The LED light has Track to install LED-units anywhere along the length. The LED-unit has pair of resilient or pop-out & fall-down movable contactor so can fit-within or add-on LED-units to track and connect with metal bus-strip(s) which has electric current or-and magnetic force to adhesive the pop-out & fall-down contactor on back of the LED-unit. LED light device including LED light source, or mini size LED fluorescent tube, or mini LED light bar, or mini LED Bulb, or mini LED lamp, mini LED Lamp as light source has housing to fit-in or add-on or magnetic adhesive on track to form a finish light device and get power from built-in or outside AC-to-DC transformer, circuit, power source and can control by switch, remote controller, motion/moving detector(s) sensor, all kind of sensor, APP software while incorporate with Wifi or wireless network to make the on-off, color changing, color mix, dimmer adjustment, moving light, all other light show for LED track light has fit-in LED-units by resilient contractors or LED track light has add-on LED-units by pop-out & fall-down movable contactor built on back of LED-unit and adhesive by magnetic force bus-strips.

Modifying a digital data stream that includes immediately consecutive code words of different length by segmenting, based on a certain block grid, the digital data stream. Each block of the block grid includes a fixed number of bits. It is determined whether all bits of the last block associated with the digital data stream are occupied by data of the digital data stream. If not all bits of the last block are occupied, the unoccupied bits of the last block are padded with bits of an end-of-record (EOR) indicator. If all bits of the last block are occupied, attaching an EOR indicator to the digital data stream is skipped.

In a length or position measuring system which has an at least locally substantially linear measuring gauge and at least one sensor to be moved relative to the measuring gauge, wherein the measuring gauge includes an incremental track and at least one absolute track and wherein the incremental track and the at least one absolute track have poles arranged in the longitudinal direction of the measuring gauge, the poles of the at least one absolute track form at least two regions in the sensor with different field strengths or signal amplitudes.

This device will calculate the note length in (milliseconds and Hz) based on the BPM input. Useful for timing decay, delay, envelope loops, etc.. to your music. 1/1, 1/2, 1/4, 1/8, 1/16, 1/32, 1/64...

Although 3D printing is being used for a variety of applications in healthcare, biomedical engineering and manufacturing, it is still pretty limited

Meet the pool tourists of Australia who go to to great lengths in their quest to get wet.

Vancouver-based Singer-songwriter And Recording Artist Nat Jay Releases Electro Pop Song "Sleep"

The Music Artist Known As NoFaceNors Has Released His Latest Full-length Album, “Nacho Pack Vol. 1.”

BELEAF, Which Releases In Stores And Online Worldwide August 16, 2019, Is A 14-track Powerhouse That Promises To Be Their Strongest, Clearest, And Most Authentic Work Yet.

Toronto-based Rock Band, Across The Board Will Release Their Second Full-length Album, "Sonic Boom" On May 4, 2018. Produced And Recorded In Toronto By MC2 Music Media, The Album Pays Homage To A Band

He's clearly not letting Dat Rona mess up his fade.

Relativistic length contraction is theoretically predicted but not directly tested, which lead to incorrect interpretation of the theory illustrated by Bell’s spaceship paradox and Ehrenfest paradox. But these paradoxes can help us designing experiments to test length contraction. Ideal direct experimental proof should contain the following steps: 1. Measure the tested object’s length at rest,...

Astrophysical jets are flows of matter that moves at relativistic speed. They are opportunity to see length contraction in action. An astrophysical jet is analyzed to explain the length contraction effect. Astrophysical jets are ejected from compact objects such as black holes. https://en.wikipedia.org/wiki/Astrophysical_jet#/media/File:M87_jet.jpg is a photograph of the jet ejected by the supermassive black hole...

Length contraction is used to explain Michelson–Morley experiment. A Michelson interferometer is formed by 2 perpendicular arms. The journey of light along the vertical arm gives the time dilation law. The journey of light along the horizontal arm gives the length contraction law. The derivation scheme of the length contraction law is: 1. The time...

There are 2 types of length contraction, the physical meaning of each is explained below with the help of the example shown in Figure 1. The Earth and the star are stationary and the spaceship mobile. The 2 types of length contraction are: 1) Object contraction: In the frame of the Earth the length of...

STARING out at the pounding Atlantic waves, I never thought I'd get in, let alone close to surfing, standing up on a board. The breakers pulsed toward me as I patted my feet in the shallows while trying to stay upright in the unrelenting wind.

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

Cholesteryl ester transfer protein (CETP) exists as full-length (FL) and exon 9 (E9)-deleted isoforms. The function of E9-deleted CETP is poorly understood. Here, we investigated the role of E9-deleted CETP in regulating the secretion of FL-CETP by cells and explored its possible role in intracellular lipid metabolism. CETP overexpression in cells that naturally express CETP confirmed that E9-deleted CETP is not secreted, and showed that cellular FL- and E9-deleted CETP form an isolatable complex. Coexpression of CETP isoforms lowered cellular levels of both proteins and impaired FL-CETP secretion. These effects were due to reduced synthesis of both isoforms; however, the predominate consequence of FL- and E9-deleted CETP coexpression is impaired FL-CETP synthesis. We reported previously that reducing both CETP isoforms or overexpressing FL-CETP impairs cellular triglyceride (TG) storage. To investigate this further, E9-deleted CETP was expressed in SW872 cells that naturally synthesize CETP and in mouse 3T3-L1 cells that do not. E9-deleted CETP overexpression stimulated SW872 triglyceride synthesis and increased stored TG 2-fold. Expression of E9-deleted CETP in mouse 3T3-L1 cells produced a similar lipid phenotype. In vitro, FL-CETP promotes the transfer of TG from ER-enriched membranes to lipid droplets. E9-deleted CETP also promoted this transfer, although less effectively, and it inhibited the transfer driven by FL-CETP. We conclude that FL- and E9-deleted CETP isoforms interact to mutually decrease their intracellular levels and impair FL-CETP secretion by reducing CETP biosynthesis. E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner.

When you read in a BigQuery table, the length of string variables might be longer than the length specified with the MAX_CHAR_LEN= option when running your SAS software   with UTF-8. By

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies.

OBJECTIVE

Telomere shortening and DNA oxidation are associated with premature vascular aging, which may be involved in lower-extremity amputation (LEA). We sought to investigate whether leukocyte telomere length (LTL) and plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of DNA oxidation, were associated with LEA in subjects with type 1 diabetes at high vascular risk.

The duration of SpaceX's first mission with astronauts on board -- planned for launch at 4:32 p.m. EDT on May 27 from Florida -- has been extended from a few days to potentially weeks aboard the space station.

Major League Baseball owners will discuss a length for the amateur draft next week and are likely to start the selections on the original date of June 10, a person familiar with the deliberations told The Associated Press.

A federal appeals court has struck down an Indiana school district's policy requiring short hair for boys on the basketball team, ruling that the lack of a similar policy for girls'-team basketball players results in illegal sex discrimination.

The bipartisan proposal to overhaul the Elementary and Secondary Education Act may take up a week or more of the Senate's time.

In 2011, the Accreditation Council on Graduate Medical Education increased restrictions on resident duty-hours. Further changes have been considered, including greater work-hour restrictions and lengthening residency. Residents’ views about these policies are unclear.

This is the first systematic, national inquiry into resident opinions on reduced work-hours and longer residency. More pediatric residents support than oppose reduced hours, and a minority would add a year to residency to achieve them. (Read the full article)

Adherence to Pediatric Advanced Life Support resuscitation guidelines for children with sepsis is low; however, few studies have been conducted in the tertiary care emergency department setting.

Adherence to septic shock guidelines in a tertiary care pediatric emergency department is low. Adherence to fluid guidelines and the entire PALS algorithm was associated with a shorter hospital length of stay. (Read the full article)

Failure to thrive (FTT) is a common and vexing pediatric problem. Evaluation has historically involved large batteries of tests, multiple consultations, radiologic studies, and prolonged hospital admissions, resulting in significant costs and inconsistent results.

Scheduled failure to thrive (FTT) admissions on weekends result in increased lengths of stay and health care costs compared with weekday admissions of similar levels of complexity. Reduction in planned weekend admissions for FTT could significantly reduce health care costs. (Read the full article)

Chorioamnionitis (CAM) is a major risk factor for early-onset neonatal sepsis. The Committee on the Fetus and Newborn recommends extending the duration of antimicrobial therapy in neonates exposed to CAM and intrapartum antibiotics if laboratory data are abnormal, even if culture results are sterile.

When managed by using a strategy similar to recent Committee on the Fetus and Newborn guidelines, a large number of term and late-preterm infants exposed to CAM who had sterile blood culture findings were treated with prolonged antibiotic therapy, subjected to additional invasive procedures, and had prolonged hospitalization. (Read the full article)

Central line–associated bloodstream infections (CLABSI) are common types of hospital-acquired infections associated with high morbidity and cost. In recent years, quality improvement initiatives have demonstrated how to reduce the incidence of CLABSI.

This study presents nationally representative estimates of the cost and length of stay attributable to pediatric CLABSI. We make the business case to justify quality improvement prevention initiatives and the adoption of strategies for cost-effective management of CLABSI. (Read the full article)

Poor health in children is associated with exposure to family violence and disruption. Telomere length has been hypothesized to be a lasting biological indicator of exposure to early adversity and potentially predictive of negative health outcomes throughout the life course.

Telomere length reflects exposure to family violence and disruption and may be an early indicator of the biological impact of early adversity. Children exposed to interpersonal violence and family disruptions had significantly shorter telomeres. Gender moderated these associations. (Read the full article)

G. J. Schwartz
Aug 1, 1976; 58:259-263
ARTICLES

Other defendants face prison for murder, assault, drug, and weapons charges The repeated sexual abuse of 2 children has led to a prison sentence of more than 100 years for a New Castle man. For a period of almost 3 years beginning in January 2014, Melvin Finney, 57, sexually assaulted 2 children in his care. […]

Hello, i am a student who is studying Allegro tool with SKILL.

I have a question about SKILL axlSegDelayAndZ0. The reference says this function "returns the delay and impedance of a cline segment."

I want to know how many components does this tool consider when calculating timing delay from the length. 

How steep is input signal's rise transition? Is rise transition shape isosceles trapezoid or differential increasing shape?

Also, if it is a multi fan-out, the rise transition time will be different net by net. How can this tool can calculate in this case?

I want to hear answers about these questions.

Thank you for reading this long boring questions, and i will be waiting for answers.

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

Title: How Many Steps Per Day to Lengthen Your Life?
Category: Health News
Created: 3/24/2020 12:00:00 AM
Last Editorial Review: 3/25/2020 12:00:00 AM

The human immune system relies on highly complex and diverse transcripts and the proteins they encode. These include transcripts encoding human leukocyte antigen (HLA) receptors as well as B cell and T cell receptors (BCR and TCR). Determining which alleles an individual possesses for each HLA gene (high-resolution HLA typing) is essential to establish donor–recipient compatibility in organ and bone marrow transplantations. In turn, the repertoires of millions of unique BCR and TCR transcripts in each individual carry a vast amount of health-relevant information. Both short-read RNA-seq-based HLA typing and BCR/TCR repertoire sequencing (AIRR-seq) currently rely on our incomplete knowledge of the genetic diversity at HLA and BCR/TCR loci. Here, we generated over 10,000,000 full-length cDNA sequences at a median accuracy of 97.9% using our nanopore sequencing-based Rolling Circle Amplification to Concatemeric Consensus (R2C2) protocol. We used this data set to (1) show that deep and accurate full-length cDNA sequencing can be used to provide isoform-level transcriptome analysis for more than 9000 loci, (2) generate accurate sequences of HLA alleles, and (3) extract detailed AIRR data for the analysis of the adaptive immune system. The HLA and AIRR analysis approaches we introduce here are untargeted and therefore do not require prior knowledge of the composition or genetic diversity of HLA and BCR/TCR loci.

Telomeres consist of TTAGGG repeats bound by protein complexes that serve to protect the natural end of linear chromosomes. Most cells maintain telomere repeat lengths by using the enzyme telomerase, although there are some cancer cells that use a telomerase-independent mechanism of telomere extension, termed alternative lengthening of telomeres (ALT). Cells that use ALT are characterized, in part, by the presence of specialized PML nuclear bodies called ALT-associated PML bodies (APBs). APBs localize to and cluster telomeric ends together with telomeric and DNA damage factors, which led to the proposal that these bodies act as a platform on which ALT can occur. However, the necessity of APBs and their function in the ALT pathway has remained unclear. Here, we used CRISPR/Cas9 to delete PML and APB components from ALT-positive cells to cleanly define the function of APBs in ALT. We found that PML is required for the ALT mechanism, and that this necessity stems from APBs’ role in localizing the BLM–TOP3A–RMI (BTR) complex to ALT telomere ends. Strikingly, recruitment of the BTR complex to telomeres in a PML-independent manner bypasses the need for PML in the ALT pathway, suggesting that BTR localization to telomeres is sufficient to sustain ALT activity.

“Dear Designer” is a blog series on orienting novice practitioners to the discipline of instructional design and learning experience design.

The post Dear Designer: 3 Considerations for Length When Shifting to VILT appeared first on e-Learning Feeds.

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

UPDATE: War veteran, 99, hits £9 million for NHS as Matt Hancock calls him an 'inspiration'

The appeal by NHS fundraiser Colonel Tom Moore topped £32 million as it closed at midnight.

David Keys speaks to scientists and health experts about the new tools that could help in the fight against Covid-19 and future coronavirus outbreaks

Plus, pictures of braided hairstyles from Rihanna and more.

A new discovery in mice shows the innate immune system has 'memory,' previously thought to be a unique feature of the adaptive immune system. Blocking this memory prevented transplanted organs from being rejected, providing a way to more specific drugs that could lengthen organ transplant survival.

Recycled Mississippi is traveling the length of one of America's iconic rivers, which also happens to be one of the most polluted, and filming a documentary along the way.

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

India's Ministry of Finance has released a new Notification that sets the "tolerable range" for arm's length dealings.

With still large government debt and interest payments in many OECD countries, actively adjusting debt maturity can help to minimise debt servicing costs.