A camera trap at an Australian nature refuge has captured a boisterous interaction between a northern hairy-nosed wombat and an echidna

Evolutionary molecular biologist Beth Shapiro on the hunt for ancient DNA and her groundbreaking de-extinction and environmental mission  

The books, TV, games and more that New Scientist staff have enjoyed this week

Genetic analysis of five individuals preserved as plaster casts in the ruins of Pompeii contradicts established beliefs about the people and their relationships

A genetic study of nearly 2700 individuals has revealed the ancestry of Indian people, and gets scientists closer to reconstructing the genomes of ancient Neanderthals

Highland and lowland populations in Papua New Guinea have different gene variants derived from Denisovan archaic humans, indicating possible adaptations for lower oxygen levels and higher malaria risk

A young boy who lived towards the end of the last glacial period had dark skin, blue eyes and a congenital heart condition, a study of his genome reveals

The Sverris saga describes how castle invaders “took a dead man and cast him unto the well, and then filled it up with stones”, in what may have been an early act of biological warfare - and now researchers believe they have found the skeleton of the man in question

Genetic analysis of five individuals preserved as plaster casts in the ruins of Pompeii contradicts established beliefs about the people and their relationships

Title: Coffee Cravings May Spring From Your DNA
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM

Title: Unrelated Folks Who Look Alike Share Similar DNA
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Title: Major Gene Study Spots DNA Tied to Autism, Other Disorders
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Somatic mutations arise and accumulate during tissue culture and vegetative propagation, potentially affecting various traits in horticultural crops, but their characteristics are still unclear. Here, somatic mutations in regenerated woodland strawberry derived from tissue culture of shoot tips under different conditions and 12 cultivated strawberry individuals are analyzed by whole genome sequencing. The mutation frequency of single nucleotide variants is significantly increased with increased hormone levels or prolonged culture time in the range of 3.3 x 10^–8–3.0 x 10^–6 mutations per site. CG methylation shows a stable reduction (0.71%–8.03%) in regenerated plants, and hypoCG-DMRs are more heritable after sexual reproduction. A high-quality haplotype-resolved genome is assembled for the strawberry cultivar "Beni hoppe." The 12 "Beni hoppe" individuals randomly selected from different locations show 4731–6005 mutations relative to the reference genome, and the mutation frequency varies among the subgenomes. Our study has systematically characterized the genetic and epigenetic variants in regenerated woodland strawberry plants and different individuals of the same strawberry cultivar, providing an accurate assessment of somatic mutations at the genomic scale and nucleotide resolution in plants.

Many RNA-binding proteins (RBPs) contain low-complexity domains (LCDs) with prion-like compositions. These long intrinsically disordered regions regulate their solubility, contributing to their physiological roles in RNA processing and organization. However, this also makes these RBPs prone to pathological misfolding and aggregation that are characteristic of neurodegenerative diseases. For example, TAR DNA-binding protein 43 (TDP-43) forms pathological aggregates associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that highly disordered, hydrophilic, and charged heat-resistant obscure (Hero) proteins may have similar effects. Specifically, Hero proteins can maintain the activity of other proteins from denaturing conditions in vitro, while their overexpression can suppress cellular aggregation and toxicity associated with aggregation-prone proteins. However, it is unclear how these protective effects are achieved. Here, we used single-molecule FRET to monitor the conformations of the aggregation-prone prion-like LCD of TDP-43. While we observed high conformational heterogeneity in wild-type LCD, the ALS-associated mutation A315T promoted collapsed conformations. In contrast, an Hsp40 chaperone, DNAJA2, and a Hero protein, Hero11, stabilized extended states of the LCD, consistent with their ability to suppress the aggregation of TDP-43. Our results link single-molecule effects on conformation to macro effects on bulk aggregation, where a Hero protein, like a chaperone, can maintain the conformational integrity of a client protein to prevent its aggregation.

Let’s try and get you up to speed on the fascinating oddity that is simulation game Ecosystem, on the off chance that Nate's coverage of it hasn't stuck with you like an unwelcome brain parasite you’re nonetheless unwilling to get removed for fear of the lingering emptiness it might cause (he once described an eel as “a quaver with erectile dysfunction”). Broadly speaking, this game is Spore’s evolutionary-biology-degree-having cousin. It’s been in early access for about three years now, but with the latest "Crustacean" update, it’s just hit 1.0. Once again, carcinization has come for all things.

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Computers made from DNA have previously only been able to store information or perform computations on it – now a new device can do both

Researchers have managed to encode enormous amounts of information, including images, into DNA at a rate hundreds of times faster than was previously possible

DNA methylation is one of several epigenetic mechanisms crucial for regulating gene expression in eukaryotic organisms.

The post Scientists Investigate Inner Workings of DNA Methylation in Plants appeared first on Sci.News: Breaking Science News.

Wastewater is a major reservoir for antibiotic resistance genes, but modified bacteria can chop up this DNA before the dangerous microbes reach people

Integrating genetic data with historic and archaeological data can enrich or correct popular narratives.

Researchers have managed to encode enormous amounts of information, including images, into DNA at a rate hundreds of times faster than was previously possible

The Sverris saga describes how castle invaders “took a dead man and cast him unto the well, and then filled it up with stones”, in what may have been an early act of biological warfare - and now researchers believe they have found the skeleton of the man in question

Genetic analysis of five individuals preserved as plaster casts in the ruins of Pompeii contradicts established beliefs about the people and their relationships

Once millions used it to find out about their family histories - this week it was almost delisted. What went wrong?

Customers of Atlas Biomed are angry and worried about what's happened to the highly sensitive data they shared.

The once-popular general DNA-testing firm holds a trove of sensitive genetic data from its customers.

Cannabis containing 10% or more of the psychoactive compound THC (Delta-9-tetrahydrocannabinol), can alter the DNA (!--ref1--). A recent study published

Beta-thalassemia, also known as (and) #946;-thalassemia is a genetic disorder marked by reduced or absent beta chain synthesis of medlinkhemoglobin/medlink,

A common ingredient in plastic may cause breaks in DNA strands, leading to egg cells with an abnormal number of chromosomes in roundworms, reveals a new

Uttar Pradesh Chief Minister Yogi Adityanath is set to visit poll-bound Maharashtra on Tuesday where he will address three public meetings and campaign for Maharashtra Deputy Chief Minister Devendra Fadnavis, including several other Bharatiya Janata Party (BJP) candidates.

1. Delhi reports record high chikungunya, malaria cases in 5 years  DNA India
2. Delhi Reports 5-Year Record High In Chikungunya, Malaria Cases  NDTV
3. Delhi sees 472 more dengue cases, total count at 4,533  Hindustan Times
4. 4,533 cases, 3 deaths due to Dengue reported in Delhi in 2024  ETHealthWorld
5. Delhi witnesses surge in Dengue cases: 472 cases in last week, 3 deaths this year so far  India TV News

Adnaan Shaikh On Wife Ayesha Converted To Islam: बिग बॉस ओटीटी 3 में नजर आ चुके एक्टर और मशहूर यूट्यूबर अदनान शेख अपनी शादी को लेकर काफी ज्यादा सुर्खियों में आए थे। इसके बाद में उनकी बहन इफत ने

Devendra Fadnavis criticises Uddhav Thackeray's complaints about bag checks by election officials, calling it a distraction from real issues ahead of Maharashtra polls.

Many revelations are being made in the investigation of this bomb blast. The connection of the blasts is also being linked to Khalistan.

There is a discussion about introducing BRICS currency so that trade between BRICS countries becomes easy.

The PAC has MPs from both the ruling party and the opposition. Congress leader KC Venugopal is the current chairman of the PAC.

Samajwadi Party has announced its candidates for all nine seats for the November 13 Uttar Pradesh Assembly bypolls.

By portraying himself as a religious person, is he attempting to distract attention from his criminal background?

Baba Bageshwar's message asks for a similar expression in the digital world by adding "Hindu" to social media names.

It is claimed that MP Pappu Yadav has been threatened by not one but two gangsters and both have claimed to be associated with Lawrence Bishnoi.

Congress hit out at the NDA government at the Centre, claiming that it was 'protecting' the Sebi chief.

By the end of September, the RBI had a total of 855 tonnes of gold, of which 510.5 tonnes were kept safe within India.

Many well-known figures have taken to their platforms to condemn fireworks, emphasizing the harmful effects on air quality and the anxiety caused to pets and wildlife.

The protests included men, women, and children, many of whom dressed like Mahant Chinmay Krishna Das to show their support.

SP chief Akhilesh Yadav alleged the postponement was an old trick of the BJP to avoid losing elections.

The campaigns of both Harris and former President Donald Trump are fighting for every vote.

This is the first time in the history of the US since 1892 that someone has won the election again after a gap of four years.

Donald Trump won this time both in terms of popular votes and electoral college votes.

For the first time, the UPPSC has scheduled UP PCS and RO/ARO examinations in two days.