atf Informing at the Crossroads of Design Science Research, Academic Entrepreneurship, and Digital Transformation: A Platform Ecosystem Roadmap By Published On :: 2022-04-13 Aim/Purpose: Developing Digital Platform Ecosystems (DPE) to transform conventional Knowledge Management Systems (KM/KMS) scenarios promises significant benefits for individuals, institutions, as well as emerging knowledge economies. Background: The academic entrepreneurship project presented is aiming for such a KMS-DPE configuration. Having consolidated this author’s own and external re-search findings, realization is currently commencing with a start-up in a business incubator. Methodology: Design science research applying mixed one-sample case study and illustrative scenario approach focusing on conceptual analysis and entrepreneurship. Contribution: Although (academic) entrepreneurship is a young research area with recently growing interest, publications focusing on this transitional stage between maturing research and projected commercial viability of digital technologies are rare. Findings: A roadmap looking beyond the immediate early-start-up perspective is out-lined by integrating recent development-stage-related DPE-research and by addressing stakeholders diverse informing needs essential for system realization. Recommendations for Practitioners and Researchers: As this transdisciplinary perspective combines KM, informing, design science, and entrepreneurial research spaces, it may assist other researchers and practitioners facing similar circumstances and/or start-up opportunities. Impact on Society: The article advances the understanding of how DPE communities may serve members with highly diverse skills and ambitions better to gainfully utilize the platform’s resources and generative potential in their personal and local settings. Future Research: As the entrepreneurial agenda will complement (not substitute) the academic research, research priorities have been highlighted aligned to three future stages. Full Article
atf Vote YES! for Brandon Herrera to Lead the Trump Administration’s ATF By www.ammoland.com Published On :: Sun, 10 Nov 2024 15:42:51 +0000 With Herrera as ATF director, there’s a real opportunity to bring accountability, strip away flawed regulations, & dismantle the entire diseased temple. Full Article Gun Rights News Shooting Industry News Brandon Herrera Bureau of Alcohol Tobacco Firearms & Explosives ATF President Trump Rogue Agencys
atf TomTom Mapping Data to Power End-to-End Analytics Platform By investors.tomtom.com Published On :: Fri, 29 Jun 2018 13:30:00 GMT TomTom Mapping Data to Power End-to-End Analytics Platform Full Article
atf TomTom to Provide Geocoding for Hotel Search Platform trivago By investors.tomtom.com Published On :: Fri, 29 Jun 2018 13:30:00 GMT TomTom to Provide Geocoding for Hotel Search Platform trivago Full Article
atf CLIMSAVE presents its Integrated Assessment Platform and final reports By www.eubon.eu Published On :: Wed, 08 Jan 2014 15:08:00 +0200 The FP7 CLIMSAVE project ("Climate Change Integrated Assessment Methodology for Cross-Sectoral Adaptation and Vulnerability in Europe") finished at the end of 2013. The project developed the CLIMSAVE Integrated Assessment Platform which is a unique user-friendly, interactive web-based tool that enables stakeholders to interactively explore the complex multi-sectoral issues surrounding impacts, adaptation and vulnerability to climate and socio-economic change within the agriculture, forest, biodiversity, coast, water and urban sectors. Two versions of the tool have been developed: one for Europe and one for Scotland. Two summary reports have been produced highlighting the policy relevant final results of the project for the European and Scottish case studies. The summary reports can be accessed from: Europe Policy Brief: http://www.climsave.eu/climsave/doc/Policy_Brief_for_Europe.pdf Scotland Policy Brief: http://www.climsave.eu/climsave/doc/Policy_Brief_for_Scotland.pdf Full Article News
atf Environment: Commission launches new platform to help resolve social conflicts over large carnivores By www.eubon.eu Published On :: Wed, 11 Jun 2014 15:54:00 +0300 Europe's brown bear, wolf, wolverine, lynx – at least one of these species can now be found in 21 EU Member States. After a lengthy period of decline their numbers are growing once more, but coexistence with man can be problematic. In an effort to solve the social and economic problems that sometimes result from this new expansion, the European Commission has launched a platform where farmers, conservationists, hunters, landowners and scientists can exchange ideas and best practices on sharing the same land with large carnivores. The EU Platform on Coexistence between People and Large Carnivores will support constructive dialogue between key stakeholder organisations at the European level. Launching the platform, EU Environment Commissioner Janez Potočnik said: "We need to treat our natural neighbours with respect – but we also need to heed the concerns of those whose lives are genuinely affected by their close proximity. My warm congratulations to the organisations that have worked together to set up this important platform, which represents a major step forward in efforts to address the issue of peaceful coexistence." The European Union is home to five species of large carnivores. All suffered dramatic declines in numbers and distribution as a consequence of human activity, but increasing protection and public awareness about their vital role in healthy ecosystems have caused many populations to stabilize or increase, and to return to areas from which they had been absent for decades or even centuries. While this recovery is seen by some as a great conservation success, it has not been without its opponents. The issue involves a diversity of stakeholders such as hunters, foresters, livestock producers, reindeer herders, landowners, rural communities, conservation organizations and the wider public. These groups are influenced by and perceive large carnivores in different ways, and in some cases these differences can be a source of conflict. The platform will facilitate exchanges of knowledge and promote ways and means to minimize, and wherever possible, find equitable solutions to these conflicts. The platform launched today follows a number of efforts to understand the conflicts between stakeholders over large carnivores, the results of which were set out in workshops conclusions and in a report. Next steps The Platform will hold its first working session immediately following the official launch today, on 10 June. It will adopt terms of reference and a work plan. The Platform will hold one annual meeting and organize additional workshops on selected topics. It will be supported by a web-based resource centre that will serve as the main tool to disseminate information on the activities of the platform, identify good practices in the form of documents or a manual, act as a gateway to the portals of the member organisations, and host media resources such as press kits for journalists. For more information: Original press release: http://europa.eu/rapid/press-release_IP-14-648_en.htm Visit the large carnivore website of DG Environment at http://ec.europa.eu/environment/nature/conservation/species/carnivores/index_en.htm http://ec.europa.eu/environment/nature/index_en.htm The signing ceremony and moderated panel discussion is streamed (https://new.livestream.com/corlive1/events/2977474/embed) on the internet (also see http://ec.europa.eu/environment/nature/conservation/species/carnivores/index_en.htm) Full Article News
atf E-seminar: Data Exchange for Biodiversity Conservation in Freshwater Ecosystems: Introducing the BioFresh Platform and Data Portal By www.eubon.eu Published On :: Thu, 21 Nov 2013 14:33:00 +0200 The FP7 projects BioFresh and WaterDiss2.0 are pleased to announce the E-seminar "Data Exchange for Biodiversity Conservation in Freshwater Ecosystems: Introducing the BioFresh Platform and Data Portal". The E-seminar will take place on Thursday, November 28 from 14:00 to 15:00 CET. It will be hosted on the seminar website (http://waterdiss.eu/eseminar-biofresh) where a link will be available for it. The E-seminar will introduce the audience to the usage of the BioFresh Platform and Data Portal, in order to ensure a better understanding of the different components. Aaike De Wever, Science Officer of BioFresh, will explain which data and information are integrated and for which contributions BioFresh is looking. Participants are encouraged to join in for a live discussion via "Citrix go to Webinar". If you want to participate in the e-seminar, you only need to send an email to evelyn.lukat@ecologic.eu. You will receive further information via mail. If you decide on participating later, you can also simply join the seminar by following the link provided on November 28th on this website. A few important notes: The e-seminar will be conducted in English The video and the questions asked during the session will be available on the websites of the BioFresh data portal and this website. Technical details on the E-seminar: When clicking on the link, the application Citrix Go To Webinar will be downloaded. Nothing will be installed on your computer. However, please make sure that your computer is able to run java applications. Please make sure that the sound system on your computer works. If your sound system does not work properly, you can also dial in via phone. Please check the dial-in number for your country on this website by November 28th. Full Article Events
atf Workshop "iMarine data platform for collaborations" By www.eubon.eu Published On :: Fri, 07 Feb 2014 09:58:00 +0200 A key goal of the iMarine initiative is to support stakeholders in a sustainable use of the marine ecosystem. On 7th March 2014, iMarine is organizing an interactive workshop "iMarine data platform for collaborations" to showcase how its powerful data infrastructure is capable of addressing the challenges of the Ecosystem Approach. The workshop also offers important opportunities to work together on developing plans related to iMarine sustainability, such as the public partnership model concept, as well as engage new potential users and partners for the future. The workshop is co-located with the Fishery Dependent Information conference and will take place at Food and Agriculture Organisation of the United Nations (FAO) headquarters, Viale delle Terme di Caracalla, 00153 Rome, Italy. Participation is free of charge but subject to registration. Full Article Events
atf International Trial Watch: experts set up platform to supervise Catalonia’s independence trial By www.collectiuemma.cat Published On :: Fri, 28 Dec 2018 17:30:00 +0100 International observers will determine if the right to defense and impartial trial are respected VILAWEB 18-12-2018 A group of judicial and human rights experts, as well as professors throughout Spain, have set up a platform called ‘International Trial Watch – Catalan Referendum case’ to supervise the trial against independence leaders, presented on Monday. At the event, criminal law professor Iñaki Rivera stated that they are creating reports to determine if the “right to defense, the existence and duration of pre-trial incarceration, and impartial trial, balance between parties, and the taking of evidence” are respected, along with the competency of the Supreme Court in the trial. Full Article
atf How Aphia—The Platform behind Several Online and Taxonomically Oriented Databases—Can Serve Both the Taxonomic Community and the Field of Biodiversity Informatics By www.eubon.eu Published On :: Tue, 22 Dec 2015 09:07:40 +0200 Full Article Events
atf The Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES): progress and next steps By www.eubon.eu Published On :: Fri, 21 Apr 2017 16:35:59 +0300 Full Article Events
atf The Worship Podcast (Episode 11): People Over Platform - Krissy Nordhoff & Amanda Blankenship By www.allaboutworship.com Published On :: Wed, 15 Aug 2018 09:56:10 -0500 On today's podcast, we're sitting down with some powerful women in the faith - Krissy Nordhoff and Amanda Blankenship. We're talking about an important subject for church leaders in general, but especially Worship Leaders, the motivation of ministry. Enjoy! The Worship Podcast is powered by All About Worship (Dustin Smith & James Galbraith) and WeAreWorship (Wisdom Moon & Morgan Shirey). Subscribe to the podcast: theworshippodcast.com linktr.ee/theworshippodcast You can also connect with The Worship Podcast on social media: The Worship Podcast on Facebook The Worship Podcast on Instagram The Worship Podcast on Twitter Full Article Podcasts
atf GMS Expands Product Offerings in Florida and Announces Further Platform Expansion Activity By www.wconline.com Published On :: Wed, 08 Jun 2022 00:00:00 -0400 Florida acquisition expands complementary product offering in Southwest Florida; four new greenfield locations expand presence in key markets. Full Article
atf Allure Energy Launches Proximity-Based Energy Management Platform at CES By www.sdmmag.com Published On :: Tue, 08 Jan 2013 00:00:00 -0500 Allure Energy Inc., Austin, Texas, introduced its latest product, EverSense 2.0 at CES in Las Vegas. Full Article
atf BriefCam Debuts Customizable Classes & Superior Real-Time Performance for its Video Analytics Platform By www.sdmmag.com Published On :: Fri, 31 Mar 2023 09:17:04 -0400 BriefCam, the leader in innovative AI-driven video analytics solutions, is showcasing version 2023 M1 of its comprehensive video analytics platform at ISC West. Full Article
atf Commercial Fire Services Platform Better Protection Formed By www.sdmmag.com Published On :: Tue, 20 Dec 2022 08:46:51 -0500 Led by a majority investment from Abry Partners, the new platform combines Assurant Fire Protection, Complete Fire Pump Service and Xtreme Fire Protection. Full Article
atf Home Energy Management: It’s All About The Platform By www.sdmmag.com Published On :: Thu, 19 Apr 2012 00:00:00 -0400 For consumers, the market for home energy management technology and products has, all at once, become highly frenzied yet tremendously exciting. From sleek, standalone ‘smart thermostats’ to solutions tightly integrated with the security system to new broadband-based home energy offerings from large cable and telco providers, consumers must not only decide which tool fits with their particular lifestyle, but which underlying platform offers the most stability and value. Full Article
atf WeSuite Enhances QuoteAnywhere Web-Based Platform By www.sdmmag.com Published On :: Tue, 12 Mar 2024 12:00:00 -0400 Both features will be available to users of WeSuite’s web-based platform, QuoteAnywhere, without the need for configuration or management via WeEstimate software. Full Article
atf Speco Technologies Launches Technical Training & Education Platform By www.sdmmag.com Published On :: Thu, 19 Sep 2024 13:11:39 -0400 Led by Daniel Sochalski, director of national training, and national sales trainers Jim Pascale and Tim O’Brien, Speco PhD will offer tailored training sessions virtually, in-person, and at major industry events/trade shows. Full Article
atf The Platform By www.sdmmag.com Published On :: Fri, 05 Dec 2003 00:00:00 -0500 For some security designs, it's the first and most basic computer decision. For dealer and installer firms serving commercial or residential clients, it's a given or a starting-point. There's many Full Article
atf Free Contact Tracing Available on Identiv’s Access Control Platform By www.sdmmag.com Published On :: Thu, 21 May 2020 16:15:00 -0400 Available via download for Hirsch customers, the free feature has been launched to support worldwide office re-openings with improved health and safety management tools. Full Article
atf PACOM Platform Manages Security By www.sdmmag.com Published On :: Thu, 06 Apr 2023 00:00:00 -0400 The “Editor’s Choice” and more new products and solutions as described by manufacturers. Full Article
atf Grating hazards on offshore platforms: Safety agency issues safety alert By www.safetyandhealthmagazine.com Published On :: Mon, 28 Feb 2022 00:00:00 -0500 Washington — In response to an “increase in incidents involving grating” on offshore energy platforms, the Bureau of Safety and Environmental Enforcement has issued a safety alert. Full Article
atf PACOM’s Platform Combines Cloud-Based Security & Business Management By www.sdmmag.com Published On :: Thu, 19 Sep 2024 14:00:00 -0400 VIGIL CORE combines access control and intrusion alarm, video verification, building management and centralized alarm monitoring all in one user-friendly platform. Full Article
atf Portable aerial work platform By www.safetyandhealthmagazine.com Published On :: Fri, 25 Oct 2013 05:00:00 -0400 The LiftPod FS60 portable aerial work platform offers an affordable alternative to ladders and scaffolding, with a working height of up to 14 feet and a 330-pound platform capacity. Full Article
atf Evolon Announces Launch of Cloud-Based Analytics & Video Storage Platform By www.sdmmag.com Published On :: Tue, 28 Mar 2023 12:30:00 -0400 The company is launching a cloud platform that leverages computer vision, AI, and video analytics to quickly and accurately detect, classify, and verify potential threats. Full Article
atf LenelS2 Announces New Elements Platform Features & Releases Expanded Options for Efficient Cloud Transition By www.sdmmag.com Published On :: Mon, 21 Aug 2023 10:00:00 -0400 Additionally, LenelS2 is offering new, cost-effective ways to transition to its Elements cloud-based solution. LenelS2 is a part of Carrier Global Corp., global provider of intelligent climate and energy solutions. Full Article
atf NMC Unveils Mobile Support for Nexus Platform By www.sdmmag.com Published On :: Wed, 28 Aug 2024 15:00:00 -0400 These features are all designed with the technician in mind, streamlining processes and making site management more efficient, according to the announcement. Full Article
atf Pimloc Integrates to Eagle Eye Video API Platform By www.sdmmag.com Published On :: Fri, 13 Sep 2024 00:00:00 -0400 The integration is particularly valuable for organizations that need to quickly respond to Data Subject Access Requests (DSARs), Freedom of Information Act (FOIA) requests, and Right of Access (ROA) requests. Full Article
atf The Axis open platform: An invitation to innovation By www.sdmmag.com Published On :: Mon, 23 Sep 2024 00:00:00 -0400 Physical security systems need to be nimble to counter a changing threat landscape. Full Article
atf AlarMax Launches E-Commerce Platform to Enhance Customer Experience By www.sdmmag.com Published On :: Fri, 01 Nov 2024 09:08:56 -0400 AlarMax’s new e-commerce platform offers security dealers and integrators a personalized, efficient tool to streamline their operations and enhance customer service. Full Article
atf How Pimloc Aims to Balance Privacy & Security With AI-Driven Platform By www.sdmmag.com Published On :: Fri, 08 Nov 2024 12:31:29 -0500 Pimloc, an AI video privacy and redaction company, helps organizations balance privacy and security by providing advanced solutions for responsibly managing video data. Full Article
atf Fall arrest platforms By www.safetyandhealthmagazine.com Published On :: Sun, 23 Oct 2016 00:00:00 -0400 These fall arrest platforms keep operators safe and mobile when work requires them to exit a mobile elevating work platform. Full Article
atf Work platform By www.safetyandhealthmagazine.com Published On :: Sun, 23 May 2021 00:00:00 -0400 FOUNDATION is a platform system designed to raise workers to ergonomic work heights while providing a safe and stable floor. Full Article
atf Elevated work platform By www.safetyandhealthmagazine.com Published On :: Sun, 23 Jan 2022 00:00:00 -0500 These custom configured elevating work platforms provide workers with a safe, stable platform that can be positioned at heights of just a few inches to several feet. They are also well suited for picking items from the multiple levels of a horizontal carousel. Full Article
atf AI platform By www.safetyandhealthmagazine.com Published On :: Sun, 29 Jan 2023 00:00:00 -0500 The 3DNeuroNET Engine’s AI-based platform allows employers to assess the physical movements of their workers, and provides insights “through easy-to-assess outcomes and form factors.” Full Article
atf Italian Coffee Trader Alkaff Turns to Dimitra’s Blockchain Platform to Ensure Compliance with Deforestation Regulation By www.foodengineeringmag.com Published On :: Fri, 16 Aug 2024 11:43:00 -0400 This platform utilizes artificial intelligence and blockchain technology to acquire and analyze farmer data and ensure market compliance with the upcoming European Union Deforestation Regulation, set to take effect at the end of 2024. Full Article
atf A new platform brings new opportunities By www.foodengineeringmag.com Published On :: Wed, 03 Feb 2021 09:00:00 -0500 Any fundamental shift in how you produce your product is a scary thing, and it requires buy-in and cooperation across multiple departments to ensure it’s done properly. Full Article
atf Versatrim Celebrates 25 Years, Announces Shopping Platform By www.floortrendsmag.com Published On :: Tue, 06 Jun 2023 12:00:00 -0400 The company announced plans to launch an e-commerce platform in the second quarter of 2023. The new site will highlight Versatrim's high-end product offering and will offer improved functionality to streamline the online order-entry process. Full Article
atf Dot Foods acquires Morsum, an AI/ML food platform technology company By www.foodengineeringmag.com Published On :: Sun, 06 Mar 2022 14:36:00 -0500 Dot Foods, Inc., said to be North America’s largest food industry redistributor, has acquired Morsum, a food industry data and AI platform technology company. Full Article
atf Evigence Introduces Freshness Management Platform with FreshSense Sensors By www.foodengineeringmag.com Published On :: Thu, 18 Jul 2024 10:57:00 -0400 Evigence offers food companies and cold-chain leaders data-driven freshness insights at the case or unit level needed to boost end-to-end supply chain efficiency, guarantee food quality, reduce food loss and manage compliance. Full Article
atf New Asset Management Platforms and Remote Service Tools Move Food Companies Closer to AI Strategies By www.foodengineeringmag.com Published On :: Thu, 17 Oct 2024 00:00:00 -0400 New remote service tools and robust asset management platforms enable food and beverage companies to envision AI-based strategies and facilitate product innovation across the enterprise. Full Article
atf Graduate Platforms Hardware Engineer, Graduates, Cambridge, UK, Software Engineering By careers.peopleclick.com Published On :: Monday, September 21, 2020 8:10:40 PM EDT About the roleWe are looking for enthusiastic Graduate Electronics or Embedded System Engineer to join Arm’s Hardware Platform team, who are working at the forefront of embedded design based around Arm IP products. We are responsible forDesigning and releasing the latest Arm IP technologies in FPGA image, enabling pre-silicon software and ecosystem development, reducing time to market.Creating physical hardware development platforms, based around Arm’s custom system-on-chip (SoC) and FPGAs for software development and validation activities for both our external partners/customers and our internal development teams.If you’re interested in:The potential to work on all aspects of product development, from specification to customer release.Eager to learn, a willingness to work across disciplines.The challenges of bringing up a new development board. Creating and validating Verilog RTL design in FPGA.Gaining a deeper understanding of system architecture and performance.Working alongside many other teams including system architects, CPU / System IP designers, physical chip layout / packaging engineers.Interaction with Arm’s partners and customers both through the support organisation and directly.Then we have a role for you!What will I be accountable for?As a Graduate, you will be placed in a development team at Arm’s offices in Cambridge, UK where you will have a mentor, and be able to get to grips with the problems ranging across many hardware and software areas. You will be working across all aspects of the product lifecycle whilst being supported by and learning from the rest of the team. Full Article
atf Graduate Embedded Platforms Software Engineer, Graduates, Cambridge, UK, Software Engineering By careers.peopleclick.com Published On :: Monday, September 21, 2020 8:09:58 PM EDT About the roleWe are looking for enthusiastic Graduate Electronics or Embedded System Engineer to join Arm’s Hardware Platform team, who are working at the forefront in the following embedded areas:Development and validation of physical hardware platforms, based around Arm’s custom system-on-chip (SoC) and FPGAs.Creating software to test Arm systems both in simulation and in hardware (FPGA & Silicon)Porting existing simulation/emulation RTL validation software to real hardwareCreate and maintain Build environments & Automation tooling to ensure we supply high quality productsSoftware design and implementation of reference firmware for Arm processors and systems – for example working on the software to enable our cutting-edge CoreLink secure subsystemsSoftware stack development to enable Arm IP. This includes implementing HALs, drivers, connectivity, security, power and control componentsBoard support firmware using STM32 and LPC11 microcontrollersOperating system development (Linux, mbedOS, FreeRTOS, etc)Development of reference software and demos for Arm Partners to use and replicate in their own products.Support and maintenanceIf you’re interested in:The potential to work on all aspects of product development, from specification to customer release.Eager to learn, willing to give anything a go.The challenges of bringing up a new development board.How to build, test and debug full software stacks on hardware that hasn’t yet been manufacturedGaining a deeper understanding of system architecture and performanceWorking alongside system hardware designers to develop the best platforms to support Arm’s partnersThen we have a role for you!What will I be accountable for?As a Graduate, you will be placed in a development team at Arm’s offices in Cambridge, UK where you will have a mentor, and be able to get to grips with the problems ranging across many software areas. You will be working across all aspects of the software lifecycle whilst being supported by and learning from the rest of the team. You will also be offered the opportunity to explore other teams within Arm during your first 12 months with us, as part of our Graduate Rotation programme.Whilst a lot of our work does involve Open Source software, many tasks require working with development platforms, or simulated hardware environments where features are being developed and tested before the physical devices have been built, so the problems you will be expected to understand and solve are ones that are yet unknown to the general community. Full Article
atf Infowars auction could determine whether Alex Jones is kicked off its platforms By www.mprnews.org Published On :: Wed, 13 Nov 2024 11:44:34 +0000 It's auction day for Alex Jones' Infowars. The Infowars studio and most other assets of the conspiracy theorist's company are expected to be sold off Wednesday. Full Article
atf The Ergonomic Solutions Group’s new SpacePole Kiosk – A modular, configurable and customisable platform for a wide range of self-service applications By www.retailtechnologyreview.com Published On :: Tue, 13 Nov 4040 16:52:00 +0000 The Ergonomic Solutions Group, the designer and manufacturer of technology mounting solutions, has launched the SpacePole Kiosk – described as a multifunctional platform with maximum flexibility for a wide range of self-service applications including self-check-in/check-out, self-ordering, endless aisle, product display & advertising, ticketing, click & collect and many more. Full Article Kiosk Technology
atf StreamSAXS: a Python-based workflow platform for processing streaming SAXS/WAXS data By journals.iucr.org Published On :: 2024-07-15 StreamSAXS is a Python-based small- and wide-angle X-ray scattering (SAXS/WAXS) data analysis workflow platform with graphical user interface (GUI). It aims to provide an interactive and user-friendly tool for analysis of both batch data files and real-time data streams. Users can easily create customizable workflows through the GUI to meet their specific needs. One characteristic of StreamSAXS is its plug-in framework, which enables developers to extend the built-in workflow tasks. Another feature is the support for both already acquired and real-time data sources, allowing StreamSAXS to function as an offline analysis platform or be integrated into large-scale acquisition systems for end-to-end data management. This paper presents the core design of StreamSAXS and provides user cases demonstrating its utilization for SAXS/WAXS data analysis in offline and online scenarios. Full Article text
atf HEIDI: an experiment-management platform enabling high-throughput fragment and compound screening By journals.iucr.org Published On :: 2024-04-12 The Swiss Light Source facilitates fragment-based drug-discovery campaigns for academic and industrial users through the Fast Fragment and Compound Screening (FFCS) software suite. This framework is further enriched by the option to utilize the Smart Digital User (SDU) software for automated data collection across the PXI, PXII and PXIII beamlines. In this work, the newly developed HEIDI webpage (https://heidi.psi.ch) is introduced: a platform crafted using state-of-the-art software architecture and web technologies for sample management of rotational data experiments. The HEIDI webpage features a data-review tab for enhanced result visualization and provides programmatic access through a representational state transfer application programming interface (REST API). The migration of the local FFCS MongoDB instance to the cloud is highlighted and detailed. This transition ensures secure, encrypted and consistently accessible data through a robust and reliable REST API tailored for the FFCS software suite. Collectively, these advancements not only significantly elevate the user experience, but also pave the way for future expansions and improvements in the capabilities of the system. Full Article text
atf Surface-mutagenesis strategies to enable structural biology crystallization platforms By journals.iucr.org Published On :: 2024-08-29 A key prerequisite for the successful application of protein crystallography in drug discovery is to establish a robust crystallization system for a new drug-target protein fast enough to deliver crystal structures when the first inhibitors have been identified in the hit-finding campaign or, at the latest, in the subsequent hit-to-lead process. The first crucial step towards generating well folded proteins with a high likelihood of crystallizing is the identification of suitable truncation variants of the target protein. In some cases an optimal length variant alone is not sufficient to support crystallization and additional surface mutations need to be introduced to obtain suitable crystals. In this contribution, four case studies are presented in which rationally designed surface modifications were key to establishing crystallization conditions for the target proteins (the protein kinases Aurora-C, IRAK4 and BUB1, and the KRAS–SOS1 complex). The design process which led to well diffracting crystals is described and the crystal packing is analysed to understand retrospectively how the specific surface mutations promoted successful crystallization. The presented design approaches are routinely used in our team to support the establishment of robust crystallization systems which enable structure-guided inhibitor optimization for hit-to-lead and lead-optimization projects in pharmaceutical research. Full Article text
atf EMhub: a web platform for data management and on-the-fly processing in scientific facilities By journals.iucr.org Published On :: 2024-10-07 Most scientific facilities produce large amounts of heterogeneous data at a rapid pace. Managing users, instruments, reports and invoices presents additional challenges. To address these challenges, EMhub, a web platform designed to support the daily operations and record-keeping of a scientific facility, has been introduced. EMhub enables the easy management of user information, instruments, bookings and projects. The application was initially developed to meet the needs of a cryoEM facility, but its functionality and adaptability have proven to be broad enough to be extended to other data-generating centers. The expansion of EMHub is enabled by the modular nature of its core functionalities. The application allows external processes to be connected via a REST API, automating tasks such as folder creation, user and password generation, and the execution of real-time data-processing pipelines. EMhub has been used for several years at the Swedish National CryoEM Facility and has been installed in the CryoEM center at the Structural Biology Department at St. Jude Children's Research Hospital. A fully automated single-particle pipeline has been implemented for on-the-fly data processing and analysis. At St. Jude, the X-Ray Crystallography Center and the Single-Molecule Imaging Center have already expanded the platform to support their operational and data-management workflows. Full Article text