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1919: The King-Crane Commission Report: Confidential Appendix

In 1991, a young Atlanta Braves pitching sensation by the name of John Smoltz was 2-11 nearing the All Star break, and like with the Nationals' Stephen Strasburg, the baseball world was wondering what was wrong.

Serving up four home runs and losing 15-0 in Cincinnati was an inauspicious Nationals debut for veteran Dan Haren. Four weeks later against the same Reds, Haren found himself in a pitcher-friendly park, aided by the force of a powerhouse team gathering momentum.

Don van Lierop had a problem…

The basketballer, who has an on-and-off relationship with Khloe Kardashian, has reportedly forced podcaster to delete a revealing interview with his former lover.

I don't disagree with the advice already provided, but I think you're using the word "boundary" in an odd way. You don't get to set boundaries on other people's behaviour, even when you're married to them. You can set a boundary around your own behaviour, then other people decide how they'll respond.

In this case, you might say: if you continue a friendship with B, our relationship will be at an end. Then, the ball is in R's court - he can decide what to do next.

My marriage is only monogamish, so I'm saying this with some bias towards polyamory:

If your spouse want to prioritize this friendship over your stated boundary, then your spouse is prioritizing the friendship over your marriage.

In this case, you really don't have to explain why. In fact, I'd stop explaining why. It's not a comprehension problem. It's that your partner doesn't want to do what you are asking.

Here's the words I would use: I do not want you to continue this friendship. If you do, I am going to have to take steps towards ending our marriage. We should discuss this in counselling.

In other words even in marriages where there's less emphasis on monogamy, the main thing is that you have to respect your partner's limits, or else you aren't partners. I'm sorry your partner is putting you through this.

SOCCER and rugby league might dominate sport in the western suburbs but Quakers Hill’s Logan Owen’s skill is executed impressively in the gymnastics arena.

Fidelis Insurance Group declared a $0.10 per share dividend, payable by December 20, 2024. In a filing with the BSX, the company said, “Fidelis Insurance Holdings Limited [NYSE:FIHL] [“Fidelis Insurance Group” or “the Company”], a global specialty insurer, announced today that its Board of Directors has approved and declared a dividend of $0.10 per share, […]

Fidelis Insurance Group declared a dividend and announced a new share repurchase authorization. A spokesperson said, “Fidelis Insurance Holdings Limited, a global specialty insurer, announced today that its Board of Directors has approved and declared a dividend of $0.10 per share, payable on September 30, 2024, to common shareholders of record on September 16, 2024. “In addition, […]

The Fidelis Partnership and 15 West Hamilton businesses hosted a festive Halloween celebration for the community. A spokesperson said, “For the first time since 2019, The Fidelis Partnership [TFP] and several businesses in the West Hamilton area joined forces to host a festive Halloween celebration outside their respective locations. This event brings together not only […]

In this episode I'm joined by Clive Palmer to discuss the departure of Charlie Patino to Deportivo la Coruna, in the context of how difficult it can be for a highly rated youth player to make the step up to the Arsenal first team. We also discuss the futures of Reiss Nelson and Eddie Nketiah, Mikel Merino's arrival (whenever it happens), why Mikel Arteta needs to demonstrate confidence in all his players for the season ahead, how an attacking signing could complete the squad, and lots more.

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"Customers must be able to reevaluate their willingness to have their genome data shared outside the original intent.”

The post Patronis Questions DNA Testing Companies’ User Confidentiality appeared first on Shark Tank.

India has built a 3km-long runway on Agalega and no-one has fully explained why, angering residents.

Shaolin Temple Cultural Centre has been able to expand classes thanks to BBC Children in Need.

Diana Samodova
Dec 1, 2020; 19:2139-2156
Technological Innovation and Resources

Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the C-terminal side of proline and alanine residues. ProAlanase achieves high proteolytic activity and specificity when digestion is carried out at acidic pH (1.5) for relatively short (2 h) time periods. To elucidate the potential of ProAlanase in proteomics applications, we conducted a series of investigations comprising comparative multi-enzymatic profiling of a human cell line proteome, histone PTM analysis, ancient bone protein identification, phosphosite mapping and de novo sequencing of a proline-rich protein and disulfide bond mapping in mAb. The results demonstrate that ProAlanase is highly suitable for proteomics analysis of the arginine- and lysine-rich histones, enabling high sequence coverage of multiple histone family members. It also facilitates an efficient digestion of bone collagen thanks to the cleavage at the C terminus of hydroxyproline which is highly prevalent in collagen. This allows to identify complementary proteins in ProAlanase- and trypsin-digested ancient bone samples, as well as to increase sequence coverage of noncollagenous proteins. Moreover, digestion with ProAlanase improves protein sequence coverage and phosphosite localization for the proline-rich protein Notch3 intracellular domain (N3ICD). Furthermore, we achieve a nearly complete coverage of N3ICD protein by de novo sequencing using the combination of ProAlanase and tryptic peptides. Finally, we demonstrate that ProAlanase is efficient in disulfide bond mapping, showing high coverage of disulfide-containing regions in a nonreduced mAb.

DNA polymerase from bacteriophage T7 undergoes large, substrate-induced conformational changes that are thought to account for high replication fidelity, but prior studies were adversely affected by mutations required to construct a Cys-lite variant needed for site-specific fluorescence labeling. Here we have optimized the direct incorporation of a fluorescent un-natural amino acid, (7-hydroxy-4-coumarin-yl)-ethylglycine, using orthogonal amber suppression machinery in Escherichia coli. MS methods verify that the unnatural amino acid is only incorporated at one position with minimal background. We show that the single fluorophore provides a signal to detect nucleotide-induced conformational changes through equilibrium and stopped-flow kinetic measurements of correct nucleotide binding and incorporation. Pre-steady-state chemical quench methods show that the kinetics and fidelity of DNA replication catalyzed by the labeled enzyme are largely unaffected by the unnatural amino acid. These advances enable rigorous analysis to establish the kinetic and mechanistic basis for high-fidelity DNA replication.

ATLANTA, Nov. 12, 2024 — Sylabs, in collaboration with Sandia National Laboratories, will host a Birds of a Feather (BoF) session at SC24 titled Integrating Confidential Computing into High-Performance Cloud Workflows. […]

The post Sylabs Highlights Confidential Computing in HPC at SC24 BoF Session appeared first on HPCwire.

Up to 50% of people admit cheating on their partner.

Fidelity is often seen as a bad word in school, but it doesn't have to be that way. In this guest blog by George Toman, the concept of fidelity is explained and defended.

Many schools that have recently opened their doors are already seeing COVID-19 cases among students and staff. Should that shake the confidence of other school leaders who are planning to reopen?

FAO Director-General José Graziano da Silva today expressed confidence that “significant progress against hunger, food insecurity and malnutrition,” will be achieved in the next four years. He made the [...]

U.S. president-elect Donald Trump has promised sweeping global tariffs in his next term, but the Canadian Steel Producers Association remains confident that the industry can come out unscathed.

The pay cut comes after city council had already taken a number of steps against the mayor, including stripping him of his duties as a city spokesperson, removing him from the Thompson Nicola Regional District board and Shuswap Watershed Council and relocating his office to the basement of city hall. 

South Africa is marketing eurobonds in its first potential international debt sale under a government of national unity following May elections.

Attorney General Jennings today called on U.S. Attorney General William Barr to reverse his abrupt change to a 40-year-old U.S. Department of Justice policy that until this week had kept the department from interfering with election results. In a letter to AG Barr, AG Jennings and 22 other attorneys general strongly objected to a November […]

Established 77 years ago, Mitsui & Co stays vibrant by building businesses and ecosystems with new technologies like generative AI and confidential computing. Digital transformation takes many forms at the Tokyo-based conglomerate with 16 divisions. In one case, it’s an autonomous trucking service, in another it’s a geospatial analysis platform. Mitsui even collaborates with a Read Article

Edo Queens head coach Moses Aduku is exuding confidence and expects his charges to go all out against FC Masar in the CAF Women’s Champions League Group B clash starting at 18:00 at Larbi Zaouli Stadium, Casablanca on Wednesday (today), PUNCH Sports Extra reports. The Nigerian and West African champions made a flying start to

A small incident in the mounting mayhem of the 2024 elections crystalized the state of the dark art of politics in these United States. In Springfield, Ohio, a small midwestern industrial city, a woman named Anna Kilgore noticed that her cat, Miss Sassy, had been missing for a few days. Kilgore notified the police that she […]

Title: Overconfident Folks May Blind Others to Their Real Abilities
Category: Health News
Created: 8/27/2014 2:36:00 PM
Last Editorial Review: 8/28/2014 12:00:00 AM

A few months ago, the rumour took root that GTA 6's release date would slip back from 2025 to 2026. An anonymous insider averred that studio heads were "worried" about the new open world game's progress - hence, perhaps, Rockstar's decision to mandate a full return to in-office work. Pshaw, say publishers Take-Two CEO. They announced a fall 2025 launch in March and have just doubled down on it in their latest financial briefing, with CEO Strauss Zelnick subsequently going on the tellybox to say that Take-Two are "highly confident in the timing", though he still has nothing to share about GTA 6 on PC.

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Indian pharma and biotech companies are confident that under the new US President Donald Trump, its strengths in high quality generics manufacture and export will continue to command respect. This view is

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Human action produces the greatest benefits when it is focused on providing rational solutions to critical problems. A wise man uses logic to determine which difficulties are to be...

Shreyas Talpade is also a brand ambassador and face of the Bombay Psychiatric Society. On the film front, the actor is also gearing up for Emergency, and Welcome To The Jungle to name a few.

Elon Musk’s X is now worth less than a quarter of its $44 billion purchase price, according to a new estimate from investor Fidelity.  The asset manager’s Blue Chip Growth Fund now values its stake in X, formerly known as Twitter, at approximately $4.19 million, based on newly released disclosures from Fidelity’s Blue Chip Growth […]

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The transcript of President Trump's call with Ukraine shed light on a method for classifying documents that's even more top secret than top secret. WSJ spoke to a former National Security Council official to understand the intricacies of the White House server security system.

India is optimistic about achieving USD 100 billion in trade with Russia before 2030, highlighting progress in logistics and payments.