Chicago, IL Nolen Entertainment And Artist Brandon James Present Soulful Sunday's. The Show Will Take Place On Sunday, October 6th, At Reggie's Chicago 2105 S State St, Chicago, IL.

With a lot of celebrities!

The post RAGE AGAINST THE MACHINE's Tom Morello Has Been Playing Weekly Dungeons & Dragons Games appeared first on Metal Injection.

The series was moved up two months to provide content-starved fans with something new to watch during the coronavirus pandemic. ESPN was originally planning to release the documentary in June, coinciding with what would have been this season’s NBA Finals.

Editor’s Note: Fifth of a five-part series on Colorado baseball icons. The first four profiled were Scott Bullock, Jenny and Steve Cavnar, Chris Hanks and Jim Danley.

he ‘Empire’ actor is accused of staging a hate crime.

Cases have increased since the coronavirus outbreak began.

Lori Lightfoot meme is being used for charity.

He's back in the gym and getting plenty of encouragement.

The former NFL star fell on hard times.

Marc Eversley has reportedly agreed to the contract.

The video shows people ignoring social distancing.

The video of Janeal Wright’s party went viral.

Cases have increased since the coronavirus outbreak began.

Lori Lightfoot meme is being used for charity.

Little Tigers Martial Arts is getting set to host the Dragon Warrior Obstacle Challenge [DWOC] on Sunday, October 27 from 1.00pm to 5.00pm in the Warwick Academy gym. A spokesperson said, “All 5 to 12-year-olds are invited to master the Dragon Warrior Obstacle Challenge on Sunday, October 27 from 1.00pm to 5.00pm in Warwick Academy’s […] (Click to read the full article)

Over this past weekend the Bermuda Gymnastics Association [BGA] had four athletes head to Chicago, IL to compete in the Chicago Style Meet. Known as the “world’s largest gymnastics meet”, the Chicago Style Meet attracts over 4,000 of the top gymnasts from the U.S., Canada, and Bermuda. Warwick Academy student, 14-year-old Gianna Webbe was first […] (Click to read the full article)

‘The Heart Of The Dragon,’ a new children’s book written by Suzie Arruda and Dr. Larry Trott to “promote the importance of having a clean mind as well as a good heart to children,” has been released. A spokesperson said, “Heart of the Dragon [HOTD] is inspired to promote a movement in holistic education where […] (Click to read the full article)

The Dragons came away with a win over the Pink Robins in Bermuda Field Hockey Federation League action at the National Sports Center. Pink Robins 0 Dragons 4 Only one game took place at the National Sports Center as the Bermuda Field Hockey Federations League season continued, with Dragons defeating the Pink Robins 4 – 0. […] (Click to read the full article)

A Bermuda Field Hockey double header produced a total of 14 goals at the National Sports Center. Dragons 9 Hawks 1 The Dragons got 4 goals off the stick of Isabel Roe, while Tyler Smith added a hat-trick and Fiona Braidwood scored the other two goals as they defeated the Hawks 9 – 1. The […] (Click to read the full article)

The Bermuda Field Hockey federation league season recently resumed at the National Sports Center with a triple header that produced 13 goals. Pink Robins 4 Longtails 2 The Pink Robins got two goals off the stick of Leana Coetzee as they defeated the Longtails 4 – 2. Also getting on the scoresheet was Joanna Heaney […] (Click to read the full article)

Action in the Bermuda Field Hockey League resumed at the National Sports Center this past weekend. Hawks 1 Longtails 3 The Longtails defeated the Hawks 3 – 1. The Hawks took the lead in the 32nd minute when Edward Ingham scored, but two minutes later the score was level when Dominique Brown scored for the […] (Click to read the full article)

The Fat Tire Massive Lagoon Park race was held yesterday [Dec 15], with 83 racers competing in slippery conditions. A spokesperson said, “Fat Tire Massive’s third event finally got the seasonal high winds and downpour that separate the hardcore cyclists from the rest. Thunderstorms spared the event, which saw 83 racers test their mud skills. […] (Click to read the full article)

Компания Xiaomi, неожиданно для всех, объявила дату анонса очередного смартфона из линейки Redmi K30.

Компания Meizu провела в Китае мероприятие, на котором анонсировала свою новую флагманскую линейку смартфонов — Meizu 17.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis.

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

IBM today announced that Joanne Wright, Vice President Supply Chain has been selected to speak at the upcoming Supply Chain Summit Conference, which takes place in Chicago on June 14-16.

Two StarWars.com writers debate Luke’s choice in Star Wars: The Empire Strikes Back.

Live at Dragonmeet, Ken and Robin talk Hindu mythology's secret role in the Norman Invasion, crisis on infinite podcasts, drinks to write by, and the real reason Ken had to make Trump president.

Práci z domova u zaměstnanců soukromých firem nelze jednostranně nařídit, vzniká jen na základě dohody obou stran. U pedagogických pracovníků a zaměstnanců škol však platí trochu jiná pravidla. Ve spolupráci s právníky Bořivojem Líbalem a Markem Polonim přinášíme odpovědi na nejčastější dotazy pedagogů.

Packed up the first of the local Mother’s Day treat packages — lily-of-the-valley soap and bath salts, baked goodies and confections. And locals get a little potted lily-of-the-valley too. Supplies limited — I think I can do 4 more before I run out of cookies. I’m done with baking for a bit…need to get back … Continue reading "There Will Be Dragons"

Experts, economen en politici: iedereen is nu al bezig met een tweede coronagolf. “Zolang er geen vaccin is, zal het nieuwe normaal blijven bestaan”  Het Nieuwsblad

More than a quarter-century ago, I was driving to Pittsburgh, with my wife, Marianne Porter, and we were talking about fantasy and about steam locomotives. I made a joke about the Baldwin Steam Dragon Works and Marianne laughed. Then, another mile or so down the road, I said, "Write that down, please."

Thus was born the Iron Dragons Trilogy, a trio of stand-alone books, the third of which, The Iron Dragon's Mother, was published just last year.

Far more recently, just an hour or so ago, I got an email from my associates at Open Road Media, telling me that The Iron Dragon's Mother, first of the three, will be on sale for $1.99 this coming Monday, March 23.

That's one day only BUT this time the sale includes Canada. Which I am very grateful for because the Canadian science fiction community has always been very warm and kind to  me.

Anyway, here's the boilerplate below, cut-and-pasted from the corporate email:


We are pleased to let you know that the following ebook(s) will be featured in price promotions soon.

ISBN13	Title	Author	Promo Type	Country	Start Date	End Date	Promo Price
9781504025669	The Iron Dragon's Daughter	Swanwick, Michael	ORM - Early Bird Books NL	US	2020-03-23	2020-03-23	$1.99
9781504025669	The Iron Dragon's Daughter	Swanwick, Michael	ORM - Early Bird Books NL	CA	2020-03-23	2020-03-23	$1.99

Open Road will promote the feature via social media. We hope you can share the deal with your network as well. You can subscribe to the newsletters at the links below so that you will get the direct link to the deal on the day that it appears.

Newsletter	Link
Early Bird Books	Subscribe Now
The Lineup	Subscribe Now
The Portalist	Subscribe Now
Murder & Mayhem	Subscribe Now
A Love So True	Subscribe Now
The Archive	Subscribe Now
The Reader	Subscribe Now

So if you (1) read e-books, (2) don't own a copy of The Iron Dragon's Daughter, and (3) would like to... well, here's your opportunity to do it on the cheap.

Just a reminder that people in Canada and the US can buy an e-book of The Iron Dragon's Mother, the first book of my stand-alone fantasy trilogy for only $1.99 today. Tomorrow will be too late:

Here's the boilerplate:

ISBN13	Title	Author	Promo Type	Country	Start Date	End Date	Promo Price
9781504025669	The Iron Dragon's Daughter	Swanwick, Michael	ORM - Early Bird Books NL	US	2020-03-23	2020-03-23	$1.99
9781504025669	The Iron Dragon's Daughter	Swanwick, Michael	ORM - Early Bird Books NL	CA	2020-03-23	2020-03-23	$1.99

Open Road will promote the feature via social media. We hope you can share the deal with your network as well. You can subscribe to the newsletters at the links below so that you will get the direct link to the deal on the day that it appears.

Newsletter	Link
Early Bird Books	Subscribe Now
The Lineup	Subscribe Now
The Portalist	Subscribe Now
Murder & Mayhem	Subscribe Now
A Love So True	Subscribe Now
The Archive	Subscribe Now
The Reader	Subscribe Now

Dragons are, as everybody knows, half fighter jet and half fire spirit.

Here's the skull of one.


Above: Image Nine. One more to go.

Iriss attended the Social Pedagogy Professional Association's conference Growing up, growing old and staying well in Edinburgh on 28 September 2018.

We spoke to a number of academics and practitioners about social pedagogy and the value it brings to practice.

These included Mark Smith, Professor of Social Work at the University of Dundee; Lotte Harbo, Social Professor at VIA University College in Denmark; Gabriel Eichsteller from ThemPra Social Pedagogy; Gemma Campbell, a practitioner at Kibble Education and Care Centre; and Graham McPheat, Senior Teaching Fellow in Social Work at the University of Strathclyde.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes

As stated in the thread title

https://www.gamestop.com/collection/dragon-ball-z-kakarot

Didn’t see it posted and decided to post it in case someone was waiting for it to drop