Mexico City — Gunmen in a truck pulled up to a bar in central Mexico and opened fire, killing 10 people, authorities said, in an area that had been spared the worst of the country's raging criminal violence.  Security camera footage published by local media showed the perpetrators leaping from the vehicle and bursting into the venue as terrified customers fled or dived to the floor.   The attack late Saturday on Los Cantaritos bar in Queretaro's downtown district left 10 people dead and at least seven injured, according to the city's public security department chief Juan Luis Ferrusca.   "Emergency services arrived at the scene and confirmed that at least four people armed with long weapons had arrived on board a pickup truck," Ferrusca said in a video on social media.  One suspect was detained and the vehicle used in the attack was found abandoned and set on fire, he said.  The victims included three women, according to the Queretaro state prosecutor's office, which said forensic experts were examining the scene of the attack and the vehicle.  Queretaro, the capital of Queretaro state, is considered one of the safer cities in Mexico, which has been plagued by years of drug cartel-related violence.  "The entire security system of Queretaro is mobilized to find the criminals" behind the attack, state governor Mauricio Kuri said on social media platform X.  "We will continue to shield our borders and maintain the security of our state," he said, adding, "Those responsible for this brutal act will be punished."  Queretaro, a city known more for its colonial architecture than for its crime, is around 200 kilometers northwest of Mexico City.   Across Mexico, spiraling violence, much of it linked to drug trafficking and gangs, has seen more than 450,000 people murdered since 2006.   Tackling the murders and kidnappings that are a daily occurrence is among the major challenges facing President Claudia Sheinbaum.  The former Mexico City mayor, who became the country's first woman president on October 1, has ruled out declaring "war" on drug cartels.  Instead, she has pledged to continue her predecessor's strategy of using social policy to tackle crime at its roots, while also making better use of intelligence.   The northwestern cartel stronghold of Sinaloa has seen a surge in violence since the July arrest of drug lord Ismael Zambada in the United States unleashed a wave of gang infighting.   There has also been a spike in bloodshed in the southern state of Guerrero, the scene of long-running gang turf wars.   Authorities said Thursday that the bodies of 11 people, including two minors, were found abandoned in a pickup truck in the state capital Chilpancingo.  They were part of a group of 17 people -- reported to be traveling merchants -- who were declared missing last month.         

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

[The Conversation Africa] It's two years since Kenyan president William Ruto, in what seemed like a political gamble, rolled out a government-run microcredit scheme popularised as the Hustler Fund. Worth 50 billion shillings (US$409 million) a year over a five-year period, the low-interest loans were touted as the "magic formula" to start or grow micro, small and medium businesses. Now the fund faces an uncertain future owing to a high default rate. Eric Magale, who studies the complex relationship between finance, livelihoods and

Electronic Music Malta has opened a new chapter in the history of contemporary Maltese music with its very own każin in Ħamrun, called ISSA

Information manipulation and misinformation are not new phenomena, but they have taken on exaggerated importance, especially with the massive use of social media. Hostile and stigmatizing narratives against civil society and civic activism, whether intentional or not, especially when propagated by authorities, create undue restrictions and hinder the exercise of the rights to freedom of […]

New institutional economics (NIE) has received another so-called Nobel prize, ostensibly for again claiming that good institutions and democratic governance ensure growth, development, equity and democracy. Daron Acemoglu, Simon Johnson, and James Robinson (AJR) are well known for their influential cliometric work. AJR have elaborated earlier laureate Douglass North’s claim that property rights have been […]

A sovereign exposure exchange is a cost-effective risk management tool used by multilateral development banks (MDBs) to reduce sovereign portfolio concentration risks. It provides capital relief for MDBs by exchanging loan guarantees on credit exposure from borrowing countries where an MDB is highly concentrated for exposure to countries where the MBD’s exposure is lower or nonexistent.

Keynote address by Masatsugu Asakawa, President, Asian Development Bank, at the 23rd Ministerial Conference of the Central Asia Regional Economic Cooperation Program, 8 November 2024

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More and more parents are choosing to only have one child. Here’s what the evidence says about how growing up without siblings affects their personality traits and well-being

A mathematical proof shows that some quantum states can resist nature’s tendency to disorder – but only under very specific conditions

A mathematical study finds that three definitions of what it means for entropy to increase, which have previously been considered equivalent, can produce different results in the quantum realm

Long feted by fossil hunters and geologists, if UNESCO recognises the extraordinary rock formation at Madygen in Kyrgyzstan, it will soon be a player on the world stage

In support of their AI ambitions, tech companies are rapidly expanding US data centres, and this growth is on track to significantly increase US gas demand by 2030

Title: Boom in Pot 'Concentrates' Could Pose Addiction Risk for Teens
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Extract

We read with great interest the correspondence by T. Bitter and co-workers in the European Respiratory Review, about our recently published review entitled "Central sleep apnoea: not just one phenotype" [1]. We first want to express our gratefulness to the authors for their support and appreciation of our work, particularly regarding the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

Internal ribosomal entry sites (IRESs) recruit the ribosome to promote translation, typically in an m7G cap-independent manner. Although IRESs are well-documented in viral genomes, they have also been reported in mammalian transcriptomes, where they have been proposed to mediate cap-independent translation of mRNAs. However, subsequent studies have challenged the idea of these "cellular" IRESs. Current methods for screening and discovering IRES activity rely on a bicistronic reporter assay, which is prone to producing false positive signals if the putative IRES sequence has a cryptic promoter or cryptic splicing sites. Here, we report an assay for screening IRES activity using a genetically encoded circular RNA comprising a split nanoluciferase (nLuc) reporter. The circular split nLuc reporter is less susceptible to the various sources of false positives that adversely affect the bicistronic IRES reporter assay and provides a streamlined method for screening IRES activity. Using the circular split nLuc reporter, we find that nine reported cellular IRESs have minimal IRES activity. Overall, the circular split nLuc reporter offers a simplified approach for identifying and validating IRESs and exhibits reduced propensity for producing the types of false positives that can occur with the bicistronic reporter assay.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

Over the past decades the zebrafish has emerged as an excellent model organism with which to study the biology of all glial cell types in nervous system development, plasticity, and regeneration. In this review, which builds on the earlier work by Lyons and Talbot in 2015, we will summarize how the relative ease to manipulate the zebrafish genome and its suitability for intravital imaging have helped understand principles of glial cell biology with a focus on oligodendrocytes, microglia, and astrocytes. We will highlight recent findings on the diverse properties and functions of these glial cell types in the central nervous system and discuss open questions and future directions of the field.

Central sleep apnoea (CSA) is characterised by recurrent episodes of airway cessation or reduction in the absence of respiratory effort. Although CSA is less common than obstructive sleep apnoea, it shares similar symptoms. CSA can be secondary to various medical conditions, high altitude and medication exposure. CSA can also emerge during obstructive sleep apnoea therapy. There are a range of treatment options and selecting the right therapy requires an understanding of the pathophysiology of CSA. This review explores the aetiology, pathophysiology and clinical management of non-hypercapnic CSA.

A chance to observe the high-speed re-entry of a falling satellite will give researchers important insights on how debris burns up in our atmosphere

Imagine a world without Facebook. For just half an hour. A group of AI leaders get together but don’t seem to invite Elon Musk. Amazon takes data centres nuclear. A new competitor for ChatGPT and Google. And public trust in AI is declining.  All this and more on the “just breath, Facebook will be back” […]

Why are there so many VPNs for Apple TV? Oh, right—geofencing.

I’ve been a big fan of SIGONO’s OPUS series of narrative adventure games for a long time. If you’ve not …

Continue reading "‘OPUS: Prism Peak’, the Newest Entry in the Amazing ‘OPUS’ Series, Gets New Gameplay Screenshots"

Ça va mal pour Sidney Crosby et ses coéquipiers.

Voyez ce que l’ancien défenseur avait à dire sur son passage dans la Belle Province!

Amoury Lapointe a résisté à son arrestation lors d’une intervention de routine à laquelle il refusait de se soumettre dans son «véhicule diplomatique»

Une ancienne boîte de poulet St-Hubert, retrouvée par hasard dans l’entretoit d’un chalet, a été remise à la famille Martin en échange d'un don.

Centrelink’s controversial data-matching program will be ‘refined’ as pressure mounts for it to be suspended.

In an effort to strengthen the regulatory activities for medical devices in the country, the Union health ministry has framed and finalised rules regulating the method of recruitment to various posts under the Central

Revelation contained in Kissinger-era documents obtained by WikiLeaks

Who controls India’s water resources: Centre, States or both? How are inter-State river disputes settled? Who supplies drinking water to Indian citizens?

National parties’ unknown income rose from 66% to 71% in the three years before and after the scheme’s introduction

Settlement Overview Video. If you lived at Huronia, Rideau, or Southwestern Regional Centres, you may be eligible to make a claim.