Escuche el programa de este lunes 10 de junio. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

El artista Gilberto Santa Rosa se encuentra en Colombia en una gira de conciertos.

Justo por esto decidieron reunirse para enfrentar la situación.

En 10am Hoy por Hoy habló Joaquín María de Arístegui Laborde, embajador de España en Colombia, las relaciones entre los dos países

En Caracol Radio estuvo Adrián Castro, subsecretario de Educación de Antioquia, conversando sobre el déficit de docentes en Antioquia

Fenómenos como el costo en los arrendamientos, plataformas digitales dedicadas a la oferta de alojamientos y misma situación económica del país, han influido desde hace un año, para que San Andrés esté viviendo una crisis en el porcentaje de turistas.

Ebed Shaday, quien celebraba su boda en una casa de campo en Valledupar, relata la tragedia en la que perdió a su mejor amiga y a una prima de 11 años por cuenta del despomle del techo

Debatimos del clásico bogotano que se definió con un emotivo 3-2 a favor de Santa Fe, agudizando el bache de Millonarios actualmente.

Mariana Pajón, una de las deportistas más representativas de Colombia en los últimos años, dialogó con 6AM Hoy por Hoy de Caracol Radio sobre su actualidad y expresó su preocupación en nombre suyo y de otros atletas por la situación que está viviendo actualmente el Ministerio del Deporte.

El Deportivo Cali es un equipo que, desde hace un par de años, sufre una crísis económica insostenible. Los estragos de esta situación ya se siente en lo deportivo, y en lo institucional. Las salidas de jugadores y cuerpo técnico sólo reafirman la lamentable situación que vive el conjunto azucarero.

Daniel Giraldo, volante de Millonarios, se mostró agradecido con la institución, luego de sumar un nuevo título con el equipo, al consagrarse campeón de la Superliga 2024 ante el Junior. El volante habló de este encuentro, la Copa Libertadores y los nuevos jugadores del equipo, entre otras cosas.

El gobierno de Gustavo Petro sigue nombrando políticos en cargos técnicos, que requieren de personal especializado para su función, ¿por qué?

En 6AM Hoy por Hoy de Caracol Radio estuvo el doctor Jorge García, director de la Fundación Retorno Vital, entidad que apoya a pacientes con énfasis en pacientes renales y trasplantados, para hablar sobre la preocupación de estos con los medicamentos que necesitan para mantener su trasplante.

A pesar de que los carrotanques prestan su servicio en Córdoba, fueron contratados con una empresa que funciona en una casa de familia de Sabana de Torres, municipio donde Sneyder Pinilla, subdirector de la UNGR, fue alcalde. Hay denuncias de sobrecostos

En 6AM Hoy por Hoy de Caracol Radio estuvo el expresidente Ernesto Samper, para dar su opinión sobre la asamblea constituyente que propuso el presidente Gustavo Petro.

En Caracol Radio estuvo Henry Cárdenas, presidente de Fedetranscarga, conversando sobre aumento del ACPM

En 6AM y el Desafío de Seguridad en las regiones del 2024, evento organizado por Prisa Media, habló Otty Patiño, alto comisionado para la paz, sobre el tema de las negociaciones con la Segunda Marquetalia y la situación que se vive actualmente en Venezuela. 

En 6AM Hoy por Hoy de Caracol Radio estuvo Denis Silva, vocero de la organización Pacientes Colombia, para habla sobre cuáles son los desacuerdos con el Gobierno, que les ha impedido llegar a un consenso sobre la reforma de salud.

En 6AM Hoy por Hoy de Caracol Radio estuvo el canciller Luis Gilberto Murillo, para hablar sobre el tema de los pasaportes en el país.

Jaime Andrés Beltrán, alcalde de Bucaramanga, habló con preocupación de la libertad y del nombramiento de uno de los cabecillas más temidos en esa ciudad

Jaime Granados, abogado de Álvaro Uribe Vélez, habló en 6AM sobre qué detonó el abogado Miguel Ángel del Río en medio de la audiencia preparatoria contra su defendido

Los representantes de CBZ Management han creado una campaña pública para culpar los problemas del complejos de apartamentos de Aurora a las actividades recientes de las pandillas.

Hate him or love him, 50 Cent is a hip hop top dog.

On October 27, Bermuda will join the global community in celebrating World Occupational Therapy Day, recognizing the vital contributions of Occupational Therapists [OTs] who empower individuals to engage fully in daily life and promoting the 2024 theme, “Occupational Therapy for All.” A Government spokesperson said, “World Occupational Therapy Day will be celebrated on October 27th, […]

And all those that supported this guy after you were warned and you saw what he unleashed on the country with his Operation Warp Speed are to blame.  Don’t even try and deny it.  Once again, Donald Trump is set to enter the People’s White House and you know that  we are going to get …

Arab and Muslim leaders demanded that Israel withdraw from occupied Palestinian territories as a precondition for regional peace, while denouncing "shocking" Israeli crimes in war-ravaged Gaza.

Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation to biliverdin, CO, and iron, forming an essential link in the heme metabolism network. Tight regulation of the cellular levels and catalytic activities of HO1 and HO2 is important for maintaining heme homeostasis. HO1 expression is transcriptionally regulated; however, HO2 expression is constitutive. How the cellular levels and activity of HO2 are regulated remains unclear. Here, we elucidate the mechanism of post-translational regulation of cellular HO2 levels by heme. We find that, under heme-deficient conditions, HO2 is destabilized and targeted for degradation, suggesting that heme plays a direct role in HO2 regulation. HO2 has three heme binding sites: one at its catalytic site and the others at its two heme regulatory motifs (HRMs). We report that, in contrast to other HRM-containing proteins, the cellular protein level and degradation rate of HO2 are independent of heme binding to the HRMs. Rather, under heme deficiency, loss of heme binding to the catalytic site destabilizes HO2. Consistently, an HO2 catalytic site variant that is unable to bind heme exhibits a constant low protein level and an enhanced protein degradation rate compared with the WT HO2. Finally, HO2 is degraded by the lysosome through chaperone-mediated autophagy, distinct from other HRM-containing proteins and HO1, which are degraded by the proteasome. These results reveal a novel aspect of HO2 regulation and deepen our understanding of HO2's role in maintaining heme homeostasis, paving the way for future investigation into HO2's pathophysiological role in heme deficiency response.

Laboratory study of field-collected mosquitoes can allow researchers to better understand the ways variation within and among mosquito populations shapes burdens of mosquito-borne disease. The Anopheles gambiae complex comprises the most important vectors of malaria, but it can be challenging to keep in the laboratory. For some species of mosquitoes, especially An. gambiae, it is very difficult to bring viable eggs into the laboratory. Instead, it is preferable to collect larvae or pupae and then transport them as carefully as possible back to the laboratory. This simple protocol allows a researcher to start new laboratory colonies from larvae or pupae collected from natural breeding sites or proceed directly to their planned experiments. The use of natural breeding sites provides additional reassurance that the resulting colonies are representative of natural populations.

Shalini Passi is a Delhi-based art collector and philanthropist

Esha, now 26, is the daughter of Ashwin and Sapna Verma and currently resides in the United States

Rupali Ganguly has issued a defamation notice to her stepdaughter, Esha Verma, demanding a compensation of Rs 50 crore

Rupali Ganguly recently issued a defamation notice to her stepdaughter, Esha Verma, demanding a compensation of Rs 50 crore

Identifying cancer therapy resistance is a key time-saving tool for physicians. Part of chemotherapy resistance includes senescence, a persistent state without cell division or cell death. Chemically inducing senescence with the combination of trametinib and palbociclib (TP) yields several tumorigenic and prometastatic factors in pancreatic cancer models with many potential antibody-based targets. In particular, urokinase plasminogen activator receptor (uPAR) has been shown to be a membrane-bound marker of senescence in addition to an oncology target. Methods: Here, 2 antibodies against murine uPAR and human uPAR were developed as immuno-PET agents to noninvasively track uPAR antigen abundance. Results: TP treatment increased cell uptake both in murine KPC cells and in human MiaPaCa2 cells. In vivo, subcutaneously implanted murine KPC tumors had high tumor uptake with the antimurine uPAR antibody independently of TP in young mice, yet uPAR uptake was maintained in aged mice on TP. Mice xenografted with human MiaPaCa2 tumors showed a significant increase in tumor uptake on TP therapy when imaged with the antihuman uPAR antibody. Imaging with either uPAR antibody was found to be more tumor-selective than imaging with [¹⁸F]FDG or [¹⁸F]F-DPA-714. Conclusion: The use of radiolabeled uPAR-targeting antibodies provides a new antibody-based PET imaging candidate for pancreatic cancer imaging as well as chemotherapy-induced senescence.

Promising to be inspiring, ‘Vijay 69’ turns out like a mildly entertaining episode in Anupam Kher’s popular play, ‘Kucch Bhi Ho Sakta Hai’

Amoury Lapointe a résisté à son arrestation lors d’une intervention de routine à laquelle il refusait de se soumettre dans son «véhicule diplomatique»

The resignation drama has helped distract attention from the DMK party's woes in advance of next years Parliamentary elections.

Socioeconomic status (SES) impacts cognitive health. Higher education, better jobs, and more wealth can lower dementia risk and improve recovery. (!--ref1--)

350-Room Cluster Property Set To Open in 2028. Accor, a global leader in hospitality, proudly announces the signing of Novotel Tirupati and ibis Styles Tirupati, a new cluster hotel in India’s pilgrimage destination of Tirupati. The expansive 350-key multi-brand hotel complex is set to transform the hospitality landscape of Tirupati, a city that draws millions of devotees to the renowned Tirumala Venkateswara Temple each year. As Tirupati evolves into a hub for education and business, bolstered by expanding infrastructure and modern amenities, this venture will play a crucial role in meeting the growing demand for quality accommodations. This milestone signing underscores Accor’s commitment to expanding its presence in key destinations across India. Developed by Shravanthi Hotels & Resorts Private Limited, the new cluster of hotels will feature 180 guest rooms at Novotel Tirupati and 170 guest rooms at ibis Styles Tirupati, ensuring a diverse range of options to accommodate all types ...

Sanjay Dutt and Ameesha Patel's relationship had strained in 2012 over an unforgetable incident. The former was not happy with the way the latter had dressed herself for the sangeet ceremony of David Dhawan's son Rohit and his concern had created a controversy.

Here are the pictures of Vijay Sethupathi from his upcoming Tamil movie Tughlaq Darbar. The film marks the directorial debut of Delhi Prasad Deendayalan.

In the notice, it was clarified that Rupali Ganguly was friends with Ashwin Verma for 12 years, before he separated from his second wife, Esha Verma's mother, in 2009. It was also said that Ganguly, along with Verma, tried to help Esha get a break into the entertainment industry, by providing opportunities for photoshoots and making special arrangements for auditions

Coupang early investor Ben Sun shares an inside look into the growth of the Korean e-commerce giant and explains how founder Bom Kim led a pivot when the company was already an established business.

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