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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
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Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article
Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
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558: Esoteric Weird Content Editable Problems with Kristin Valentine

By shoptalkshow.com
Published On :: Mon, 27 Mar 2023 07:34:54 +0000

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"


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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

By shoptalkshow.com
Published On :: Mon, 05 Jun 2023 19:53:09 +0000

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.


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Investing in companies with ‘indicorn’ potential

By www.thehindubusinessline.com
Published On :: Sun, 13 Oct 2024 20:01:00 +0530

Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years


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IIT Delhi’s annual Open House shows AI’s potential use in health care, tech

By www.thehindu.com
Published On :: Sun, 10 Nov 2024 00:34:59 +0530


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Data and its discontents

By www.thehindubusinessline.com
Published On :: Sun, 05 Sep 2021 21:11:37 +0530

The quality of the statistics of a country is a measure of its goodness, say the authors


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Paddy varieties with protein, zinc content get thumbs up in Odisha’s tribal pocket

By www.thehindu.com
Published On :: Wed, 08 Nov 2023 11:37:33 +0530

Paddy varieties have high protein (10.1%) and moderately high level of zinc (20 ppm) content


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TNAU, Coimbatore, gets design patent for seed cube making machine

By www.thehindu.com
Published On :: Wed, 19 Jun 2024 18:39:33 +0530


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Dynamics of switching processes: general results and applications to intermittent active motion

By pubs.rsc.org
Published On ::

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01054J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ion Santra, Deepak Gupta, Kristian S Olsen
Systems switching between different dynamical phases is an ubiquitous phenomenon. The general understanding of such a process is limited. To this end, we present a general expression that captures fluctuations...
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Self-consistent electrostatic formalism of bulk electrolytes based on the asymmetric treatment of the short- and long-range ion interactions

By pubs.rsc.org
Published On ::

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01174K, Paper
Sahin Buyukdagli
Internal energy of monovalent electrolytes (left) and dimensionless screening parameter of multivalent electrolytes (right).
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QCFI Tirupati chapter’s tenth anniversary concludes

By www.thehindu.com
Published On :: Sun, 10 Nov 2024 23:50:02 +0530


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Good potential for cosmetic, textile, food processing sectors in Andhra Pradesh: South Korean diplomat

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 20:30:19 +0530

South Koreans are familiar with Andhra Pradesh and since Kia Motors is here, more Korean companies may wish to come too, says Sangwoo Lim


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Karnataka’s untapped tourism potential

By www.thehindu.com
Published On :: Tue, 29 Oct 2024 01:08:00 +0530

The State has not capitalised on its rich cultural, religious, and natural heritage


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Curriculum content is same across education boards: CISCE chief

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 22:38:38 +0530

He speaks with The Hindu regarding misconceptions about the school board, using technology to beat malpractices, and his plans to improve the quality of school education


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As its industry struggles, Germany services sector offers untapped growth potential

By www.thehindu.com
Published On :: Mon, 11 Nov 2024 15:50:06 +0530


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Synthesis of bambusurils with perfluoroalkylthiobenzyl groups as highly potent halide receptors

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01746C, Research Article
Open Access
Matúš Chvojka, Hennie Valkenier, Vladimír Šindelář
Four new fluorinated bambusuril macrocycles were prepared to show exceptional high binding affinity towards halide anions in acetonitrile.
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Nickel-catalysed enantioselective cross-electrophile coupling reaction with the retention of the β-fluorine atom

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, 11,6459-6469
DOI: 10.1039/D4QO01555J, Research Article
Xin-Yi Shi, Xueyuan Yan, Xiaodong Tang, Shi-Jing Zhai, Genping Huang, Jun-An Ma, Fa-Guang Zhang
A nickel-catalysed enantioselective reductive cross-coupling reaction of a new monofluoromethyl building block with acid chlorides is developed to give chiral α-monofluoromethyl acyloin derivatives.
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I will prove my that my retention was right decision: Shashank

By www.thehindu.com
Published On :: Fri, 01 Nov 2024 16:16:44 +0530

Shashank established himself as a fine finisher for Punjab Kings in the last season where he was their top run-getter with 354 runs at a strike rate of 164.65. He averaged 44.25.


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'Lengthy' physics section kept students on tenterhooks

By www.thehindu.com
Published On :: Mon, 02 May 2016 09:07:50 +0530

Many of them said they had not prepared thoroughly for AIPMT as it was only ‘an option’


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Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35215-35219
DOI: 10.1039/D4RA05941G, Paper
Open Access
Antonia Behnsen, Gesa Hertrampf, Sandra Vojnović, Jasmina Nikodinović-Runić, Tobias A. M. Gulder
The myxocoumarins are natural products with strong antibiotic activity. We herein explored structural simplification of the myxocoumarins while aiming to retain their antibacterial properties. This led to the discovery of potent myxochromene diones.
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Design, synthesis, and evaluation of novel thiadiazole derivatives as potent VEGFR-2 inhibitors: a comprehensive in vitro and in silico study

By pubs.rsc.org
Published On ::

RSC Adv., 2024, 14,35505-35519
DOI: 10.1039/D4RA04158E, Paper
Open Access
Ibrahim H. Eissa, Walid E. Elgammal, Hazem A. Mahdy, Susi Zara, Simone Carradori, Dalal Z. Husein, Maymounah N. Alharthi, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Hazem Elkady, Ahmed M. Metwaly
This study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining in vitro and in silico analyses.
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I know I am one of the best, the other guys know it too: Tentoglou

By www.thehindu.com
Published On :: Fri, 10 May 2024 21:40:46 +0530

The Greek jumper, like Neeraj Chopra, kicks off his Olympic defence in Doha and is focussed more on easing into competition than jumping far.


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Neeraj Chopra lives in the moment and is remarkably consistent, says AFI chief Adille Sumariwalla

By www.thehindu.com
Published On :: Fri, 19 Jul 2024 21:25:51 +0530

Rumours have swirled around the Olympic and world champion being troubled by an adductor niggle as he sets sights on retaining the gold medal at the Paris Olympics a few days from now


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The Different (and Modern) Ways to Toggle Content

By css-tricks.com
Published On :: Fri, 08 Nov 2024 13:57:09 +0000

Let’s spend some time looking at disclosures, the Dialog API, the Popover API, and more. We’ll look at the right time to use each one depending on your needs. Modal or non-modal? JavaScript or pure HTML/CSS? Not sure? Don’t worry, we’ll go into all that.

The Different (and Modern) Ways to Toggle Content originally published on CSS-Tricks, which is part of the DigitalOcean family. You should get the newsletter.


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Unravelling the potential of low-valent tunable vanadium complexes in the nitrogen reduction reaction (NRR)

By pubs.rsc.org
Published On ::

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02217C, Paper
Bijoy Ghosh, Sahtaz Ahmed, Ashwini K. Phukan
Comprehensive computational investigations predict the potential of several hitherto unknown tripodal vanadium complexes in the nitrogen reduction reaction (NRR) without the probability of generation of hydrazine as a side product.
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Cheluvarayaswamy accuses HDK of collecting ₹1,000 cr. from steel industries to fund elections; JD(S) terms it a strategy to divert attention from ‘excise scam’

By www.thehindu.com
Published On :: Mon, 11 Nov 2024 04:25:28 +0530

After Prime Minister Narendra Modi accused the Congress government of collecting ₹700 crore from excise sources to fund the Maharashtra elections, it was the turn of N. Cheluvarayaswamy


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EAM Jaishankar says success of Central govt's policies linked to state's intentions

By www.newkerala.com
Published On :: Mon, 28 Oct 2024 02:02:03 +0530


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Mathematical modeling to size anaerobic stabilization ponds intended for slaughterhouse wastewater treatment – the role of temperature and hydraulic retention time

By pubs.rsc.org
Published On ::

Environ. Sci.: Water Res. Technol., 2024, 10,2882-2896
DOI: 10.1039/D4EW00557K, Paper
P. E. S. Soldera, R. F. Dantas, E. Fagnani
A new mathematical model for constructing anaerobic stabilization pond treatment systems for high organic load wastewater, based on biochemical oxygen demand, temperature and hydraulic retention time, is discussed.
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‘Selectors were whimsical then, maybe to a lesser extent now’

By www.thehindu.com
Published On :: Sun, 31 Jan 2016 01:44:40 +0530

"The national and Bombay selectors were whimsical, otherwise why should 49 cricketers play only one Test match."


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Extent of leak, key to ordering NEET-UG re-test: Apex court

By www.thehindubusinessline.com
Published On :: Mon, 08 Jul 2024 22:20:19 +0530

Supreme Court considers cancellation of NEET-UG 2024 due to leaked questions affecting 23 lakh students, seeks extent of leak.


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WATCH | Electoral bond not poll issue; people understand intent was to ensure clean money coming to politics: Tejasvi Surya

By www.thehindu.com
Published On :: Fri, 19 Apr 2024 21:06:29 +0530


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  • Lok Sabha Elections
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Congress is competent to fight polls on its own in Haryana: Bhupinder Singh Hooda

By www.thehindu.com
Published On :: Wed, 14 Aug 2024 17:52:38 +0530

‘I am satisfied with our performance in the Lok Sabha election because the INDIA bloc vote share was the highest in Haryana among all other States — 47.62%,’ the former Haryana CM said


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The LAC agreement, the détentes and the questions

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 01:21:00 +0530

A democratically elected government needs to take its citizens into confidence about moves that have deep consequences


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LatentView Analytics Q2FY25 net profit grows 17%

By www.thehindubusinessline.com
Published On :: Fri, 08 Nov 2024 16:50:20 +0530

The acquisition of Decision Point Analytics has concluded and integration of the GTM and delivery teams is underway


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Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex

By pubs.rsc.org
Published On ::

Food Funct., 2024, 15,10746-10760
DOI: 10.1039/D4FO03023K, Paper
Open Access
Aleksandra Zambrowicz, Katarzyna Kapczyńska, Paweł Kania, Jakub Stanisław Nowak, Marta Kaszowska, Katarzyna Szymczak-Kulus, Wioletta Kazana-Płuszka, Marta Piksa, Sabina Górska, Dominika Jakubczyk, Józefa Macała, Agnieszka Zabłocka
The nutraceutical potential of yolkin health benefits from hen egg yolk.
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Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage

By pubs.rsc.org
Published On ::

Food Funct., 2024, 15,10795-10810
DOI: 10.1039/D4FO03217A, Paper
Sara Gonçalves, Francisco Peixoto, Tayse F. F. da Silveria, Lillian Barros, Isabel Gaivão
The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing.
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Exploring the potential of sorghum with reference to its bioactivite, physicochemical properties and potential health benefits

By pubs.rsc.org
Published On ::

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04128C, Review Article
Sakshi Singh, Mehvish Habib, David J McClements, Khalid Bashir, Shumaila Jan, Kulsum Jan
Sorghum is a resilient and adaptable cereal grain recognized for its rich nutritional profile. It is a valuable source of dietary fiber (around 6%), protein (9-13%), and essential minerals such...
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Review on mechanisms of hypoglycemic effects of compounds from highland barley and potential applications

By pubs.rsc.org
Published On ::

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00940A, Review Article
Yanan Liu, Yuanqiang Jia, Yingying Wu, Huijuan Zhang, Feiyue Ren, Sumei Zhou
The value and mechanism of highland barley in the prevention of diabetes and its application in food products.
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Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk

By pubs.rsc.org
Published On ::

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04381B, Paper
Yaping Zheng, Shasha Cheng, Hongxuan Li, Yilin Sun, Ling Guo, Chaoxin Man, Yu Zhang, Wei Zhang, Yujun Jiang
Lacticaseibacillus paracasei JM053 has a high ability to convert soy isoflavones and can be used as a fermentation strain to ferment soymilk, thereby increasing the content of free aglycones in...
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Sinner beats Fritz again in rematch of U.S. Open final, Medvedev back in contention at ATP Finals

By www.thehindu.com
Published On :: Wed, 13 Nov 2024 05:53:18 +0530

Top-ranked Jannik Sinner has made it two wins in two matches before his home fans at the ATP Finals by beating Taylor Fritz 6-4, 6-4 in a rematch of the U.S. Open final


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NiFe2O4: harnessing catalytic potential in water splitting

By pubs.rsc.org
Published On ::

Catal. Sci. Technol., 2024, 14,6155-6175
DOI: 10.1039/D4CY00627E, Review Article
A. Anantha Krishnan, Sreehari Harikumar, M. A. Aneesh Kumar, Revathy B. Nair, Sajith Kurian, M. Ameen Sha, P. S. Arun
NiFe2O4 is a potential catalyst for energy conversion and storage, owing to their electrical conductivity, catalytic activity, and stability.
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Ag/Cu foam catalyst for selective reduction of CO2 to CH3OH at low potential

By pubs.rsc.org
Published On ::

Catal. Sci. Technol., 2024, Accepted Manuscript
DOI: 10.1039/D4CY01056F, Paper
Ruitao Nie, Xiaolong Deng, Haoyu Yang, Hongwei Chen, Jie Yang, Meiyi Lu, Keqi Peng, Xiaoyu Zhou, Yang Chen, Juan Xie, Hu Wang
Electrocatalytic selective reduction of CO2 to liquid phase products, particularly methanol, is a promising technique for CO2 utilization. However, the challenge is daunting because the reduction of carbon dioxide to...
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Heteroatom-doped carbon nanomaterials as potential heterogeneous Fenton reaction catalysts

By pubs.rsc.org
Published On ::

Catal. Sci. Technol., 2024, 14,6662-6669
DOI: 10.1039/D4CY00248B, Paper
Haobin Tan, Xiuli Hou, Chen Zhou, Shengbo Wang, Qiang Liu, Zhenhui Xu, Peng Zhang
A volcano relationship between the catalytic activity and the adsorption energies of reaction intermediates was found for the H2O2 dissociation on heteroatom-doped carbon nanomaterials.
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Synthesis, Characterization, Genotoxicity Assessment and Antibacterial Applications of Zanthoxylum armatum Silver Nanoparticles (ZASNP) with Antibiotic Efficacy Enhancement Potential

By pubs.rsc.org
Published On ::

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03608E, Paper
Open Access
Nikita Quadri, Manjunath M. Setty, Anshumali Awasthi, Usha Yogendra Nayak, Minakshi Singh, Sharad Sharma
The study aimed to develop alternative antibacterial treatments by combining traditional herbal knowledge with modern nanotechnology. This approach targets multiple bacterial strains, combats antibiotic resistance, and offers solutions for treating...
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