At drupa 2024 (Messe Düsseldorf, 28 May – 7 June 2024, Hall 8a), Canon is showcasing its full capabilities as a leading provider of end-to-end digital production print solutions and services. Under the banner of ‘The Power to Move’, Canon is demonstrating how, in collaboration with partners, it works closely with customers to deliver the transformative technologies...

The incommensurately modulated structure of (2S,3S)-2-amino-3-hy­droxy-3-methyl-4-phen­oxy­butanoic acid dihydrate (C11H15NO4·2H2O or I·2H2O) is described in the (3+1)-dimensional superspace group P212121(0β0)000 (β = 0.357). The loss of the three-dimensional periodicity is ascribed to the occupational modulation of one positionally disordered solvent water mol­ecule, where the two positions are related by a small translation [ca 0.666 (9) Å] and ∼168 (5)° rotation about one of its O—H bonds, with an average 0.624 (3):0.376 (3) occupancy ratio. The occupational modulation of this mol­ecule arises due to the com­petition between the different hy­dro­gen-bonding motifs associated with each position. The structure can be very well refined in the average approximation (all satellite reflections disregarded) in the space group P212121, with the water mol­ecule refined as disordered over two positions in a 0.625 (16):0.375 (16) ratio. The refinement in the commensurate threefold supercell approximation in the space group P1121 is also of high quality, with the six corresponding water mol­ecules exhibiting three different occupancy ratios averaging 0.635:0.365.

Fragment-based drug design using X-ray crystallography is a powerful technique to enable the development of new lead compounds, or probe molecules, against biological targets. This study addresses the need to determine fragment binding orientations for low-occupancy fragments with incomplete electron density, an essential step before further development of the molecule. Halogen atoms play multiple roles in drug discovery due to their unique combination of electronegativity, steric effects and hydrophobic properties. Fragments incorporating halogen atoms serve as promising starting points in hit-to-lead development as they often establish halogen bonds with target proteins, potentially enhancing binding affinity and selectivity, as well as counteracting drug resistance. Here, the aim was to unambiguously identify the binding orientations of fragment hits for SARS-CoV-2 nonstructural protein 1 (nsp1) which contain a combination of sulfur and/or chlorine, bromine and iodine substituents. The binding orientations of carefully selected nsp1 analogue hits were focused on by employing their anomalous scattering combined with Pan-Dataset Density Analysis (PanDDA). Anomalous difference Fourier maps derived from the diffraction data collected at both standard and long-wavelength X-rays were compared. The discrepancies observed in the maps of iodine-containing fragments collected at different energies were attributed to site-specific radiation-damage stemming from the strong X-ray absorption of I atoms, which is likely to cause cleavage of the C—I bond. A reliable and effective data-collection strategy to unambiguously determine the binding orientations of low-occupancy fragments containing sulfur and/or halogen atoms while mitigating radiation damage is presented.

Coarse colorless single crystals of lithium lutetium bis­[orthomolybdate(VI)], LiLu[MoO4]2, were obtained as a by-product from a reaction aimed at lithium derivatives of lutetium molybdate. The title compound crystallizes in the scheelite structure type (tetra­gonal, space group I41/a) with two formula units per unit cell. The Wyckoff position 4b (site symmetry overline{4}) comprises a mixed occupancy of Li+ and Lu3+ cations in a 1:1 ratio. In comparison with a previous powder X-ray study [Cheng et al. (2015). Dalton Trans. 44, 18078–18089.] all atoms were refined with anisotropic displacement parameters.

The National Institute for Occupational Safety and Health (NIOSH) should lead a collaborative effort with the U.S. Bureau of Labor Statistics (BLS), Occupational Safety and Health Administration (OSHA), and the states to establish and strengthen regional occupational safety and health surveillance programs, says a new report by the National Academies of Sciences, Engineering, and Medicine.

AIHA announced the availability of free resources to support rail operators in reducing health risks associated with work conducted on railroads.

 As the world’s leading international trade fair for the occupational safety and health sector, A+A is renowned for its wide range of products and international reach.

Do your employees truly know what to look for and can they recognize the hazards and risks associated with their tasks? Is it psychologically safe to openly recognize hazards and risks and choose safe actions within the culture? 

Rachel E. Palmeri, GSP is noted for her work in research and development at the Southwest Research Institute

Anupama D. Ravi, PhD, is an expert in biomarker operations as an associate director at Revolution Medicines Inc.

Dr. Neal Frankel, podiatrist in DuPage County, invites patients to visit one of his three convenient locations for A Foot & Ankle Centre.

Unit 112 is 1600 square feet with a restroom and office and 14' bay doors to make for easy shipping and receiving.

Project's exclusive landlord leasing representative Kelly Wilson of Ackerman Retail completes lease with Sucré; Ackerman Retail's Brian Lefkoff and Stephany Cruz represent tenant in the lease signing

Poupak Afshar is a finalist for The Executive of the Year ($25M to $50M) category.

A free family-friendly cultural event commemorating Jurupa Valley's rich history featuring altars, food booths, Ballet Folklorico, Lucha Libre, Escaramuzas, artist exhibits, and new this year is a Catrina contest.

The U.S. Department of Labor is seeking nominations for four positions on the National Advisory Committee on Occupational Safety and Health. The department said it is seeking one public representative, one…

Two senators in Connecticut announced plans to introduce legislation that would treat substance abuse as an occupational hazard. “If a worker is injured on the job, they receive treatment, but if…

West Virginia’s Intermediate Court of Appeals upheld the denial of a widow’s claim for benefits, finding her late husband’s occupational pneumoconiosis had not materially contributed to his death. Sherman Bailey received…

The West Virginia Supreme Court upheld the denial of a worker’s occupational pneumoconiosis claim. Case: Lewis v. Columbia West Virginia Corp., No. 23-616, 09/23/2024, published. Facts: Jackie W. Lewis Sr. worked for…

The West Virginia Supreme Court upheld an award of occupational disease-dependent death benefits to a worker’s widow. Case: Appalachian Boiler & Fab LLC v. Caruthers, No. 23-345, 09/23/2024, published. Facts: Johnny A.

West Virginia’s Intermediate Court of Appeals upheld a determination that a worker was not entitled to an increase in his permanent partial disability award for occupational pneumoconiosis. Case: Lucey v. Murray…

The Maryland Appellate Court upheld the denial of a worker’s claim of occupational disease and accidental injury from his alleged chemical exposure. Robert Butler worked as a driver for Velocity Rail…

West Virginia’s Intermediate Court of Appeals upheld an award of 0% permanent partial disability for a worker’s occupational pneumoconiosis. Case: Foster v. Kingston Mining Inc., No. 24-ICA-172, 10/28/2024, published. Facts: Nelson Foster…

The Ohio Court of Appeals upheld a determination that a widow timely filed her claim for benefits for a worker’s death from an occupational disease caused by his asbestos exposure…

Oupas Design, a creative studio from Portugal, has spent over 12 years crafting playful, custom paper art for brands like Salesforce, Hermès, and The Atlantic. Founded by three friends—Cidália, Joana, and Sofia—the studio’s work reflects their passion and expertise in paper art, evident in their detailed, whimsical creations that bring ideas to life. More: Oupas […]

Packaged rooftop units are the workhorses of the commercial market, providing cooling to approximately 60% of U.S. commercial building floor area.

Ant Wilson of Supabase discusses building an open source alternative to Firebase with PostgreSQL. SE Radio host Jeremy Jung spoke with Wilson about how Supabase compares to Firebase, building an API layer with postgREST, authentication using GoTrue...

"Preocupación" en el Madrid por los resultados y la imagen del equipo en las últimas semanas, pero confianza en el técnico. Los blancos no encajaban 3 goles o más en partidos seguidos en casa desde mayo de 2009. Leer

En Puerto de Sagunto, su pueblo, aún se preguntan por qué recorrió 13 kilómetros con la intención de «matar a todos los frailes» del Monasterio de Santo Espíritu del Monte, en Gilet Leer

La intervención se ha producido en la Dehesa de Batán en el barrio de Reyes Católicos Leer

La paliza tuvo lugar en la puerta de una conocida discoteca de la ciudad y la víctima desconoce los motivos de la agresión Leer

Los Suelos Utilizados (GSU) en el yacimiento de Galería, en Atapuerca, como ya hemos comentado con anterioridad no son homogéneos, puesto que aumenta la representación de registro conforme la excavación de la superficie prospera. Los primeros suelos excavados son poco significativos mientras que los últimos incrementan de manera exponencial las evidencias tanto óseas como líticas. 

Sensors act as a middle ground between the physical and digital. They measure all sorts of variables from touch, temperature, and heart rate across many different sectors, which IDTechEx’s report “Printed and Flexible Sensors 2024-2034: Technologies, Players, Markets” explores in detail.

At drupa 2024 (Messe Düsseldorf, 28 May – 7 June 2024, Hall 8a), Canon is showcasing its full capabilities as a leading provider of end-to-end digital production print solutions and services. Under the banner of ‘The Power to Move’, Canon is demonstrating how, in collaboration with partners, it works closely with customers to deliver the transformative technologies...

FirstCry's CEO Maheshwari saw a 49% compensation drop. The company plans an IPO, approaching SEBI. Employee benefits decreased, with a Rs 23,000 crore valuation and an expected IPO of $3.5-3.75 billion.

We'll continue to invest in our brand, technology, products, and grow our offline online touchpoints. We are going to open around 350 stores over the next three years and grow our multi-channel competitive strengths. We will also enhance our in-house brands and their distribution through pharmacies and grocery stores. We also plan to invest in manufacturing, international markets and Globalbees, our brand aggregator platform,Supam Maheshwari, cofounder and CEO of FirstCry said.

“Subscription, oversubscription, listing gains, do not matter much to me, personally. What matters is this milestone of launching the IPO, which gives a feeling of accomplishment to all our families, and extended families. I am sure performance will always proceed when it comes to the outcome in terms of numbers on the stock market. So, that is okay,” Supam Maheshwari, cofounder and CEO of the Pune-based company, told ET on the sidelines of the listing ceremony.

Tupac Shakur is one of the most famous rappers in history. Until his murder in 1996 at the age of 25, Shakur was a figurehead of the West Coast rap scene. So Tupac Shakur’s connection to Georgia might surprise you.

Panelistas consideran que aumento en optimismo se debe a mejora en cifras de pandemia; pero creen que cifras en seguridad y economía preocupan.

Doble tributación, destinación de los recursos y el impacto en el sector de hidrocarburos, los temas que más les preocupan a los panelistas.

En Hora 20 de Caracol Radio, estuvo Carla Aguas, quien es periodista en Ecuador, para hablar un poco sobre la situación que se vive en el país actualmente.

En este episodio, La Luciérnaga se enciende para
hablar de los casos de paseo millonario y robos que involucran el uso de
sustancias como la escopolamina y la "droga Z". Además, según el DANE
la economía creció un 8,5%. También, Francia Marquez comentó sobre el origen de
algunos productos de la canasta familiar. 



La Luciérnaga un espacio de humor,
análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus
oyentes en el regreso a casa.

Escuche el programa de este miércoles 24 de enero. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña por más de 30 años a sus oyentes en su regreso a casa.

Escuche el programa de este martes 26 de marzo. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.