'Having lived through cancer, through so many ups and downs, I'm not particularly attached to attention or success -- it's lovely if it's there, it's fine if it's not.'

With Viswanathan Anand resting, the Indian team managed to hold their own against the favourites before Yu Yangyi subdued B Adhiban with black pieces to secure another victory in the tournament.

Of the total three patients discharged on Saturday, a 18-month-old child was also discharged after defeating Covid-19.The total patients discharged in the city stands at 24.

Bidentate and tridentate coordination of a 2,4-di-tert-butyl-substituted bridging amine bis­(phenolate) ligand to a palladium(II) center are observed within the same crystal structure, namely di­chlorido­({6,6'-[(ethane-1,2-diylbis(methyl­aza­nedi­yl)]bis­(methyl­ene)}bis­(2,4-di-tert-butyl­phenol))palladium(II) chlorido­(2,4-di-tert-butyl-6-{[(2-{[(3,5-di-tert-butyl-2-hy­droxy­phen­yl)meth­yl](meth­yl)amino}­eth­yl)(meth­yl)amino]­meth­yl}phenolato)palladium(II) methanol 1.685-solvate 0.315-hydrate, [PdCl2(C34H56N2O2)][PdCl(C34H55N2O2)]·1.685CH3OH·0.315H2O. Both complexes exhibit a square-planar geometry, with unbound phenol moieties participating in inter­molecular hydrogen bonding with co-crystallized water and methanol. The presence of both κ2 and κ3 coordination modes arising from the same solution suggest a dynamic process in which phenol donors may coordinate or dissociate from the metal center, and offers insight into catalyst speciation throughout Pd-mediated processes. The unit cell contains di­chlorido­({6,6'-[(ethane-1,2-diylbis(methyl­aza­nedi­yl)]bis­(methyl­ene)}bis­(2,4-di-tert-butyl­phenol))palladium(II), {(L2)PdCl2}, and chlorido­(2,4-di-tert-butyl-6-{[(2-{[(3,5-di-tert-butyl-2-hy­droxy­phen­yl)meth­yl](methyl)amino}eth­yl)(meth­yl)amino]­meth­yl}phenolato)palladium(II), {(L2X)PdCl}, mol­ecules as well as fractional water and methanol solvent mol­ecules.

X-ray diffraction studies of crystals under pressure and quantitative experimental charge density analysis are among the most demanding types of crystallographic research. A successful feasibility study of the electron density in the mineral grossular under 1 GPa pressure conducted at the CRISTAL beamline at the SOLEIL synchrotron is presented in this work. A single crystal was placed in a diamond anvil cell, but owing to its special design (wide opening angle), short synchrotron wavelength and the high symmetry of the crystal, data with high completeness and high resolution were collected. This allowed refinement of a full multipole model of experimental electron distribution. Results are consistent with the benchmark measurement conducted without a diamond-anvil cell and also with the literature describing investigations of similar structures. Results of theoretical calculations of electron density distribution on the basis of dynamic structure factors mimic experimental findings very well. Such studies allow for laboratory simulations of processes which take place in the Earth's mantle.

Current software tools for the automated building of models for macro­molecular X-ray crystal structures are capable of assembling high-quality models for ordered macromolecule and small-molecule scattering components with minimal or no user supervision. Many of these tools also incorporate robust functionality for modelling the ordered water molecules that are found in nearly all macromolecular crystal structures. However, no current tools focus on differentiating these ubiquitous water molecules from other frequently occurring multi-atom solvent species, such as sulfate, or the automated building of models for such species. PeakProbe has been developed specifically to address the need for such a tool. PeakProbe predicts likely solvent models for a given point (termed a `peak') in a structure based on analysis (`probing') of its local electron density and chemical environment. PeakProbe maps a total of 19 resolution-dependent features associated with electron density and two associated with the local chemical environment to a two-dimensional score space that is independent of resolution. Peaks are classified based on the relative frequencies with which four different classes of solvent (including water) are observed within a given region of this score space as determined by large-scale sampling of solvent models in the Protein Data Bank. Designed to classify peaks generated from difference density maxima, PeakProbe also incorporates functionality for identifying peaks associated with model errors or clusters of peaks likely to correspond to multi-atom solvent, and for the validation of existing solvent models using solvent-omit electron-density maps. When tasked with classifying peaks into one of four distinct solvent classes, PeakProbe achieves greater than 99% accuracy for both peaks derived directly from the atomic coordinates of existing solvent models and those based on difference density maxima. While the program is still under development, a fully functional version is publicly available. PeakProbe makes extensive use of cctbx libraries, and requires a PHENIX licence and an up-to-date phenix.python environment for execution.

In the structural biology of bacterial substrate-binding proteins (SBPs), a growing number of comparisons between substrate-bound and substrate-free forms of metal atom-binding (cluster A-I) SBPs have revealed minimal structural differences between forms. These observations contrast with SBPs that bind substrates such as amino acids or nucleic acids and may undergo >60° rigid-body rotations. Substrate transfer in these SBPs is described by a Venus flytrap model, although this model may not apply to all SBPs. In this report, structures are presented of substrate-free (apo) and reconstituted substrate-bound (holo) YfeA, a polyspecific cluster A-I SBP from Yersinia pestis. It is demonstrated that an apo cluster A-I SBP can be purified by fractionation when co-expressed with its cognate transporter, adding an alternative strategy to the mutagenesis or biochemical treatment used to generate other apo cluster A-I SBPs. The apo YfeA structure contains 111 disordered protein atoms in a mobile helix located in the flexible carboxy-terminal lobe. Metal binding triggers a 15-fold reduction in the solvent-accessible surface area of the metal-binding site and reordering of the 111 protein atoms in the mobile helix. The flexible lobe undergoes a 13.6° rigid-body rotation that is driven by a spring-hammer metal-binding mechanism. This asymmetric rigid-body rotation may be unique to metal atom-binding SBPs (i.e. clusters A-I, A-II and D-IV).

The Inorganic Crystal Structure Database (ICSD) is the world's largest database of fully evaluated and published crystal structure data, mostly obtained from experimental results. However, the purely experimental approach is no longer the only route to discover new compounds and structures. In the past few decades, numerous computational methods for simulating and predicting structures of inorganic solids have emerged, creating large numbers of theoretical crystal data. In order to take account of these new developments the scope of the ICSD was extended in 2017 to include theoretical structures which are published in peer-reviewed journals. Each theoretical structure has been carefully evaluated, and the resulting CIF has been extended and standardized. Furthermore, a first classification of theoretical data in the ICSD is presented, including additional categories used for comparison of experimental and theoretical information.

Recently, researchers from Boston University and the Smithsonian Tropical Research Institute in Panama have been taking a closer look at the vibrations that red-eyed treefrog embryos use as cues to trigger early hatching. They discovered that treefrog embryos can evaluate different features of vibrations.

The post Researchers discover treefrog embryos can evaluate different features of vibrations appeared first on Smithsonian Insider.

A roundup of recent articles featuring spiders, bats and rats....

The post A Halloween roundup featuring recent articles on spiders, bats and rats appeared first on Smithsonian Insider.

Smithsonian Tropical Research Institute community ecologist Sunshine Van Bael primarily examines the relationship between leaf cutter ants–the world’s first farmers–and the fungi that they cultivate.

The post New online video series to feature Tropical Research Institute scientists appeared first on Smithsonian Insider.

Office of Public Affairs videographers Johnny Gibbons and Brian Ireley recently headed down to the Punta Culebra Nature Center on the edge of Panama City […]

The post New online video series to feature Tropical Research Institute scientists appeared first on Smithsonian Insider.

The awarded film features STRI marine biologist Héctor M. Guzman diving with a group of five whale sharks while traveling in the Tropical Eastern Pacific. In the video, Guzmán tags a radiotransmitter to one of the sharks in order to follow its voyages.

The post Whale sharks featured in award-winning documentary following the work of Tropical Research Institute’s Héctor Guzman appeared first on Smithsonian Insider.

The April 5 exhibits, “In the Mummy’s Tomb,” “Making a Mummy” and “What’s in a Face,” focus on Egyptian burial rites.

The post Mummies featured in new Smithsonian exhibition appeared first on Smithsonian Insider.

In a new paper appearing this week in Science, a group of biologists have shown that females themselves can also limit the evolution of increased elaboration.

The post Females can place limits on evolution of attractive features in males, research shows appeared first on Smithsonian Insider.

Ornithologists Carla Dove and Storrs Olson used 700- to 1,100-year-old feathers from a long extinct species of Hawaiian ibis to help determine the bird’s place in the ibis family tree. The feathers are the only known plumage of any of the prehistorically extinct birds that once inhabited the Hawaiian Islands.

The post Fossil feathers from a Hawaiian cave help reveal lineage of extinct, flightless ibis appeared first on Smithsonian Insider.

Recent spectroscopic analysis of macaroni penguin (Eudyptes chrysolophus) crest feathers and king penguin (Aptenodytes patagonicus) neck feathers have shown they contain a yellow pigment that […]

The post Yellow pigment in penguin feathers is chemically distinct, spectroscopic studies reveal appeared first on Smithsonian Insider.

Finding a fossil is the first step, recognizing it for what it truly is, is the real challenge. While closely studying three fossil skeletons from […]

The post One Scary Chicken—New species of large, feathered dinosaur discovered appeared first on Smithsonian Insider.

A research team from the Smithsonian and Arizona State University have developed a new, non-destructive method using spectroscopic analysis to help unravel the complex chemistry […]

The post Feathers yield mysteries of pigment chemistry to spectroscopic analysis appeared first on Smithsonian Insider.

The majestic feathers of the greater bird of paradise (Paradisaea apoda) have inspired people for thousands of years. Like many birds on the isolated island […]

The post Feathers of seduction – the connection between birds and people of New Guinea appeared first on Smithsonian Insider.

Xian Hu, Salma Jalal, Michael Sheetz, Oddmund Bakke, and Felix Margadant

Despite progress made in confocal microscopy, even fast systems still have insufficient temporal resolution for detailed live cell volume imaging, such as tracking rapid movement of membrane vesicles in three-dimensional space. Depending on the shortfall, this may result in undersampling and/or motion artifacts that ultimately limit the quality of the imaging data. By sacrificing detailed information in the Z-direction, we propose a new imaging modality that involves capturing fast "projections" from the field of depth which shortens imaging time by approximately an order of magnitude as compared to standard volumetric confocal imaging. With faster imaging, radiation exposure to the sample is reduced, resulting in less fluorophore photobleaching and potential photodamage. The implementation minimally requires two synchronized control signals that drive a piezo stage and trigger the camera exposure. The device generating the signals has been tested on spinning disk confocals and instant structured-illumination-microscopy (iSIM) microscopes. Our calibration images show that the approach provides highly repeatable and stable imaging conditions that enable photometric measurements of the acquired data, in both standard live imaging and super-resolution modes.

The post “How Soil Savvy are You?, is featured in the exhibition “Dig It! The Secrets of Soil,” from the Smithsonian Traveling Exhibition Service appeared first on Smithsonian Insider.

The post Short video featuring the fieldwork of Smithsonian scientists created in 2000, posted by the Smithsonian Archives appeared first on Smithsonian Insider.

Ever wonder why only male peacocks have such extravagant plumage? We ask caretaker Gwendolyn Cooper at Smithsonian’s National Zoo to explain.

The post Why are male peacock feathers more colorful appeared first on Smithsonian Insider.

By now, most of the United States has started to feel the first cool caresses of winter. Everything is pumpkin spiced, and the last crickets […]

The post Feathered diplomats unite pupils in North and Central America appeared first on Smithsonian Insider.

A scientifically accurate and valid epidemiologic study of reproductive problems among the families of veterans exposed to radiation from atomic bombings and nuclear weapons tests is not feasible, concluded an Institute of Medicine (IOM) committee in a new report.

Argentina-based fintech Mercado Pago has announced it will now be possible to share...

India-based merchant payment and lending service provider BharatPe has announced disbursing funds...

Flowbird Group has announced recent developments that limit...

With the release of the Windows 10 May 2019 Update, Microsoft introduced a new security feature called Tamper Protection that protects security settings for Windows Defender antivirus from being disabled by malware or third-party programs. [...]

"Deepfakes" are digitally altered images that make incidents appear real when they are not. Such altered files could have broad implications for politics.; Credit: /Marcus Marritt for NPR

Sophisticated fake media hasn't emerged as a factor in the disinformation wars in the ways once feared — and two specialists say it may have missed its moment.

Deceptive video and audio recordings, often nicknamed "deepfakes," have been the subject of sustained attention by legislators and technologists, but so far have not been employed to decisive effect, said two panelists at a video conference convened on Wednesday by NATO.

One speaker borrowed Sherlock Holmes' reasoning about the significance of something that didn't happen.

"We've already passed the stage at which they would have been most effective," said Keir Giles, a Russia specialist with the Conflict Studies Research Centre in the United Kingdom. "They're the dog that never barked."

The perils of deepfakes in political interference have been discussed too often and many people have become too familiar with them, Giles said during the online discussion, hosted by NATO's Strategic Communications Centre of Excellence.

Following all the reports and revelations about election interference in the West since 2016, citizens know too much to be hoodwinked in the way a fake video might once have fooled large numbers of people, he argued: "They no longer have the power to shock."

Tim Hwang, director of the Harvard-MIT Ethics and Governance of AI Initiative, agreed that deepfakes haven't proven as dangerous as once feared, although for different reasons.

Hwang argued that users of "active measures" (efforts to sow misinformation and influence public opinion) can be much more effective with cheaper, simpler and just as devious types of fakes — mis-captioning a photo or turning it into a meme, for example.

Influence specialists working for Russia and other governments also imitate Americans on Facebook, for another example, worming their way into real Americans' political activities to amplify disagreements or, in some cases, try to persuade people not to vote.

Other researchers have suggested this work continues on social networks and has become more difficult to detect.

Defense is stronger than attack

Hwang also observed that the more deepfakes are made, the better machine learning becomes at detecting them.

A very sophisticated, real-looking fake video might still be effective in a political context, he acknowledged — and at a cost to create of around $10,000, it would be easily within the means of a government's active measures specialists.

But the risks of attempting a major disruption with such a video may outweigh an adversary's desire to use one. People may be too media literate, as Giles argued, and the technology to detect a fake may mean it can be deflated too swiftly to have an effect, as Hwang said.

"I tend to be skeptical these will have a large-scale impact over time," he said.

One technology boss told NPR in an interview last year that years' worth of work on corporate fraud protection systems has given an edge to detecting fake media.

"This is not a static field. Obviously, on our end we've performed all sorts of great advances over this year in advancing our technology, but these synthetic voices are advancing at a rapid pace," said Brett Beranek, head of security business for the technology firm Nuance. "So we need to keep up."

Beranek described how systems developed to detect telephone fraudsters could be applied to verify the speech in a fake clip of video or audio.

Corporate clients that rely on telephone voice systems must be wary about people attempting to pose as others with artificial or disguised voices. Beranek's company sells a product that helps to detect them and that countermeasure also works well in detecting fake audio or video.

Machines using neural networks can detect known types of synthetic voices. Nuance also says it can analyze a recording of a real known voice — say, that of a politician — and then contrast its characteristics against a suspicious recording.

Although the world of cybersecurity is often described as one in which attackers generally have an edge over defenders, Beranek said he thought the inverse was true in terms of this kind of fraud detection.

"For the technology today, the defense side is significantly ahead of the attack side," he said.

Shaping the battlefield

Hwang and Giles acknowledged in the NATO video conference that deepfakes likely will proliferate and become lower in cost to create, perhaps becoming simple enough to make with a smartphone app.

One prospective response is the creation of more of what Hwang called "radioactive data" — material earmarked in advance so that it might make a fake easier to detect.

If images of a political figure were so tagged beforehand, they could be spotted quickly if they were incorporated by computers into a deceptive video.

Also, the sheer popularity of new fakes, if that is what happens, might make them less valuable as a disinformation weapon. More people could become more familiar with them, as well as being detectable by automated systems — plus they may also have no popular medium on which to spread.

Big social media platforms already have declared affirmatively that they'll take down deceptive fakes, Hwang observed. That might make it more difficult for a scenario in which a politically charged fake video went viral just before Election Day.

"Although it might get easier and easier to create deepfakes, a lot of the places where they might spread most effectively, your Facebooks and Twitters of the world, are getting a lot more aggressive about taking them down," Hwang said.

That won't stop them, but it might mean they'll be relegated to sites with too few users to have a major effect, he said.

"They'll percolate in these more shady areas."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Attorney General William Barris pictured at a coronavirus task force meeting at the White House on March 23. The Justice Department is looking to crack down on coronavirus-related fraud.; Credit: Alex Brandon/AP

The coronavirus pandemic has brought out the good side of many Americans, but certainly not all Americans. Officials say that fraud related to COVID-19 — like hoarding equipment, price gouging and hawking fake treatments — are spreading as the country wrestles with the outbreak.

"It's a perfect ecosystem for somebody like a fraudster to operate in," said Craig Carpenito, the U.S. attorney for New Jersey and the head of the Justice Department's COVID-19 price gouging and hoarding task force.

"People want to believe that there's a magic pill that they can take or that if they buy a certain kind of mask or a certain kind of protective gear that it's going to protect them and their families," he said. "That creates opportunities for the types of people that prey upon scared people. They prey upon their fear."

A month ago, Attorney General William Barr instructed federal prosecutors around the country to aggressively investigate and prosecute scams and other crimes related to the COVID-19 pandemic. He also created the price gouging and hoarding task force and put Carpenito in charge of it.

From that perch, Carpenito has one of the best views of virus-related crime nationwide.

"Instead of seeing that tremendous support from all aspects of society, we're still seeing that sliver, that that dark underbelly, that small percentage of folks who instead of putting the interests of the country and support for those medical professionals that are putting themselves at risk in the forefront, they're finding ways to try and take advantage of this situation and illegally profiteer from it," he said. "And it's despicable."

The most prevalent kind of fraud that federal authorities are seeing at this point, he and others say, is tied to personal protective equipment like N95 masks, gloves or face shields.

In one notable case, prosecutors brought charges against a Georgia man, Christopher Parris, for allegedly trying to sell $750 million worth of masks and other protective equipment to the Department of Veterans Affairs but with a sizable advance payment.

The problem, prosecutors say, is the masks and other items didn't exist, at least not in the quantities Parris was offering.

Steven Merrill, the head of the FBI's financial crimes section, says the bureau refers to these sorts of operations as advance-fee schemes.

"We're getting many complaints that different entities are entering into these agreements, paying money upfront, sometimes hundreds of millions of dollars, and may or may not get any masks or other PPE ordered at all," Merrill said. "So our guidance to the public is to please be wary of these frauds and solicitations."

Other problems, such as hoarding and price gouging, can arise even when the medical gear does exist.

The FBI is trying to identify individuals who are stockpiling protective equipment and trying to sell it at exorbitant markups, sometimes 40 to 70 times the value, Merrill said.

A few weeks ago, the FBI seized nearly 1 million respirator masks, gloves and other medical gear from a Brooklyn man who was allegedly stockpiling them and selling them to nurses and doctors at what officials say was around a 700% markup.

The man, Baruch Feldheim, has been charged with lying to the FBI about price gouging. He's also been charged with allegedly assaulting a federal officer after he coughed on agents and claimed he had COVID-19.

The confiscated items, meanwhile, have been distributed to medical workers in the New York area.

Carpenito said the Justice Department has more than 100 investigations open into price gouging. It has hundreds more, he said, into other crimes tied to the pandemic, including fake treatments and cures.

In one case out of California, prosecutors charged a man who was allegedly soliciting large investments for what he claimed was a cure for COVID-19.

"He was doing so by broadcasting this scheme via, notably, YouTube, where had thousands of hits and views," Merrill said.

In a separate case out of Florida last week, the Justice Department got a court order to stop a Florida church from selling on its website an industrial bleach that was being marketed as a miracle treatment for the virus.

To be clear, the Centers for Disease Control and Prevention says there is no cure at this point for the virus.

More than a month into this crisis, there's no sense COVID-related crime is going to slow down.

In fact, Carpenito and Merrill say that with the massive $2 trillion economic relief package beginning to be doled out, they expect to see even more fraud in the weeks and months ahead.

"What we're worried about is that not only do we have these existing conditions, but we are awaiting — like everybody in the country — the arrival of $2 trillion to hit the streets," Merrill said. "And anytime there's that much money out there, you can just multiply the amount of frauds that are going to take place. So we're preparing for many more complaints to come in and new schemes to arrive on a daily basis."

This content is from Southern California Public Radio. View the original story at SCPR.org.

A new German study suggests that residents??? level of satisfaction with their urban neighbourhood can be predicted from their perceptions of multiple and co-occurring burdens, such as poor air quality, lack of green space, noise and low cleanliness.

Microsoft Edge is now giving users the ability to hide those pesky browser notification dialog boxes that are commonly used by web sites to push their content, or even spam, on visitors. [...]

Natural predators of agricultural pests are influenced by the type and range of habitats within a farming landscape. A new study has developed an approach which predicts the risk of pest infestation and natural predation according to landscape features, to help land managers structure landscapes that encourage natural pest control.

Researchers have developed a new tool to evaluate the economic viability of biogas production from agricultural waste, such as manure and straw. It focused on a co-digestion method where farmers treat several types of waste together, including industrial by-products, such as glycerol.

Reluctance to use cost-benefit analysis (CBA) in environmental decision making in Germany stems from a preference for traditional approaches and a fear that it leads to loss of influence. This is suggested by new research based on interviews with those responsible for water policy management.

Samsung has created an ecommerce platform in partnership with Benow.in along with mobile phone retailers across the country that will allow them to sell and deliver smartphones. Offline stores are also being used to fulfil orders placed on Samsung’s e-store for television and appliances.

The new features will allow admins to disable the use of a Personal Meeting ID (PMI) for scheduling or starting an instant meeting. As per the company, disabling the use of PMIs reduces that risk altogether and doesn’t leave PMI security up to individual users.

Facebook has announced to expand its Community Help feature as part of COVID-19 efforts which will help people offer help to those affected by the new coronavirus pandemic, as well as donate to nonprofit organisations.

Apple has finally rolled out its hardware disconnect feature to its iPad models for improved security.

Biological control agents are an environmentally-friendly way of controlling pests and diseases on crops and are advocated in the EU’s Sustainable Use of Pesticides Directive1. The authors of a new review of the current state of biological control refer to a recent UN report2 which states that it is possible to produce enough food to feed a world population of nine billion with substantially less chemical pesticides — and even without these pesticides if sufficient effort is made to develop biocontrol-based Integrated Pest Management (IPM) methods. The study suggests that policy measures can speed up the development and use of environmentally-friendly crop protection.

Today I am happy to welcome guest blogger Quique Hernandez Hurtado Esquilas.... read more >>

In September 2015, the United States Environmental Protection Agency (EPA) alleged that Volkswagen (VW) violated the US Clean Air Act by fitting ‘defeat devices’ in their light-duty diesel vehicles to falsify the results of emissions tests. According to a study assessing the potential impact of this decision, an extra 59 early deaths in the US are likely to be caused by exposure to PM2.5 and ozone.