The amendment, part of a pending transportation bill, marks the Gulf Coast's 'most important conservation victory in a decade,' advocates say.

Yellowstone grizzly bears were removed from the U.S. endangered species list in 2017.

Fuel-cell advocates are none too happy about Department of Energy Secretary Steven Chu’s abrupt decision earlier this month to cancel $100 million in hydrogen

The ancient weapon, likely owned by a Roman Centurion, was discovered in Germany by a 19-year-old intern.

Researchers are digging deeper into how tomato flavors have changed over time, and now they've found a specific gene that's missing in many modern varieties.

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The law firm graciously donated food and essentials to the victims affected by the 7.8 magnitude earthquake in Ecuador.

Center for Cosmetic Dentistry provides quality dental restorations and cosmetic care

All-on-4 Dental Surgery Is A Method Used To Restore Teeth, All Within The Same Day

Famed Conservator Tapped For Work Attributed To Whistler

Our Xbox crew discusses the Gears 5 campaign now that the review embargo has lifted (don't worry, no spoilers!). Plus: our impressions of Ghost Recon Breakpoint after playing six hours of it, Cyberpunk 2077's surprising multiplayer announcement, Telltale's even more surprising sorta-resurrection, and more!

Covid-19: JLR restores three-fourth of its budgeted production in China

The Silvies Valley Ranch is an example of using local innovation to combat the global problem of incised streams on rangelands. Incised channels reduce the flow between water in the channel and water in the surrounding soils, which reduces the vegetation available for wildlife habitat and cattle forage. One of the ranch owners, Scott Campbell, a doctor of veterinary medicine, believes that stream incision is related to the decline of beaver populations; thus, the ranch’s approach to restoration includes efforts to mimic beavers’ influence on the system. He is using an extensive network of low-rise dams made from locally available materials (dirt, gravel, rock, and logs), commonly referred to as “artificial beaver dams” (ABDs). Campbell said that the ABDs on the ranch successfully increased stream connectivity to their floodplains and increased the quantity and forage quality of wet meadows on the property, with no changes in where cattle were grazing. The experiences of this landowner exemplify a unique approach that provides a model for others facing similar challenges to doing restoration on private land. The transformation taking place on the Silvies Valley Ranch has garnered the attention of neighboring ranch owners, some of whom are beginning to experiment with similar restoration technologies. Campbell would like to continue installing structures, but has encountered numerous roadblocks in the permitting process. He has since taken an active role in building legislative support for the ABD technology being used on the ranch, and in facilitating its adoption in other places. This case study—based on interviews with stakeholders involved in the Silvies Valley Ranch project—highlights the social benefits and challenges experienced by one rancher using ABDs as a restoration tool, and provides insights for improving their use in the future. It is part of a larger interdisciplinary study that explores the potential of different beaver-related restoration approaches for achieving watershed restoration and livestock production goals on rangelands in the Western United States.

A century of effective fire suppression has radically transformed many forested landscapes on the east side of the Cascades. Managers of dry forests critically need information to help plan for and implement forest restoration. Management priorities include the stabilization of fire regimes and the maintenance of habitat for the northern spotted owl and other old-forest associates.

Have you chosen Mac for its reliable system? They really have a lot of advantages and are of the best quality. Mac users don’t face serious problems with hard drives often. But the reality is such...

A regenerated spent hydroprocessing catalyst treated with a chelating agent and having incorporated therein a polar additive.

Can these lockdown patterns of urban behaviour change how we shape our cities, one man's mission to de-plastic our sea and sand, how Cape York communities have had zero infection on a shoestring budget, and a landmark Dylan song falls back into relevance.

A north Queensland man has helped to create a club for car lovers with a disability or mental illness the kind of program he wished was around 14 years ago, when he attempted suicide.

A Sunshine Coast man launches a campaign to reinvigorate community organisation Rotary by attracting young people.

There is no shortage of heritage to celebrate and preserve at the New Norcia Monastery in Western Australia's Mid West.

It took two years, countless phone calls and the determination of 84-year-old grain farmer Jim Sawyer, but Australia's only known cross-legged Stover windmill has been restored to its original glory.

Scottish stonemasons with experience in restoring castles, restore a historic woolshed in South Australia's outback with quite a bit of help from the locals.

Award-winning 'heritage hero' Roy Taplin breathes new life into a 1917 Commonwealth Railways dining car.

Albert H. Fox, who restored and rebuilt close to 6,000 pianos and tuned several thousand more, has now restored a famous 145-year-old Pleyel piano.

An unlikely partnership involving scientists and the fishing industry is at the centre of efforts to restore seagrass stocks in Corner Inlet.

A priceless 17th-century map of Australia is back on display after being painstakingly restored.

More than 1,000 pipes from Albury's St Matthew's Church's renowned Letourneau organ will be removed and restored after being damaged by fire three years ago.

Apparently. But we’re so incredulous, we’re gonna test those claims on live internet TV…

Webcast “The journey to cloud” echoes through all organisations. It’s a Bildungsroman – a story of empowerment and betterment. A shiny, towering cityscape of gleaming edifices and elegant spires. It’s like an ascension into the actual clouds. Like dying and waking up in heaven.…

Researchers have built a prosthesis that enabled a man who lost his hand to text, pluck grapes from their stems, and stuff a pillow into its case.

Lawrence Welk is newly hip at Modernism Week in Palm Springs: The late entertainer's home has been lovingly restored, and is now opening its doors.

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation of its promoter in acute myeloid leukemia (AML). However, why SKIP activity is silenced in primary AML cells is unclear. Here, we investigated the consequences of SKIP down-regulation in AML primary cells and the effects of SKIP re-expression in leukemic cell lines. Using targeted ultra-HPLC-tandem MS (UPLC-MS/MS), we measured sphingolipids (including S1P and ceramides) in AML and control cells. Primary AML cells had significantly lower SK activity and intracellular S1P concentrations than control cells, and SKIP-transfected leukemia cell lines exhibited increased SK activity. These findings show that SKIP re-expression enhances SK activity in leukemia cells. Furthermore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells. Of note, SKIP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling protein extracellular signal-regulated kinase, and increased apoptosis following serum deprivation or chemotherapy. These results indicate that SKIP down-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apoptosis in leukemia cells. The findings of our study contrast with previous results indicating that SKIP inhibits SK function in fibroblasts and therefore challenge the notion that SKIP always inhibits SK activity.

Central to the development of diabetic macro- and microvascular disease is endothelial dysfunction, which appears well before any clinical sign but, importantly, is potentially reversible. We previously demonstrated that hyperglycemia activates nuclear factor of activated T cells (NFAT) in conduit and medium-sized resistance arteries and that NFAT blockade abolishes diabetes-driven aggravation of atherosclerosis. In this study, we test whether NFAT plays a role in the development of endothelial dysfunction in diabetes. NFAT-dependent transcriptional activity was elevated in skin microvessels of diabetic Akita (Ins2^+/–) mice when compared with nondiabetic littermates. Treatment of diabetic mice with the NFAT blocker A-285222 reduced NFATc3 nuclear accumulation and NFAT-luciferase transcriptional activity in skin microvessels, resulting in improved microvascular function, as assessed by laser Doppler imaging and iontophoresis of acetylcholine and localized heating. This improvement was abolished by pretreatment with the nitric oxide (NO) synthase inhibitor l-N^G-nitro-l-arginine methyl ester, while iontophoresis of the NO donor sodium nitroprusside eliminated the observed differences. A-285222 treatment enhanced dermis endothelial NO synthase expression and plasma NO levels of diabetic mice. It also prevented induction of inflammatory cytokines interleukin-6 and osteopontin, lowered plasma endothelin-1 and blood pressure, and improved mouse survival without affecting blood glucose. In vivo inhibition of NFAT may represent a novel therapeutic modality to preserve endothelial function in diabetes.

Environmental economics.

Walvis Bay, Namibia :: Logos Hope's volunteers rebuild a flimsy church and encourage the grieving pastor and congregation.

Is your favorite music missing on your iPhone or iPad? Maybe you inadvertently turned off syncing or accidentally deleted those tunes. All is not lost; here's how to recover your music.

In a shocking display of ignorance, pay for performance has become reformers' blitzkrieg. Both common sense and research are being ignored.

The House appropriations committee voted Wednesday to advance a bill providing a slight funding increase for the U.S. Department of Education, bringing overall funding to about $71 billion.