outcome Improving Patient Outcomes through the Diagnostic and Care Planning Process By jdh.adha.org Published On :: 2024-10-15T09:18:40-07:00 Full Article
outcome The noninvasive ventilation outcomes score in patients requiring NIV for COPD exacerbation without prior evidence of airflow obstruction By beta.openres.ersjournals.com Published On :: 2024-11-11T01:50:25-08:00 Introduction Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry. Methods In the 10-centre NIVO validation study there was no pre-admission spirometry in 111 of 844 consecutive patients (termed "clinical diagnosis" patients). We compared the performance of the NIVO, DECAF and CURB-65 scores for in-hospital mortality in the clinical diagnosis cohort. Usual clinical practice was not influenced, but confirmation of COPD in the year following discharge was captured. Results In the clinical diagnosis cohort, in-hospital mortality was 19.8% and rose incrementally across the NIVO risk categories, consistent with the NIVO validation cohort. NIVO showed good discrimination in the clinical diagnosis cohort: area under the receiver operating curve 0.724, versus 0.79 in the NIVO validation cohort. At 1 year after discharge, 41 of 89 clinical diagnosis patients had undertaken diagnostic spirometry; 33 of 41 had confirmation of airflow obstruction (forced expiratory volume in 1 s/(forced) vital capacity <0.7), meaning the diagnosis of COPD was incorrect in 19.5% of cases. Discussion These data support the use of the NIVO score in patients with a "clinical diagnosis" of COPD. NIVO can help guide shared decision-making, assess risk-adjusted outcomes by centre and challenge prognostic pessimism. Accurate diagnosis is critical to ensure that acute and long-term treatment is optimised; this study highlights failings in the follow-up of such patients. Full Article
outcome Initial Experience with [177Lu]Lu-PSMA-617 After Regulatory Approval for Metastatic Castration-Resistant Prostate Cancer: Efficacy, Safety, and Outcome Prediction By jnm.snmjournals.org Published On :: 2024-11-01T04:25:31-07:00 [177Lu]Lu-PSMA-617 was approved by the U.S. Food and Drug Administration for patients with prostate-specific membrane antigen (PSMA)–positive metastatic castration-resistant prostate cancer (mCRPC). Since the time of regulatory approval, however, real-world data have been lacking. This study investigated the efficacy, safety, and outcome predictors of [177Lu]Lu-PSMA-617 at a major U.S. academic center. Methods: Patients with mCRPC who received [177Lu]Lu-PSMA-617 at the Johns Hopkins Hospital outside clinical trials were screened for inclusion. Patients who underwent [177Lu]Lu-PSMA-617 and had available outcome data were included in this study. Outcome data included prostate-specific antigen (PSA) response (≥50% decline), PSA progression-free survival (PFS), and overall survival (OS). Toxicity data were evaluated according to the Common Terminology Criteria for Adverse Events version 5.03. The study tested the association of baseline circulating tumor DNA mutational status in homologous recombination repair, PI3K alteration pathway, and aggressive-variant prostate cancer–associated genes with treatment outcome. Baseline PSMA PET/CT images were analyzed using SelectPSMA, an artificial intelligence algorithm, to predict treatment outcome. Associations with the observed treatment outcome were evaluated. Results: All 76 patients with PSMA-positive mCRPC who received [177Lu]Lu-PSMA-617 met the inclusion criteria. A PSA response was achieved in 30 of 74 (41%) patients. The median PSA PFS was 4.1 mo (95% CI, 2.0–6.2 mo), and the median OS was 13.7 mo (95% CI, 11.3–16.1 mo). Anemia of grade 3 or greater, thrombocytopenia, and neutropenia were observed in 9 (12%), 3 (4%), and 1 (1%), respectively, of 76 patients. Transient xerostomia was observed in 23 (28%) patients. The presence of aggressive-variant prostate cancer–associated genes was associated with a shorter PSA PFS (median, 1.3 vs. 6.3 mo; P = 0.040). No other associations were observed between circulating tumor DNA mutational status and treatment outcomes. Eighteen of 71 (25%) patients classified by SelectPSMA as nonresponders had significantly lower rates of PSA response than patients classified as likely responders (6% vs. 51%; P < 0.001), a shorter PSA PFS (median, 1.3 vs. 6.3 mo; P < 0.001), and a shorter OS (median, 6.3 vs. 14.5 mo; P = 0.046). Conclusion: [177Lu]Lu-PSMA-617 offered in a real-world setting after regulatory approval in the United States demonstrated antitumor activity and a favorable toxicity profile. Artificial-intelligence–based analysis of baseline PSMA PET/CT images may improve patient selection. Validation of these findings on larger cohorts is warranted. Full Article
outcome Predictors and Outcomes of Periprocedural Intracranial Hemorrhage after Stenting for Symptomatic Intracranial Atherosclerotic Stenosis [CLINICAL PRACTICE] By www.ajnr.org Published On :: 2024-11-07T15:14:12-08:00 BACKGROUND AND PURPOSE: Periprocedural intracranial hemorrhage is one of common complications after stent placement for symptomatic intracranial atherosclerotic stenosis. This study was conducted to demonstrate predictors and long-term outcomes of periprocedural intracranial hemorrhage after stent placement for symptomatic intracranial atherosclerotic stenosis. MATERIALS AND METHODS: We retrospectively analyzed patients with symptomatic intracranial atherosclerotic stenosis stent placement in a prospective cohort at a high-volume stroke center. Clinical, radiologic, and periprocedural characteristics and long-term outcomes were reviewed. Periprocedural intracranial hemorrhage was classified as procedure-related hemorrhage (PRH) and non-procedure-related hemorrhage (NPRH). The long-term outcomes were compared between patients with PRH and NPRH, and the predictors of NPRH were explored. RESULTS: Among 1849 patients, 24 (1.3%) had periprocedural intracranial hemorrhage, including PRH (4) and NPRH (20). The postprocedural 30-day mRS was 0–2 in 9 (37.5%) cases, 3–5 in 5 (20.8%) cases, and 6 in 10 (41.7%) cases. For the 14 survivors, the long-term (median of 78 months) mRS were 0–2 in 10 (76.9%) cases and 3–5 in 3 (23.1%) cases. The proportion of poor long-term outcomes (mRS ≥3) in patients with NPRH was significantly higher than those with PRH (68.4% versus 0%, P = .024). Anterior circulation (P = .002), high preprocedural stenosis rate (P < .001), and cerebral infarction within 30 days (P = .006) were independent predictors of NPRH after stent placement. CONCLUSIONS: Patients with NPRH had worse outcomes than those with PRH after stent placement for symptomatic ICAS. Anterior circulation, severe preprocedural stenosis, and recent infarction are independent predictors of NPRH. Full Article
outcome Are federal IT systems supporting the targeted service outcomes? Deloitte examines the future role of the government By www.itbusiness.ca Published On :: Fri, 01 Mar 2024 13:01:26 +0000 In an interview with IT World Canada, consulting giant Deloitte highlighted the importance of an ecosystem-based approach to tackle issues around digital equity in Canada and service delivery challenges in the public sector. “Our strong view is that the people of Canada benefit when there’s effective collaboration between public and private organizations, including on critical […] The post Are federal IT systems supporting the targeted service outcomes? Deloitte examines the future role of the government first appeared on ITBusiness.ca. Full Article Digital Transformation Government & Public Sector Deloitte Government of Canada Top Story
outcome How Field Reimbursement Services Help Overcome Coverage Barriers and Improve Patient Outcomes By feeds.feedblitz.com Published On :: Fri, 01 Nov 2024 11:00:00 +0000 Today’s guest post comes from Kimberley Chiang, Vice President of Biopharma Commercial Solutions at CoverMyMeds Kimberley highlghts the crucial roles of field reimbursement managers in removing access and reimbursement barriers. She then identifies the keys to successful implementation of field reimbursement services. To learn more, register for CoverMyMeds' November 13, 2024, webinar: Specialty Therapies & Field Reimbursement Services: Driving Better Outcomes for Brands and Patients. Read on for Kimberley’s insights. Read more » Full Article Guest Post Sponsored Post
outcome Medications for Opioid Use Disorder Improve Patient Outcomes By www.pewtrusts.org Published On :: Thu, 17 Dec 2020 12:43:00 -0500 In 2018, opioid overdoses in the United States caused one death every 11 minutes, resulting in nearly 47,000 fatalities. The most effective treatments for opioid use disorder (OUD) are three medications approved by the Food and Drug Administration (FDA): methadone, buprenorphine, and naltrexone. Full Article
outcome Examining the Outcomes of COP 28: A Conversation with Amy Harder By www.belfercenter.org Published On :: Dec 20, 2023 Dec 20, 2023 Amy Harder, the founding Executive Editor of the climate policy publication Cipher News, expressed her surprise with several positive outcomes from the recent 28th Conference of the Parties of the United Nations Framework Convention on Climate Change (COP 28) in Dubai during a special episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.” Full Article
outcome Accelerated Partial Breast Irradiation with Brachytherapy Achieves Excellent Long-Term Toxicity and Cosmetic Outcomes - Robert Kuske, MD By www.multivu.com Published On :: 27 Oct 2015 15:58:00 EDT Robert Kuske, MD Full Article Biotechnology Healthcare Hospitals Medical Pharmaceuticals Medical Equipment Pharmaceuticals FDA Approval Clinical Trials Medical Discoveries MultiVu Video
outcome Exploring the Consistent Outcomes of an Antiviral Drug By www.medindia.net Published On :: Regardless of HIV status, medlinktecovirimat/medlink, an medlinkantiviral drug/medlink that has been extensively employed to treat medlinksmallpox/medlink Full Article
outcome AI-Powered Nasal Endoscopy: Enhancing Precision and Outcomes By www.medindia.net Published On :: New study investigates how convolutional neural networks (CNNs) can enhance nasal endoscopy accuracy and efficiency. The study focuses on overcoming diagnostic Full Article
outcome Mobile Health Apps Linked to Improved Health and Economic Outcomes By www.medindia.net Published On :: Study finds that diabetic Asian patients that used smart mobile health (or mHealth) technologies had better health and economic outcomes than those who didn't use mHealth applications. Full Article
outcome Prehabilitation: Preparing Patients for Surgery Boosts Outcomes By www.medindia.net Published On :: 'Prehabilitation' meaning pre-surgery exercise and education is associated with improving some outcomes for patients undergoing medlinkorthopedic surgery/medlink Full Article
outcome Medicaid Improves Cancer Survival Outcomes in the US By www.medindia.net Published On :: Among young adults aged 18-39 newly diagnosed with cancer, the expanded Medicaid coverage under the Affordable Care Act (ACA) led to better survival outcomes, Full Article
outcome Medicaid Expansion and Pregnancy Outcomes in Gestational Diabetes By www.medindia.net Published On :: The Affordable Care Act (ACA) seeks to enhance healthcare accessibility, yet its impact on maternal and newborn health in women with medlinkgestational Full Article
outcome Chasing the most meaningful outcome of entrepreneurship By www.thehindubusinessline.com Published On :: Sun, 15 Sep 2024 20:33:00 +0530 Are there any metrics to decide if a founder is successful or not? Full Article Emerging Entrepreneurs
outcome Functional silver-based nanomaterials affecting zebrafish development: the adverse outcomes in relation to the nanoparticle physical and chemical structure By pubs.rsc.org Published On :: Environ. Sci.: Nano, 2024, Accepted ManuscriptDOI: 10.1039/D3EN00813D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Patrizia Bonfanti, Anita Colombo, Rossella Daniela Bengalli, Maurizio Gualtieri, Ilaria Zanoni, Magda Blosi, Anna Costa, Paride ManteccaThe growing demand for effective antimicrobials determined a significant increase of new nanoformulated materials to fight against bacteria and viruses, to be used in many industrial sectors including textiles, cosmetics,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
outcome Empowering Pharma with AI, Analytics: Accelerating Drug Discovery, Optimizing Healthcare Outcomes By Rajesh Munirathnam By www.dnaindia.com Published On :: Mon, 04 Nov 2024 12:06:35 GMT While AI is making significant strides in healthcare, it is also transforming other industries, such as insurance. Full Article Technology
outcome Dewan Housing Finance Corporation Ltd. - Outcome Of The Meeting Of The Special Committee For Resolution Plan Held On Tuesday, 6Th August, 2019 And Disclosures Under Regulation 30 Of Securities And Exchange Board Of India (Listing Obligations And Disclosur By www.thehindubusinessline.com Published On :: Tue, 06 Aug 2019 12:22:02 +0530 Full Article Disclosures
outcome Dewan Housing Finance Corpn Ltd, - Outcome Of The Meeting Of The Special Committee For Resolution Plan Held On Tuesday, 6Th August, 2019 And Disclosures Under Regulation 30 Of Securities And Exchange Board Of India (Listing Obligations And Disclosure Requ By www.thehindubusinessline.com Published On :: Tue, 06 Aug 2019 12:22:03 +0530 Full Article Disclosures
outcome The remarkable surge of interest in plotted developments is an outcome of the pandemic By www.thehindu.com Published On :: Fri, 14 Jul 2023 16:13:01 +0530 High- and ultra-high-net-worth individuals are increasingly investing in weekend homes or private villas, built in the peripheries of cities Full Article Homes and gardens
outcome Women's Empowerment, the Gender Gap in Desired Fertility, and Fertility Outcomes in Developing Countries [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Wealth Shocks and Health Outcomes: Evidence from Stock Market Fluctuations [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Robot Imports and Firm-Level Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Randomizing Religion: The Impact of Protestant Evangelism on Economic Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
outcome Poor Little Rich Kids? The Role of Nature versus Nurture in Wealth and Other Economic Outcomes and Behaviors [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
outcome Police Response Times and Injury Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome The Lost Ones: the Opportunities and Outcomes of Non-College Educated Americans Born in the 1960s [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
outcome Lift the Ban? Initial Employment Restrictions and Refugee Labour Market Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome The Lasting Legacy of Seasonal Influenza: In-Utero Exposure and Labor Market Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Intersectoral linkages: Good shocks, bad outcomes? [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome The Importance of Beliefs in Shaping Macroeconomic Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
outcome Impact of Syrian Refugees on Education Outcomes in Jordan [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome The Human Side of Austerity: Health Spending and Outcomes During the Greek Crisis [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
outcome Field of study and family outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Experimental Evidence of Exposure to a Conditional Cash Transfer During Early Teenage Years: Young Women's Fertility and Labor Market Outcomes [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome The Economic Outcomes of an Ethnic Minority: the Role of Barriers [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Does pre-play social interaction improve negotiation outcomes? [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Do Preferences and Biases predict Life Outcomes? Evidence from Education and Labor Market Entry Decisions [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Can Credit Rating Agencies Affect Election Outcomes? [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
outcome Carnatic music export: Positive outcomes and areas of concern By www.thehindu.com Published On :: Fri, 18 Oct 2024 15:52:08 +0530 The increasing Carnatic music festivals abroad show the growing interest of the NRIs, and a huge financial market for the art form Full Article Music
outcome Haryana — social dynamics, electoral outcomes By www.thehindu.com Published On :: Wed, 13 Nov 2024 00:08:00 +0530 The recent Assembly polls are an example of how changing social dynamics impact the election result Full Article Comment
outcome Redesigned programmes can vastly improve TB treatment outcomes By www.thehindu.com Published On :: Sat, 19 Oct 2024 21:15:00 +0530 Doubling the direct benefit transfer to Rs.1,000 per month, disbursing Rs.3,000 at the time of diagnosis, and nutrition support to TB patients can have a huge impact Full Article Science
outcome Tinna Trade Ltd - Outcome Of Board Meeting And Unaudited Financial Results Of The Company For The Quarter Ended On 30Th June, 2019, As Per Regulation 33 Of SEBI (Listing Obligations And Disclosure Requirements) Regulation, 2015 By www.thehindubusinessline.com Published On :: Tue, 06 Aug 2019 18:06:15 +0530 Full Article Results
outcome Lok Sabha 2024 poll verdict: a rare outcome that pleases all By www.thehindu.com Published On :: Sun, 09 Jun 2024 20:10:12 +0530 Full Article India
outcome Birla Cable Ltd - Shareholder Meeting / Postal Ballot-Outcome of AGM By www.thehindubusinessline.com Published On :: Wed, 07 Aug 2019 10:53:37 +0530 Full Article Others
outcome Icici Securities Ltd - Announcement under Regulation 30 (LODR)-Analyst / Investor Meet - Outcome By www.thehindubusinessline.com Published On :: Wed, 07 Aug 2019 10:57:50 +0530 Full Article Others
outcome Keerthi Industries Ltd. - Shareholder Meeting / Postal Ballot-Outcome of AGM By www.thehindubusinessline.com Published On :: Wed, 07 Aug 2019 11:01:25 +0530 Full Article Others
outcome Aarti Drugs Ltd. - Shareholder Meeting / Postal Ballot-Outcome of AGM By www.thehindubusinessline.com Published On :: Wed, 07 Aug 2019 11:26:18 +0530 Full Article Others
outcome Simplex Realty Ltd. - Outcome of Board Meeting By www.thehindubusinessline.com Published On :: Wed, 07 Aug 2019 11:35:53 +0530 Full Article Others