Today it is increasingly on the back foot, with the loss of dozens of outposts, bases and strategic cities that even its leaders concede will be challenging to regain

Turnhout : Brepols, 2022.

If brought into the new drug bracket, manufacturing, marketing and sale of antibiotics will be documented; patients will be able to buy antibiotics on prescription only

Here are the intraday supports and resistances for widely traded stocks such as Reliance Industries, ITC, ONGC, Infosys, HDFC Bank, TCS, and SBI

Funds from the Gates Foundation and U.K. government will help address antimicrobial resistance in low- and middle-income countries

Funds from the Gates Foundation and U.K. government will help address antimicrobial resistance in low- and middle-income countries

A Princeton University-led study has found that trees worldwide develop thicker bark when they live in fire-prone areas. The findings suggest that bark thickness could help predict which forests and savannas will survive a warmer climate in which wildfires are expected to increase in frequency.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Cecile Rol Tanguy (pictured) died yesterday at her home in Monteaux, central France, as Europe commemorated the 75th anniversary of the surrender of Nazi Germany to Allied forces.

Sanjay Kak's latest film Red Ant Dream weaves together disparate stories of people's movements and transports the viewer to hidden pockets of resistance to paint a picture of conflict and revolutionary potential in India today. Freny Manecksha reviews the film.

The recently held Kolkata People’s Film Festival – an offshoot of the founding movement called The Cinema of Resistance – screened powerful documentaries and feature films portraying the struggle and resistance of the marginalised and downtrodden. Shoma Chatterji reports.

Rb0.21(H2O)yWS2, rubidium hydrate di­thio­tungstate, is a new quasi two-dimensional sulfide. Its crystal structure consists of ordered WS2 layers, separated by disordered Rb+ ions and water mol­ecules. All atomic sites are located on mirror planes. The WS2 layers are composed of edge-sharing [WS6] octa­hedra and extend parallel to (001). The presence of structural water was revealed by thermogravimetry, but the position and exact amount could not be determined in the present study. The temperature dependence of the electrical resistance indicates that Rb0.21(H2O)yWS2 is semiconducting between 80–300 K.

Bacteria that resist antibiotics can be passed from food animals to humans, but not enough is known to determine the public health risks posed by such transmission, says a new report by a committee of the National Research Council.

Young athletes in the U.S. face a culture of resistance to reporting when they might have a concussion and to complying with treatment plans.

University of Oregon researchers have found links between the levels of antimicrobial chemicals and antibiotic-resistance genes in the dust of an aging building used for athletics and academics.

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Widespread use of antibiotics to prevent and treat infections in people and animals as well as for promoting growth in livestock is causing environmental contamination. A new study highlights the need for extra measures to reduce environmental pollution from antibiotics. Such pollution can increase the risk of diseases caused by bacteria that become resistant to antibiotics.

Contrary to some established views, the local animal population is unlikely to be the major source of resistance diversity for Salmonella Typhimurium DT104 in humans in Scotland, according to a study. The researchers suggest that a broader approach to fighting antibiotic resistance is needed, which goes beyond focusing solely on curbing the use of antibiotics in domestic animal populations.

The application to crops of struvite (magnesium ammonium phosphate) recovered from waste water may cause antibiotic resistance genes (ARGs) present in this fertiliser to enter the food chain. Chinese researchers who conducted this study on Brassica plants suggest that ARGs in struvite pass from the soil into the roots of the plant, and from the roots to the leaves, via the bacterial community already present. The results of this research highlight the need for struvite production methods and agricultural practices that minimise the risk of antibiotic-resistance transmission from struvite to humans or animals via the environment.

Marine fisheries play a key role in feeding human populations, but are faced with the twin threats of overexploitation and climate change. Using a comprehensive database of global reef-fish communities, a team of researchers has found that the greater the diversity of fish in an assemblage, the less vulnerable that assemblage is to climate change. The researchers suggest climate change mitigation efforts should include a focus on maintaining a wide range of species in at-risk communities.

The ability of organisms to adapt to toxic chemicals like pesticides is essential for their survival, but also an agricultural annoyance. This study shows that interactions between different species can delay the development of pesticide resistance and therefore suggests that biodiversity supports effective pest management.

Widespread use of antibiotics has led to pollution of waterways, potentially creating resistance among freshwater bacterial communities. A new study looked for antibiotic resistance genes in a river basin in Spain, revealing that wastewater discharges can promote the spread of antibiotic resistance in streams and small rivers.

Sewage sludge and manure are sometimes added to soil to improve crop production. However, these ‘natural fertilisers’ may contain not only nutrients and organic matter but also antibacterial agents. This study investigated their impact on the microbes in soil, revealing an increase in antibiotic resistance genes. The researchers recommend greater efforts to remove antibiotic residues from wastewater and manure.

A new study has investigated the movement of antibiotic resistance genes between farm animals, soil and water in Finland. The results show that many of these genes are spread from animals to the soil through manure application; however, these genes do not appear to persist in soil. The study suggests that practices that minimise the use of antibiotics, as used in Finland, may lead to lower levels of clinically relevant resistance genes in agricultural soils.

A method of creating a semiconductor device is disclosed. An end of a carbon nanotube is unzipped to provide a substantially flat surface. A contact of the semiconductor device is formed. The substantially flat surface of the carbon nanotube is coupled to the contact to create the semiconductor device. An energy gap in the unzipped end of the carbon nanotube may be less than an energy gap in a region of the carbon nanotube outside of the unzipped end region.

The present invention relates to epoxy group-terminated polymers of the formula (I). Said epoxy group-terminated polymers are suited extremely well as impact resistance modifiers, particularly in epoxy resin compositions. They are particularly suited for use in heat-curing epoxy resin adhesives. It has been found that such epoxy resin compositions not only have excellent mechanical properties and high glass transition temperatures, but also above all improved impact resistance properties, both at room temperature and at low temperatures.

Aqueous copolymer dispersions for a variety of uses, including coating compositions or binders for plasters and paints, are disclosed. The aqueous copolymer dispersions may comprise one or more silicon containing compounds, in particular hydrolyzable silane compounds without any additional reactive group.

The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is covalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative thereof. Preferably, the organometallic compounds are half-sandwich (“piano-stool”) compounds. The compounds of the present invention offer a high variability with respect to the bioactive compound and to the nature of the ligand bound to a central transition metal.

Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.

It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The present disclosure relates to therapeutic agents, compositions and methods for treating a muscle disease or condition characterized by impaired insulin-dependent signaling by targeting components of the defective insulin signaling pathway. The disease or condition may be treated by administering a therapeutic agent that activates the insulin signaling pathway, in particular, therapeutic agents that act post-insulin receptor to modulate intracellular effector molecules. An exemplary modulator is metformin. Metformin may be administered alone or may be coadministered with another therapeutic agent for treating the muscle disease or condition, such as a corticosteroid.

Described herein are methods and compositions for enhancing pathogen immunity in plants and improving plant growth.

The embodiments relate to modeling resistance in a multi-fin multi-gate field effect transistor (MUGFET). In these embodiments, a design for a multi-fin MUGFET comprises a gate structure with a horizontal portion traversing multiple semiconductor fins and comprising a plurality of first resistive elements connected in series, with vertical portions adjacent to opposing sides of the semiconductor fins and comprising second resistive elements connected in parallel by the horizontal portion, and with contact(s) comprising third resistive element(s). The total gate resistance is determined based on resistance contributions from the first resistive elements, the second resistive elements and the third resistive element(s), particularly, where each resistive contribution is based on a resistance value of the resistive element, a first fraction of current from the semiconductor fins entering the resistive element and a second fraction of the current from the semiconductor fins exiting the resistive element.

For reading the frets of a stringed electronic musical instrument, a plurality of resistance wire strings are secured to a nut end and a bridge of the instrument, with the strings superposing in parallel relationship over a plurality of conducting frets mounted on a fingerboard on the instrument. The voltages produced by depressing the strings to the conducting frets, after being inverted and linearized, are quantized to levels representative of the particular frets to obviate the effects of contact resistance, and decision voltage levels are selected so as to account for such contact resistance. To enable the signals to be fed as conventional information through a MIDI channel to a synthesizer for generating frequencies corresponding to the signals, an analog to digital converter is used. The different components, as well as the digitized linearized signals, are selectively controlled and fed, respectively, to a microprocessor.

An apparatus includes a writer, an arrangement comprising a plasmonic near-field transducer (NFT) adjacent the writer and comprising a material having a temperature coefficient of resistance (TCR), and a lead arrangement connected to the NFT arrangement. In some configurations, the NFT arrangement includes a heat sink, and the lead arrangement is connected to the heat sink. In other configurations, the lead arrangement is connected directly to the NFT.

An insect-resistant protein exhibiting a sufficient resistance to insects; an insect-resistance gene encoding the insect-resistant protein; a recombinant vector containing the insect-resistance gene; a host cell and a plant cell having the recombinant vector transfected thereinto; a transformant transformed by the insect-resistance gene and a method for producing the same; a protein recovered thereby; and an insect-resistant agent comprising them as active ingredients. In accordance with the present invention, the insect-resistant protein is derived from a plant.

A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign.

A head transducer, configured to interact with a magnetic recording medium, includes a first sensor having a temperature coefficient of resistance (TCR) and configured to produce a first sensor signal, and a second sensor having a TCR and configured to produce a second sensor signal. One of the first and second sensors is situated at or near a close point of the head transducer in relation to the magnetic recording medium, and the other of the first and second sensors spaced away from the close point. Circuitry is configured to combine the first and second sensor signals and produce a combined sensor signal indicative of one or both of a change in head-medium spacing and head-medium contact. Each of the sensors may have a TCR with the same sign (positive or negative) or each sensor may have a TCR with a different sign.

Methods for providing magnetic storage elements with high magneto-resistance using Heusler alloys are provided. One such method includes depositing a substrate including NiFe, depositing a seed layer on the substrate, depositing a buffer layer on the seed layer, and growing, epitaxially, an upper layer on the buffer layer, the upper layer including a Heusler alloy.

A resistance component includes a stack of ceramic layers and inner electrodes. Inner electrodes of a first type are electrically conductively connected to a first external contact and inner electrodes of a second type are electrically conductively connected to a second external contact. The inner electrodes of the first type are arranged such that there is no overlap with the inner electrodes of the second type. An inner electrode of a third type, which is electrically conductively connected neither to the first external contact nor to the second external contact, at least partially overlaps the inner electrodes of the first type and the inner electrodes of the second type.

An axial resistance sheathed heater is presented. The axial resistance sheathed heater includes a retaining sheath having a first end and a second end and a resistance wire completely disposed within the retaining sheath. The heater further includes a first conductor rod partially disposed within the retaining sheath and extending beyond the first end of the retaining sheath, the first conductor rod in direct electrical communication and direct mechanical communication with the resistance wire; and a second conductor rod partially disposed within said retaining sheath and extending beyond the second end of the retaining sheath, the second conductor rod in direct electrical communication and direct mechanical communication with the resistance wire. The resistance wire, the first conductor rod and the second conductor rod comprise a circuit achieving a power to voltage rating of about 5000:24.

The invention relates to methods and compositions for identifying and selecting maize plants with enhanced resistance to northern leaf blight. Maize plants generated by the methods of the invention are also a feature of the invention.

The present invention provides an apparatus for enhancing Q factor of an inductor. The apparatus includes a negative resistance generator coupled to the inductor for providing a negative resistance, and a bias circuit coupled to the negative resistance generator for biasing the negative resistance generator.

Provided are a bake hardening steel having a crystalline grain size of ASTM No. 9 or more and a method for preparing the bake hardening steel by controlling the winding, rolling and cooling conditions. The bake hardening steel includes: C:0.0016˜0.0025%, Si:0.02% or less, P:0.01˜0.05%, S:0.01% or less, sol.Al:0.08˜0.12%, N:0.0025% or less, Ti:0.003% or less, Nb:0.003˜0.011%, Mo:0.01˜0.1%, B:0.0005˜0.0015% or less, balance Fe and other inevitable impurities, wherein % is weight %, and Mn and P satisfy the relation of −30(° C.)≧803P−24.4Mn−58.

A SAW filter circuit having improved ESD resistance is specified, in which a series interconnection composed of SAW resonators is interconnected between a first signal port and a dual-mode SAW filter port. The static capacitance of the series interconnection is at most four times the static capacitance of the dual-mode SAW filter transducers interconnected therewith.

An electric switch for application to high- and very high-voltage circuit breakers and switches comprising a flexible toroidal helical spring (8) placed in a groove of a control rod (1) carrying a movable resistance-insertion contact (2), and springs (4) placed about the movable resistance-insertion contact to cause the springs to be compressed until a certain value is reached, at which value the movable resistance-insertion contact causes the flexible toroidal helical spring (8) to deform under pressure enabling the movable resistance-insertion contact (2) to be withdrawn. Among other uses, the switch is suitable for use in a resistance-inserting device that does not need additional mechanical moving parts. For application to high- and very high-voltage circuit breakers and switches.

A carbon exchanging system for a carbon-arc weather resistance testing apparatus having a carbon drive system including a reversible motor for automatically moving upper and lower arc producing carbons toward and away from each other along a vertical line for keeping the discharge current and voltage substantially constant. The carbon exchanging system has remotely operable upper and lower carbon chucks for holding the upper and lower carbons, a carbon replacing device having a remotely operable exchanging chuck and a drive for moving the exchanging chuck along a path of movement toward and away from the upper and lower carbon chucks when they are in position on the vertical line, a shifting device for shifting the carbon drive system and the carbon replacing means relative to each other for moving the upper and lower chucks and the exchanging chuck laterally relative to the vertical line, a carbon supply adjacent the path of movement of the exchanging chuck for holding replacement carbons and moving them into position opposite a position of the exchanging chuck along the path, and a moving device for moving the exchanging chuck and the carbon supply relative to each other in a direction toward and away from each other. The system can also include a control device for automatically controlling the operation thereof.

A pump system (120) has a central pump unit (110), with which at least one hook-up unit (130). The least one hook-up unit (130) is from a group of a plurality of hook-up units (130) that can be combined in modular form for setting an operating point of a pump (10) that forms the pump unit (110). A method uses such a hook-up unit (130) in a pump system (120) for setting an operating point of the pump unit (110) thereof. A medical device is provided with such a pump unit (110) or with such a pump unit (110) and at least one hook-up unit (130) combined with the pump unit (110).