In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

Examples of a thermal management unit and an electronic apparatus utilizing the thermal management unit are described. In one aspect, the thermal management unit includes a heat sink. The heat sink includes a base portion, a first protrusion structure and a second protrusion structure. The base portion has a first side and a second side opposite the first side. The first protrusion structure protrudes from the first side of the base portion, and includes multiple fins. The second protrusion structure protrudes from the second side of the base portion, and includes multiple ribs. The heat sink may be made of silicon.

Apparatuses and methods for applying a transfer material onto the surface of an article are disclosed, including apparatuses and methods of transfer printing on and/or decorating three-dimensional articles, as well as the articles printed and/or decorated thereby. In some cases, the apparatuses and methods involve providing a deposition device, such as a printing device; providing a transfer component; depositing a material onto a portion of the transfer component with the deposition device; modifying the portion of the transfer component with the transfer material thereon to conform the transfer component to at least a portion of the surface of the three-dimensional article; and transferring the transfer material onto the surface of the article.

A container for food or beverage which has a heat exchange unit secured internally thereof to be in contact with the food or beverage, the heat exchange unit is filled with liquid carbon dioxide and has a valve which when activated allows the liquid carbon dioxide to pass from the liquid state directly to the gaseous state through a restricted orifice which functions to maintain residual carbon dioxide in the heat exchange unit in the liquid state until all of the liquid carbon dioxide is exhausted from the heat exchange unit.

The end to the fluoride saga in the Southampton city region will put a big hole in the correspondence bag for this paper’s daily letters page.

News you don't want to miss for April 8:

1. Schools in Alameda County, and five other Bay Area counties, will not re-open this academic year, the San Francisco Chronicle reports.…

News you don't want to miss for April 20:

1. Fifty-one employees at Safeway's distribution warehouse in Tracy have been infected with covid-19, including one death, the San Francisco Chronicle reports.…

News you don't want to miss for April 23:

1. BART learned on Thursday that $250 million in recent federal relief funds will allow it to balance its budget for this fiscal year, with $78 million remaining, BART Board Director Rebecca Saltzman said.…

Plus, the Alameda County Sheriff's Department updates it budget request. Body-camera video of the fatal shooting of Steven Taylor by San Leandro Police last Saturday shows the officer and the victim were face-to-face just moments before he was shot in the chest. The San Leandro Police Department released what they called a "critical incident video" last week.…

News you don't want to miss for May 1:

1. Oakland's lawsuit against the Raiders and the NFL over the team's relocation to Las Vegas was dismissed by a federal court judge on Thursday, according to Bleacher Report.…

An employee at a Dunkin' (formerly Dunkin' Donuts) restaurant in Concord has inspired the company's brand-new DIY Dunkin' Donut Kits.

Norma Valkenaar asked the restaurant's franchisee, Matt Cobo, whether she could bring home some donuts, frosting, and sprinkles so that her young nephews could experiment with customizing their own treats.…

A method for providing parts of waterproof and breathable shoes, parts of waterproof and breathable shoes provided with the method, and waterproof and breathable soles provided with the shoe parts. The method uses a mold including a first element and a second element, at least one of which has hollow regions of a matrix of impressions, which are filled with polymeric material in the fluid state by depositing it in the hollow regions or by injecting it while the mold is closed; a support made of flexible sheet is interposed between the first element and the second element and includes a waterproof and breathable functional element, on which, when the mold is closed, the polymeric material sets and adheres to the support.

POLICE are investigating a incident in which shots were fired outside one of Southampton's best-known pubs.

CIVIC chiefs are working with police and residents’ groups after an attempted murder in the city centre.

Every bride wants to look spectacular on her wedding day, so here trainer Janette Cardy shares her top 10 tips for getting in shape and looking radiant.

A HAMPSHIRE charity has launched its annual search for local good causes that need a cash boost.

A SCHOOLBOY who was apart from his soldier dad for four months was stunned when he turned up out of the blue to pick him up from class - just in time for Christmas.

Ben Strevens is hoping that Eastleigh will sign him some reinforcements as his injury crisis worsens.

CIVIC chiefs are being urged to approve plans to replace a redundant New Forest theatre with better facilities for sports teams.

POLICE are appealing for witnesses following a serious incident.

AN UNDER-FIRE health trust has admitted it missed chances to intervene when a mentally ill Southampton man was in “crisis”.

A CELEBRATED Guide and Scout show which was cancelled for the first time in 63 years was turned into an uplifting online video instead.

A WOMAN was injured after she was attacked by two dogs while out on a run in the Stockbridge countryside.

WORK to install a bridge over a major Southampton road has been completed.

A WELL known and much-loved local personality who served Southampton Amateur Boxing Club for over 60 years, has died.

POLICE are appealing for witnesses following a serious incident.

The video for HIGHER THAN THE SUN is out now!! This is part one of three special videos from the album.

RESIDENTS have had their first chance to have their say on major plans for a new ferry terminal on Southampton’s waterfront.

LEISURE bosses are today bracing themselves to make the next step towards the development of a huge, multi-million-pound, Las Vegas-style casino planned for Southampton.

ONLY a small number of mass cycling events would be affected by the proposed cap on cyclists in New Forest events.

Whether it's at home, at work, on the bus, in the pub or on social media, everybody is raving about Kodi and what it can do.

Square Enix, Eidos-Montréal, and Crystal Dynamics today revealed the first full trailer for Shadow of the Tomb Raider. 

SOUTHAMPTON'S biggest and best free music festival is back.

A HAMPSHIRE resident has been rescued from their home by emergency services.

THIS exceptional country house on an exclusive private estate close to the River Hamble could be yours for £2.65 million.

THIS unique period property, set in rolling grounds and paddocks of nearly eight acres, is a rare find, having been owned by the same family for more than 40 years.

PALACE House on the outskirts of Bishop's Waltham enjoys stunning gardens and an intriguing medieval history.

THIS imposing eight bedroom family home of over 6,000 sq ft with a tennis court, guest lodge, annexe and grounds of more than five acres could be yours for just £2.65 million.

The Old Parsonage is a handsome country house on the edge of Stockbridge with beautiful countryside views, a pool and tennis court. It's on the market for £2,150,000.

THIS fine country farmhouse in the New Forest is on the market for £2.25 million

THIS stunning Hampshire barn conversion with period charm and a side gate to one of the county's best golf clubs could be yours for less than £1.5 million.

CHRISTMAS is typically a time for cheer and celebration, but with the festive season approaching, many of us are starting to think about buying a tree.

A Hampshire council is considering a rule change to lower the amount of dogs one person can walk in a public space.

Slate Digital just released the Virtual Mix Rack plugin and while I was trying it out I made a quick demo video. I’m using presets…

A short video on using feedback with analog tape.

In this episode, Dave Nason and Thomas Domville are joined by John Sturt, the man behind such hit games as Super Tile Smash, Wordfinder, Knight Commander and Minesweeper Deluxe, with yet more fun games to come it seems.

In this podcast, Thomas Domville shows us how to hide alert for group texts in iOS.

Dive in with Thomas Domville as he listens to the LIVE actions as they happen with Scanner Radio for iOS. A free app that you don't want to miss out that brings a wide range of scanner feeds to follow and listen such as Police, Fire, EMS, Railways, Aviation, Marine and others that may interest you.

Scanner Radio: Police & Fire on the App Store
https://apps.apple.com/us/app/scanner-radio-deluxe/id498405045

Columbus-based Nationwide Insurance plans to require coporate office employees in Columbus, Des Moines, Scottsdale and San Antonio to work from home permanently.

Delaware County Sheriff's deputies say they have solved the 36-year-old murder of a teen.