Rail prides itself as being a green alternative to competing modes of transport, and with hydrogen-powered trains now a viable proposition, can this fuel a step-change in the pursuit of new low carbon rail services? There have been a number of recen...

With the dust settling after the recent General Election, it is possible to better speculate as to the likely direction of travel of the new Conservative government. The new administration has a slim majority, therefore, there still may be an elemen...

Default retirement age to be abolished next year The Government has this morning confirmed that it plans to abolish the default retirement age (DRA) next year. The aim is that from 6 April 2011 the statutory retirement procedure in Schedule 6 of th...

On 16 October 2019, the FCA published their feedback statement FS19/6 on Climate Change and Green Finance[1]. This feedback statement summarises the responses from stakeholders to the Discussion Paper (DP18/8) on Climate Change and Green Finance[2] ...

Falkland Islands schools in Stanley are making final preparations for reopening on Monday, May 11. Camp Education, an integral part of the schooling system also re-opens on the same day.

The Minister of Health, Dr Osagie Ehanire, says the federal government needs to re-engage the Kogi State Governor, Yahaya Bello so he can allow officials of the Nigeria Centre for Disease Control, NCDC, test residents for COVID-19. Recall that the NCDC officials sent to the State had returned to Abuja after Bello ordered them to […]

COVID-19: FG reveals next line of action on Kogi

In light of the recent two-week extension of the lockdown, there is a lot of uncertainty regarding what may possibly transpire at the end of the lockdown period. There is also uncertainty regarding the extent of the Government’s powers, in res...

With the dust settling after the recent General Election, it is possible to better speculate as to the likely direction of travel of the new Conservative government. The new administration has a slim majority, therefore, there still may be an elemen...

UK GOVERNMENT RECOGNISES ROUTE TO MARKET CHALLENGES AND SHOWS SIGNIFICANT SHIFT IN APPROACH FOR UK RENEWABLES On 2 March 2020, the UK Department for Business, Energy and Industrial Strategy (BEIS) published a consultation on the Contracts for Differ...

Earlier this week, the Internet revisited clips of America’s Next Top Model, which premiered in 2003 on UPN and has aged pretty badly ever since, in which host ... More » ......

THE Supreme Court will raffle off next week media giant ABS-CBN’s petition to set aside the closure order issued by the National Telecommunications Commission (NTC). “The petition will be raffled to a member-in-charge on Monday, 11 May 2020, who will then make a recommendation for the consideration of the Court en banc,” Brian Keith Hosaka, […]

Efforts to fast-track the opening of pubs next month have been delivered a body blow by Chief Medical Officer Dr Tony Holohan.

Israeli doctors and scientists look back at how the country has handled COVID-19 and predict what might happen next

Shopping malls, gyms and amusement parks, considered high-density venues, are expected to reopen next if the number of new Covid-19 infections continues to drop for another week.

China’s will face an increasingly hostile world over the next five years, meaning its policy plan should be focused on its vast domestic market, home-grown technological innovation and improving its citizens’ welfare, according to recommendations in a new paper.The report by the Chinese Academy of Social Sciences (CASS), a think tank affiliated with the State Council, foresees the next five years presenting “major changes unseen in a century” for China, as “the strategic game between…

As the coronavirus death toll surpasses 250,000 and the world scrambles to find a vaccine, a new scientific task force is headed to the wilderness to try and stop the next pandemic.After decades of patchy global investment into researching the linkages between animal and human health, more than 40 scientists will embark on an Australian government-funded programme that will teach veterinary surgeons in Southeast Asia and the Pacific how to detect infectious diseases – before they make the leap…

Sanjay Leela Bhansali wants to cast Ranbir Kapoor, Deepika Padukone for his next film

Netflix says the first two seasons of 'Keeping Up With The Kardashians' are arriving next month

Madrid and Barcelona will not progress to the next phase of Spain's exit from one of Europe’s strictest lockdowns that will allow bars, restaurants and places of worship to reopen in some areas from Monday, the government announced.

The pandemic has highlighted the shortcomings of the globalized supply chain model.

Investments in climate-resilient infrastructure should be the centerpiece of the billions of dollars in economic stimulus being used to rebuild Asia’s economies.

Colorado Springs is the beachhead. But it's always been clear In-N-Out Burger planned to feed its fanatical following along the Front Range by building more than just the one restaurant coming to that city in 2020.

Next-Generation Miniaturized Rubidium Atomic Clock Improves Performance and adds Features without Increasing Size

New Delhi: Nearly 60 percent of Indians think that next one month would be a good time to buy real estate with improvement in consumer sentiments following formation of a stable government, according to a survey by global research firm Ipsos. “Almost six in ten (57 percent) Indians think the next 30 days will be a good time to buy real estate, such as a house, vacation property or investment property,” Ipsos said in a statement. Founded in France in 1975, Ipsos is an independent market research company controlled and managed by research professionals. “With the formation of a new stable government at the Centre, the consumer sentiment which was […]

AN3467 - Crystals and Oscillators for Next Generation Timing Solutions

CES 2016, Las Vegas – Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced the next generation of the Infinity® Kappa Series Subwoofers. The...

CES 2017, Las Vegas – January 4, 2017 - Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced the Infinity BassLink DC compact powered ...

Google's quantum computer can outpace supercomputers at a useless calculation, but there are still plenty of hurdles left before the technology hits the big time

LOS ANGELES, CA – HARMAN (NYSE: HAR), the premier global audio and infotainment group, is making its mark at this year’s Los Angeles Auto Show with several leading automakers debuting vehicles that feature HARMAN branded audio systems. With brands like Harman Kardon, JBL, Infinity, Mark Levinson and Lexicon, HARMAN technology and solutions can be found on automaker stands throughout the show -- a reflection of the company’s strong, longstanding automotive OEM partnerships and industry-leading audio innovation.

Shanghai Auto Show 2019 – SHANGHAI – April 16, 2019 – HARMAN , a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today announced a continued partnership with the...

Each year, HARMAN kicks off the New Year at CES, the premier consumer electronics show that takes place each January in Las Vegas. From the legendary HARMAN showcase at the Hard Rock, we’ll be once again showing what’s coming next when it comes to...

Mexican President Andres Manuel Lopez Obrador said on Friday he aims to present plans next week to reopen the economy, as key sectors like carmaking look to begin business again after over a month of quarantine measures to curb the coronavirus outbreak.

ABSTRACT

Human adenoviruses (HAdVs) have developed mechanisms to manipulate cellular antiviral measures to ensure proper DNA replication, with detailed processes far from being understood. Host cells repress incoming viral genomes through a network of transcriptional regulators that normally control cellular homeostasis. The nuclear domains involved are promyelocytic leukemia protein nuclear bodies (PML-NBs), interferon-inducible, dot-like nuclear structures and hot spots of SUMO posttranslational modification (PTM). In HAdV-infected cells, such SUMO factories are found in close proximity to newly established viral replication centers (RCs) marked by the adenoviral DNA binding protein (DBP) E2A. Here, we show that E2A is a novel target of host SUMOylation, leading to PTMs supporting E2A function in promoting productive infection. Our data show that SUMOylated E2A interacts with PML. Decreasing SUMO-E2A protein levels by generating HAdV variants mutated in the three main SUMO conjugation motifs (SCMs) led to lower numbers of viral RCs and PML-NBs, and these two structures were no longer next to each other. Our data further indicate that SUMOylated E2A binds the host transcription factor Sp100A, promoting HAdV gene expression, and represents the molecular bridge between PML tracks and adjacent viral RCs. Consequently, E2A SCM mutations repressed late viral gene expression and progeny production. These data highlight a novel mechanism used by the virus to benefit from host antiviral responses by exploiting the cellular SUMO conjugation machinery.

IMPORTANCE PML nuclear bodies (PML-NBs) are implicated in general antiviral defense based on recruiting host restriction factors; however, it is not understood so far why viruses would establish viral replication centers (RCs) juxtaposed to such "antiviral" compartments. To understand this enigma, we investigate the cross talk between PML-NB components and viral RCs to find the missing link connecting both compartments to promote efficient viral replication and gene expression. Taken together, the current concept is more intricate than originally believed, since viruses apparently take advantage of several specific PML-NB-associated proteins to promote productive infection. Simultaneously, they efficiently inhibit antiviral measures to maintain the viral infectious program. Our data provide evidence that SUMOylation of the viral RC marker protein E2A represents the basis of this virus-host interface and regulates various downstream events to support HAdV productive infection. These results are the basis of our current attempts to generate and screen for specific E2A SUMOylation inhibitors to constitute novel therapeutic approaches to limit and prevent HAdV-mediated diseases and mortality of immunosuppressed patients.

An 18-yr-old man with a history of intellectual disability, craniofacial dysmorphism, seizure disorder, and obesity was identified to carry a de novo, pathogenic variant in ASXL1 (c.4198G>T; p.E1400X) associated with the diagnosis of Bohring–Opitz syndrome based on exome sequencing. In addition, he was identified to carry a maternally inherited and likely pathogenic variant in MC4R (c.817C>T; p.Q273X) associated with monogenic obesity. Dual genetic diagnosis occurs in 4%–6% of patients and results in unique clinical phenotypes that are a function of tissue-specific gene expression, involved pathways, clinical expressivity, and penetrance. This case highlights the utility of next-generation sequencing in patients with an unusual combination of clinical presentations for several pillars of precision medicine including (1) diagnosis, (2) prognosis and outcome, (3) management and therapy, and (4) utilization of resources.

Live streaming isn’t a trend; it’s fast becoming the dominant form of communication in the connected age. In fact, 78% of online audiences are already […]

The post How to Bring Your Live Events to the Next Level with Interactive Video Streaming appeared first on e-Learning Feeds.

Season 5 of Respawn Entertainment’s hero-based battle royale kicks off next week and it looks like they’re doing more than just blowing up the map. This new Apex Legends trailer shows off what appears to be a horde mode PvE quest initiated by the newest Legend of the bunch: Loba. It looks like you’ll be […]

For most of Doom Eternal‘s demonic foes, the best they can expect is to make a nice corpse. A particularly pleasing splash of gore on the Doom Slayer’s boot. But for those lucky few that manage to take down our man in green, a special reward will soon be in store. Doom Eternal’s first major […]

STATE pension age is continually being reviewed and altered by the government. The latest change occurred earlier this week.

Out of 28,000 suggestions, NASA selected the name Perseverance for its Mars 2020 rover, which will search for signs of life on the Red Planet

SpaceX is partnering with a US start-up called Axiom Space to launch three space tourists on a 10-day trip to the International Space Station

Job postings from a NASA contractor suggest that a new humanoid robot is under development

A Facebook executive challenges the Arm processor community to create tech building blocks for augmented reality glasses

Hindsight is 20/20, even if you’re smizing.

FIFA 20 Team Of The Season So Far continues this week, hopefully with the release of the La Liga FUT Squad. Here some predictions on who might be included, plus when they'll be announced.