BACKGROUND AND PURPOSE:

Reocclusion after treatment is a concern in endovascular therapy for isolated intracranial atherothrombotic stroke-related large-vessel occlusion (AT-LVO). However, the optimal endovascular therapy technique for AT-LVO has not yet been investigated. This study evaluated the optimal endovascular therapy technique for AT-LVO in a real-world setting.

PURPOSE

HIV pre-exposure prophylaxis (PrEP) may increase rates of bacterial sexually transmitted infections (STIs) among gay, bisexual, and other men who have sex with men (GBM) through risk compensation (eg, an increase in condomless sex or number of partners); however, longitudinal studies exploring the time-dependent nature of PrEP uptake and bacterial STIs are limited. We used marginal structural models to estimate the effect of PrEP uptake on STI incidence.

David Parker, TBA’s founder, chief ideologist and chief executive, tweeted “Veni, vedi, vici” last night. Just remember, Caesar said it first, and it sounded like “Weenie, Weedy, Weakie.”

The post Take Back Alberta completes take over of UCP board appeared first on rabble.ca.

U.S.-backed Syrian Democratic Forces announced Tuesday that they had captured the city of Raqqa from Islamic State militants.

“Everything is finished in Raqqa, our forces have taken full control of Raqqa,” SDF spokesman Talal Sello told AFP. A formal declaration would be announced after operations to clear any remaining sleeper cells and to remove landmines in the city were completed, Sello added.

The move is a major setback for the Islamic State which considered Raqqa the de-facto capital of its self-declared caliphate. It comes on the third anniversary of the global effort to defeat ISIS.

Raqqa was the first provincial capital to fall from government control in March 2013 after it was captured by a rebel army. The army included both Syrian opposition groups and more hard line  parties including al-Nusra and the Islamic State.

A civilian government  that was established in the city divided two months later, and less than a year later ISIS recaptured Raqqa and named the the capital of their caliphate.

About 900 civilians have been killed since the the start of the five-month operation, including 570 people in coalition air raids, according to the Syrian Network for Human Rights. The Britain-based Syrian Observatory for Human Rights put the civilian death toll at 1,130 people. American journalist James Foley was beheaded in the mountains south of the city.

SDF fighters pulled down the Islamic State’s black flag from the city’s National Hospital near the city’s stadium, according to a Reuters report.

Special presidential envoy for the Global Coalition to Defeat ISIS Brett McGurk said in August that the U.S. would attempt to perform a “stabilization” in Raqqa — including demining, removing rubble from major pathways to allow trucks and equipment through, and “basic electricity, sewage, water, the basic essentials to allow populations to come back to their home.”

It is not clear when the 300,000 civilians who have fled Raqqa since April during the operation will be able to return.

The post U.S.-backed Syrian forces recapture Raqqa from Islamic State group appeared first on PBS NewsHour.

PAULINE Hanson has described Rod Culleton as a “pain in the backside”, and despite being disqualified from the Senate he’s continuing to cause her pain.

NATWEST has moved to reduce the UK Government’s stake in the bank after buying back a significant tranche of shares from the Treasury in what it described as a “another important milestone”, it was announced this morning.

A former aid to Tony Blair has been criticised by the SNP after he said the Government "should do farmers what Thatcher did to the miners".

Two runners saved by the same public defibrillator appeal for all the life-saving devices to be publicly available. Tens of thousands of defibs are unregistered so ‘invisible’ in an emergency.

Joshua asks “Am I fighting a house?!” (spoilers: he is). Chris is on the wrong side of 40, and somehow forgets JRPGJuly. Kelley espouses “Exposure: The Cryptocurrency of Artists.” Anna Marie is teaching the whole RPGamer staff how to speedrun FF4: Free Enterprise. Yes, things got a little…weird this week.

The post RPG Cast – Episode 590: “Get Back in the House, Yona!” appeared first on RPGamer.

Robert finds out what Godzilla sushi tastes like. Josh pimps his Segway. Phil has a pictomancer at home. The awards all Chris's fault, because he didn't vote. Also, PoE is to Chris, as CoH is to Phil.

The post RPG Cast – Episode 710: “Xenoblade Chronicles X Doesn’t Love You Back” appeared first on RPGamer.

Chris saw a wizard in Tokyo in Trader Vic's, his robe and wizard hat were perfect. Kelley got tired of Alf memes. Josh shoved his Steam Link in a closet somewhere. Gamers suck, tune in next week for monitor cast.

The post RPG Cast – Episode 740: “Truck-Kun in the Background Is Slightly Less Blurry” appeared first on RPGamer.

Remedy's Alan Wake 2 has now "recouped most of its development and marketing expenses", CEO Tero Virtala has announced in a business review for January-September 2024. Speaking as somebody who would quite like there to be more Alan Wake games - or at least, moderately weird and pretty decent blockbuster singleplayer horror games - I am both pleased by this news and a little troubled that Remedy's eldritch forest fable (which came out in October 2023) has yet to break even.

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Like a plague doctor delicately administering another handful of leeches, Ice Pick Lodge have shared a bit more about the recently announced Pathologic 3, explaining how their plans for the cult epidemic-battling series have progressed since the release of Pathologic 2.

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JUDY WOODRUFF: Firefighters say they are making some progress battling the wildfires in Northern California. In all, the fires have consumed more than 220,000 acres, an area larger than New York City.

More than 5,700 structures have been destroyed. And at least 41 people have died, making it the deadliest wildfire in the state’s history.

The wine industry and the tourism business connected with it are trying to take stock. More than $50 billion in California’s economy comes from the wine business. And nearly 24 million people visit the region for that reason every year.

Special correspondent Joanne Jennings reports from Napa County.

JOANNE JENNINGS, Special Correspondent: The Mayacamas mountain range creates a natural barrier between Sonoma and Napa Counties. And it is here where the massive Nuns fire is posing a tough challenge for some 11,000 firefighters who are taming the blaze with aircraft and units on the ground.

CAPT. MARK BRENNERMAN, Viejas fire Department: We’re going around and making sure none of these fires that are still smoldering and smoking, we’re not going to get another big fire out of them.

JOANNE JENNINGS: Even as firefighters are battling shifting winds, owners and workers in Wine Country are trying to determine just how much damage has been done.

The tony Highlands gated community was among the first to be consumed by flames when the Atlas fire raced through this canyon, leaving several mansions in rubble. Down the hill, at the Silverado resort, charred remnants of the Safeway PGA Tour remain. The major golf event had just wrapped up last Sunday afternoon, a few hours before flames engulfed tents and grandstands, forcing spectators and athletes to evacuate.

MAN: Do you see how it burned right up to the retaining wall here?

JOANNE JENNINGS: Silverado resident Steve Messina stayed behind and shot video of fire crews containing the flames, which consumed some condos. Within minutes, flames raced three miles down Silverado Trail, home to several storied hillside vineyards.

Most wineries in the region have been spared the worst. But hundreds suffered some damage. And at least eight vineyards have been significantly damaged or destroyed.

Pierre Birebent, who has been making wines for the family-owned Signorello estate for 20 years, rushed to his winery as quickly as he could.

PIERRE BIREBENT, Signorello Estate Vineyards: I jumped right in my truck, came down, and then when I was riding down, I saw the hill all flaming.

JOANNE JENNINGS: Two vineyard workers joined him to help save the estate’s tasting room.

PIERRE BIREBENT: But the smoke was getting very thick, and the wind was very strong. And after an hour, we couldn’t breathe anymore. At the moment, I was so upset. It was rage to see that I couldn’t do anything. But it was like fighting a giant.

JOANNE JENNINGS: The tasting room, which also housed the winery’s office and a dining room, burned to the ground. But Birebent says he wants to focused on what survived.

Fortunately, he said, the fire stopped short of reaching the vineyard, the crush pad, or any of the barrels of wine stored on site; 95 percent of this year’s grapes were already picked.

But, to be on the safe side, Birebent is taking these samples to a lab to make sure the juice is not too acidic for winemaking. If the crops are OK, a staff of 25 employees will have jobs to return to.

As the fires begin to recede and the smoke clears, people here are beginning to wonder when the tourists, who fuel much of the economy, will return.

It’s a serious concern for Andrew and Jeni (ph) Schluter, who are self-employed and are raising a young family.

ANDREW SCHLUTER, Andrew’s Tours and Transportation: I do wine tours and transportation for people. And my business started to do really, really well. I was on track to have the best month ever.

JOANNE JENNINGS: Andrew just bought this new SUV, which has been idle in his driveway collecting ash. Jeni is a personal trainer and has family who lost their homes in the fires. She’s just not sure how they’re going to make ends meet.

WOMAN: I think we’re just overwhelmed, you know? And uncertainty is kind of scary.

ANDREW SCHLUTER: We will hopefully get by for awhile, but we might make — have to make some hard decisions shortly.

JOANNE JENNINGS: While fires burn nearby, some vineyards are already open to tourists. At the Raymond Vineyard, workers are crushing grapes at a feverish pitch. The tasting room is open for the first time since the fires started.

Jeremy and Erika Moore arrived from Tennessee yesterday. They considered canceling their trip, but decided the best way they could help people here is to give them their business.

JEREMY MOORE, Tourist: On the one hand, a few hundred yards from here, you can see them shuttling up with the helicopters fighting fires, but then here it’s beautiful. They are doing some great tastings, and they are working outside on the crops. So, it’s a weird combination of tragedy, but then at the same time business must go on, too.

JOANNE JENNINGS: Proprietor Jean-Charles Boisset owns several wineries in California, France and Canada, but like many other people here, he and his family had to evacuate their home when the flames came dangerously close.

Still, he is bullish about the future of the wine industry in this region.

JEAN-CHARLES BOISSET, Boisset Collection: Napa has been one of the most amazing agricultural places in California for a long time, so it will survive those fires. What I love, as a Frenchman here in California, is that amazing American positive attitude.

We will recover. We will walk again, run again, and we will welcome all our guests and give them the dreams of fine wine.

JOANNE JENNINGS: For the PBS NewsHour, I’m Joanne Jennings in Napa Valley, California.

The post California wine country tries to get back to business despite wildfire destruction appeared first on PBS NewsHour.

The International Space Station will burn up and splash down into the Pacific sometime around 2030. What could possibly go wrong? And will we ever see anything like the ISS again?

Space missions are extremely hard. Things going wrong should be expected, so having a sensible plan B is crucial

Genetic analysis shows that microbes growing inside the International Space Station have adaptations for radiation and low gravity, and may pose a threat to astronauts

We're trying to avert Judgment Day yet again – this time in an anime series for Netflix. But striking visuals can't make up for shortcomings in narrative and character development

If artificial intelligence chatbots are fine-tuned to improve their responses using human feedback, they can become more likely to give deceptive answers that seem right but aren’t

AI models have safeguards in place to prevent them creating dangerous or illegal output, but a range of jailbreaks have been found to evade them. Now researchers show that writing backwards can trick AI models into revealing bomb-making instructions.

He just can’t help it.

Mike Tyson has not fought professionally since suffering a stoppage defeat to Kevin McBride in 2005.

Elon Musk has joined the chorus of conservative and MAGA voices online backing Sen. Rick Scott (R-Fla.) for Senate GOP leader - after calling Sen. John Thune (R-S.D.) the "top choice of Democrats."

Overwatch 2 is bringing 6v6 gameplay back from Overwatch 1 - and fans are overjoyed. Here's all we know so far, including when you can finally play the Classic mode

If rumours are true and this one should be, I started it, we have a special edition of the Weekend show where we talk about the evolution of the role of the CIO with two incredible CIOs as the CIO Association of Canada turns 20. Don’t miss it.  MUSIC UP Can HP make you love […]

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

Boeing's Starliner spacecraft landed on Earth Saturday morning, with two test pilots left behind because of NASA's concerns that their return was too risky.

Despite a shaky beginning, Turtle Rock's cooperative shooter is a worthy successor to Left4Dead.

Doubled number of specialists should make up for the switch from the classic class system.

Wastewater is a major reservoir for antibiotic resistance genes, but modified bacteria can chop up this DNA before the dangerous microbes reach people

A better understanding of what happens to our bodies when we get fitter can unlock ways to speed up the journey – and it might be simpler than you think

We are living in a vaccine-hesitant moment, with conspiracy theories thriving on social media. We need to push back, says Simon Williams

Israeli President Isaac Herzog says hostages are "going through hell in the dungeons of Gaza" during meeting with President Biden at White House.

Health officials in Saskatchewan Canada are urging customers of Domino’s Pizza in Martensville to watch for symptoms of typhoid fever. The restaurant’s customers may have been exposed to Salmonella typhi, also known as typhoid fever. Anyone who consumed food or drink from the Domino’s store at 717 Centennial Drive South... Continue Reading

Australia’s leading media agencies have ducked questions about cash kickbacks.

Delta Goodrem and her revolving chair have proved their star power, helping to reverse Nine’s horror start to the year.

Tactile controls are back in vogue. Apple added two new buttons to the iPhone 16, home appliances like stoves and washing machines are returning to knobs, and several car manufacturers are reintroducing buttons and dials to dashboards and steering wheels.

With this “re-buttonization,” as The Wall Street Journal describes it, demand for Rachel Plotnick’s expertise has grown. Plotnick, an associate professor of cinema and media studies at Indiana University in Bloomington, is the leading expert on buttons and how people interact with them. She studies the relationship between technology and society with a focus on everyday or overlooked technologies, and wrote the 2018 book Power Button: A History of Pleasure, Panic, and the Politics of Pushing (The MIT Press). Now, companies are reaching out to her to help improve their tactile controls.

Rachel Plotnick on...

• Researching the history of buttons
• The renaissance of physical controls
• Working with companies on “re-buttoning”

You wrote a book a few years ago about the history of buttons. What inspired that book?

Rachel Plotnick: Around 2009, I noticed there was a lot of discourse in the news about the death of the button. This was a couple years after the first iPhone had come out, and a lot of people were saying that, as touchscreens were becoming more popular, eventually we weren’t going to have any more physical buttons to push. This started to happen across a range of devices like the Microsoft Kinect, and after films like Minority Report had come out in the early 2000s, everyone thought we were moving to this kind of gesture or speech interface. I was fascinated by this idea that an entire interface could die, and that led me down this big wormhole, to try to understand how we came to be a society that pushed buttons everywhere we went.

Rachel Plotnick studies the ways we use everyday technologies and how they shape our relationships with each other and the world.Rachel Plotnick

The more that I looked around, the more that I saw not only were we pressing digital buttons on social media and to order things from Amazon, but also to start our coffee makers and go up and down in elevators and operate our televisions. The pervasiveness of the button as a technology pitted against this idea of buttons disappearing seemed like such an interesting dichotomy to me. And so I wanted to understand an origin story, if I could come up with it, of where buttons came from.

What did you find in your research?

Plotnick: One of the biggest observations I made was that a lot of fears and fantasies around pushing buttons were the same 100 years ago as they are today. I expected to see this society that wildly transformed and used buttons in such a different way, but I saw these persistent anxieties over time about control and who gets to push the button, and also these pleasures around button pushing that we can use for advertising and to make technology simpler. That pendulum swing between fantasy and fear, pleasure and panic, and how those themes persisted over more than a century was what really interested me. I liked seeing the connections between the past and the present.

[Back to top]

We’ve experienced the rise of touchscreens, but now we might be seeing another shift—a renaissance in buttons and physical controls. What’s prompting the trend?

Plotnick: There was this kind of touchscreen mania, where all of a sudden everything became a touchscreen. Your car was a touchscreen, your refrigerator was a touchscreen. Over time, people became somewhat fatigued with that. That’s not to say touchscreens aren’t a really useful interface, I think they are. But on the other hand, people seem to have a hunger for physical buttons, both because you don’t always have to look at them—you can feel your way around for them when you don’t want to directly pay attention to them—but also because they offer a greater range of tactility and feedback.

If you look at gamers playing video games, they want to push a lot of buttons on those controls. And if you look at DJs and digital musicians, they have endless amounts of buttons and joysticks and dials to make music. There seems to be this kind of richness of the tactile experience that’s afforded by pushing buttons. They’re not perfect for every situation, but I think increasingly, we’re realizing the merit that the interface offers.

What else is motivating the re-buttoning of consumer devices?

Plotnick: Maybe screen fatigue. We spend all our days and nights on these devices, scrolling or constantly flipping through pages and videos, and there’s something tiring about that. The button may be a way to almost de-technologize our everyday existence, to a certain extent. That’s not to say buttons don’t work with screens very nicely—they’re often partners. But in a way, it’s taking away the priority of vision as a sense, and recognizing that a screen isn’t always the best way to interact with something.

When I’m driving, it’s actually unsafe for my car to be operated in that way. It’s hard to generalize and say, buttons are always easy and good, and touchscreens are difficult and bad, or vice versa. Buttons tend to offer you a really limited range of possibilities in terms of what you can do. Maybe that simplicity of limiting our field of choices offers more safety in certain situations.

It also seems like there’s an accessibility issue when prioritizing vision in device interfaces, right?

Plotnick: The blind community had to fight for years to make touchscreens more accessible. It’s always been funny to me that we call them touchscreens. We think about them as a touch modality, but a touchscreen prioritizes the visual. Over the last few years, we’re seeing Alexa and Siri and a lot of these other voice-activated systems that are making things a little bit more auditory as a way to deal with that. But the touchscreen is oriented around visuality.

It sounds like, in general, having multiple interface options is the best way to move forward—not that touchscreens are going to become completely passé, just like the button never actually died.

Plotnick: I think that’s accurate. We see paradigm shifts over time with technologies, but for the most part, we often recycle old ideas. It’s striking that if we look at the 1800s, people were sending messages via telegraph about what the future would look like if we all had this dashboard of buttons at our command where we could communicate with anyone and shop for anything. And that’s essentially what our smartphones became. We still have this dashboard menu approach. I think it means carefully considering what the right interface is for each situation.

[Back to top]

Several companies have reached out to you to learn from your expertise. What do they want to know?

Plotnick: I think there is a hunger out there from companies designing buttons or consumer technologies to try to understand the history of how we used to do things, how we might bring that to bear on the present, and what the future looks like with these interfaces. I’ve had a number of interesting discussions with companies, including one that manufactures push-button interfaces. I had a conversation with them about medical devices like CT machines and X-ray machines, trying to imagine the easiest way to push a button in that situation, to save people time and improve the patient encounter.

I’ve also talked to people about what will make someone use a defibrillator or not. Even though it’s really simple to go up to these automatic machines, if you see someone going into cardiac arrest in a mall or out on the street, a lot of people are terrified to actually push the button that would get this machine started. We had a really fascinating discussion about why someone wouldn’t push a button, and what would it take to get them to feel okay about doing that.

In all of these cases, these are design questions, but they’re also social and cultural questions. I like the idea that people who are in the humanities studying these things from a long-term perspective can also speak to engineers trying to build these devices.

So these companies also want to know about the history of buttons?

Plotnick: I’ve had some fascinating conversations around history. We all want to learn what mistakes not to make and what worked well in the past. There’s often this narrative of progress, that things are only getting better with technology over time. But if we look at these lessons, I think we can see that sometimes things were simpler or better in a past moment, and sometimes they were harder. Often with new technologies, we think we’re completely reinventing the wheel. But maybe these concepts existed a long time ago, and we haven’t paid attention to that. There’s a lot to be learned from the past.

[Back to top]

Humans perfected how to identify wild animals over millennia, and now biologists are rediscovering the exceptional worth of the tracks and marks left behind

Sen. Marsha Blackburn (R-TN) told Breitbart News exclusively on Tuesday evening that she is supporting Sen. Rick Scott (R-FL) for Senate GOP leader in the upcoming vote on Wednesday morning in the Senate GOP conference.

The post Exclusive—Marsha Blackburn Backs Rick Scott for Senate GOP Leader appeared first on Breitbart.

Election deniers have spent the past four years focused on false claims that 2020 was rigged. This year, it raised similar alarms about fraud — only for those claims to evaporate as returns came in.

Team at Kolkata institute engineers bacteria to solve maths problems  The Hindu

1. Study reveals how 3D environments affect bacterial growth and survival  The Hindu
2. 3D environments influence bacterial growth & survival  The Times of India
3. Shape Matters: New Research Reveals Impact of 3D Environments on Bacterial Growth  Research Matters
4. Study reveals role of 3D environments in influencing bacterial survival and growth  Bangalore Mirror

1. Netflix's The Great Indian Kapil Show: Navjot Singh Sidhu is back after 5 years of exit, Archana Puran Singh says, 'He’s taken over my...'  Firstpost
2. Did you know! Navjot Singh Sidhu was ousted from The Kapil Sharma Show for this reason  The Times of India
3. Navjot Singh Sidhu makes a roaring comeback; Archana Puran Singh worried about her The Great Indian Kapil Show throne  Hindustan Times
4. The Great Kapil Sharma Show: Navjot Sidhu shares his fast-track fatherhood plan. Kapil’s response is too f  The Economic Times
5. Navjot Singh Sidhu shares BTS pics from The Great Indian Kapil's show set with Archana Puran Singh and...  Moneycontrol

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Analysis sees loot box spending ballooning 62 percent, to $47 billion, by 2022.