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Secretary of State Orders Emergency Classification of Xylazine aka “Tranq” as Schedule III Controlled Substance

Delaware Secretary of State Jeff Bullock has placed xylazine, also known as “Tranq”— a non-opioid drug used primarily in veterinary medicine—in Schedule III of the Uniform Controlled Substance Act. Tranq has been used increasingly as an additive in opioid abuse to create a “zombie-like” condition for users. Secretary Bullock’s actions follow a recommendation from the […]




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Forest Service to conduct controlled burn in Lewes

The Delaware Forest Service plans to conduct a 48-acre controlled burn in the City of Lewes on Friday, April 23, beginning around mid-morning. Residents and visitors in the area might see smoke and should not be alarmed. The 48-acre site is primarily coastal marsh with phragmites and other vegetation. The purpose of the burn is to reduce hazardous fuel buildup and restore native marsh habitat. The area was last burned in 2008. The area has been treated several times over the past ten years to control phragmites, (Phragmites australis), which outcompetes native vegetation and lowers the local plant biodiversity.




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Controlled Burn at Brandywine Creek State Park Aims to Boost Native Wildlife and Plant Growth

The Delaware Department of Natural Resources and Environmental Control is working with the Delaware Department of Agriculture to execute a controlled burn at Brandywine Creek State Park in February or March. This prescribed burn will help manage nearly 30 acres of meadowland near the park’s nature center.



  • Department of Agriculture
  • Department of Natural Resources and Environmental Control
  • Division of Air Quality
  • Division of Parks and Recreation
  • Forest Service
  • News
  • Brandywine Creek State Park
  • controlled burn
  • DDA Forest Service
  • Delaware Department of Agriculture
  • Delaware Department of Natural Resources and Environmental Control
  • Delaware Fire Service
  • Delaware State Parks
  • Delaware Volunteer Firefighters Association
  • dnrec
  • EC Division of Air Quality
  • prescribed burn

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‘The need for a strong and decisive response has never been greater’: Tourism operators on taxi patroller extortion




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Teenage boy arrested for fatally stabbing a patroller and leaving two injured




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Turkish-Made Drone Crashes in Al-Shabaab-Controlled Farsooley, Somalia

[Radio Dalsan] A Turkish-made drone armed with missiles reportedly crashed on Tuesday in the Al-Shabaab-controlled village of Farsooley, located in Somalia's Lower Shabelle region, local sources have confirmed.




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For Uncontrolled Tremor, Ultrasound Instead of Brain Surgery?

Title: For Uncontrolled Tremor, Ultrasound Instead of Brain Surgery?
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM




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Reply to Letter to Editor Concerning “Nocturnal Pressure Controlled Ventilation Improves Sleep Efficiency in Patients Receiving Mechanical Ventilation”




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Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation

BACKGROUD:Lung volume measurements are important for monitoring functional aeration and recruitment and may help guide adjustments in ventilator settings. The expiratory phase of airway pressure release ventilation (APRV) may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (expiratory time [TE]). We hypothesized that expiratory flow would correlate with estimated lung volume (ELV) as measured using a modified nitrogen washout/washin technique in a large-animal lung injury model.METHODS:Eight pigs (35.2 ± 1.0 kg) were mechanically ventilated using an Engström Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration, which was adjusted based on the expiratory flow curve. Abdominal pressure was increased to 15 mm Hg in normal and injured lungs to replicate a combination of pulmonary and extrapulmonary lung injury. ELV was estimated using the Carescape FRC INview tool. The expiratory flow-time slope and TE were measured from the expiratory flow profile.RESULTS:Lung elastance increased with induced lung injury from 29.3 ± 7.3 cm H2O/L to 39.9 ± 15.1cm H2O/L, and chest wall elastance increased with increasing intra-abdominal pressures (IAPs) from 15.3 ± 4.1 cm H2O/L to 25.7 ± 10.0 cm H2O/L in the normal lung and 15.8 ± 6.0 cm H2O/L to 33.0 ± 6.2 cm H2O/L in the injured lung (P = .39). ELV decreased from 1.90 ± 0.83 L in the injured lung to 0.67 ± 0.10 L by increasing IAP to 15 mm Hg. This had a significant correlation with a TE decrease from 2.3 ± 0.8 s to 1.0 ± 0.1 s in the injured group with increasing insufflation pressures (ρ = 0.95) and with the expiratory flow-time slope, which increased from 0.29 ± 0.06 L/s2 to 0.63 ± 0.05 L/s2 (ρ = 0.78).CONCLUSIONS:Changes in ELV over time, and the TE and flow-time slope, could be used to demonstrate evolving lung injury during APRV. Using the slope to infer changes in functional lung volume represents a unique, reproducible, real-time, bedside technique that does not interrupt ventilation and may be used for clinical interpretation.




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Degradation of Obidoxime Chloride Solution for Injection upon Long-Term Storage under Field Conditions of Mediterranean Climate vs the Controlled Environment

Obidoxime chloride is an antidote for nerve gas intoxication. As an emergency medicine, it is being stored by the Israel Defense Forces (IDF) scattered throughout Israel in depots without a controlled environment (field conditions), thus being exposed to high and fluctuating temperatures. These conditions do not meet the manufacturer’s requirements. In addition, due to possible supply shortages, the utilization of expired batches was suggested. The current work investigated these matters. Long-term (15 years) storage under different conditions was initiated. Chemical stability and toxicity in rats were assessed. No difference was found between field conditions vs the controlled environment. The obidoxime assay remained >95% for 5 years and >90% for 7 years. The pH remained above the lower specification limit for 7–8 years. The major degradation product, 4-pyridinealdoxime, surpassed the allowed limit at 5 years. The content of total unknown impurities reached its maximum allowed by the IDF limit at 4–5 years. Threefold higher than clinically utilized doses of valid-to-date Toxogonin batches administered to rats did not cause any abnormality. However, expired batches produced significant toxic effects. Although no difference was found between storage of obidoxime ampoules when adhering to manufacturer’s recommendations vs field conditions, accumulation of degradants over the limit allowed by the IDF at 4–5 years of storage and the toxicity of the expired batches observed in rats led the IDF to a decision to shorten the shelf-life of this product from 5 to 4 years when stored in an uncontrolled environment of the Mediterranean climate.




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Artificial Intelligence Efficacy as a Function of Trainee Interpreter Proficiency: Lessons from a Randomized Controlled Trial [RESEARCH]

BACKGROUND AND PURPOSE:

Recently, artificial intelligence tools have been deployed with increasing speed in educational and clinical settings. However, the use of artificial intelligence by trainees across different levels of experience has not been well-studied. This study investigates the impact of artificial intelligence assistance on the diagnostic accuracy for intracranial hemorrhage and large-vessel occlusion by medical students and resident trainees.

MATERIALS AND METHODS:

This prospective study was conducted between March 2023 and October 2023. Medical students and resident trainees were asked to identify intracranial hemorrhage and large-vessel occlusion in 100 noncontrast head CTs and 100 head CTAs, respectively. One group received diagnostic aid simulating artificial intelligence for intracranial hemorrhage only (n = 26); the other, for large-vessel occlusion only (n = 28). Primary outcomes included accuracy, sensitivity, and specificity for intracranial hemorrhage/large-vessel occlusion detection without and with aid. Study interpretation time was a secondary outcome. Individual responses were pooled and analyzed with the t test; differences in continuous variables were assessed with ANOVA.

RESULTS:

Forty-eight participants completed the study, generating 10,779 intracranial hemorrhage or large-vessel occlusion interpretations. With diagnostic aid, medical student accuracy improved 11.0 points (P < .001) and resident trainee accuracy showed no significant change. Intracranial hemorrhage interpretation time increased with diagnostic aid for both groups (P < .001), while large-vessel occlusion interpretation time decreased for medical students (P < .001). Despite worse performance in the detection of the smallest-versus-largest hemorrhages at baseline, medical students were not more likely to accept a true-positive artificial intelligence result for these more difficult tasks. Both groups were considerably less accurate when disagreeing with the artificial intelligence or when supplied with an incorrect artificial intelligence result.

CONCLUSIONS:

This study demonstrated greater improvement in diagnostic accuracy with artificial intelligence for medical students compared with resident trainees. However, medical students were less likely than resident trainees to overrule incorrect artificial intelligence interpretations and were less accurate, even with diagnostic aid, than the artificial intelligence was by itself.




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Hori’s spiritual successor to the Steam Controller is up for preorder on Amazon today

Hori's latest addition to its controller lineup, the "Horipad Wireless for Steam," is now available for preorder on Amazon. After already releasing in Japan at the end of October, now the gamepad is coming to the US.

Read more




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Principles of PID Controllers



Thanks to their ability to adjust the system’s output accurately and quickly without detailed knowledge about its dynamics, PID control loops stand as a powerful and widely used tool for maintaining a stable and predictable output in a variety of applications. In this paper, we review the fundamental principles and characteristics of these control systems, providing insight into their functioning, tuning strategies, advantages, and trade-offs.

As a result of their integrated architecture, Zurich Instruments’ lock-in amplifiers allow users to make the most of all the advantages of digital PID control loops, so that their operation can be adapted to match the needs of different use cases.






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Stempeucel for Buerger's Disease Receives Limited Approval from Drug Controller of India

An effective cure for one of the most devastating disease could be in the cards as the Drug Controller of India (DGCI) has granted limited approval for




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'Trolls': Bright And Cheerfully Appealing

"Trolls"; Directors: Mike Mitchell, Walt Dohrn; Cast: Anna Kendrick, Justin Timberlake, Zooey Deschanel, Christopher Mintz-Plasse, Christine Baranski, Russell Brand, Gwen Stefani, John Cleese, James Corden and Jeffrey Tambor.




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Who did it better: Zendaya-Tom Holland or Janhvi-Shikhar Pahariya; latter trolled on Reddit

Netizens have accused Janhvi and Shikhar of trying to replicate a sweet romantic moment between Hollywood love birds Zendaya and Tom Holland.




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Kiara Advani's first look in Ram Charan starrer 'Game Changer' trolled; here's why

The first look-poster of Kiara Advani's character from Game Changer, directed by Shankar, is out and netizens are finding it absolutely hilarious.




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How Rashami Desai deals with trolls, social media negativity; talks about Bigg Boss 13 [Exclusive]

In an exclusive conversation with International Business Times, India, Rashami Desai spoke about her stint on BB 13, when things about her personal life were blown out of proportion, how the industry has changed over the years after the OTT boom, whether she will be part of any more reality shows, and more. Read on.




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Mukesh Khanna trolled as he returns as Shaktimaan; fans say 'Is he teasing Ranveer Singh?'

Mukesh Khanna said, "I am even happier than the others about becoming Shaktimaan again. I am carrying out my duty that I started in 1997 and which went on till 2005. I think that my work should reach the public in 2027 ."




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Sony PS5 Chroma Collection Accessories and Custom Fortnite DualSense Controller Launched in India

Sony has introduced the Chroma Collection accessories and a Fortnite Limited Edition DualSense wireless controller for PlayStation 5 users in India. These new offerings provide stylish customisation options with unique colours and designs, enhancing the gaming experience. The Chroma Collection features




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Controlling the droplet cell environment in scanning electrochemical cell microscopy (SECCM) via migration and electroosmotic flow

Faraday Discuss., 2024, Advance Article
DOI: 10.1039/D4FD00080C, Paper
Open Access
Samuel F. Wenzel, Heekwon Lee, Hang Ren
The contributions of migration and electroosmotic flow induced by electrochemical redox molecules in dual-barrel SECCM were characterised.
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Coming of Age : Constructing and Controlling Youth in Munich, 1942-1973 [Electronic book] / Martin Kalb.

New York; Oxford : Berghahn Books, [2016]




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Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00891F, Paper
Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi Li
The DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.
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Synthesis and photocatalytic property of Au–TiO2 nanocomposites with controlled morphologies in microfluidic chips

Lab Chip, 2024, 24,2253-2261
DOI: 10.1039/D3LC01053H, Paper
Ziran Ye, Ping Lu, Yiben Chen, Zhixian Xu, Haixia Huang, Mingjia Zhi, Zi Ang Chen, Bo Yan
We present an efficient approach for the consecutive synthesis of Au–TiO2 nanocomposites with controlled morphologies in a microfluidic chip.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Fabricating multi-scale controllable PEDOT:PSS arrays via templated freezing assembly

Soft Matter, 2024, 20,3021-3021
DOI: 10.1039/D4SM90038C, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yang Lin, Junqiang Mao, Qingrui Fan, Jianjun Wang
The content of this RSS Feed (c) The Royal Society of Chemistry




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Achieving controllable and reversible snap-through in pre-strained strips of liquid crystalline elastomers

Soft Matter, 2024, 20,3256-3270
DOI: 10.1039/D4SM00037D, Paper
Open Access
James T. Waters, Anna C. Balazs
Deformable, elastic materials that buckle in response to external stimuli can display “snap-through”, which involves a transition between different, stable buckled states.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Current status of controlled onco-therapies based on metal organic frameworks

RSC Adv., 2024, 14,12817-12828
DOI: 10.1039/D4RA00375F, Review Article
Open Access
Yixuan Yang, Xiaofeng Dai
Most MOFs for controllable cancer treatment act as drug delivery vehicle and/or anti-cancer agent. Molecules with anti-cancer roles such as chemotherapies, gases, peptides or nucleic acids can be loaded into MOFs that decompose in cancer cells or in the TME to release its cargoes.
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A facile and versatile platform for preparing uniform π-conjugated nanofibers with controlled length and varying shells

Polym. Chem., 2024, 15,4231-4243
DOI: 10.1039/D4PY00979G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Bo Xiang, Hongluo Wu, Rang Chen, Xiaoyu Huang, Guolin Lu, Chun Feng
A versatile and facile platform is developed for the generation of uniform π-conjugated nanofibers with controlled length and varying shells by the combination of pentafluorophenyl ester chemistry and a self-seeding strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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High-temperature emulsification coupled with low-temperature gelation for fabrication of agarose microsphere implants with well-controlled size for skin tissue enhancement

J. Mater. Chem. B, 2024, 12,10983-10993
DOI: 10.1039/D4TB01564A, Paper
Qi Wang, Huiyu Yan, Ying Guo, Bei Tian, Jianxi Xiao
Agarose offers self-gelation, biodegradability, and biocompatibility. We have developed a high-temperature emulsification followed by low-temperature gelation method to create agarose microsphere implants for skin tissue augmentation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Photoresponsive prodrug-based liposomes for controllable release of the anticancer drug chlorambucil

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01620C, Paper
Xiaoting Wang, Guangtian Suo, Shinan Ma, Chunxi Yang, Chunyan Bao
A photoresponsive lipid prodrug was designed to form nanomedicines for accurate and controllable drug release in response to light irradiation.
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Nanobiopolymers in cancer therapeutics: advancing targeted drug delivery through sustainable and controlled release mechanisms

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00599F, Review Article
Shikha Gulati, Nabeela Ansari, Yamini Moriya, Kumud Joshi, Disha Prasad, Gargi Sajwan, Shefali Shukla, Sanjay Kumar, Rajender S. Varma
Nanobiopolymers in cancer therapeutics offer sustainable and targeted drug delivery with controlled release, enhancing treatment efficacy while ensuring sustainability and biodegradability for improved patient care.
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Controlled therapeutic cholesterol delivery to cells for the proliferation and differentiation of keratinocytes

J. Mater. Chem. B, 2024, 12,11110-11122
DOI: 10.1039/D4TB01015A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Krzysztof Berniak, Ahmadreza Moradi, Agata Lichawska-Cieslar, Weronika Szukala, Jolanta Jura, Urszula Stachewicz
The research concept involves investigating how cholesterol endocytosis impacts cells using electrospun fibers as a carrier. We studied keratinocyte proliferation and evaluated gene expression levels for markers of early and late differentiation.
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'I should have controlled my anger'

'I never fought with anyone.''I was not rude to anyone. 'I did not argue with anyone.''I did not misbehave with any girl.''The only person I did not get along was Abhishek.'




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Advances in morphology-controlled alumina and its supported Pd catalysts: synthesis and applications

Chem. Soc. Rev., 2024, Advance Article
DOI: 10.1039/D3CS00776F, Review Article
Yanpeng Yang, Chenglin Miao, Ruoyu Wang, Rongxin Zhang, Xiaoyu Li, Jieguang Wang, Xi Wang, Jiannian Yao
This review highlights the preparation and regulation strategies of alumina materials from different dimensions and summarizes the preparation, metal–support interaction, and application of Pd/Al2O3 catalysts on important industrial catalysis.
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Constructing efficient organic solar cells by highly volatile solid additives with controlled phase morphology

Chem. Commun., 2024, 60,13424-13427
DOI: 10.1039/D4CC04675G, Communication
Yueheng Liu, Yetai Cheng, Shenbo Zhu, Zhengdong Wei, Chenyi Zhang, Shuyue Song, Xinyue Cui, Ya-Nan Chen, Andong Zhang, Yahui Liu, Hao Lu, Huawei Hu, Zhishan Bo
We synthesized two highly volatile and low-cost solid additives, PT and TFT.
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Wireframe DNA origami nanostructure with the controlled opening of edges

Mol. Syst. Des. Eng., 2024, Advance Article
DOI: 10.1039/D4ME00144C, Paper
Maryam Mogheiseh, Reza Hasanzadeh Ghasemi
Design and simulation of wireframe DNA origami nanostructures with fast and controlled opening capability using modified DAEDALUS code.
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Ni–Co alloys via controlled pyrolysis of NiCo–MOF as heterogeneous hydrogenation catalysts

New J. Chem., 2024, Advance Article
DOI: 10.1039/D4NJ00664J, Paper
Lidan Deng, Xingwang Liu, Chong Chen, Lu Wang, Fan Liu, Jie Zhang
The pyrolysis in H2 at lower temperatures can obtain MNP/MOF with more complete MOFs structure and dispersed Ni–Co alloy nanoparticles, which display significantly better activity for the hydrogenation of toluene to methylcyclohexane.
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The good, the bad and the trolls

When they are good they are really very funny, but when they are bad they are horrid, says PARSHATHY J. NATH about trolls on social media




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Fe–carbon nanofiber-modified Mo-MOF for the controlled release and translocation of micronutrients in plants

Environ. Sci.: Nano, 2024, 11,1597-1611
DOI: 10.1039/D3EN00833A, Paper
Komal Pandey, Rishabh Anand Omar, Nishith Verma, Govind Gupta
Fe-CNF/Mo-MOF releases Mo and Fe in soil upon degradation by resident rhizobacteria and translocates the micronutrients to plant roots, shoots, and leaves.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Solvent-polarity-controlled assembly of polynuclear titanium-calixarene complexes: constructing isolated {Ti7}, {Ti13}, {Ti24} and {Tb2Ti13} clusters

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D3CE01275A, Paper
Yanyan Wang, Ying Xiong, Wuping Liao
The assembly of polynuclear titanium-calixarene complexes is based on Ti4–C8A SBUs.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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CPI(M) went after trolley bag to hide government failure, says Muraleedharan

Both the State and Union governments are uninterested in people’s issues, says the Congress leader




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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
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How Mind-Controlled Bionic Arms Fuse To The Body

A game-changer in prosthetics has been introduced to the world, and for the first time, amputees are regaining sensation through an electrical signal from their prosthetic arm. Max Ortiz-Catalan, a professor of bionics, explains the process of implanting these mind-controlled bionic arms through direct skeletal attachment. The researcher takes us through every step of this groundbreaking advancement in bionic medicine, from surgically implanting electrodes to fitting the prosthesis and training for everyday use. Director: Lisandro Perez-Rey Editor: Jordan Calig Expert: Prof. Max Ortiz Catalan Line Producer: Joseph Buscemi Associate Producer: Kameryn Hamilton Production Manager: D. Eric Martinez Production Coordinator: Fernando Davila Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Justin Symonds




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LAC breakthrough: India, China agree on patrolling arrangements in border area

Move could help India play down anti-China sentiments, increase economic engagement, say experts




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Indian Army begins patrolling at Demchok but not at Depsang in Ladakh

Indian Army sources stated patrolling at Depsang is expected to resume shortly




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Controlling CO2 flux in a CO2-permeable membrane with a H2O driving force

J. Mater. Chem. A, 2024, 12,30821-30830
DOI: 10.1039/D4TA05021E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jacqueline A. Penn, Wenting Hu, Ian S. Metcalfe, Greg A. Mutch
A H2O driving force in the opposite direction to CO2 permeation exerts control over CO2 flux in a molten-salt membrane fabricated using hydroxides.
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Low-pressure hydrogen sensing mechanism based on the field emission of defect-controlled ZnO nanorods

J. Mater. Chem. C, 2024, 12,17419-17428
DOI: 10.1039/D4TC01951B, Paper
Mingliang Dong, Weijin Qian, Youqing Tu, Guitao Chen, Weijun Huang, Haijun Luo, Changkun Dong
The work function of ZnO is reduced with H adsorbed on oxygen defects, leading to the hydrogen sensing effect.
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One-pot and large-scale production of uniform ytterbium-doped perovskite nanocrystals with controllable optical properties

J. Mater. Chem. C, 2024, 12,17647-17657
DOI: 10.1039/D4TC03364G, Paper
Jing Chu, Linxuan Zhang, Quanjie Lv, Yijun Han, Kang Sun, Ke Tao
Monodispersed Yb3+:CsPbCl3 nanocrystals with tunable optical properties were synthesized via a scalable one-pot method. The mechanism of size evolution based on digestive ripening was proposed.
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