Andreas Anastasiou, Robert E. Gaunt.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 136--149.

Abstract:
We use the delta method and Stein’s method to derive, under regularity conditions, explicit upper bounds for the distributional distance between the distribution of the maximum likelihood estimator (MLE) of a $d$-dimensional parameter and its asymptotic multivariate normal distribution. Our bounds apply in situations in which the MLE can be written as a function of a sum of i.i.d. $t$-dimensional random vectors. We apply our general bound to establish a bound for the multivariate normal approximation of the MLE of the normal distribution with unknown mean and variance.

Delta said it is making the move to protect employees amid the coronavirus pandemic, but planes have been flying near empty

Peter M. Zygmunt
Jun 1, 2002; 22:4720-4727
Behavioral

Calcineurin inhibitors, such as tacrolimus (FK506) and cyclosporine, are widely used as standard immunosuppressants in organ transplantation recipients. However, these drugs can cause severe pain in patients, commonly referred to as calcineurin inhibitor-induced pain syndrome (CIPS). Although calcineurin inhibition increases NMDAR activity in the spinal cord, the underlying mechanism remains enigmatic. Using an animal model of CIPS, we found that systemic administration of FK506 in male and female mice significantly increased the amount of α2-1–GluN1 complexes in the spinal cord and the level of α2-1–bound GluN1 proteins in spinal synaptosomes. Treatment with FK506 significantly increased the frequency of mEPSCs and the amplitudes of monosynaptic EPSCs evoked from the dorsal root and puff NMDAR currents in spinal dorsal horn neurons. Inhibiting α2-1 with gabapentin or disrupting the α2-1–NMDAR interaction with α2-1Tat peptide completely reversed the effects of FK506. In α2-1 gene KO mice, treatment with FK506 failed to increase the frequency of NMDAR-mediated mEPSCs and the amplitudes of evoked EPSCs and puff NMDAR currents in spinal dorsal horn neurons. Furthermore, systemic administration of gabapentin or intrathecal injection of α2-1Tat peptide reversed thermal and mechanical hypersensitivity in FK506-treated mice. In addition, genetically deleting GluN1 in dorsal root ganglion neurons or α2-1 genetic KO similarly attenuated FK506-induced thermal and mechanical hypersensitivity. Together, our findings indicate that α2-1–bound NMDARs mediate calcineurin inhibitor-induced tonic activation of presynaptic and postsynaptic NMDARs at the spinal cord level and that presynaptic NMDARs play a prominent role in the development of CIPS.

SIGNIFICANCE STATEMENT Calcineurin inhibitors are immunosuppressants used to prevent rejection of transplanted organs and tissues. However, these drugs can cause severe, unexplained pain. We showed that calcineurin inhibition enhances physical interaction between α2-1 and NMDARs and their synaptic trafficking in the spinal cord. α2-1 is essential for calcineurin inhibitor-induced aberrant activation of presynaptic and postsynaptic NMDARs in the spinal cord. Furthermore, inhibiting α2-1 or disrupting α2-1–NMDAR interaction reduces calcineurin inhibitor-induced pain hypersensitivity. Eliminating NMDARs in primary sensory neurons or α2-1 KO also attenuates calcineurin inhibitor-induced pain hypersensitivity. This new information extends our mechanistic understanding of the role of endogenous calcineurin in regulating synaptic plasticity and nociceptive transmission and suggests new strategies for treating this painful condition.

Delta Industrial Automation DCISoft version 1.12.09 suffers from a stack buffer overflow vulnerability.

…directs Area Commander, DPO to disarm disbanded vigilante members By Festus Ahon ASABA – DELTA State Commissioner of Police, Mr Hafiz Inuwa has waded into the communal crisis rocking Evwreni Kingdom in Ughelli North Local Government Area of the State over the disbandment of the local vigilante team of the kingdom. Speaking at a stakeholder’s
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Nigeria (Blank NEWS Online) –:  In addition to the actions taken so far by the Delta State Government to address the menace of flood in Asaba, the state capital, further […]

Some of the first dinosaurs may have lived and hunted on the largest delta plain ever discovered, which was 10 times the size of the Amazon river delta

ABSTRACT

Satellite viruses, most commonly found in plants, rely on helper viruses to complete their replication cycle. The only known example of a human satellite virus is the hepatitis D virus (HDV), and it is generally thought to require hepatitis B virus (HBV) to form infectious particles. Until 2018, HDV was the sole representative of the genus Deltavirus and was thought to have evolved in humans, the only known HDV host. The subsequent identification of HDV-like agents in birds, snakes, fish, amphibians, and invertebrates indicated that the evolutionary history of deltaviruses is likely much longer than previously hypothesized. Interestingly, none of the HDV-like agents were found in coinfection with an HBV-like agent, suggesting that these viruses use different helper virus(es). Here we show, using snake deltavirus (SDeV), that HBV and hepadnaviruses represent only one example of helper viruses for deltaviruses. We cloned the SDeV genome into a mammalian expression plasmid, and by transfection could initiate SDeV replication in cultured snake and mammalian cell lines. By superinfecting persistently SDeV-infected cells with reptarenaviruses and hartmaniviruses, or by transfecting their surface proteins, we could induce production of infectious SDeV particles. Our findings indicate that deltaviruses can likely use a multitude of helper viruses or even viral glycoproteins to form infectious particles. This suggests that persistent infections, such as those caused by arenaviruses and orthohantaviruses used in this study, and recurrent infections would be beneficial for the spread of deltaviruses. It seems plausible that further human or animal disease associations with deltavirus infections will be identified in the future.

IMPORTANCE Deltaviruses need a coinfecting enveloped virus to produce infectious particles necessary for transmission to a new host. Hepatitis D virus (HDV), the only known deltavirus until 2018, has been found only in humans, and its coinfection with hepatitis B virus (HBV) is linked with fulminant hepatitis. The recent discovery of deltaviruses without a coinfecting HBV-like agent in several different taxa suggested that deltaviruses could employ coinfection by other enveloped viruses to complete their life cycle. In this report, we show that snake deltavirus (SDeV) efficiently utilizes coinfecting reptarena- and hartmaniviruses to form infectious particles. Furthermore, we demonstrate that cells expressing the envelope proteins of arenaviruses and orthohantaviruses produce infectious SDeV particles. As the envelope proteins are responsible for binding and infecting new host cells, our findings indicate that deltaviruses are likely not restricted in their tissue tropism, implying that they could be linked to animal or human diseases other than hepatitis.

Key Points

High magnetic fields have revealed a surprisingly small Fermi surface in underdoped cuprates, possibly resulting from Fermi-surface reconstruction due to an order parameter that breaks translational symmetry of the crystal lattice. A crucial issue concerns the doping extent of such a state and its relationship to the principal pseudogap and...

Background

Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C- (PKC) in renal tubular injury during cisplatin nephrotoxicity and albumin-associated kidney injury, but whether PKC is involved in ischemic or transplantation-associated kidney injury is unknown.

The constantly increasing number of new real estate projects which have been implemented in the Mekong Delta region has led to the rising land price and strong fluctuation in the local property market.

Delta ID provides the most convenient authentication solution to secure your digital ID.

The Department of Justice issued a statement today after the Department of Transportation (DOT) issued its order involving US Airways’ and Delta Airlines’ acquisition of slots at Washington’s Ronald Reagan National Airport and New York’s LaGuardia Airport.

After a thorough investigation of the competitive effects of the proposed equity investment and joint venture, the Antitrust Division concluded that the facts and circumstances did not warrant further investigation or action.

Since that moment – thanks to the work of groups like this one, and the dedication of passionate advocates like all of you – our nation has experienced remarkable, once-unimaginable progress.

Samuel James captures must-see photos of bootleg oil refining taking place in Nigeria's Niger Delta.

In a compelling new documentary, The Flood, Angela Bassett narrates the story of the life in one of the world's last great wildernesses.

The clothing production process is full of toxic chemicals that can harm human health.

In a new map from St Louis University in Missouri, countries along the Mississippi Delta were found to pose the highest risk for Zika transmission as well as some on the Atlantic coast.

Mohammed Ali Sajet, one of Abu Bakr al-Baghdadi's closest confidants, provided key information that led U.S. forces to the ISIS leader's compound in Syria.

She appeared to confirm a romance with rocker Matthew Copley last month. And Delta Goodrem playfully serenaded her 'boyfriend' in Sydney with sexy dance moves on stage this week.

She's found love in the arms of guitarist Matthew Copeland.

Delta Goodrem has reportedly been paid an eye-watering $250,000 to sing at the 85th birthday of billionaire Harry Triguboff over the weekend.

Taking to Twitter to vent, one frustrated fan wrote: 'Either press the button or sit the F (sic) down.'

'Delta's convinced someone on The Voice is trying to make her look bad,' the source told the publication.

According to another report in the magazine, the duo 'have discussed plans for kids, with Seal meeting Delta's mother Lea to get her tick of approval'.

Delta Goodrem's struggling love life is about to receive a Royal intervention courtesy of the Duchess of Sussex, it has been reported.

The Voice finale took place on Sunday evening, with looping sensation Sam Perry taking home the winning title. 

The 33-year-old songstress looked a little weary as she stepped out in chilly Sydney on Monday.

Last week, Channel Nine revealed she'll return for another round of judging duties on The Voice Australia next year.

It's been a busy year for Delta Goodrem with The Voice Australia and preparing for the upcoming release of her third fragrance.

Delta Goodrem has shared a touching tribute to The Voice star Natasha Stuart, after she tragically lost her battle with breast cancer aged 43.

Last month she was announced as the new host of The Voice Australia.

It was back to work for the cast and crew of The Voice - and it also happened to be the first day on set for new host Renee Bargh.

James Lafferty, 47, was arrested outside the singer's Sydney CBD unit on Saturday and charged with stalking after pleading for Delta Goodrem to come outside for two days.

James Joseph Lafferty had already sent Ms Goodrem more than 300 poems when he showed up at The Voice star's apartment building in Sydney with gifts on Valentine's Day.

James Joseph Lafferty, 47, appeared at Sydney's Downing Centre court on Tuesday with his mother where he pleaded guilty to stalking Australian pop singer Delta Goodrem.

James Joseph Lafferty, 47, was arrested in Grafton, NSW at 11pm on Friday night accused of breaching a court-order taken out by the singer to prevent him contacting her.

Delta Goodren stole the show on Saturday night when she performed in the Music From The Home Front online concert. 

Delta Goodrem earned herself an army of new fans on Sunday morning. 

Delta Goodrem invited the world inside her $4.8million Sydney home on Sunday.

Delta Air Lines said that reservations through March 2 on flights to Bologna, Milan and Venice in northern Italy, where cases have climbed, are eligible for rescheduling.

Her Voice co-stars Kelly Rowland, Boy George and Guy Sebastian caught a $50 million private jet back to Sydney on Sunday night following the Logie Awards on the Gold Coast. 

Santini heads the nine entries for the Paddy Power Cotswold Chase at Cheltenham on Saturday but fellow entry Delta Work looks unlikely to line up.