лгунья. Она утверждала, что там были парни с автоматическим оружием. Я точно знаю, что в этом протесте не было ни одного автомата. Они лжецы — они лгут, они лгут, они лгут. Они одержимы ненавистью к свободе и индивидуальному выбору по некоторым вопросам, но потом они заставляют сделать этот индивидуальный выбор всем остальным по другим вопросам — нужно ли что-то ещё объяснить?

Итак, да благословит Господь протестующих, но сейчас время гражданского неповиновения незаконным законам, несправедливым указам, и я горжусь тем, что это происходит. И семья Nugent стоит плечом к плечу со всеми этими великими независимыми, свободолюбивыми... Нельзя просто любить свободу — нужно её требовать. Так что благослови их Господь!» #Ted_Nugent #TedNugent #HardRock #Hard_Rock

Criminal Minds newcomer Damon Gupton (Stephen Walker) celebrated his birthday yesterday, January 4. He was born on that day in 1973. Here...

An updated Disaster Resilience Scorecard to help cities and local government agencies improve their preparedness and reduce risks from disasters was launched today at the Global Platform for Disaster Risk Reduction. Developed for the UN Office for Disaster Risk Reduction by AECOM, IBM with support from USAID and the European Commission, the Scorecard gives better access to information, knowledge resources, and tools to effectively reduce risks from the impacts of natural hazards and climate change.

Taking place tomorrow 1:00PM PT/4:00PM ET

The post WB announces a watch party for JL DARK: APOKOLIPS WAR, the endgame of the DC Animated Movie Universe appeared first on The Beat.

PSA Peugeot Citroën and IBM today announced a partnership to help various industries within the Internet of Things economy to analyze data to deliver new services from connected vehicles.

Each year, weather-related power outages cost the U.S. economy as much as $33 billion a year. Additionally, one severe weather event has the potential to impact the daily lives and routines of millions of people. As 2017 marks the fifth anniversary of Superstorm Sandy, The Weather Company, an IBM Business (NYSE: IBM) and Zpryme are releasing the results of a survey that found that U.S. utility companies still feel underprepared for weather-related outages and that their reactive approach to outage prediction leads to lost time and resources.

IBM and SAP SE have teamed up to provide a co-innovated solution for the retail and consumer packaged goods industries to help both increase profitability and improve the consumer experience.

MAP Health Management and IBM Watson Health today announced a partnership that aims to address the pervasive problem of relapse among Americans suffering from Substance Use Disorder, a chronic disease. MAP will integrate Watson cognitive technologies into the MAP Recovery Network Platform to enhance the platform’s existing capabilities around patient risk models. In doing so, it is anticipated that behavioral health and substance abuse treatment providers that use the MAP platform will be better able to predict and prevent incidence of relapse nationwide.

I posted a second round of pirate signs and heard from the city parking manager.

was inspired to make a giant geometrical shape, that of the 20-side die, or isocahedron.

A few people sent in STL files for their 3D models. Here's what they look like in plastic!

IBM is bringing its expertise in sports venue infrastructure design and implementation to the practice field for newly formed Major League Soccer Club, Atlanta United, providing a year-round, state-of-the art technological experience for the players and staff.

La Universidad Anáhuac México e IBM México celebraron hoy la firma de la Cátedra Corporativa en beneficio de la comunidad universitaria. El acuerdo fue signado por el Dr. Cipriano Sánchez, LC, Rector de la Universidad Anáhuac México y Antonio Martins, Presidente y Gerente General de IBM México.

ASL to benefit from IBM Cloud and IBM PureApplication to deliver for secure real time payments for NPP Australia

IBM Watson Customer Engagement tools help extend the Bank’s leadership in customer experience.

One of Australia’s leading digital banks taps cognitive technology to simplify the home loan application process with innovative virtual assistan

Six-year-old Teddy Lupin was feeling unnaturally nervous. One-shot Teddy's speech for his primary school about his parents, or people like his parents. R&R!

My week has been stressful. They called Thursday and offered me the half-time job. They needed to know that day -- we haven't heard back on the lucrative job James has applied for, so I declined, citing the fact that I'm the only breadwinner and James hasn't heard back about the job he was waiting to hear from (I didn't mention to the HR person that it's a job at my same employer, because it's probably not her fault they're lagging on his job, and I'm not an asshole). She wanted to know when I'd know, and I said, "Well, I was supposed to know two weeks ago, so I mean, soon, I hope, but no guarantees."

She called me back an hour later and offered to give me a week to decide (because they actually don't want the other two people who interviewed, is my surmise), so yeah, rollercoaster day on Thursday.

And then a student's mom called and cussed me out for like half an hour. I don't take that stuff personally, but it does wear on me. My co-workers marvelled over and over about how calm I stayed, and I said (and I meant it), "She was frustrated. That's understandable. And I don't have to attend every fight I'm invited to," which became a theme for the week.

My mom got in a fracas with another member of her senior center, and I shared my week's theme with her. I think she felt a little chastised, but she also seemed to latch onto the theme as a potential sanity saver.

And then today at the donut shop, I accidentally passed up another person who was waiting to pay (because I followed the person who gave me our donuts to the register and didn't notice the other person who was standing away from the registers at the window. She berated me for many minutes about how rude I was, and how I should give a bitch some space, and how in America, we call this White Privilege, and and and... I just apologized, didn't engage beyond that, (felt frankly detached and mildly amused -- not sure what that says about me) and then once she'd left, the cashier apologized to me for the customer.

Me: "Nah, she's not wrong. I didn't see her, but I did cut in front of her."

I mean, I don't like being yelled at, or having people behave in ways that I perceive as rude towards me, but I'm not gonna fault someone for standing up for their space when I've violated it, so long as they're not hitting me or something. Not a fight I need to get into; not a hill I'm gonna die on.

So yeah, stressful week for many reasons, but not something that's gonna ruin my Saturday, which will now be completed by spending many many many hours writing and catching up on webcomics.

And how are YOU, dear ones?

comments

May the 4th be with you with these special sales and discounts on items from around the galaxy.

Celebrate May the 4th with Death Star-sized deals on some the biggest Star Wars games.

Hello Everyone!

Chapter 02 of Starfighter has officially begun! I have really been looking forward to this moment and hope you enjoy the next installment of the story. With the first chapter of Starfighter in the capable hands of our printers, I am now free to work on pages again! Thank you so much for your patience and support; it is truly appreciated!

If you haven't already, feel free to check out the shop and subscribe to the RSS feed!

Much love, - HamletMachine

In the latest episode of their thoroughly vetted podcast, Ken and Robin talk converting standard GUMSHOE scenarios to QuickShock, a Ukraine mole, QuestWorlds with Ian Cooper, and moving Lovecraft to Chicago.

Laundry. Built deer protection for my garden. Purchased materials for deer protection for my apple trees. Dishes. Mended one sweater and one pair of jeans. Reinforced neckline on another sweater in an attempt to have it fit better. Culled my wardrobe. Verified that garden deer protection withstands wind warning type winds.

Anyone know what this lovely tree is? Spotted in Mills Park.

The Worst Things For Sale is Drew's blog. It updates every day. Subscribe to the Worst Things For Sale RSS!