Post-transcriptional modifications of pre-mRNAs expand the diversity of proteomes in higher eukaryotes. In the brain, these modifications diversify the functional output of many critical neuronal signal molecules. In this study, we identified a brain-specific A-to-I RNA editing that changed glutamine to arginine (Q/R) at exon 20 and an alternative splicing of exon 4 in Tmem63b, which encodes a ubiquitously expressed osmosensitive cation channel. The channel isoforms lacking exon 4 occurred in ∼80% of Tmem63b mRNAs in the brain but were not detected in other tissues, suggesting a brain-specific splicing. We found that the Q/R editing was catalyzed by Adar2 (Adarb1) and required an editing site complementary sequence located in the proximal 5' end of intron 20. Moreover, the Q/R editing was almost exclusively identified in the splicing isoform lacking exon 4, indicating a coupling between the editing and the splicing. Elimination of the Q/R editing in brain-specific Adar2 knockout mice did not affect the splicing efficiency of exon 4. Furthermore, transfection with the splicing isoform containing exon 4 suppressed the Q/R editing in primary cultured cerebellar granule neurons. Thus, our study revealed a coupling between an RNA editing and a distant alternative splicing in the Tmem63b pre-mRNA, in which the splicing plays a dominant role. Finally, physiological analysis showed that the splicing and the editing coordinately regulate Ca2+ permeability and osmosensitivity of channel proteins, which may contribute to their functions in the brain.

A true-life saga involving organized crime, racial prejudice, and evolving American identity, David Grann’s 2017 nonfiction book Killers of the Flower Moon: The Osage Murders and the Birth of the F.B.I. seemed at first glance like a perfect fit for Martin Scorsese, the beloved filmmaker whose dozens of critically adored movies include Taxi Driver, GoodFellas, and The Departed. But when Jim Gray, a former chief of the Osage Nation, and other Osage leaders invited the filmmaker to Oklahoma to hear their concerns about his new project, Scorsese came. Scorsese listened. And then he rewrote and reconfigured Killers of the Flower Moon from soup to nuts, with a result that has earned a rapturous response from Native viewers like Gray and journalist Sandra Hale Schulman, and from the broader critical community, too. The movie opens in theatres tomorrow and will appear on the Apple+ streaming service before the end of the year. In this episode, Schulman walks me through a brief history of how Native Americans have been depicted in a century’s worth of movies. Then, Chief Gray tells me about his personal connection to Killers of the Flower Moon, the pattern of Native American erasure from national discourse, and how he and his colleagues persuaded Scorsese to rethink the new movie. A transcript of this episode can be found here (https://www.smithsonianmag.com/smithsonianmag/how-the-osage-changed-martin-scorseses-mind-180983094smithsonianmag.com/smithsonianmag/how-the-osage-changed-martin-scorseses-mind-180983094) . Sandra’s Smithsonian story about Native representation in cinema is here (https://www.smithsonianmag.com/history/a-brief-history-of-native-representation-in-film-180983043/) . You can learn more about Sandra and her work at her site (http://www.sandraschulman.com/) . Dennis McAuliffe Jr.’s The Deaths of Sybil Bolton: An American History, which Chief Gray cites as formative in this episode, is here (https://www.amazon.com/Deaths-Sybil-Bolton-American-History/dp/081292150X) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

It takes two weeks to dress the venue (which is in a mall, remember) for the occasion each year

Although classified as a compact tropical cyclone and considered one of the smallest in the North Atlantic, Hurricane Oscar has caused considerable damage in eastern Cuba since it made landfall on October 20, 2024. Cuban authorities have confirmed that the death toll has risen to seven, in additional to the damage in infrastructure. Communications and […]

Movies can’t, by definition, be all things to all people, and yet Anora—winner of the Cannes Film Festival’s highest honor, the Palme d’Or—manages to vacillate between assorted registers with stunning, and ultimately affecting, aplomb.

Another of The Florida Project and Red Rocket writer/director Sean Baker’s tales of marginalized individuals struggling to survive and find themselves in an often-unforgiving world, the film is a character study, romance, crime saga, screwball comedy, and vérité drama all wrapped into one unique and dexterous package. More impressive than its nimbleness, however, is its poise and empathy, the latter of which is chiefly bestowed upon its protagonist, whose life is thrown for a rollercoaster-grade loop-di-loop thanks to a chance introduction.

Ani (Mikey Madison, in a star-making turn) is a Brighton Beach 23-year-old who lives with her sister and earns a living stripping at a local club. Anora, which hits theaters Oct. 18, introduces her at the end of a long pan along a bench where men are receiving lap dances from erotic professionals. Fixating on Ani’s face as she flashes the fake smile that her customers crave and her superiors demand, Baker’s camera creates immediate, intimate engagement with the young woman, and that continues as it presents snapshots of her daily (or, rather, nightly) routine at her place of employment.

Read more at The Daily Beast.

People with medlinkknee osteoarthritis/medlink (OA) often avoid doing exercise, reports a new study. bKnee osteoarthritis patients refrain from

Take a look at the pictures.

Stars get ready for Oscars!

Hollywood's biggest stars attended the 94th Annual Academy Awards.

India is shining, although I will argue that it is a temporary acceptance until India once again makes a mega-successful film like RRR or another beautiful, moving, documentary like The Elephant Whisperers, notes Aseem Chhabra.

Singer Billie Eilish moved everyone to tears when she performed the Barbie soundtrack, What Was I Made For?, at the Oscars 2024.

In the biggest surprise of the night, Emma Stone grabbed the Best Actress trophy for the complex portrayal of a Frankenstein-like character Bella, in Yargos Lanthimos' electrifying and most original film Poor Things. Aseem Chhabra recaps the 96th Annual Academy Awards.

Which of the 28 films in contention gets your vote?

Paul Giamatti deserves a Best Actor Oscar for his performance in The Holdovers

[New York] : Criterion Collection, [2014]

'I believe FFI has made a mistake,' notes Aseem Chhabra.

To an award show that's famous for honouring artists belatedly, we have sent as our official entry one of our major film-makers's weakest work yet, feels Sreehari Nair.

How wonderful it would be for all of us to watch the Oscar ceremony on March 2, 2025 and watch AWIAL win an Oscar, notes Aseem Chhabra.

Organ sheet music by A. M. Goodhart | Zwei töne – Tenore Ostinato

'My greatest joy is to make my country proud.'

The Academy of Motion Picture Arts and Sciences recently announced its membership invitations, and Indian film celebrities Ram Charan, Jr NTR, Mani Ratnam, Karan Johar, Siddharth Roy Kapur, Chandrabose and MM Keeravaani have been invited to be members.

'Ours is a disaster movie with no big stars, songs or commercial ingredients.''Yet, it is Malayalam cinema's highest grosser.'

Sunflowers Were the First Ones to Know, an award-winning Kannada short film by Film and Television Institute of India students, has qualified for the 2025 Oscars in the live action short film category.

Google's Chromebook Pixel is quite versatile after all. I can run Chrome OS and Linux at the same time, and switch between the two, allowing me to use Skype and other third party apps!

The former chancellor has told friends he is well placed to replace Christine Lagarde, who was picked as head of the European Central Bank this week.

The former chancellor was spotted walking through the grounds before taking up his position in Centre Court's Royal Box, where he was seen chatting with former Bank of England governor Mervyn King.

Former Chancellor and London Evening Standard editor George Osborne, 48, and his author wife Frances, 50, are getting divorced after 21 years of marriage, they announced in a statement today.

The abrupt departure of Sir Kim Darroch following his extraordinary spat with Donald Trump has left a vacancy in the Foreign Office's most prominent overseas post.

The post was vacated last month when France's Christine Lagarde stepped down following her appointment as the next head of the European Central Bank.

The number of non-doms, people who are not legally domiciled in the UK but enjoy tax advantages, fell from 98,500 to 78,300 last year, a record low. The tax they contributed also dropped by £2billion.

Receipts from residential purchases fell 10 per cent in 2018/19 to £8.4billion compared with the previous year. This is the biggest fall since house prices collapsed during credit crunch in 2008.

Judge Louis Walsh was filming scenes with his act, Love Actually star Olivia Olson, on a London street when George, who proclaimed himself a huge fan of the IITV show, turned up.  

The former Chancellor was pictured with colleague Laura Weir, editor-in-chief of the Evening Standard's weekly magazine at a charity dinner for Rod Stewart at the Rosewood Hotel.

George Osborne has urged Boris Johnson not to scrap HS2 after the Prime Minister launched a major review of all government projects with plans to axe those which are deemed a waste of money.

The former Remain Tory chancellor, who was accused of being the architect of 'Project Fear' during the referendum, acknowledged the City could thrive when free from Brussels.

Conservative heavyweights were out in force today for Lord Bell's memorial service at St Paul's in Knightsbridge.

The 3 per cent stamp duty surcharge on additional properties was introduced by the former Chancellor in 2016 and it was hoped it would raise £2.9billion in tax by the end of the 2019/2020 tax year.

The former politician, who oversaw austerity in the years following the 2008 financial crisis, raised the spectre of banks refusing to lend money if businesses start going to the wall.

The backdrop of the stage with the Oscar Award is seen onstage during the 84th Academy Awards announcement held at the Academy of Motion Picture Arts and Sciences Samuel Goldwyn Theater on Jan. 24, 2012 in Los Angeles.; Credit: Kevin Winter/Getty Images

The Academy Awards have made history with breakthroughs for minorities in the past — but with this year's nominations, observers are noting how white the Oscars are, with no actors of color nominated in any of this year's acting categories.

It marks the least diverse nominations since 1998. People have been speaking out about this disconnect, with films like "Selma" being shut out of the acting nominations (though it did pick up a Best Picture nomination).

This content is from Southern California Public Radio. View the original story at SCPR.org.

Announcement cards and envelopes by designer Marc Friedland which are used by presenters at the Oscars to announce winners are on display at the food and decor preview Feb. 4, 2015 of this years Governors Ball, the post-Oscar celebration which follows the 87th Oscars ceremony on Feb. 22 in Hollywood.; Credit: Robyn Beck/AFP/Getty Images

Ready for your 2015 Oscars party? We've got printable Oscars ballots and the bingo cards you need to prove your superiority over your movie-loving friends during your Academy Awards viewing party. Here are the party printables you'll need to play along with Sunday's show, with TV coverage kicking off at 4 p.m. Pacific. (Get caught up on KPCC's 2015 Oscars coverage right here to have more fun and help make your picks!)

Printable official Oscars ballot

• Download, print, and play at home. Listen to "The Frame's" preview of the Academy Awards, see what "FilmWeek's" critics have to say about who will win, then make your own decisions on Sunday. Our crystal ball Oscars predictor/awards tracker can also help the prognostication efforts with a rundown of nominee buzz, awards already won, official trailers, photos and more.
• You can also play along with friends online on the official Academy Awards site or with the New York Times. (If you want to see KPCC's Mike Roe's picks and play against him in either online game, go here for the official site and here for the New York Times.)

2015 Oscars ballot

Printable Oscars bingo cards

• Download, print and play at home. Use our custom generator to create as many cards as you need for your party.
• How to play: Mark off each block when you hear these words or see these things happen during the Oscars telecast on Sunday. When you get five blocks in a row (horizontally, vertically, or diagonally) stand up and shout "OSCAR!!" Alternate rules: Play as a drinking game and for every block, take a sip. Finished a row? Finish your scotch.

Interactive Oscars bingo cards 

• WNYC pays tribute to the annual exercise in entertainment award show parody with a portable, computerized bingo. Play on your phone, iPad, computer or print a card. Refresh for new combinations.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Naomie Harris' 100% biodegradable Oscars gown, which took 120 hours to make, will be on display at the Hampton Court Palace in London.

From the Governor’s Ball to gift suites, Academy Awards events keep charity in mind.

XHits combines ActivHearts™ to create the best Team-Wear earphones with heart rate sensing hearable technology. Team-Wear's features include Team Captain Liaison, Team Mates Interaction, SOS, superb acoustics and IPX5 waterproof.

A surface acoustic wave (SAW) resonator and a SAW oscillator and an electronic apparatus including the resonator are to be provided. A SAW resonator includes: an IDT exciting a SAW using a quartz crystal substrate of Euler angles (−1.5°≦φ≦1.5°, 117°≦θ≦142°, 42.79°≦|ψ|≦49.57°); one pair of reflection units arranged so as allow the IDT to be disposed therebetween; and grooves acquired by depressing the quartz crystal substrate located between electrode fingers. When a wavelength of the SAW is λ, and a depth of the grooves is G, “0.01λ≦G” is satisfied.

A reverse osmosis (RO) water filtration device includes a body, a RO cartridge, a first cartridge, a second cartridge and a storage tank all mounted inside the body. Water to be filtered sequentially goes through a water inlet of the RO water filtration device, the first cartridge, the RO cartridge, the storage tank, the second cartridge, and a faucet to get the water filtered. The storage tank provides additional water supply when the pressure between the faucet and RO cartridge is below the water pressure inside the storage tank to increase water volume upon opening a faucet.