Resolution 29 - (Rev. Geneva, 2022) - Alternative calling procedures on international telecommunication networks

Alternatives for carrier selection and network identification

Roofing contractors sought alternatives during a spate of challenges, a pandemic followed by supply chain disruptions and capped by a spike in inflation. But was it at a price?

As the world races towards digital transformation, the technologies we choose will have a lasting impact on our planet. Blockchain, NFTs, and other crypto assets have garnered much attention for their ability to securely and immutably store records. However, the environmental cost of maintaining these technologies is often overlooked. The energy consumption required to sustain blockchains, particularly those using Proof of Work (PoW), is enormous...

Location: Engineering Library- TJ163.2.N49 2016

Location: Engineering Library- TD793.9.W367 2015

Mortgage rates are at their highest levels in 22 years and house prices are at record highs. Hardworking people cannot get on the property ladder, and retirees are struggling to sell in order to downsize. The Biden administration has done little to help alleviate the problem. This Washington Examiner series, Home Economics, will investigate how we got here, the toll on people around the country, and the alternatives people are embracing to survive the market. The last part of this four-part series focuses on the alternatives to traditional fixed-rate mortgages gaining new consideration among prospective home buyers.

Here are the key takeways from The Times' yearlong investigation into the science behind magnetic resonance therapy, or MERT, as a therapy for autism.

THIS WEEK:  Loretta Napoleoni – The ISIS Crisis. Loretta Napoleoni is a leading expert on money laundering and terror financing. She has worked as London correspondent and columnist for La Stampa, La Repubblica, El País, and Le Monde.

Alternative Radio is an internationally syndicated, one-hour, weekly radio program, featuring serious interviews with humanitarian and progressive thinkers. Host, David Barsamian.

West Midlands Cycle Hire launched in Wolverhampton and Sutton Coldfield.

I really gotta get off Twitter/X, but I'd like to have all my data on one service. Have any of the alternate federated services implemented an importer for archived data yet? If not, are there any good third-party ways to do this now?

I looked into this a couple years ago, before I set up my mefi.social Mastodon account. But I only found some GitHub repos with scripts to do things like this, and it looked like doing it on Mastodon, for instance, if you'd already created an account would run the risk of flooding the server you're on with your old posts.

But people have been leaving Twitter/X for a couple years now, and the services have had some time to catch up after the flood of initial interest. Is there a way to import this data? Especially is there a way to do this on Mastodon that won't spam mefi.social? Heh.

LEDs are found in our phones, TVs, lightbulbs and cars, but this technology is also revolutionizing film and television production.

Seventy-nine years ago, the era of atomic weapons began with the Trinity test. My novel about J. Robert Oppenheimer and the Manhattan Project is The Oppenheimer Alternatvie, and, in my humble opinion, it’s the best of my 25 novels: “Incredibly realistic: the characters, locations, the era, and even the science. I felt like I was […]

The dream of every gardener is to see endless fields of green grass in their backyard. With determination, most gardeners manage to attain this dream, but at a cost. Within no time, there is a need to mow and control weeds. After mowing, it needs watering to grow again. This cycle continues for as long as the gardener wants to enjoy the beauty of green turf.[...]

In a world captivated by the glimmer of diamonds, these gems epitomize luxury, romance, and opulence. However, in recent times, traditional diamonds have not only become increasingly costly but also subject to scrutiny due to ethical concerns surrounding their mining. For lovebirds desiring the sparkle without the extravagant price tag, or for ethical buyers, the ... Read more

The post Diamonds On A Budget: Affordable Alternatives And Lab-Grown Options appeared first on Star Two.

Cavtat, Croatia, might be the biggest surprise of your trip! This peaceful seaside town in the far south of Croatia is so close to Dubrovnik, and yet a world away. If you want to visit Dubrovnik but would rather stay somewhere with a quiet, more relaxing atmosphere — oh, and cheaper, too! — Cavtat (pronounced […]

The post Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik appeared first on Adventurous Kate.

The US election could create the need for a G7 alternative – without American representation Expert comment jon.wallace 15 October 2024

Traditional allies of the US need to find a way to work together on some global policy issues even when the US itself is not engaged. A ‘G6 plus’ group could provide an answer.

When Jamaica pulled out of the nascent West Indies Federation in 1961, Trinidad and Tobago’s then prime minister, Dr Eric Williams, famously said ‘One from ten leaves nought’. In the run up to the US elections on 5 November, the US’s longstanding allies need to ask themselves if the same logic must apply to the G7. 

A Donald Trump victory will result in stark differences between the US and its closest partners on key global economic issues. US allies would no doubt try and persuade the new president to moderate his position, but experience suggests that this will have little, if any, effect.  

They may then want to work around the US, or on a parallel track. But doing so will be very hard unless they have a framework for discussing and developing ideas collectively. Could some form of ‘G6 plus’ forum help?

The role of the G7 today

The G7 no longer acts as a steering group for the global economy. However, it remains a critical forum for the US and its allies to coordinate their efforts to help solve global problems, to defend common Western interests, to resolve internal disputes and to underpin information exchange. 

In the past two years, the G7 has come to be seen by the US and other members as one of the most effective international mechanisms. It has played a critical role coordinating Western efforts to recover from the last pandemic and prepare for future ones.  

It has been pivotal in weakening Russia’s economy following the attack on Ukraine and has acted to strengthen Western economic security and resilience more broadly.  

The G7 has also responded to ‘Global South’ calls for help in dealing with the pandemic aftermath and the Ukraine war. 

Trump’s approach to the G7

The problem is that the G7’s effectiveness depends critically on full US engagement, sometimes as a leader of initiatives (such as the decision to impose an ‘oil price cap’ on Russia in autumn 2022) or as an essential partner. 

If elected, former President Trump is likely to abandon the G7 as an instrument of international economic policy. This is effectively what happened during his first presidency and there are reasons to expect this to be repeated. 

Many of Trump’s international economic policies are highly controversial with US allies, including his apparent determination to withdraw from the Paris Agreement, impose across the board 10-20 per cent tariffs and even punish countries for not using the dollar. His domestic policies, including mass deportation of undocumented immigrants and aggressive deregulation and fiscal easing could lead to further sharp disagreements.  

Furthermore, Trump demonstrates general antipathy towards multilateralism. Under his presidency, US representatives in the G7 and G20 sought to weaken core values and policies that have underpinned international economic cooperation for decades – including the importance of a rules based international system, the IMF’s global safety net role, and the responsibility of the advanced world to assist the poorest countries financially.  

Other G7 and G20 countries tried to preserve as much as possible of the previous consensus. But in the case of climate change, the only solution was to have a separate text for the US. Critically, such efforts diverted time and attention from the enormous challenges facing the world at the time. 

Trump went through four different G7/G20 Sherpas during his presidency and disowned the final declaration of the 2018 Canadian G7 summit after hundreds of hours of negotiation, and despite previously signing off on the text. The US failed to host a final leaders’ summit, even virtually, during his administration’s G7 presidency.  

Of course, how far Trump carries through his most radical policies will depend, among other things, on the outcome of the Congressional elections and the stance taken by US courts. 

He may also have second thoughts if elected. His first administration sometimes supported significant multilateral economic initiatives, notably the G20’s Debt Service Suspension Initiative and ‘Common Framework’ for debt rescheduling. 

But, in the event of a second Trump administration, the most likely scenario for the G7 is a repeat of the paralysis of 2017-20, which would be even more costly today.

Should Vice President Kamala Harris win on 5 November, the situation should in theory be very different. She will likely continue with President Joe Biden’s collaborative approach to the G7.

Nonetheless, major issues may still arise where America’s allies want to take a fundamentally different approach and need a mechanism to do so. These could include policy on the WTO, de-risking the economic relationship with China, restricting carbon leakage, and regulating US-dominated big tech.  

How should US allies respond?

No US ally will want to be seen to be leading development of a new ‘G6’ that excludes the US. The top priority will be securing the best possible relationship with the incoming president. Political weakness and/or new governments in France, Germany, the UK and Japan will add to this hesitancy.

Any new forum will therefore need to be as low profile as possible. The concept should initially be discussed in private by sherpas from each participating country. Once established, officials should as far as possible meet online. Leaders should only meet online, at least initially.  

Participants should be fully transparent about the forum’s existence and avoid any grand ‘framing’ along the lines of the EU’s ‘strategic autonomy’. Instead, it should be described as a practical, largely technocratic forum intended to coordinate activity among Western economic powers in those areas where the US chooses not to engage. A suitably innocuous name – such as the ‘the sustainable growth club’ could help.

Topics should be limited to those requiring urgent collective global action, such as climate, health, tech governance, development finance and trade – and where the US federal government is not an ‘essential’ partner. Such a forum should not therefore address defence.  

Diana Samodova
Dec 1, 2020; 19:2139-2156
Technological Innovation and Resources

Post-transcriptional modifications of pre-mRNAs expand the diversity of proteomes in higher eukaryotes. In the brain, these modifications diversify the functional output of many critical neuronal signal molecules. In this study, we identified a brain-specific A-to-I RNA editing that changed glutamine to arginine (Q/R) at exon 20 and an alternative splicing of exon 4 in Tmem63b, which encodes a ubiquitously expressed osmosensitive cation channel. The channel isoforms lacking exon 4 occurred in ∼80% of Tmem63b mRNAs in the brain but were not detected in other tissues, suggesting a brain-specific splicing. We found that the Q/R editing was catalyzed by Adar2 (Adarb1) and required an editing site complementary sequence located in the proximal 5' end of intron 20. Moreover, the Q/R editing was almost exclusively identified in the splicing isoform lacking exon 4, indicating a coupling between the editing and the splicing. Elimination of the Q/R editing in brain-specific Adar2 knockout mice did not affect the splicing efficiency of exon 4. Furthermore, transfection with the splicing isoform containing exon 4 suppressed the Q/R editing in primary cultured cerebellar granule neurons. Thus, our study revealed a coupling between an RNA editing and a distant alternative splicing in the Tmem63b pre-mRNA, in which the splicing plays a dominant role. Finally, physiological analysis showed that the splicing and the editing coordinately regulate Ca2+ permeability and osmosensitivity of channel proteins, which may contribute to their functions in the brain.

Trypsin is the protease of choice in bottom-up proteomics. However, its application can be limited by the amino acid composition of target proteins and the pH of the digestion solution. In this study we characterize ProAlanase, a protease from the fungus Aspergillus niger that cleaves primarily on the C-terminal side of proline and alanine residues. ProAlanase achieves high proteolytic activity and specificity when digestion is carried out at acidic pH (1.5) for relatively short (2 h) time periods. To elucidate the potential of ProAlanase in proteomics applications, we conducted a series of investigations comprising comparative multi-enzymatic profiling of a human cell line proteome, histone PTM analysis, ancient bone protein identification, phosphosite mapping and de novo sequencing of a proline-rich protein and disulfide bond mapping in mAb. The results demonstrate that ProAlanase is highly suitable for proteomics analysis of the arginine- and lysine-rich histones, enabling high sequence coverage of multiple histone family members. It also facilitates an efficient digestion of bone collagen thanks to the cleavage at the C terminus of hydroxyproline which is highly prevalent in collagen. This allows to identify complementary proteins in ProAlanase- and trypsin-digested ancient bone samples, as well as to increase sequence coverage of noncollagenous proteins. Moreover, digestion with ProAlanase improves protein sequence coverage and phosphosite localization for the proline-rich protein Notch3 intracellular domain (N3ICD). Furthermore, we achieve a nearly complete coverage of N3ICD protein by de novo sequencing using the combination of ProAlanase and tryptic peptides. Finally, we demonstrate that ProAlanase is efficient in disulfide bond mapping, showing high coverage of disulfide-containing regions in a nonreduced mAb.

Political Opposition and Policy Alternatives in Zambia 31 October 2017 — 10:30AM TO 11:30AM Anonymous (not verified) 19 October 2017 Chatham House, London

In Zambia’s 2016 national election, the Patriotic Front (PF) was re-elected by a narrow margin. The PF’s Edgar Lungu secured 50.35 per cent of the vote according to the Electoral Commission of Zambia, narrowly avoiding a second round, while his main rival, Hakainde Hichilema, won 47.67 per cent. The UPND, led by Mr Hichilema, alleges electoral fraud and has challenged the result in the courts and through direct protests. Mr Hichilema was imprisoned for 100 days.

At this meeting, Hakainde Hichilema will discuss his UPND priorities, how to strengthen opposition parties and their role in Zambia’s democratic future.

Read transcript

Knee replacement doesn’t have to be ‘total’

More than 100,000 AutoCAD software users download free compatibility solution from SolidWorks Corporation

New Solar Thermal Power Plant Developed in SolidWorks 3D CAD Software Goes Online Near L.A.

The Delaware Department of Agriculture (DDA) is offering extensions and COVID credit exemptions for individuals who have exhausted all options in earning their continuing education credits needed to maintain their nutrient management or pesticide certifications.

Some businesses overlook alternative data. That's probably a mistake.

The post Alternative data may feel risky: Here's why it's not appeared first on The Data Roundtable.

“Cyprus has gone from zero to over 330 licensed investment entities managing €9 billion in assets in just a decade,” according to Maria Panayiotou, president of the Cyprus Investment Fund Association (CIFA). Speaking at the 5th Fund and Asset Management Conference in Athens, Panayiotou attributed this growth to “relentless effort and strategic vision.” She added […]

Is it worth including activated charcoal in your terrarium’s potting mix? James Wong isn’t convinced by this pricey product

Title: Monkey Trials Raise Hope for Non-Addictive Opioid Alternative
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM

Title: Alternative Medicine Popular Among Seniors, But Most Don't Tell Their Doctors About It
Category: Health News
Created: 7/27/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how to quantify this structural abundance has been an ongoing challenge. Here, we show by DMS and dual-luciferase functional assays that previously predicted FSE mutants (using the RAG graph theory approach) suppress structural transitions and abolish frameshifting. Furthermore, correlated mutation analysis of DMS data by three programs (DREEM, DRACO, and DANCE-MaP) reveals important differences in their estimation of specific RNA conformations, suggesting caution in the interpretation of such complex conformational landscapes. Overall, the abolished frameshifting in three different mutants confirms that all alternative conformations play a role in the pathways of ribosomal transition.

Hepatocyte nuclear factor 4 alpha antisense 1 (HNF4A-AS1) is a long noncoding RNA (lncRNA) gene physically located next to the transcription factor HNF4A gene in the human genome. Its transcription products have been reported to inhibit the progression of hepatocellular carcinoma (HCC) and negatively regulate the expression of cytochrome P450s (CYPs), including CYP1A2, 2B6, 2C9, 2C19, 2E1, and 3A4. By altering CYP expression, lncRNA HNF4A-AS1 also contributes to the susceptibility of drug-induced liver injury. Thus, HNF4A-AS1 lncRNA is a promising target for controlling HCC and modulating drug metabolism. However, HNF4A-AS1 has four annotated alternative transcripts in the human genome browsers, and it is unclear which transcripts the small interfering RNAs or small hairpin RNAs used in the previous studies are silenced and which transcripts should be used as the target. In this study, four annotated and two newly identified transcripts were confirmed. These six transcripts showed different expression levels in different liver disease conditions, including metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, and obesity. The expression patterns of all HNF4A-AS1 transcripts were further investigated in liver cell growth from human embryonic stem cells to matured hepatocyte-like cells, HepaRG differentiation, and exposure to rifampicin treatment. Several HNF4A-AS1 transcripts highly displayed correlations with these situations. In addition, some of the HNF4A-AS1 transcripts also showed a strong correlation with CYP3A4 during HepaRG maturation and rifampicin exposure. Our findings provide valuable insights into the specific roles of HNF4A-AS1 transcripts, paving the way for more targeted therapeutic strategies for liver diseases and drug metabolism.

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of Food and Drug Administration–approved opioid antagonist or agonist medications, as well as the nonopioid flumazenil, in decreasing oxycodone choice self-administration in nonhuman primates. Adult squirrel monkeys (n = 7; four females) responded under concurrent second-order fixed-ratio (FR)-3(FR5:S);TO45s schedules of reinforcement for intravenous oxycodone (0.1 mg/kg) or saline on one lever and 30% sweetened condensed milk or water on the other. Doses of naltrexone (0.00032–1.0 mg/kg), nalbuphine (0.32–10 mg/kg), buprenorphine (0.0032–0.032 mg/kg), methadone (0.32–1.0 mg/kg), or flumazenil (1–3.2 mg/kg) were administered intramuscularly prior to oxycodone self-administration sessions that occurred with either milk or water as the alternative. Naltrexone, a μ-opioid receptor antagonist, was >30-fold more potent when milk was available compared with water and abolished oxycodone intake (injections/session) while concomitantly increasing milk deliveries at the highest dose tested. Pretreatment with the low-efficacy μ-agonist nalbuphine was most effective in the presence of milk compared with water, decreasing oxycodone preference to <50% of control values. The higher efficacy μ-agonists, methadone and buprenorphine, and the benzodiazepine antagonist flumazenil did not appreciably alter the reinforcing potency of oxycodone under either condition. These results suggest that antagonist medications used in combination with alternative reinforcers may be an effective strategy to curtail opioid abuse–related behaviors.

BACKGROUND AND PURPOSE:

Angioplasty and stent placement have been described as a bailout technique in individuals with failed thrombectomy. We aimed to investigate Stent retriever AssIsted Lysis (SAIL) with tirofiban before angioplasty and stent placement.

May 29, 2024

The energy transition is driving demand for critical minerals and metals, such as lithium, nickel, cobalt, graphite, and rare earth elements. Sodium-based batteries could provide a more secure, affordable alternative to lithium-ion batteries and highly concentrated lithium supply chains.

"Check out Visual Studio optimizing their rating system to only include the ratings used," shared Fiorenzo R. Imagine the performance gain!

"This sounds about right," says Colin A.

"Wow! Must snap up some sweet Anker kit with this amazing offer; but less than four days to go!" exclaims Dave L., who then goes on to explain
"The actual WTF is this though. I sent this image to Anker with this email: But only 3days left? I hope this offer continues!
Anker replied: Thank you for your feedback! I understand that you appreciate the savings on the Anker SOLIX PS100 Portable Solar Panel and wish the offer could be extended beyond the current 3-day limit. Your suggestion is valuable and will be considered for future promotions to enhance customer satisfaction. If you have any other requests or need further assistance, please let me know.
I for one welcome our new AI overlords. "

Graham F. almost stashed this away for later. "Looks like Dropbox could use a few lessons in how to do Maths! Although maybe their definition of 'almost' differs from mine."

Finally Joshua found time to report a brand-new date-handling bug. "Teams is so buggy; this one just takes the cake. I had to check with the unix cal program to make sure I wasn't completely bonkers." For the readers, November 8 this year is supposed to be a Friday. I suppose things could change after the US election.

The nose, a portal to our bodies, filters air, scents, and medlinkpathogens/medlink. Within the nasal passage, the turbinates, bone structures resembling seashells, play a crucial role.

The WHO has issued a report urging the prioritization of health in climate action. The report, developed with over 100 organizations, calls for an end to fossil fuel reliance and investment in sustainable alternatives.

We’ll be straight with you. There’s no 1:1 Twitter replacement, but there are plenty of social apps that might be worth substituting into your obsessive timeline-checking routines if you’re done with Twitter for whatever reason (we can think of plenty). Twitter’s current situation — advertisers leaving, Nazis logging back on — presents an opportunity to […]

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If Call of Duty: Black Ops 6 is proving too demanding for your PC, don't worry-Xbox Game Pass offers a fantastic selection of shooters that are engaging and easier on hardware. Here's a deeper look at six titles that provide everything

Feeling like X (formerly Twitter) just isn't your vibe anymore? You're not alone. But don't worry! There's a whole world of social media alternatives waiting to be explored. Here are 6 awesome platforms to check out, each with something unique to

Manchester : Manchester University Press, [2018]

London : Pluto Press, 2023.

Manchester : Manchester University Press, [2019]

We sample inventive menus across the lush, experimental township, which draws visitors from across the world