On this episode of the HomeKit Insider Podcast we talk about Apple's new betas, discuss the major Matter 1.4 release which adds new categories and other improvements, and more!

The third round of developer betas for iOS 18.2, iPadOS 18.2, and macOS Sequoia 15.2 have arrived, alongside the second round builds of tvOS 18.2, and watchOS 11.2.

The third developer beta of iOS 18.2 is now available for all compatible iPhone models, as Apple Intelligence testing continues. Here's everything you need to know about the update.

One day after most of the other developer betas get new builds, visionOS 2.2 turns up for testers using the Apple Vision Pro.

iOS 18.2 Developer Beta 3 update for iPhone was released by Apple on Monday. It builds upon the previous updates as the Cupertino-based tech giant continues to test the second batch of features powered by Apple Intelligence — the company’s artificial intelligence (AI) suite for iPhone and other devices. Apple’s latest update is not a substantial introduction but still includes tweaks to the video player in the Photos app, updated dark mode icons for apps, and more.

Hi all,

I have been following the tutorial "Innovus Block Implementation with Stylus Common UI", version 23.1.

While I was doing the clock tree synthesis, the tutorial calls for a command

clock_opt_design

But my tool tells me this is a beta feature which needs to be enabled.

Warning: clock_opt_design requires beta feature innovusClockOptFlow enabled.

Can I ask how do I enable this beta feature?

My version of Innovus is v21.35-s114_1, is it because of the version incompatibility?

Many thanks

This November, the engineering and simulation community is set to converge in China for an event that promises to be nothing short of revolutionary. The 2024 BETA CAE Systems China Open Meeting, taking place in the vibrant cities of Beijing and Shanghai on November 5 and 7 , respectively, is a must-attend for anyone looking to stay at the forefront of technological innovation in simulation solutions. Prepare to be inspired by Ben Gu , the visionary Corporate VP of Research and Development at Cadence. He will lead both meetings in Beijing and Shanghai with his keynote on " A New Millennium in Multiphysics System Analysis ." This thought-provoking keynote is expected to provide attendees with a glimpse into the future of engineering simulation and analysis. What sets the BETA CAE Systems Open Meetings apart is not just the high caliber of speakers but also the hands-on training sessions designed to enhance your technical expertise with the BETA CAE software suite. Whether you are an inexperienced individual seeking to acquire fundamental knowledge or an accomplished professional endeavoring to hone your expertise, these training sessions following the open meetings are meticulously tailored to meet your needs. Join Us at the BETA CAE Systems Open Meeting in Beijing The BETA CAE Systems Open Meeting in Beijing will feature a keynote speech by Peng Qiao , Senior Engineer at Great Wall Motors Co., Ltd, on Multidisciplinary Optimization Techniques for Automotive Control Arms . ( View detailed agenda for Beijing. ) When: November 5, 2024 Where: Grand Metropark Hotel Beijing If this sounds interesting, register today for the BETA CAE Systems Beijing Open Meeting by clicking the button below. Don't Miss Out on the BETA CAE Systems Open Meeting in Shanghai After the BETA CAE Systems Open Meeting in Beijing, the next meeting in China will be in Shanghai. During this event, Liu Deping, CAE Engineer from Zhejiang Geely Automobile Research Institute Co., Ltd, will deliver a keynote speech on the Application of ANSA in the Simulation Development Cycle . ( View detailed agenda for Shanghai. ) When: November 7, 2024 Where: InterContinental Shanghai Jing'an Following the open meeting on November 7 will be an exclusive training day on November 8. This session will provide attendees with practical experience using the BETA CAE software to improve their technical skills and provide hands-on knowledge of the software. If you find this intriguing, register now for the BETA CAE Systems Shanghai Open Meeting by clicking the button below. Why Attend? Gain firsthand insights into the latest developments in simulation technology Learn from real-world applications and success stories from various industries Connect and exchange ideas with experts in a collaborative environment Mark your calendars for this unparalleled opportunity to explore the forefront of simulation technology. Whether you're aiming to broaden your knowledge, enhance your technical skills, or connect with industry leaders, the BETA CAE Systems Open Meetings are your gateway to the future of engineering. Join us and be part of shaping the next wave of innovation in the simulation world.

Apple's latest beta for iOS 18.2 features some important AI features you can test out now.

For 65 years China has been taking over Tibet, abusing Tibetans and destroying their culture, and no one's doing anything about it.

Thousands of bones found in a Tibetan cave have been analysed to learn how mysterious ancient humans known as Denisovans lived

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC₅₀ and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC₅₀ values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

The -aminobutyric acid type A (GABA_A) receptor is modulated by a number of neuroactive steroids. Sulfated steroids and 3β-hydroxy steroids inhibit, while 3α-hydroxy steroids typically potentiate the receptor. Here, we have investigated inhibition of the α1β32L GABA_A receptor by the endogenous neurosteroid 3α-hydroxy-5β-pregnan-20-one (3α5βP) and the synthetic neuroactive steroid 3α-hydroxy-5α-androstane-17β-carbonitrile (ACN). The receptors were expressed in Xenopus oocytes. All experiments were done using two-electrode voltage-clamp electrophysiology. In the presence of low concentrations of GABA, 3α5βP and ACN potentiate the GABA_A receptor. To reveal inhibition, we conducted the experiments on receptors activated by the combination of a saturating concentration of GABA and propofol to fully activate the receptors and mask potentiation, or on mutant receptors in which potentiation is ablated. Under these conditions, both steroids inhibited the receptor with IC₅₀s of ~13 μM and maximal inhibitory effects of 70–90%. Receptor inhibition by 3α5βP was sensitive to substitution of the α1 transmembrane domain (TM) 2-2' residue, previously shown to ablate inhibition by pregnenolone sulfate. However, results of coapplication studies and the apparent lack of state dependence suggest that pregnenolone sulfate and 3α5βP inhibit the GABA_A receptor independently and through distinct mechanisms. Mutations to the neurosteroid binding sites in the α1 and β3 subunits statistically significantly, albeit weakly and incompletely, reduced inhibition by 3α5βP and ACN.

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

BackgroundBetween 2003 and 2018, incident prescriptions of beta-blockers for anxiety increased substantially, particularly for young adults. National Institute for Health and Care Excellence guidance for anxiety does not recommend beta-blockers, probably due to a lack of evidence to support such use. Recent reports have highlighted the potential risks of beta-blockers.AimTo understand when and why GPs prescribe beta-blockers for people with anxiety.Design and settingIn-depth interviews with 17 GPs in Bristol and the surrounding areas.MethodInterviews were held by telephone or video call. A topic guide was used to ensure consistency across interviews. Interviews were audio-recorded, transcribed verbatim, and analysed thematically.ResultsMany GPs viewed beta-blockers as ‘low risk’, particularly for young adults. Some GPs viewed beta-blockers as an alternative to benzodiazepines, acting quickly and not leading to dependence. GPs reflected that some patients appeared to want an ‘immediate fix’ to their symptoms, which GPs thought beta-blockers could potentially offer. This is salient in light of substantial waiting lists for talking therapies and delays in antidepressants taking effect. GPs described how some patients seemed more willing to try beta-blockers than antidepressants, as patients did not perceive them as ‘mental health drugs’ and therefore viewed them as potentially more acceptable and less stigmatising. Further, GPs viewed beta-blockers as ‘patient-led’, with patients managing their own dose and frequency, without GP input.ConclusionMany GPs believe that beta-blockers have a role to play in the management of anxiety. Given recent increases in the prescribing of these drugs in primary care, there is a need to assess their safety and effectiveness as a treatment for people with anxiety disorders.

Stroll on down to Uncle Capcom's garage, girls and boys, because it's time to meddle with a cat's voicebox, ride a combat peacock and meticulously injure a vast, blubbery teddybear. By which I mean, the Monster Hunter Wilds beta is now live on Steam through to 4th November at 2.59am GMT. That's 2.59am sharp. If you're hurrying along at 3am on Monday absolutely desperate to polish the aesthetics of a small enslaved catperson, you can sod off and play Dragon Age: The Veilguard instead.

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I didn’t get much further in the extremely popular beta for the haute-couture-asaurus action of Monster Hunter Wilds than perfecting the exact orange-to-white ratio of my cat. Not because I wasn’t having fun, but because I immediately started looking up GPU prices after playing for ten minutes. As such, I didn’t spend enough time with the combat to get a proper feel for it. Cultural osmosis has once again allowed me to form an uneducated take, however, and I’m getting the sense there’s been some mixed reactions re: bonk quality. According to a clip shared on X by user Blue Stigma, there's a good reason for those misgivings. It's all about frames, you see.

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Doubled number of specialists should make up for the switch from the classic class system.

Another mobile reveal from Gamescom Opening Night Live 2024 was the latest trailer for the open world dress up game …

Continue reading "Open World Dress Up Game ‘Infinity Nikki’ Gets New Trailer With Closed Beta Sign Ups Now Live, Pre-Registrations Also Available"

Back in October last year, Feral Interactive announced that cross platform multiplayer was in the works for Company of Heroes …

Continue reading "‘Company of Heroes’ Mobile Multiplayer Beta Announced for Next Week on Android, Full Update Coming to iOS and Switch As Well"

NVIDIA has been testing a single app that merges the GeForce Experience and Control Panel over the past year. After rolling out several betas to make sure it works as intended, the company has officially launched the NVIDIA application, which is now available to download for users with its GPUs in their PCs and laptops. 

The company says the app is meant to make it easy to keep their NVIDIA Studio and GeForce Game Ready drivers updated and to give users quick access to its latest programs. In its home screen, users will find a prominently displayed section that will lead them to the latest driver downloads, as well as sections that will take them to other NVIDIA applications. At the bottom, they'll find a Library section showing their most recently opened games and programs that they can launch from there. 

Since it's supposed to provide a unified experience, users will be able to fine-tune the settings for their games and programs from within the app. Users will be able to access Optimal Playable Settings with relevant Control Panel options, and they'll be able to configure their displays, enable G-SYNC, enhance videos with AI and fine-tune their GPU's performance from within its interface. 

NVIDIA explains that it designed the unified application to be 50 percent more responsive than the GeForce Experience. It also installs in half the time. It's also worth noting that app will introduce a redesigned in-game overlay that simplifies access to gameplay recording tools capable of capturing video in 4K at 120 FPS, as well as AI-powered filters for those with RTX GPUs. They'll then be able to view their screenshots and new videos in the app's Gallery. 

The latest update to Nothing's operating system is now available for users with the Phone (2a), as the company rolls out the second open beta for Nothing OS 3.0. While this version is currently exclusive to the Phone (2a), users of

A Swedish study has challenged the widespread use of beta-blockers for all heart attack patients. While these medications are commonly prescribed to regulate

With FDA approval, UCSF Benioff Children's Hospital Oakland pioneers gene therapy for beta thalassemia, a rare genetic blood disorder, potentially alleviating

Common heart medications, like beta blockers, could have side effects including triggering depression in heart attack patients.

Beta-blockers, a common medicine used by patients who have had a heart attack, can lead to depression in patients who did not have heart failure, claims a study on Monday.

Apple has released the AI-powered version of its latest mobile operating system, iOS 18.2, to its public beta users. The update includes new features like an AI emoji generator app called Genmoji, an Image Playground AI image app, ChatGPT integration with Siri, and visual search using the iPhone 16 cameras, among other things. Previously, these […]

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For its most recent Camp, VC and accelerator Betaworks was on the lookout for startups building native applications made possible by AI. The program was first announced in May. To explain this focus, managing partner John Borthwick wrote at the time that while things like AI chatbots and writing assistants exist, “we aren’t yet living […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Apple has introduced a new tool within its Find My ecosystem aimed at improving how users track their belongings, especially when traveling. The “Share Item Location” feature allows users to share the location of accessories, such as items tagged with an

Who won what at the Star Parivaar Awards?

WhatsApp channel notification feature is available for both iOS and Android users

The Tibetan Plateau, often dubbed the “Roof of the World,” is a colossal expanse of land that towers over much of Asia. Its average altitude of over 4,500 metres (14,764 feet) is enough to make even the most seasoned mountaineer gasp. But what about aeroplanes? Why do these magnificent machines, capable of soaring through the clouds, avoid this imposing landmass?

Abstract: Variations in cuisine among the Tibetan minority of China are due in part to environmental diversity. Different ecologies yielded varied adaptive strategies of resource use (economies), and resulted in three main types of food production: pastoralism, agriculture, and a mixed economy with both kinds of production. These strategies in turn affect the type

The post Tibetan Cuisine appeared first on Berkshire Publishing.

Settings has an option to remove the Apple iOS ‘security response’

Next week, the hardware company is set to release iOS 18.1 which will include the first set of Apple Intelligence features

The iOS 18.1 beta 1 update added ChatGPT integration with Siri, the iOS 18.2 beta 2 update will let developers subscribe to ChatGPT Plus directly from Settings

Until then, users have been advised to uninstall the beta version and use the version 2.24.24.4 which is working fine

Scientists estimate that thawing ground could be a major source of the greenhouse gas

Scientists estimate that thawing ground could be a major source of the greenhouse gas

Thalassemia is a group of inherited blood disorders that has a similar characteristic: defective and reduced production of haemoglobin, the iron-containing protein in red blood cells that helps in carrying oxygen throughout the body. Beta-thalassemia (BT) is one of

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

MySQL Lite Administrator version Beta 1 suffers from multiple cross site scripting vulnerabilities.

ZedLog is a robust cross-platform input logging tool (or key logger). It is based on a flexible data logging system which makes it easy to get the required data. It captures all keyboard and mouse events, has a full GUI, and supports logging to a file and basic hiding.

ZedLog is a robust cross-platform input logging tool (or key logger). It is based on a flexible data logging system which makes it easy to get the required data. It captures all keyboard and mouse events, has a full GUI, and supports logging to a file and basic hiding.