After last day in Banos including one last visit to guitar shop traveled to Latacunga which is Capital of Cotopaxi Province and home to Latacunga Rotary local club supporting efforts in Malinguapamba MP and having excellent track record on many project

Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. However, its functional mechanisms remain unknown. Here we observed widespread MEIS2 expression in the developing palate in mice. Wnt1Cre-mediated Meis2 inactivation in cranial neural crest cells led to a secondary palate cleft. Importantly, about half of the Wnt1Cre;Meis2f/f mice exhibited a submucous cleft, providing a model for studying palatal bone formation and patterning. Consistent with complete absence of palatal bones, the results from integrative analyses of MEIS2 by ChIP sequencing, RNA-Seq, and an assay for transposase-accessible chromatin sequencing identified key osteogenic genes regulated directly by MEIS2, indicating that it plays a fundamental role in palatal osteogenesis. De novo motif analysis uncovered that the MEIS2-bound regions are highly enriched in binding motifs for several key osteogenic transcription factors, particularly short stature homeobox 2 (SHOX2). Comparative ChIP sequencing analyses revealed genome-wide co-occupancy of MEIS2 and SHOX2 in addition to their colocalization in the developing palate and physical interaction, suggesting that SHOX2 and MEIS2 functionally interact. However, although SHOX2 was required for proper palatal bone formation and was a direct downstream target of MEIS2, Shox2 overexpression failed to rescue the palatal bone defects in a Meis2-mutant background. These results, together with the fact that Meis2 expression is associated with high osteogenic potential and required for chromatin accessibility of osteogenic genes, support a vital function of MEIS2 in setting up a ground state for palatal osteogenesis.

Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. However, its functional mechanisms remain unknown. Here we observed widespread MEIS2 expression in the developing palate in mice. Wnt1Cre-mediated Meis2 inactivation in cranial neural crest cells led to a secondary palate cleft. Importantly, about half of the Wnt1Cre;Meis2f/f mice exhibited a submucous cleft, providing a model for studying palatal bone formation and patterning. Consistent with complete absence of palatal bones, the results from integrative analyses of MEIS2 by ChIP sequencing, RNA-Seq, and an assay for transposase-accessible chromatin sequencing identified key osteogenic genes regulated directly by MEIS2, indicating that it plays a fundamental role in palatal osteogenesis. De novo motif analysis uncovered that the MEIS2-bound regions are highly enriched in binding motifs for several key osteogenic transcription factors, particularly short stature homeobox 2 (SHOX2). Comparative ChIP sequencing analyses revealed genome-wide co-occupancy of MEIS2 and SHOX2 in addition to their colocalization in the developing palate and physical interaction, suggesting that SHOX2 and MEIS2 functionally interact. However, although SHOX2 was required for proper palatal bone formation and was a direct downstream target of MEIS2, Shox2 overexpression failed to rescue the palatal bone defects in a Meis2-mutant background. These results, together with the fact that Meis2 expression is associated with high osteogenic potential and required for chromatin accessibility of osteogenic genes, support a vital function of MEIS2 in setting up a ground state for palatal osteogenesis.

Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. However, its functional mechanisms remain unknown. Here we observed widespread MEIS2 expression in the developing palate in mice. Wnt1Cre-mediated Meis2 inactivation in cranial neural crest cells led to a secondary palate cleft. Importantly, about half of the Wnt1Cre;Meis2f/f mice exhibited a submucous cleft, providing a model for studying palatal bone formation and patterning. Consistent with complete absence of palatal bones, the results from integrative analyses of MEIS2 by ChIP sequencing, RNA-Seq, and an assay for transposase-accessible chromatin sequencing identified key osteogenic genes regulated directly by MEIS2, indicating that it plays a fundamental role in palatal osteogenesis. De novo motif analysis uncovered that the MEIS2-bound regions are highly enriched in binding motifs for several key osteogenic transcription factors, particularly short stature homeobox 2 (SHOX2). Comparative ChIP sequencing analyses revealed genome-wide co-occupancy of MEIS2 and SHOX2 in addition to their colocalization in the developing palate and physical interaction, suggesting that SHOX2 and MEIS2 functionally interact. However, although SHOX2 was required for proper palatal bone formation and was a direct downstream target of MEIS2, Shox2 overexpression failed to rescue the palatal bone defects in a Meis2-mutant background. These results, together with the fact that Meis2 expression is associated with high osteogenic potential and required for chromatin accessibility of osteogenic genes, support a vital function of MEIS2 in setting up a ground state for palatal osteogenesis.

IN April 2004, the Victoria & Albert museum in London staged an exhibition of the work of Vivienne Westwood. The show was a celebration and a culmination of the fashion designer’s move from the margins of the industry in the 1970s, where she was creating clothes for the punks who hung around the King’s Road, to her 21st-century incarnation as first among equals in British haute couture.

Adults born at very low birth weight (VLBW) (<1.5 kg) have higher blood pressure and higher fasting insulin levels than their peers born at term. However, they show no signs of endothelial dysfunction in childhood and in adolescence.

Adults born at a VLBW showed no endothelial dysfunction compared with term adults. They had, however, a thicker intima-media layer in relation to lumen size. More rapid growth during their first weeks of life was associated with better endothelial function. (Read the full article)

A previous study of inflatable bouncer–related fractures has shown that upper extremity fractures are most common, and many fractures are caused by collisions; however, no study has examined nonfracture injuries or used nationally representative data to investigate inflatable bouncer–related injuries.

This is the first study to use nationally representative data to calculate national injury rates, assess risk factors, and examine trends for pediatric inflatable bouncer–related injuries treated in US emergency departments over a 21-year period (1990–2010). (Read the full article)

Apple's new $4,999 Pro Display XDR monitor (and its $1,000 stand) may sound mighty expensive on the surface. It has the potential to upend a whole industry, however—it's made to compete with panels five to ten times the price. We have one in-house, and here are our first impressions.

Latin America’s abundant and varied mineral resources attract a large portion of the global mining investment.

The Energy & Infrastructure team is delighted to launch its third edition of the Renewable Energy is Looking Good in Latin America brochure. Latin American countries represent 4 of the top 20 most attractive renewable energy markets in the world...

Wearing a dress she made of eight giant plastic inflatable roses over a wire structure and a headpiece crowned by a globe, Chinese performance artist Kong Ning is using fashion to draw attention to environmental protection on Earth Day.

An inflatable luminous maze called the 'Luminarium Arboria' proves to be a relaxing summer activity in Geneva. Rough Cut (no reporter narration).

Neville believes no football would be played if decision was purely about health, rather than economics

Syria’s northwestern province of Idlib is experiencing a deepening humanitarian crisis. As the Russia-backed Syrian regime pushes to retake this last major enclave of the Syrian opposition, hundreds of thousands of people have fled towards Turkey’s borders. According to the United Nations, 700,000 people have fled Idlib since December 1. As the main backer of…

Syria’s northwestern province of Idlib is experiencing a deepening humanitarian crisis. As the Russia-backed Syrian regime pushes to retake this last major enclave of the Syrian opposition, hundreds of thousands of people have fled towards Turkey’s borders. According to the United Nations, 700,000 people have fled Idlib since December 1. As the main backer of…

The inventors of the innovative LuminAID solar lantern are Kickstarting another version of their device, this time with the added feature of a charging port for portable electronics.

The student invention just won the James Dyson Award for its intelligent design.

Fairbanks, Alaska, will be home to the demonstration project of the next generation Buoyant Airborne Turbine, which will fly 1000 feet off the ground.

Shraddha Kapoor is an actress who has a penchant for having the ability to adapt to various characters on-screen. In 2020, we saw the actress enticing the audience of the Indian film industry with her dance moves in Street Dancer 3D and we also saw her as a rebel in the action-packed movie Baaghi 3. In both the movies she had a dazzling look and an impressive physique, due to that many have pondered over how she controls her diet to maintain her physique and the answer will certainly astound the audience!

Recently, when Shraddha was in an interview with a magazine she was asked if she was mindful of her diet and if yes, then did she have any tips and tricks to maintaining a healthy physique, she said, "I am not rigid with my diet because I love food. However, I do try to keep a balance between junk food and eating healthy."

The actress describes to the audience how she is a foodie and just regulates her diet by balancing between junk food and eating healthy. She is truly a source of inspiration. Shraddha Kapoor is definitely captivating the hearts of the audience as an actress and even as a person. The actress had an amazing 2019 with hits like Saaho and Chhichhore. She is emerging glorious due to the success of Baaghi 3 and will be seen alongside Ranbir Kapoor in a Luv Ranjan directorial.

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Posting a picture of himself, megastar Amitabh Bachchan on Wednesday quoted lyrics of Lata Mangeshkar's famous song 'Subah hoti hai' to describe how time is flying during lockdown.

Bachchan who is quite active on social media took to Instagram and posted the picture. In the picture, he is seen wearing a black coloured sherwani paired with black glasses.

The picture also featured a couple of murals of the superstar in the background. "Subah hoti hai, shaam hoti hai; Umr yunhi tamaam hoti hai!" he wrote in the caption.

The song sung by Lata was originally penned by Munshi Amirullah Tasleem according to Rekhta foundation. Bachchan is one of the most socially active veteran actors of the Bollywood industry. He keeps treating his fans with his pictures and his thoughts on contemporary issues on social media.

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LA Galaxy midfielder Joao Pedro has made sensational claims that his former teammate Zlatan Ibrahimovic went on an angry rant in the dressing room after team's defeat in the final match of 2018 Major League Soccer (MLS) season. Despite taking a 2-0 lead, Galaxy lost to Houston Dynamo in the final match of the season on home turf as one of the most recognised American football teams ended the season at a lowly 13th place.

Ibrahimovic, who is known for his unnerving winning mentality, lashed out at his teammates after the end of the match and even went on to the extent of threatening to kill them, according to the Swede's former teammate Pedro, who is currently on loan from Galaxy to Tondela in Portugal.

"At the end of the game, he gave us a talking to," Pedro was quoted as saying by a Portuguese outlet Record. "He said ‘if you are going to come here to go to the beach or take a walk in Hollywood, just say so. I have 300 million on my account, an island, I don't need this for anything. The first one who says something to me, I will kill him'."

Despite not adding any trophy into his bulging cabinet in the USA, Ibrahimovic scored 52 goals in his two MLS seasons. After his goal-laden spell in North America, Ibrahimovic returned to Europe for his second spell with Italian giants Milan.

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This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Baarish Season 2 Review: The ALTBalaji and ZEE5 series starring Sharman Joshi and Asha Negi return with new twists and turns with few heartwarming and endearing moments.

OECD’nin yayınladığı en son Büyümeye Geçiş raporuna göre kapsamlı bir reform gündemi doğrultusunda kararlı ve sistemli adımların atılması hükümetlere, zayıf talebi canlandırmak, sağlıklı ekonomik büyümeyi canlandırmak, iş olanakları yaratmak ve kazanımları toplumun her kesimine ulaştırmak için fırsatlar sunmaktadır.

Future of finance: Brazil’s main Latin rival for the attention of emerging market fund managers is Mexico