Charlie Plowman, who started the La Cañada Outlook in 1998, will acquire the three community news titles.

After tossing his Scottsdale, Ariz., home on the market last year, retired pitcher Mark Mulder has sold the amenity-loaded home for $1.81 million.

Volkswagen of America CEO Scott Keogh wants to regain your trust.

THE QUEEN has one of the most extensive jewellery collections in the world, and is particularly noted for her tiaras. The Belgian Sapphire is a particular favourite of Her Majesty's - and it has a scandalous former royal owner.

Rafael Nadal expressed his worry this week that there may not be any more tennis in 2020 due to the coronavirus pandemic.

Rafael Nadal has been outspoken with his thoughts on how the Spanish government handled the coronavirus pandemic.

Roger Federer and Rafael Nadal are both waiting for the signal to resume action.

There is an ongoing debate to crown a member of the 'Big Three' as the greatest of all time.

Rafael Nadal has enjoyed a historic career and he is not done yet.

Todd Martin coached Novak Djokovic in his formative years on the ATP Tour and knows what makes him special.

Rafael Nadal revealed this week he was doubtful there will be further tennis in 2020.

Ivan Lendl has weighed in on the ongoing GOAT debate.

EMMERDALE fans could be saying goodbye to Al Chapman later this year if Jai Sharma has anything to do with it.

Ivan Lendl has weighed in on the ongoing GOAT debate.

I wanted to get an understanding of what opening meant to businesses around Dallas. Were they opening? What precautions were they taking? Were employees in safe environments? And bigger picture, I wanted to know if these are places that I would feel safe taking my family to. So I hired a company that specialized in...

Zion National Park officials announced this weekend the park will be reopening May 13 "certain areas" of the park. Here's what that means.

As Dallara's Stefano DePonti saw his parent company begin to manufacture parts for ventilators back in Italy, he knew the IndyCar shop needed to step in to help fight COVID-19.

Through his personal streaming platform, IndyCar veteran Conor Daly's Twitch offers fans a front-row seat to a driver's race-day mind.

Another NASCAR legend will join IndyCar's iRacing Challenge event on Saturday, the first one held on an oval track.

Though he's been heavily into iRacing in recent years, Dale Earnhardt Jr. had never ventured into the world of IndyCar. This week, he's gotten a heavy dose.

He's unsure when he might return to the virtual IndyCar grid, but it's sure not from Dale Earnhardt Jr.'s lack of enjoyment in Saturday's event.

Broadcast on NBC Sports for the second consecutive week, IndyCar's iRacing audience grew 25% from the previous week.

Colts continue adding players after NFL Draft.

A federal judge overseeing the college admissions case on Friday declined to dismiss charges against Lori Loughlin and her co-defendants.

The brand will live on, thanks to Jon Favreau and Baby Yoda.

Darth Vader's former apprentice Ahsoka Tano, as played by Rosario Dawson, will compete with Baby Yoda for attention this fall on Disney Plus.

Princess Cruises were the first cruise line to introduce the Ocean Medallion smart wearable device that is supposed to change the way you cruise. It helps you board the ship faster, find your way around the ship, order food and drink to wherever you are on the ship, gamble and play games , locate your friends and more. But how does it really work? What are the pros and cons? Find out my thoughts, take and review of the Princess Cruises Ocean Medallion.

Andalusia, Southern Spain

Hear about travel to the Andalucia region of Spain as the Amateur Traveler talks to Crawford Hill from Chill Expeditions about his adopted home in Southern Spain. Crawford traveled in that area and then fell in love and bought a second home here.

Hear about travel to Dallas, Texas  as the Amateur Traveler talks to Penny Sadler from adventuresofacarryon.com about her hometown of Dallas, Texas. Penny tells us why we might be surprised at all Dallas has to offer and why we should leave our cowboy hats at home.

Rafael Nadal insists all players, including Novak Djokovic, will need to take a coronavirus vaccine should one become available.

The following article, Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant”, was first published on 100PercentFedUp.com.

Warren Norred, attorney for Shelley Luther, joined Tucker Carlson to discuss the decision by an Obama loyalist Texas judge to jail his client for reopening her salon during the COVID-19 pandemic. Norred said the judge has exposed himself for the “tiny tyrant” that he is. The judge jailed Luther and even fined her $7,000. Texas […]

Continue reading: Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant” ...

The following article, Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut, was first published on 100PercentFedUp.com.

When Dallas, Texas salon owner Shelley Luther opened her salon in defiance of the lockdown order in Texas, she was visited numerous times by the local police and then sentenced to 7 days in jail with a fine of $7,000. After public outrage at her punishment, the Texas Supreme Court stepped in to demand her […]

Continue reading: Video: Dallas Salon Owner Shelley Luther Gets Surprise Visit from Sen Ted Cruz for a Celebratory Haircut ...

In this week's UK Tech Weekly Podcast host Matt Egan is joined by online editor at Techworld.com Scott Carey to discuss all of the news coming out of Microsoft's Build 2016 developer conference, before being joined by producer Chris to talk about the company's genocidal AI chatbot Tay's public meltdown (13:00). Then, acting editor at Macworld.co.uk David Price jumps in to discuss the apparent resolution to the Apple vs FBI fight (29:00).  

See acast.com/privacy for privacy and opt-out information.

It's episode 105, and David Price takes on hosting duties as the team dissect the best and absolute worst of the week's tech developments.

Scott Carey talks us through the troubling and wide-ranging allegations of sexual misconduct at Google, and discusses how this relates to the tech industry's culture of protected privilege, and to the #metoo movement.

Then Henry Burrell, fresh from a briefing at Apple HQ, reports his distinctly positive first impressions of the iPhone XR, which he would gladly recommend to tech newbie grandmas, and also to Scott.

See acast.com/privacy for privacy and opt-out information.

MADRID, Spain (AP): Rafael Nadal says Novak Djokovic will need to be vaccinated to keep playing if the governing bodies of tennis make coronavirus shots obligatory once they become available. Nadal told the Spanish newspaper La Voz de Galicia this...

Inflammation contributes to ventricular remodeling after myocardial ischemia, but its role in nonischemic heart failure is poorly understood. Local tissue inflammation is difficult to assess serially during pathogenesis. Although ¹⁸F-FDG accumulates in inflammatory leukocytes and thus may identify inflammation in the myocardial microenvironment, it remains unclear whether this imaging technique can isolate diffuse leukocytes in pressure-overload heart failure. We aimed to evaluate whether inflammation with ¹⁸F-FDG can be serially imaged in the early stages of pressure-overload–induced heart failure and to compare the time course with functional impairment assessed by cardiac MRI. Methods: C57Bl6/N mice underwent transverse aortic constriction (TAC) (n = 22), sham surgery (n = 12), or coronary ligation as an inflammation-positive control (n = 5). MRI assessed ventricular geometry and contractile function at 2 and 8 d after TAC. Immunostaining identified the extent of inflammatory leukocyte infiltration early in pressure overload. ¹⁸F-FDG PET scans were acquired at 3 and 7 d after TAC, under ketamine-xylazine anesthesia to suppress cardiomyocyte glucose uptake. Results: Pressure overload evoked rapid left ventricular dilation compared with sham (end-systolic volume, day 2: 40.6 ± 10.2 μL vs. 23.8 ± 1.7 μL, P < 0.001). Contractile function was similarly impaired (ejection fraction, day 2: 40.9% ± 9.7% vs. 59.2% ± 4.4%, P < 0.001). The severity of contractile impairment was proportional to histology-defined myocardial macrophage density on day 8 (r = –0.669, P = 0.010). PET imaging identified significantly higher left ventricular ¹⁸F-FDG accumulation in TAC mice than in sham mice on day 3 (10.5 ± 4.1 percentage injected dose [%ID]/g vs. 3.8 ± 0.9 %ID/g, P < 0.001) and on day 7 (7.8 ± 3.7 %ID/g vs. 3.0 ± 0.8 %ID/g, P = 0.006), though the efficiency of cardiomyocyte suppression was variable among TAC mice. The ¹⁸F-FDG signal correlated with ejection fraction (r = –0.75, P = 0.01) and ventricular volume (r = 0.75, P < 0.01). Western immunoblotting demonstrated a 60% elevation of myocardial glucose transporter 4 expression in the left ventricle at 8 d after TAC, indicating altered glucose metabolism. Conclusion: TAC induces rapid changes in left ventricular geometry and contractile function, with a parallel modest infiltration of inflammatory macrophages. Metabolic remodeling overshadows inflammatory leukocyte signal using ¹⁸F-FDG PET imaging. More selective inflammatory tracers are requisite to identify the diffuse local inflammation in pressure overload.

OBJECTIVE

To assess the impact of a telemedicine visit using the platform Diabetic compared with a face-to-face visit on clinical outcomes, patients’ health-related quality of life (HRQoL), and physicians’ satisfaction in patients with type 1 diabetes.

The Dallas Cowboys agreed to terms with free-agent offensive lineman Cameron Erving, the team announced Wednesday.

Dalton signed with the Cowboys on Monday after he was released May 30. Dak Prescott has started every game for the Cowboys since 2016.

The U.S. Navy Flight Demonstration Squadron, also known as the Blue Angels, will fly over Dallas/Fort Worth, Houston and New Orleans Wednesday to honor frontline workers fighting the COVID-19 pandemic.

Gregory G. Schwartz
May 1, 2020; 43:1077-1084
Emerging Therapies: Drugs and Regimens

A Texas appeals court has issued a stay of execution for a death row inmate on grounds he is intellectually disabled.

What band was he with before?