La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Even though the Colorado State football team has already checked a couple of boxes off its to-do list for this season, the stakes are still as high as ever for Friday night's Border War game against Wyoming.

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Jorge Narvaez habla sobre la unión y la fuerza de la familia

It's been a while since we've seen Lt. Potter

Researchers at the Queen Mary University of London developed and tested an algorithm that detects familial hypercholesterolemia. They named the algorithm

Chef Jason DeSouza’s White Plate serves glocal food with the theatrics of molecular gastronomy wrapped in marble and crystal chandeliers

Folk melodies with urban interpretations was the highlight of Lok Sangeet Sammelan, while versatility of gharanas was the hallmark of Ibtida.

Rasaranjani’s ‘Pampakalu’ was an engaging play with impressive performances.

Friday’s CTUA protest was initially planned to demand restoration of the third surviving route, Ballygunge-Tollygunge, which was shut down temporarily about four months ago due to pipeline work; but by Friday they had more things to protest against as media reports showed bituminisation of not-in-use tram tracks in Alipore.

Dwayne Bravo puts on his dancing shoes for “Jhalak Dikhhlaa Jaa”

Kochi, India :: Jeannette Zandbergen (Netherlands) is surprised to see an old friend in a photograph.

Visakhapatnam, India :: Teams from the ship visit Logos Church.

As sales and exports of fish crash, another huge crisis is staring at Sri Lanka’s fisherfolk.

As history has shown us, environmental regulations often help the economy, not hurt it. Why can't corporations -- and Congress -- learn from the past?

This year National Public Lands Day at Grand Canyon National Park will be commemorated with more than free admission and volunteer opportunities. Park staff and friends will also be celebrating the park’s first Dia de la Familia. https://www.nps.gov/grca/learn/news/news_2009-09-01_npld-dia.htm

https://www.nps.gov/grca/learn/news/grand-canyon-national-park-to-celebrate-dia-de-la-familia-on-national-public-lands-day.htm

The 10th restaurant from Bay Area restaurateur Hoyul Steven Choi offers a creative take on Korean-infused cuisine. You'd think that after opening nearly a dozen successful restaurants in the ultra-competitive Bay Area dining scene, restaurateur Hoyul Steven Choi would have calmed his new restaurant jitters by now. But Choi says that's not the case.…

A new environment has a way of bringing out something new in us, for American singer-songwriter, Charli Adams, it comes in the form of new single "Superpowers." The acoustic composition puts the indie artist in the familiar position of vulnerability and seclusion that first propelled her from secret shows in her native Alabama to the […]

The post Charli Adams reaches for something familiar in new single "Superpowers" appeared first on EARMILK.

¿Es legal que la empresa de los hermanos del Secretario de Hacienda de Medellín se beneficie con nombramientos del municipio?

GARDENING IS A restorative act grounded in natural rhythms and constancy. Thank goodness! I’m not a doctor or a mental health expert. I’m a gardener. But I know from years of plotting and planting the many ways my garden tends me as I care for it. So, I thought I’d share a little unsolicited but […]

From balcony book clubs to re-reading, we asked professional readers how and what they're reading through the lockdown.

Why do old books smell like chocolate, vanilla, grass clippings and old socks? There's a scientific explanation.

Remember these lines?

Remember these lines?

[Updated with photos] Two helicopters from the Royal Fleet Auxiliary ship RFA Argus will “conduct familiarisation flights” across Bermuda. In an online post, the Bermuda Police Service said, “On Monday afternoon, two helicopters from Royal Fleet Auxiliary ship RFA Argus, will conduct familiarisation flights over a number of helicopter landing sites across Bermuda. “This was […] (Click to read the full article)

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.

The Iron Dragon's Mother received a long, thoughtful, and positive review from Matt Hilliard in the March 30 issue of Strange Horizons. Rather than give you the usual pull-quote carefully excised from the corpus of the text, I thought I'd share with you one of Hilliard's observations:

That raises the question: what is Swanwick up to with this setting? If he wants to write fun faerie stories, why not just write about faeries the normal way? Or, since a valid way to describe this book is to say it’s “about a faerie fighter pilot, but it’s reallyabout living in a corrupt world and dealing with death,” why not just write about corruption and death in the real world where both can be found in abundance? To answer the second question, a common defense of genre fiction is that both fantasy and science fiction give us a different perspective on things that don’t change. They defamiliarize the world around us by situating us in the future or a past that never existed, and in doing so they can teach us things about humanity that we wouldn’t otherwise have known.

It’s been sixty-five years since J. R. R. Tolkien published The Fellowship of the Ring and spawned a host of imitators, and for most of Swanwick’s readers, fantasy has become deeply familiar. If it’s too familiar, it no longer defamiliarizes. What to do? Some authors, such as those of the New Weird, responded by moving away from Tolkien’s folklore influences, pushing into stranger territory. Swanwick has done the opposite, hewing closely to the peoples and monsters of folklore traditions from around the world (albeit with the occasional references to Tolkien himself, as with Caitlin’s brother, named Fingolfinrhod). But by mixing together elves and Gucci handbags, dwarves and cigarettes, or dragons and jet fighters, Swanwick continually shifts the context his reader must use. Whenever you find yourself getting comfortable, the novel suddenly sounds like this: “With the easy, racist phrasing of his class, her brother said, ‘Well, the kobold is in the henhouse now, to be sure’” (p. 289).

Overall, the review is positive, the sort of thing that warms a writer's heart. Hilliard has some negative things to say along the way, but since they're based on a careful reading of the book I actually wrote, I don't see that I have any right to complain.

You can read the whole review here.  Or go to Strange Horizons here and wander around, maybe read a story or two while you're there.

Above: Cleaning office, I came across the above photo of myself at age 23, when I was new to Philadelphia and determined to be a science fiction writer. It captures my mood then pretty well.

The danger of a new euro crisis is growing. Weak member states like Italy need help if they're going to survive the coronavirus lockdown financially. But the call for euro bonds has been met with stiff resistance -- especially from the Germans.

In 'Upload,' a new Amazon comedy from 'The Office' and 'Parks and Recreation' whiz Greg Daniels, Robbie Amell stars as a man in a (digital) afterlife.

31 January 2020

Despite being free of the constraints and the theatre of a hung parliament, there is a risk that over the coming year the British government repeats too many of the mistakes of the withdrawal negotiations.

Some districts are using new “response lessons” to identify the talented students that traditional assessments miss.

Schools must make the critical decision whether to reinforce the learning that students have already done this year or introduce new content.

Berlin : J. Springer, 1893.

Students from OM Panama’s International Intensive School of Missions experience a different world inside a mosque in Panama City.

"There's a science of learning, and ... there's not a single teacher who couldn't benefit, I think, from knowing these principles," said the executive director of Deans for Impact, a group of education school leaders.

The Samsung Galaxy A21s has been popping-up in the rumor mill from time to time, over the last couple of months. Now, a new leak claims to showcase a render of its front side. It's a slightly odd, yet totally believable development, since the front of the phone, as shown here, looks nearly identical to a set of recent Galaxy A21 leaked renders. Not only that, but the Galaxy A11 and M11 appear to be in the exact same boat, as well. Interestingly enough, despite their lower standing in the lineup, the latter two sems to show slimmer chins and top bezels in their respective renders. Alongside...

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Rokuro Inui uses familiar elements of Japanese culture and history to build the world of his 2019 novel “Automatic Eve” (originally published in Japanese in ...

Background:

Relatives of patients with bladder cancer have been shown to be at increased risk for kidney, lung, thyroid, and cervical cancer after correcting for smoking-related behaviors that may concentrate in some families. We demonstrate a novel approach to simultaneously assess risks for multiple cancers to identify distinct multicancer configurations (multiple different cancer types that cluster in relatives) surrounding patients with familial bladder cancer.

Methods:

This study takes advantage of a unique population-level data resource, the Utah Population Database (UPDB), containing vast genealogy and statewide cancer data. Familial risk is measured using standardized incidence risk (SIR) ratios that account for sex, age, birth cohort, and person-years of the pedigree members.

Results:

We identify 1,023 families with a significantly higher bladder cancer rate than population controls (familial bladder cancer). Familial SIRs are then calculated across 25 cancer types, and a weighted Gower distance with K-medoids clustering is used to identify familial multicancer configurations (FMC). We found five FMCs, each exhibiting a different pattern of cancer aggregation. Of the 25 cancer types studied, kidney and prostate cancers were most commonly enriched in the familial bladder cancer clusters. Laryngeal, lung, stomach, acute lymphocytic leukemia, Hodgkin disease, soft-tissue carcinoma, esophageal, breast, lung, uterine, thyroid, and melanoma cancers were the other cancer types with increased incidence in familial bladder cancer families.

Conclusions:

This study identified five familial bladder cancer FMCs showing unique risk patterns for cancers of other organs, suggesting phenotypic heterogeneity familial bladder cancer.

Impact:

FMC configurations could permit better definitions of cancer phenotypes (subtypes or multicancer) for gene discovery and environmental risk factor studies.

Today Attorney General Eric Holder announced the arrest of nearly 1,200 individuals on narcotics-related charges and the seizure of more than 11.7 tons of narcotics as part of a 44-month multi-agency law enforcement investigation known as “Project Coronado.”

The Justice Department today announced a settlement of its lawsuit alleging that Lee Enterprises Inc. and its subsidiary, Lee Publications Inc., violated the Fair Housing Act (FHA) by publishing an advertisement that discriminated on the basis of familial status in the Elko Daily Free Press.

The Justice Department has filed a lawsuit against the owners of Yorkshire Apartments, Thackeray Ledges and Wales Ridge Apartments in Massillon, Ohio, for discriminating on the basis of race and familial status when renting their apartments in violation of the Fair Housing Act.

A second superseding indictment was unsealed today adding 19 counts including racketeering conspiracy and attempted murder against three defendants for their alleged participation in the violent Nuestra Familia gang.

The big Danish design competition really has similar goals to TreeHugger: to promote good green design that makes the world better

Finally, the inside of the Sagrada Familia in Barcelona is done. The church, set out to build 125 years ago and expected to be finished in 2026, attracts millions of visitors every year. This is no surprise due to the

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