Awards season is officially over — but not until we hand out the awards for best dressed at the Oscars afterparties.

[do action=”custom_iframe” url=”https://www.google.com/maps/embed?pb=!1m14!1m12!1m3!1d4817.01329563402!2d-121.84475178011013!3d48.27989084960848!2m3!1f0!2f0!3f0!3m2!1i1024!2i768!4f13.1!5e1!3m2!1sen!2sus!4v1395604021176″ width=”600″ height=”500″ scrolling=””/] This is a Google Earth view of the area along SR 530 before the mudslide came down late Saturday morning. The view is looking north. The slide moved from the forested area north of the Stillaquamish River,  crossed the river and into the developed area all the way to […]

'Extra time for you to test,' you lucky, lucky developers

Google has applied the brakes to Android 11, pushing things out by a month as it grapples with a world that is much changed since planning for the release began.…

I was still determined not to be the girl who moved across the country for a guy, but what would happen if I loosened my grip on that idea? After we dated almost a year, I applied for a job in Los Angeles and I got it. Just try it, I told myself. If it all falls apart, New York will always be there.

Stars aren't the only ones who should look great, right? Here are fresh beauty and skin-care options around L.A. worth trying.

Bong Joon Ho's mesmerizing movie deserves to win best picture. But can it?

Sure, the Oscars are exciting, but what about the film moments they don't celebrate? That's where the Envy Awards step in.

A luxurious house in "Parasite" and visions of '80s urbanism in "Joker" paint vivid pictures of haves and have nots for #Oscars2020.

We can't control what wins best picture at the Academy Awards. Can we control our emotions when our favorite movie doesn't win?

I've spent 20 years covering the Oscars, and yes, they're splendid and ridiculous, flawed and inspirational. That's why they still matter.

"Did you know this is the 'Pretty Woman' hotel?" a publicist asked Dr. Amani Ballour.

Before the Oscars on Sunday, watch the wildly different and entertaining acceptance speeches Brad Pitt and Joaquin Phoenix have made this awards season.

'Harriet' star Cynthia Erivo already has a Daytime Emmy, a Tony and a Grammy. All that's left is Oscar — and she's nominated for two this year.

Join us backstage at the Academy Awards for behind-the-scenes bits with a jubilant Bong Joon Ho, an emotional Joaquin Phoenix, Billie Eilish, Spike Lee, Maya Rudolph and others.

While honoring last year's Governors Awards recipients, new Oscar winner Taika Waititi also saluted Los Angeles' ancestral lands during the 2020 Oscars.

"Parasite" won the Oscar for best picture, becoming the first non-English language movie to do so. How did it win?

Joaquin Phoenix gave a weighty speech about commonalities, cows and second chances after winning the Oscar for lead actor Sunday night. Read the transcript.

Joaquin Phoenix, who discussed animal cruelty in his acceptance speech, was one of several famous vegans at the Oscars, including Billie Eilish.

With "Parasite," the academy gave best picture to the actual best picture. It also made history.

The rules for the international feature category mean director Bong personally won three Academy Awards in the stunning "Parasite" march to glory.

More than film critics or a more international film academy, Netflix has proved that subtitles are a bridge, not a barrier.

Behind the scenes at this year's Pebble Beach Concours d'Elegance, the most prestigious car show in the world.

¿Cómo pueden los artistas responder a la pandemia de COVID-19? El muy ridiculizado discurso de aceptación de Oscar de Joaquín Phoenix en realidad sugiere una respuesta.

Coronavirus may have shut down movie theaters, but even if they stayed closed, we'd have a strong slate of Oscar contenders beyond Elisabeth Moss in "Invisible Man."

At today's board of governors meeting, the Academy of Motion Picture Arts and Sciences voted to create one consolidated category: "Achievement in Sound."

From James Baskett to James Dean, Indiana has produced impressive group of Oscar winners and nominees over the years.

An overview of the OSCE, including its background, structure and key activities

DC's "Joker" may have the edge on Marvel.

Bone is the most common site of distant metastatic spread in prostate adenocarcinoma. Prostate-specific membrane antigen uptake has been described in both benign and malignant bone lesions, which can lead to false-positive findings on ⁶⁸Ga-prostate-specific membrane antigen-11 positron emission tomography (⁶⁸Ga-PSMA-11 PET). The purpose of this study was to evaluate the diagnostic accuracy of ⁶⁸Ga-PSMA-11 PET for osseous prostate cancer metastases and improve bone uptake interpretation using semi-quantitative metrics. METHODS: 56 prostate cancer patients (18 pre-prostatectomy, 38 biochemical recurrence) who underwent ⁶⁸Ga-PSMA-11 PET/MRI or PET/CT examinations with osseous PSMA-ligand uptake were included in the study. Medical records were reviewed retrospectively by board-certified nuclear radiologists to determine true or false positivity based on a composite endpoint. For each avid osseous lesion, biological volume, size, PSMA-RADS rating, maximum standardized uptake value (SUV_max), and ratio of lesion SUV_max to liver, blood pool, and background bone SUV_max were measured. Differences between benign and malignant lesions were evaluated for statistical significance, and cut-off values for these parameters were determined to maximize diagnostic accuracy. RESULTS: Among 56 participants, 13 patients (22.8%) had false-positive osseous ⁶⁸Ga-PSMA-11 findings and 43 patients (76.8%) had true-positive osseous ⁶⁸Ga-PSMA-11 findings. Twenty-two patients (39%) had 1 osseous lesion, 18 (32%) had 2-4 lesions, and 16 (29%) had 5 or more lesions. Cut-off values resulting in statistically significant (p<0.005) differences between benign and malignant lesions were: PSMA-RADS ≥4, SUV_max ≥4.1, SUV_max ratio of lesion to blood pool ≥2.11, to liver ≥0.55, and to bone ≥4.4. These measurements corresponded to lesion-based ⁶⁸Ga-PSMA-11 PET lesion detection rate for malignancy of 80%, 93%, 89%, 21%, 89%, and a specificity of 73%, 73%, 73%, 93%, 60%, respectively. CONCLUSION: PSMA-RADS rating, SUV_max, and SUV_max ratio of lesion to blood pool can help differentiate benign from malignant lesions on ⁶⁸Ga-PSMA-11 PET. SUV_max ratio to blood pool above 2.2 is a reasonable parameter to support image interpretation and presented superior lesion detection rate and specificity when compared to visual interpretation by PSMA RADS. These parameters hold clinical value by improving diagnostic accuracy for metastatic prostate cancer on ⁶⁸Ga-PSMA-11 PET/MRI and PET/CT.

The septo-hippocampal cholinergic system is critical for hippocampal learning and memory. However, a quantitative description of the in vivo firing patterns and physiological function of medial septal (MS) cholinergic neurons is still missing. In this study, we combined optogenetics with multichannel in vivo recording and recorded MS cholinergic neuron firings in freely behaving male mice for 5.5–72 h. We found that their firing activities were highly correlated with hippocampal theta states. MS cholinergic neurons were highly active during theta-dominant epochs, such as active exploration and rapid eye movement sleep, but almost silent during non-theta epochs, such as slow-wave sleep (SWS). Interestingly, optogenetic activation of these MS cholinergic neurons during SWS suppressed CA1 ripple oscillations. This suppression could be rescued by muscarinic M₂ or M₄ receptor antagonists. These results suggest the following important physiological function of MS cholinergic neurons: maintaining high hippocampal acetylcholine level by persistent firing during theta epochs, consequently suppressing ripples and allowing theta oscillations to dominate.

SIGNIFICANCE STATEMENT The major source of acetylcholine in the hippocampus comes from the medial septum. Early experiments found that lesions to the MS result in the disappearance of hippocampal theta oscillation, which leads to speculation that the septo-hippocampal cholinergic projection contributing to theta oscillation. In this article, by long-term recording of MS cholinergic neurons, we found that they show a theta state-related firing pattern. However, optogenetically activating these neurons shows little effect on theta rhythm in the hippocampus. Instead, we found that activating MS cholinergic neurons during slow-wave sleep could suppress hippocampal ripple oscillations. This suppression is mediated by muscarinic M₂ and M₄ receptors.

Issues with Microsoft's Windows 10 April 2018 Update are a warning of what's to come.

There is evidence that Kingella kingae, the major bacterial cause of osteoarticular infection in children <4 years of age, first colonizes the oropharynx before penetrating the bloodstream and invading distant organs. Diagnosis remains challenging because clinical findings at admission may be normal.

Our study demonstrated for the first time that a simple technique of detecting of K kingae DNA in the oropharynx can provide strong evidence that this microorganism is responsible for the OAI, or even stronger evidence that it is not. (Read the full article)

Bacteria accumulate small, organic compounds called compatible solutes via uptake from the environment or biosynthesis from available precursors to maintain the turgor pressure of the cell in response to osmotic stress. The halophile Vibrio parahaemolyticus has biosynthesis pathways for the compatible solutes ectoine (encoded by ectABC-asp_ect) and glycine betaine (encoded by betIBA-proXWV), four betaine-carnitine-choline transporters (encoded by bccT1 to bccT4), and a second ProU transporter (encoded by proVWX). All of these systems are osmotically inducible with the exception of bccT2. Previously, it was shown that CosR, a MarR-type regulator, was a direct repressor of ectABC-asp_ect in Vibrio species. In this study, we investigated whether CosR has a broader role in the osmotic stress response. Expression analyses demonstrated that betIBA-proXWV, bccT1, bccT3, bccT4, and proVWX are repressed in low salinity. Examination of an in-frame cosR deletion mutant showed that expression of these systems is derepressed in the mutant at low salinity compared with the wild type. DNA binding assays demonstrated that purified CosR binds directly to the regulatory region of both biosynthesis systems and four transporters. In Escherichia coli green fluorescent protein (GFP) reporter assays, we demonstrated that CosR directly represses transcription of betIBA-proXWV, bccT3, and proVWX. Similar to Vibrio harveyi, we showed betIBA-proXWV was directly activated by the quorum-sensing LuxR homolog OpaR, suggesting a conserved mechanism of regulation among Vibrio species. Phylogenetic analysis demonstrated that CosR is ancestral to the Vibrionaceae family, and bioinformatics analysis showed widespread distribution among Gammaproteobacteria in general. Incidentally, in Aliivibrio fischeri, Aliivibrio finisterrensis, Aliivibrio sifiae, and Aliivibrio wodanis, an unrelated MarR-type regulator gene named ectR was clustered with ectABC-asp, which suggests the presence of another novel ectoine biosynthesis regulator. Overall, these data show that CosR is a global regulator of osmotic stress response that is widespread among bacteria.

IMPORTANCE Vibrio parahaemolyticus can accumulate compatible solutes via biosynthesis and transport, which allow the cell to survive in high salinity conditions. There is little need for compatible solutes under low salinity conditions, and biosynthesis and transporter systems need to be repressed. However, the mechanism(s) of this repression is not known. In this study, we showed that CosR played a major role in the regulation of multiple compatible solute systems. Phylogenetic analysis showed that CosR is present in all members of the Vibrionaceae family as well as numerous Gammaproteobacteria. Collectively, these data establish CosR as a global regulator of the osmotic stress response that is widespread in bacteria, controlling many more systems than previously demonstrated.

Following a strikingly white and male list of Bafta nominees, this year’s Academy Awards shortlists are barely more diverse. It’s a chronic problem in an industry running out of excuses for its slow pace of change. Lanre Bakare examines why the Oscars are still so white. Plus: Joan E Greve on a hectic week of US politics

When the lists of nominees for the major film awards in 2020 were announced, there was, once again, a glaring anomaly. Not a single person of colour was nominated in the Bafta acting categories, while the Oscars managed only Cynthia Erivo for her part in Harriet.

It is an issue that the industry is well aware of: in 2015, the ceremony saw #OscarsSoWhite trending on Twitter, while actors such as Eddie Murphy were rebuking the academy from the stage back in the 1990s. So what explains the glacial pace of change? Guardian arts and culture correspondent Lanre Bakare tells Anushka Asthana that there have been plenty of false dawns over the years in the quest for greater diversity.

Coronavirus illnesses to date may touch as little as 4 percent of meat and poultry employment, but it been enough to roil the industry over how much protection the plants need to be safe. Actions taken in tight proximity to one another by U.S. Secretary of Agriculture Sonny Perdue and U.S. District Court Judge Greg... Continue Reading

The team behind The Artist will have spent the first day of the rest of their lives conforming to the grandest, and most lucrative, of Hollywood traditions.

The comic has presented the Golden Globes five times

Six imaginative tales contend for the £5,000 prize

Let's hope that unlike the Oscars, they make the right choices and open the right envelopes.

Resistant hypertension patients who suffer from obstructive sleep apnea (OSA) are at a higher risk of having high blood pressure (HBP), reports a new study.

New mobile app can help relieve osteoarthritis pain by notifying you to complete a few simple physical exercises every day, and also provide reliable

U.S. tech giants Microsoft and Google have partnered wherein Office for Android will be supported on Chrome OS-based devices via the Google Play Store.

While walking the red carpet of her new film Maleficent: Mistress of Evil, Angelina Jolie revealed why she wore her iconic Versace dress to the Oscars in 2012.

The 49-year-old Bourne Legacy actor was seen tugging the 30-year-old Mexican beauty by the arm as they enjoyed an intimate conversation outside the Vanity fair party.

Whisper this softly, but we might just be falling out of love with film awards. The television ratings for last weekend's Bafta awards were the lowest for 12 years.

Disney's Star Wars: The Rise of Skywalker is already a hit at the box office, currently the third highest-grossing movie of the year, and now it has added a trio of Oscar nominations.

The latest leader of the anti-EU party responded by pointing out that at least he'd stuck to his birth name, unlike the former chancellor, who swapped from Gideon to George as a teenager.