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Phocus combines hydration, energy

Experts suspect that the future is bright for both the energy drink and sparkling water market, Phocus is looking to be the go-to solution for consumers seeking both.




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Consumers prefer performance beverages with qualities beyond hydration

Experts note that convenience, drinkability and protein content are key drivers of the performance beverage market.




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Beverage-makers go beyond hydration, deliver on fortification trends

Health considerations have impacted the beverage industry by way of fortified beverages. 




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Earthy Andy Hawaiian Hydration

NBPure, in partnership with influencer, bestselling author and mom Andrea Hannemann, announced the launch of Earthy Andy Hawaiian Hydration.




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World's First AI Smart Hydration Reminder App Powered by GPT-4 Technology Launches

AI Water is an intelligent voice-controlled hydration assistant application that leverages advanced artificial intelligence technology, including GPT analysis features It provides users with comprehensive services.




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3 Potent Signs Your Skin is Dehydrated

Skin dehydration is one of the major reasons why your skin looks dull and lacks that fresh and glowing look. This is a common mistake to not understand what your skin actually needs. For any instant pick up, make sure you slather on a good hydrating serum. Moving on, there a few signs that show your skin is dehydrated. Some are pretty obvious and some are not so obvious or you might fail to notice in the rush of your work. So, let me list them for you.




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Webb Telescope Unveils Evidence of Water and Hydration on Asteroid Psyche

Could a metallic asteroid contain water and what can this teach us about the asteroid’s formation and evolution? This is what a recent study due for



  • Space & Astronomy

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Hydraulic Universal Testing Machine

When the materials testing application calls for up to 3,000 kN of hydraulic force applied by advanced digital control, Tinius Olsen offers its all-new SL series, replacing the company’s Super L series.




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Hydraulic Institute Unveils 2 Training Programs

The Hydraulic Institute's new on-demand courses are designed to support the pump and fluid-handling industry with workforce development and onboarding resources.




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National PTA, Nestlé Waters North America and Nestlé Pure Life Team Up for Healthy Hydration

Through a healthy hydration program developed by the alliance, grants, recycling bins and thousands of bottles of water will be awarded to PTAs across the country with the goal to help families live healthier lives by encouraging them to choose water.




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CECLOR cefaclor 250mg/5mL (as monohydrate) powder for oral liquid bottle (cefaclor monohydrate)

Unexpected increase in consumer demand




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SEVREDOL morphine sulfate pentahydrate 10mg tablet blister pack (morphine sulfate pentahydrate)

Commercial Changes / Commercial viability




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TACROGRAF tacrolimus 1 mg capsule bottle (tacrolimus monohydrate)

Manufacturing




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Pfizer (Australia) BUPIVACAINE HYDROCHLORIDE 0.5% (50mg/10mL) injection BP ampoule (bupivacaine hydrochloride monohydrate)

Manufacturing




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Ezetast 10/10 ezetimibe and atorvastatin (as calcium trihydrate) 10 mg/10 mg tablets blister pack (atorvastatin calcium trihydrate)

Manufacturing




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NORADRENALINE JUNO noradrenaline (norepinephrine) (as acid tartrate) 4 mg/4 mL concentrated solution for injection ampoule (noradrenaline (norepinephrine) acid tartrate monohydrate)

Manufacturing




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APX-AMOXICILLIN/CLAVULANIC ACID 500/125 amoxicillin 500 mg (as trihydrate) & clavulanic acid 125 mg (as potassium) tablet strip pack (potassium clavulanate)

Commercial Changes / Commercial viability




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APX-AMOXICILLIN/CLAVULANIC ACID 500/125 amoxicillin 500 mg (as trihydrate) & clavulanic acid 125 mg (as potassium) tablet strip pack (amoxicillin trihydrate)

Commercial Changes / Commercial viability




hydra

BICILLIN L-A benzathine benzylpenicillin tetrahydrate 1,200,000 Units / 2.3 mL suspension for injection pre-filled syringe with needle (benzathine benzylpenicillin tetrahydrate)

Manufacturing




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'Next-Level' Contractor Job Perk: Mobile IV Hydration

In response to extreme heat this summer, Solid Roofing in Oklahoma provided IV hydration through a mobile service to its crews working in triple-digit weather, highlighting the importance of staying hydrated in such conditions.




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Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding [Glycobiology and Extracellular Matrices]

VAR2CSA is the placental-malaria–specific member of the antigenically variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of Plasmodium falciparum-infected host red blood cells and binds to specific chondroitin-4-sulfate chains of the placental proteoglycan receptor. The functional ∼310 kDa ectodomain of VAR2CSA is a multidomain protein that requires a minimum 12-mer chondroitin-4-sulfate molecule for specific, high affinity receptor binding. However, it is not known how the individual domains are organized and interact to create the receptor-binding surface, limiting efforts to exploit its potential as an effective vaccine or drug target. Using small angle X-ray scattering and single particle reconstruction from negative-stained electron micrographs of the ectodomain and multidomain constructs, we have determined the structural architecture of VAR2CSA. The relative locations of the domains creates two distinct pores that can each accommodate the 12-mer of chondroitin-4-sulfate, suggesting a model for receptor binding. This model has important implications for understanding cytoadherence of infected red blood cells and potentially provides a starting point for developing novel strategies to prevent and/or treat placental malaria.




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Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues

Colin T. McDowell
Nov 24, 2020; 0:RA120.002256v1-mcp.RA120.002256
Research




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Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues [Research]

The early detection of pancreatic ductal adenocarcinoma is a complex clinical obstacle yet is key to improving the overall likelihood of patient survival. Current and prospective carbohydrate biomarkers CA19-9 and sTRA are sufficient for surveilling disease progression yet are not approved for delineating PDAC from other abdominal cancers and non-cancerous pancreatic pathologies. To further understand these glycan epitopes, an imaging mass spectrometry approach was utilized to assess the N-glycome of the human pancreas and pancreatic cancer in a cohort of PDAC patients represented by tissue microarrays and whole tissue sections. Orthogonally, these same tissues were characterized by multi-round immunofluorescence which defined expression of CA19-9 and sTRA as well as other lectins towards carbohydrate epitopes with the potential to improve PDAC diagnosis. These analyses revealed distinct differences not only in N-glycan spatial localization across both healthy and diseased tissues but importantly between different biomarker-categorized tissue samples. Unique sulfated bi-antennary N-glycans were detected specifically in normal pancreatic islets. N-glycans from CA19-9 expressing tissues tended to be bi-, tri- and tetra-antennary structures with both core and terminal fucose residues and bisecting N-acetylglucosamines. These N-glycans were detected in less abundance in sTRA-expressing tumor tissues, which favored tri- and tetra-antennary structures with polylactosamine extensions. Increased sialylation of N-glycans was detected in all tumor tissues. A candidate new biomarker derived from IMS was further explored by fluorescence staining with selected lectins on the same tissues. The lectins confirmed the expression of the epitopes in cancer cells and revealed different tumor-associated staining patterns between glycans with bisecting GlcNAc and those with terminal GlcNAc. Thus, the combination of lectin-IHC and IMS techniques produces more complete information for tumor classification than the individual analyses alone. These findings potentiate the development of early assessment technologies to rapidly and specifically identify PDAC in the clinic that may directly impact patient outcomes.




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Stay Cool, Hydrated, And Informed to Prevent Heat-Related Illness

As temperatures soar into the high 80s this week and humidity rises, the Division of Public Health (DPH) reminds Delawareans how to avoid heat-related illnesses such as heat stroke, heat exhaustion, and heat cramps.




hydra

to work with and modify the turbo hydra matic 40

to work with and modify the turbo hydra matic 40




hydra

to work with and modify the turbo hydra matic 400

to work with and modify the turbo hydra matic 400




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What Can You Eat on the Specific Carbohydrate Diet (SCD)?

Title: What Can You Eat on the Specific Carbohydrate Diet (SCD)?
Category: Health and Living
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM




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Coppertone� Teams Up With Soccer Stars Christen Press, Kelley O'Hara, Graham Zusi And Matt Besler To Inspire Daily Sun Protection - Christen Hydrate TV Spot Use and reapply as directed.

When Christen Press puts her game face on, she makes sure she helps protect it with Coppertone� Sport. Use and reapply as directed.




hydra

Stay Hydrated

NO MORE CLUBBING




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Hydrabad|Techie death: কথাবার্তা বন্ধ করে দিয়েছিল বয়ফ্রেন্ড, চরম পদক্ষেপ নিলেন তরুণী ইঞ্জিনিয়ার

Hydrabad|Techie death: গত ৭ নভেম্বর থেকে ফোনও তুলছিলেন না তিনি। অভিযোগ পাওয়ার পরই তদন্ত নামে পুলিস। তারা পৌঁছে যায় ইরামের ফ্ল্যাটে। সেখানে গিয়ে দেখা যায় ফ্ল্যাট তালাবন্ধ




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Monarchs and hydrarchs : the conceptual development of Viking activity across the Frankish realm (c. 750-940) [Electronic book] / Christian Cooijmans.

Abingdon, Oxon ; New York, NY : Routledge, 2020.




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Bishydrazone ligand and its Zn-complex: synthesis, characterization and estimation of scalability inhibition mitigation effectiveness for API 5L X70 carbon steel in 3.5% NaCl solutions

RSC Adv., 2024, 14,13258-13276
DOI: 10.1039/D4RA00404C, Paper
Open Access
Ola. A. El-Gammal, Dina A. Saad, Marwa N. El-Nahass, Kamal Shalabi, Yasser M. Abdallah
Zn-complex: characterization and estimation of scalability inhibition mitigation effectiveness for API 5L X70 carbon steel in 3.5% NaCl solutions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A unimolecular artificial cation channel based on cascaded hydrated acid groups

J. Mater. Chem. B, 2024, 12,10835-10838
DOI: 10.1039/D4TB01508H, Communication
Pengyang Xin, Hailong Yuan, Long Zhang, Qiuhui Zhu, Xunpeng Ning, Yufei Song, Yuqing Shu, Yonghui Sun
Based on the cascade dehydration concept, an amphiphilic unimolecular cation channel was synthesized by attaching multiple carboxyl groups to both sides of hybrid molecule, resulting in excellent cation transport activity and pH-modulated properties.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Mitigating intubation stress, mucosa injury, and inflammatory response in nasogastric tube intubation via suppression of the NF-κB signaling pathway by engineering a hydration lubrication coating

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01171F, Paper
Xi Liao, Meng-Han Bai, Yu-Wei Liu, Yu-Qing Wei, Jun-Yang Wang, Zhi-Guo Wang, Rui Hong, Ju-Xiang Gou, Jia-Zhuang Xu, Zhong-Ming Li, Ka Li
The hydrated micelle coating, composed of hyaluronic acid and Pluronic, demonstrated superior hydrophilicity and aqueous lubricity to effectively alleviate mucosal lesions and inflammation caused by NGT insertion.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Intercellular lipid-cored, hectorite nanoplatelet-armored pickering emulsions with enhanced transdermal delivery and epidermal hydration

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01610F, Paper
Boryeong Lee, Lakshmishri Prabakaran, Minkyoung Jang, Song Hua Xuan, Kyounghee Shin, Sung Ho Lee, Jin Woong Kim
An intercellular lipid-cored, hectorite nanoplatelet-armored Pickering emulsion system is proposed to enhance dermal penetration and moisture retention.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




hydra

Hydrazone-linked Covalent Organic Frameworks for Fluorescence Detection of Hg2+

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC05468G, Communication
Xuefeng Wang, Zhaowei Yang, Lingsuo Meng, Xuehui Li, Hongtao Wei, Jing Ning, Shitao Wang, Dapeng Cao, Long Hao
A hydrazone-linked COF (DvDf-C3XJ-COF) with hydrogen-bond reinforcement and abundant coordination sites was synthesized, exhibiting strong fluorescence and high sensitivity/selectivity for Hg²⁺ detection, with a detection limit of 1.65 × 10⁻⁶...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Polarizable AMOEBA force field predicts thin and dense hydration layer around monosaccharides.

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC04415K, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Luke A Newman, Mackenzie G Patton, Breyanna A Rodriguez, Ethan W Sumner, Valerie Vaissier Welborn
Polarizable force fields crucially enhance the modeling of macromolecules in polar media. Here, we present new parameters to model six common monosaccharides with the polarizable AMOEBA force field. These parameters...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Catalytic decomposition of hydrazine nitrate and hydroxylamine nitrate in radioactive nitric acid waste liquid using Ru/AC catalyst

New J. Chem., 2024, Advance Article
DOI: 10.1039/D4NJ00916A, Paper
Deyan Yu, Baole Li, Zhi Cao, Qi Chen, Chen Zuo, Tiansheng He, Taihong Yan, Weifang Zheng
The 5 wt% Ru/AC catalysts were prepared using the impregnation method.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Local concentration controls the hydrate phase of calcium oxalate

CrystEngComm, 2024, Advance Article
DOI: 10.1039/D3CE01286G, Paper
Zhaodong Wang, Lala Du, Qihang Wang, Jingjing Xie, Zhengyi Fu, Zhaoyong Zou
The calcium oxalate phase selection in supersaturated solution is determined by a combination of thermodynamic and kinetic factors.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Structural diversity and tetrel bonding significance in lead(II) complexes with pyrazoylisonicotinoylhydrazone and varied anionic co-ligands

CrystEngComm, 2024, Accepted Manuscript
DOI: 10.1039/D4CE00325J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ghodrat Mahmoudi, Isabel Garcia-Santos, Roi Fernández-Vázquez, Rosa Maria Gomila, Alfonso Castineiras, Esmail Doustkhah, Ennio Zangrando, Antonio Frontera
Four lead(II) complexes featuring pyrazoylisonicotinoylhydrazone ligand paired with various anionic co-ligands (azido, thiocyanato, nitrito, and nitrato) were synthesized and thoroughly examined using structural, analytical, and spectroscopic techniques. These ligands, in...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00190G, Paper
Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
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On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00241E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Julia A. Turner, Hendrik Zipse, Mark S. Taylor
Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state.
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Sweet MOFs: Exploring the Potential and Restraints of Integrating Carbohydrates with Metal-Organic Frameworks for Biomedical Applications

Nanoscale Horiz., 2024, Accepted Manuscript
DOI: 10.1039/D4NH00525B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alessio Zuliani, Victor Ramos, Alberto Escudero, Noureddine Khiar
The unique features of metal-organic frameworks (MOFs) such as biodegradability, reduced toxicity and high surface area offer the possibility of developing smart nanosystems for biomedical applications through the simultaneous functionalization...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nutrition, hydration & neighbourhood runs

Marathoner shares 20-year fitness regime of cardio, strength, and stability, prioritising training and recovery for marathon success




hydra

Photochemical carboborylation and three-component difunctionalization of α,β-unsaturated ketones with boronic acids via tosylhydrazones

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06537A, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Álvaro Valdés-Maqueda, Manuel Plaza, Carlos Valdés
The photochemical carboborylation of α,β-unsaturated tosylhydrazones with boronic acids gives tertiary allylboronates. A one pot sequence involving an aldehyde allylation provides a powerful three-component method for diversity oriented synthesis.
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hydra

HYDRAA clears encroachments on Bam Rukn Ud-Dowlah lake

High tension prevailed in Kings Colony and Shastripuram areas as the houses of some VIPs were allegedly demolished




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Analysis of O-acetylated sialic acids by 3-nitrophenylhydrazine derivatization combined with LC-MS/MS

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00330F, Paper
Chenhao Zhao, Xingdan Wang, Jing Wu, Yeli Hu, Qiwei Zhang, Qi Zheng
The 3-NPH-labeled sialic acids produce a high abundance of reporter ions, which can improve the accuracy of quantitative analysis of O-acetylated species.
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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article
Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00663A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin Krátký
Linking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.
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