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BODIPY(aryl)iodonium salts in the efficient synthesis of diversely functionalized BODIPYs and selective detection of serum albumin

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00336E, Paper
Open Access
Bintu Kumar, Anindita Bhatta, Prakriti Saraf, Taur Prakash Pandurang, Krishnan Rangan, Madhushree Sarkar, Sivaprasad Mitra, Dalip Kumar
Using readily available BODIPY and iodoarenes various BODIPY(aryl)iodonium salts were prepared and successfully utilized for the direct syntheses of functionalized BODIPYs, bis-BODIPYs and for the selective detection of serum protein.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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New 2-pyridone-based donor–acceptor dyes: the effect of the donor group position, type of π-linker and acid–base characteristics of the medium on the photophysical properties

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00177J, Paper
Saveliy P. Sorokin, Mikhail Yu. Ievlev, Oleg V. Ershov
Synthesis of a series of new donor–acceptor dyes based on 2-pyridone and the study of the effect of the position of the donor group, the type of π-linker and the acid–base characteristics of the medium on their photophysical properties.
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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00190G, Paper
Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00238E, Communication
Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
A method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.
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HFIP-mediated C-3-alkylation of indoles and synthesis of indolo[2,3-b]quinolines & related natural products

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00414K, Paper
Auqib Rashid, Waseem I. Lone, Preeti Dogra, Showkat Rashid, Bilal A. Bhat
An expeditious metal free C-3 alkylation of indoles and its NIS-mediated deviation to indolo[2,3-b]quinolines is reported. Applications of these strategies in accessing bioactive natural products have also been demonstrated.
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Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids

Org. Biomol. Chem., 2024, 22,2948-2952
DOI: 10.1039/D4OB00233D, Communication
Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
An expeditious diatereoselective synthesis of pyrano[2,3-c]pyrroles thanks to a domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction to alkylidene Meldrum's acid derivatives.
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Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics

Org. Biomol. Chem., 2024, 22,2974-2977
DOI: 10.1039/D4OB00278D, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew Nutter, Henry Stone, Michael Shipman, Stefan Roesner
Stereoselective synthesis of both enantiomers of orthogonally protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol and its application in peptidomimetics.
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Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)–H functionalization of indolin-2-ones

Org. Biomol. Chem., 2024, 22,3073-3079
DOI: 10.1039/D4OB00133H, Paper
Wei Chen, Lang-Qi Wen, Xiao-Bing Lu, Hui Zhou
We have developed a clean and efficient iron-catalyzed C(sp3)–H functionalization of indolin-2-ones for the chemodivergent synthesis of value-added indole derivatives, including isatins, and symmetrical and non-symmetrical isoindigos.
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Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00421C, Communication
Srinivasarao Yaragorla, Tabassum Khan, Sayonika Chakroborty
We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)2/HFIP as the excellent promoter system.
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Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
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How long do commercial aircraft last?

What airlines can do to extend the longevity of their fleet




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Wanted: A booster dose for airlines

As vaccination numbers increase, airlines and the government look for the middle path to revive the beleagured travel sector




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A time when hijackings were dime-a-dozen in the US

Unthinkable in today’s hyper-security post-9/11 environment, forced diversions were commonplace in the ’60s




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Indian aviation: A study in paradox

Accurate reading of the market is critical




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Domestic air travel leads airline recovery: Boeing

Low-cost carriers aid market with point-to-point structure and affordable rates




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Tech adoption will not lead to loss of jobs

Every half per cent increase in GDP requires 10 per cent growth in travel




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Breaking down airline engineering and maintenance

An aircraft has three critical phases; induction, in-service and redelivery




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Domestic airline industry may face a rejig

The pandemic laid bare fault-lines within India’s airlines




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Do pilots really need to be good at maths?

Being accurate with calculations can never go wrong




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Why do planes leave a white trail behind them?




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Why do plane crashes happen?




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How do commercial aircraft navigate?




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Why opening the emergency door mid-flight is not possible




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Why do planes dump excess fuel in the sky?




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 Instagram downgrades quality of less popular videos

Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were




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Indonesia bans sales of Google phones days after blocking Apple's iPhone 16

Indonesia said it has banned sales of smartphones made by Alphabet's Google due to rules requiring the use of locally manufactured components




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Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy

YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion




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Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies

Global efforts to understand and manage long Covid post-pandemic, with varied symptoms and limited treatment guidelines worldwide




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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Doctors stress healthy lifestyle, regular check-up to prevent strokes in young adults

The webinar was held as part of The Hindu’s Wellness Series




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Lifestyle changes a major cause for stroke, say doctors

Speaking at a public awareness meeting organised at GRH on the occasion of World Stroke Day on Tuesday, Dr. Murugan, attributed these negative factors to a sedentary lifestyle because of the youth’s job nature and location




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As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors




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Doctors urge National Medical Commission to simplify centralised registration process

The register is a centralised repository that contains the name, address, and qualifications of licensed medical practitioners; however the registration process is complex and cumbersome, say doctors




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The Hrithik Roshan You Don't Know

'Later, I asked Hrithik how he could have remained so calm in the circumstances. He told me simply, "What could have happened? At the most, they would have killed me".'




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'Katrina didn't want to do Tamil version'

'It would have made (Producer) Ramesh Taurani very happy if I taken two Bombay stars, but the reason why I kept mentally rejecting the regular sort of casting was to discover this excitement, you know, can I crack it?'




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'I don't like people messing with me'

'Television actors are people who play with fire.'




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'Life is all about ups and downs'

'When one is low, all you can do is buckle up and get up and prepare for the next challenge.'




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'I haven't done homework for my films'

'I am a spontaneous actor. I follow what works for the character.'




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'Women don't have to only sing and dance'

'When you are new, you don't know how the industry works'. 'But when you know where you are headed, the possibilities of being conned or facing unpleasant instances is reduced.'




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What's This American Doing In Bollywood?

'In India, I'm able to work with the biggest stars on creating a scene, creating that emotion, without being too hung up on their persona.'





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'Oh My God! We've Done Something Great'

'The real change will happen when more powerful roles come to me.''I am looking forward to that change.'




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What Happened To Alka Yagnik: A Doctor...

'The earlier you get your treatment done, the better the chance of recovery.'




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'I Don't Preach About Keeping Two Wives'

'My primary reason to participate was -- and I told my wives as well -- that the three of us would live happily together on the show and create history. We would make sure that people remember us for the longest time.'




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'Don't Involve My Family!'

'My weakness is my family, and the people I love.''I don't think I will receive any kind of backlash from the audience because I am not someone who drags someone's family into fights and arguments.'




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'Stars Don't Make A Movie But Vice-Versa'

'Stars have made stacks of wealth at the cost of the rest of the film industry.'