Thermoregulation, responsible for maintaining a stable core temperature during wide fluctuations in external and internal thermal environments, is an iconic homeostatic process. However, we suggest that despite its fundamental physiological significance, the potential for required cool housing temperatures and thermoregulatory mechanisms to influence the interpretation of experimental data is not sufficiently appreciated. Moreover, although it is generally assumed that the major thermoregulatory pathways are well understood, here we discuss new research that suggests otherwise and reveals the emergence of a new wave of exciting ideas for this "old" field of research.

Recent work has highlighted the central role the brain–body axis plays in not only maintaining organismal homeostasis but also coordinating the body's response to immune and inflammatory insults. Here, we discuss how science is poised to address the many ways that our brain is directly involved with disease. In particular, we feel that combining cutting-edge tools in neuroscience with translationally relevant models of cancer will be critical to understanding how the brain and tumors communicate and modulate each other's behavior.

The brain's capacity to predict and anticipate changes in internal and external environments is fundamental to initiating efficient adaptive responses, behaviors, and reflexes that minimize disruptions to physiology. In the context of feeding control, the brain predicts and anticipates responses to the consumption of dietary substances, thus driving adaptive behaviors in the form of food choices, physiological preparation for meals, and engagement of defensive mechanisms. Here, we provide an integrative perspective on the multisensory computation between exteroceptive and interoceptive cues that guides feeding strategy and may result in food-related disorders.

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

The world of cancer science is moving toward a paradigm shift in making connections with neuroscience. After decades of research on genetic instability and mutations or on the tumor microenvironment, emerging evidence suggests that a malignant tumor is able to hijack and use the brain and its network of peripheral and central neurons as disrupters of homeostasis in the body. Whole-body homeostasis requires brain–body circuits to maintain survival and health via the processes of interoception, immunoception, and nociception. It is now likely that cancer disturbs physiological brain–body communication in making bidirectional brain tumor connections.

The study of biological mechanisms, while crucial, cannot fully explain complex phenomena like the instinct to eat. The mind–body connection, as exemplified by the concept of "voodoo death," highlights the profound influence of belief and cultural context on physiology. Indigenous knowledge systems further emphasize the interconnectedness of humans with their environment. Recent discoveries in gut–brain communication reveal the intricate neural circuits that drive our visceral desires, but a holistic approach that integrates both physiological mechanisms and the subjective experience of life, informed by diverse cultural perspectives, will be essential to truly understand what it means to be alive.

The dorsal vagal complex contains three structures: the area postrema, the nucleus tractus solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both anatomically and functionally, and have important yet distinct roles in not only conveying peripheral bodily signals to the rest of the brain but in the generation of behavioral and physiological responses. Reports on the new discoveries in these structures were highlights of the symposium. In this outlook, we focus on the roles of the area postrema in mediating brain–body interactions and its potential utility as a therapeutic target, especially in cancer cachexia.

Our approaches toward understanding cancer have evolved beyond cell-intrinsic and local microenvironmental changes within the tumor to encompass how the cancer interfaces with the entire host organism. The nervous system is uniquely situated at the interface between the brain and body, constantly receiving and sending signals back and forth to maintain homeostasis and respond to salient stimuli. It is becoming clear that various cancers disrupt this dialog between the brain and body via both neuronal and humoral routes, leading to aberrant brain activity and accelerated disease. In this outlook, I discuss this view of cancer as a homeostatic challenge, emphasize cutting-edge work, and provide outstanding questions that need to be answered to move the field forward.

Over the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are currently used for a variety of systems pharmacology applications, as a complement or a surrogate for activity of the corresponding proteins. A symposium at the 25th North American International Society for the Study of Xenobiotics meeting, in Boston, in September 2023, was held to explore current and emerging applications of quantitative proteomics in translational pharmacology and strategies for improved integration into model-informed drug development based on practical experience of each of the presenters. A summary of the talks and discussions is presented in this perspective alongside future outlook that was outlined for future meetings.

SIGNIFICANCE STATEMENT

This perspective explores current and emerging applications of quantitative proteomics in translational pharmacology and precision medicine and outlines the outlook for improved integration into model-informed drug development.

Adam J. Fein, Ph.D., president of Drug Channels Institute (DCI) and the author of Drug Channels, invites you to join him for DCI’s new live video webinar:

Friday, December 13, 2024,

from 12:00 p.m. to 1:30 p.m. ET

This post describes the event and explains how to purchase a registration. (Or, just click here to order.) The webinar will be broadcast from the Drug Channels studio in beautiful downtown Philadelphia.

This event is part of The Drug Channels 2024 Video Webinar Series. (Please note that our December 2024 webinar is *not* included with next year’s 2025 Video Webinar Series.)

WHAT YOU WILL LEARN

Join Dr. Fein as he helps you and your team get ready for 2025 by outlining key issues and uncertainties that will surely affect your planning. This event can be both a capstone of your annual learning and a touchpoint for the future. DCI’s Outlook webinars have proven to be reliable and informative guides to crucial aspects of the ever-evolving healthcare industry.

During the event, Dr. Fein will share his latest thinking and projections on a wide range of topics, including:

• Latest predictions for the Inflation Reduction Act

• Expectations for the Medicare Part D market in 2025 and beyond

• Update on 340B Drug Pricing Program’s controversies

• Impact of the new Trump administration and Congress on the drug channel

• Vertical integration and consolidation trends—and prospects for dis-integration and de-consolidation

• The state of biosimilar markets

• What’s next for PBMs’ private label products and GPOs

• Retail pharmacy’s future

• Prospects for direct-to-patient channels

• What’s ahead for discount cards and cash-pay pharmacies

• The outlook for state and federal legislation on PBMs and the drug channel

• Gross-to-net bubble developments

• And much more!

PLUS: During the webinar, Dr. Fein will give participants an opportunity to unmute themselves and ask live questions. The webinar will last at least 90 minutes to accommodate audience questions.

As always, Dr. Fein will clearly distinguish his opinions and interpretations from the objective facts and data. He will draw from exclusive information found in DCI's economic reports .

Read on for full details on pricing and registration.
Read more »

Tarin requested that an additional $500 million of U.S. assistance flow through the GOP - in addition to the $174 million already committed - to bolster GOP credibility and allow the GOP to more adequately support its priorities.

Moody�s Investors Services has confirmed India with a Baa3 rating, maintaining a positive outlook on the results. It has also affirmed India�s P-3 short-term local currency rating.

The U.S. Energy Information Administration (EIA) will host a webinar on Wednesday, October 9, to discuss price, consumption, and expenditure trends for major heating fuels for U.S. households for the upcoming winter. EIA’s Winter Fuels Outlook includes U.S. national and regional forecasts for electric heat, natural gas, heating oil, and propane. We will publish the Winter Fuels Outlook forecasts on Tuesday, October 8, as part of the Short-Term Energy Outlook.

Gold Price Outlook: अमेरिकी राष्ट्रपति चुनाव में डोनाल्ड ट्रंप ने बंपर वापसी की है. उन्होंने 270 सीटों के बहुमत को पार कर लिया है. ट्रंप 20 जनवरी को अमेरिका के 47वें राष्ट्रपति के तौर पर शपथ ग्रहण करेंगे. चुनावी में ट्रंप

RSS feeds are great for getting alerted to new articles on your favorite sites. But your personal time should not be taken up with reading work articles. Split your professional and personal subscriptions by adding work feeds to Microsoft Outlook instead.

Managing feeds in Outlook is super easy, although it can only be done in the desktop Outlook client.

An uptick in cargo handled, aids revenue growth as the company focuses on capacity addition

Nifty futures posted a marginal gain of 0.2 per cent and Bank Nifty futures appreciated 1.5 per cent over the past week

One more leg of downmove is still a possibility before the broader uptrend resumes 

We zoom in on the prospects of Infibeam Avenues, as also the prospects of three other stocks — HFCL, Oil India, NGL Fine-Chem

Nifty 50 November futures contract can oscillate in a range of 24,150-24,400

Rupee makes the much-awaited bearish breakout

We zoom in on the prospects of TVS Holdings, as also the prospects of three other stocks — Gujarat State Fertilizers & Chemicals (GSFC), Ideaforge Technology and Niyogin Fintech

Strong resistance coming up to halt the rally in the Dow Jones

Traders can stay out for now

The IMF’s ‘mediocre’ medium-term outlook merits policy attention

Underlying positives in sub-7 pc Q1 growth

Outlook update: Systems thinks that Outlook will be down until noon today.

Total tractor sales in the domestic market grew by 23%per cent to 144,675 units in October 2024

Hints for rate cut and weak economic data triggers the fall

Immediate resistance ahead has to be broken to gain more strength

A bullish euro leaves the bias negative for the greenback

High chances to see a rally within the broad range

Strong rise in the Treasury yield aids the greenback

A short-lived correction looks likely in the near term

Volatility is guaranteed as the week is packed with key events

Weighing-in on global debate on whether AI will lead to major layoffs, she said Artificial Intelligence needs to be seen as an enabler that can help amplify skills and boost productivity

As per estimates released by IDC, India’s smart wearable device market grew by merely 2.1 per cent in March quarter

Thursday’s gain partially helped to retrace Wednesday’s 3% rout, when Trump’s win triggered a powerful rally in the dollar, reducing the appeal of commodities priced in the currency

Composer Vayu''s new song ''Mummy'' an ode to mothers  Outlook India

The ratings for long-term bank facilities for Arvind Fashion was reaffirmed CARE A- with outlook revised from stable to negative.

There’s absence of catalysts to narrow holdco and conglomerate discount that has risen of late; ‘Hold’ retained with TP of Rs 550.

Moody's had, in November 2019, downgraded India's outlook to negative from stable on concerns of lower economic growth.

Moody�s Investors Services has confirmed India with a Baa3 rating, maintaining a positive outlook on the results. It has also affirmed India�s P-3 short-term local currency rating.

The outlook for the global steel market has become more uncertain, according to industry and government officials at the OECD’s Steel Committee meeting in Paris on 5-6 2011 . Policies to support open markets for raw materials are key, they said.

Business spending on research and development has been hit hard by the economic crisis, with nearly all OECD countries seeing a fall in investment which could impact innovation and long-term growth, according to a new OECD report.

Excess capacity in steel as growth in investment projects outpaces demand will pose risks for the sector for the foreseeable future, according to industry and government officials at the OECD’s Steel Committee meeting in Cape Town on 12 December 2014. The risk of trade conflicts in the industry also appears to have increased of late, they said, and Committee members discussed options for closer co-operation to try and prevent disputes.

Latin America and the Caribbean’s (LAC) GDP will shrink by between 0.9% and 1% in 2016, according to the latest estimates, the second consecutive year of negative growth and a rate of contraction the region has not seen since the early 1980s. According to the Latin American Economic Outlook 2017, the region should recover in 2017, but with modest GDP growth of between 1.5% and 2%, below expected growth in advanced economies.