All eyes were on right-hander Forrest Whitley, MLB Pipeline's top pitching prospect, when he threw in the bullpen for the first time Friday in Major League camp. Astros manager AJ Hinch, assistant general manager Brandon Taubman and director of player development Pete Putila were all watching intently as Whitley threw 21 pitches -- fastballs, changeups and cutters.

For the final two spots in the D-backs' bullpen, good luck trying to figure that out just yet. In fact, manager Torey Lovullo has even declined to narrow it down to who could be in contention for those spots.

A young bull went wandering on a Massachusetts highway after escaping from a trailer and was captured without causing any incidents, police said.

Not having to negotiate with federal officials on the finer points of teacher evaluation, rigorous standards, or school turnarounds has made it easier to chart their own paths, some education leaders say.

Looking for new ways to combat kids who bully, some communities are threatening to fine parents with no evidence that the approach is effective.

Huntington's disease -- Patients -- Care.

Depression, Mental -- Etiology.

Heidelberg : C. Winter, 1891.

Leipzig : Vogel, 1904.

London : Layton, 1903.

Paris : A. Davy, 1888.

Paris : O. Doin, 1881.

London : Macmillan, 1896.

Leipzig : Toeplitz & Deuticke, 1887.

London (Braynes-Row, Spa-Fields) : Publish'd ... by R. Pollard printseller, Jany: 30th; 1797.

[Spain?], An. 1817.

Durham, N.C. : [publisher not identified], [1946-1965]

Durham, N. C., Foundation for Research on the Nature of Man, 1965-1969.

Tatiana Stepanova
Apr 1, 2003; 23:2655-2664
Cellular

Giving birth triggers a wide repertoire of physiological and behavioral changes in the mother to enable her to feed and care for her offspring. These changes require coordination and are often orchestrated from the CNS, through as of yet poorly understood mechanisms. A neuronal population with a central role in puerperal changes is the tuberoinfundibular dopamine (TIDA) neurons that control release of the pituitary hormone, prolactin, which triggers key maternal adaptations, including lactation and maternal care. Here, we used Ca²⁺ imaging on mice from both sexes and whole-cell recordings on female mouse TIDA neurons in vitro to examine whether they adapt their cellular and network activity according to reproductive state. In the high-prolactin state of lactation, TIDA neurons shift to faster membrane potential oscillations, a reconfiguration that reverses upon weaning. During the estrous cycle, however, which includes a brief, but pronounced, prolactin peak, oscillation frequency remains stable. An increase in the hyperpolarization-activated mixed cation current, I_h, possibly through unmasking as dopamine release drops during nursing, may partially explain the reconfiguration of TIDA rhythms. These findings identify a reversible plasticity in hypothalamic network activity that can serve to adapt the dam for motherhood.

SIGNIFICANCE STATEMENT Motherhood requires profound behavioral and physiological adaptations to enable caring for offspring, but the underlying CNS changes are poorly understood. Here, we show that, during lactation, neuroendocrine dopamine neurons, the "TIDA" cells that control prolactin secretion, reorganize their trademark oscillations to discharge in faster frequencies. Unlike previous studies, which typically have focused on structural and transcriptional changes during pregnancy and lactation, we demonstrate a functional switch in activity and one that, distinct from previously described puerperal modifications, reverses fully on weaning. We further provide evidence that a specific conductance (I_h) contributes to the altered network rhythm. These findings identify a new facet of maternal brain plasticity at the level of membrane properties and consequent ensemble activity.

The question of bulletproofing vexed physicians and public figures for years, before pioneering inventors experimented with silk

A virus that spreads fear and stigma, as well as disease. It’s the story of HIV/AIDS as well as COVID-19. The former executive director of AIDS Thunder Bay reflects on the similarities he sees between HIV 35 years ago, and the coronavirus now.

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Justin Bieber ignores online bullying | RSS Feeds – IMC OnAir ...: Teen sensation Justin Bieber is used to get bul... http://bit.ly/c455Kn</span></span>

The BIS Statistical Bulletin is published quarterly and summarises all BIS statistics in tabular form. It includes introductions to each data set and a glossary of statistical terms.

Publication by Mr Dimitar Radev, Governor of the Bulgarian National Bank, in the Quarterly Bulletin of the Association of Banks in Bulgaria, issue 61, March 2020.

There are better sports documentaries than The Last Dance, but the entertaining series on the Michael Jordan-led Bulls dynasty might be a better fit for this particular time.

The Chicago Bulls announced Marc Eversley as their new general manager on Friday, making him the first Canadian GM in NBA history.

Carving out a section of low-hanging basement ceiling was a small price to pay to give Travis Bondy the space he needed to play in the Isolation Dart League.

Apple's Jeff Williams says that supply chains are running well and that the company is optimistic about the future for the economy both for itself and for America as a whole.

German translation of the BIS press release about the BIS Quarterly Review, March 2018

Bulgaria coach Luboslav Penev and his staff encouraged over 120 children taking part in a grassroots event in Sofia designed to increase participation in football and other sports.

Hosts Istanbul have the early initiative in Group A after a stunning long-range strike from Serkan Uysal, a free-kick and a late penalty earned a 3-0 win against Ukraine's Ingulec.

Croatia's Zagreb head into the final group game knowing that victory will secure a place in the UEFA Regions' Cup final after they replaced Istanbul at the top of Group A.

Ramazan Kallıoğlu struck deep into added time for the ten-man hosts, to hand Lisboa a third Group A draw, David Cardoso's goal not enough to earn them victory.

Every year about this time, I write a series of articles about suicide and bullying prevention, and this year will be no different. I can always count on advocates and education companies from all over the world to send me information about what's new in the field. Out of all the companies and produ

Some common ways schools work to prevent and respond to bullying are ineffective and, in some cases, counterproductive, concludes a report by the National Academies of Sciences, Engineering, and Medicine.

Almost 20 percent of children, including some as young as 6-10, report being cyberbullied via social media sites and apps, according to a new study.

Supporters of the bill say it would extend critical civil rights protections to more students. But opponents say it ignores parents' rights in schools and could lead to confusing situations for some children.

President Donald Trump has invited a 6th-grade student from Wilmington, Del., to sit in first lady Melania Trump's box during Tuesday's annual address to Congress.

Amid public concerns about school safety fueled by high-profile school shootings, new federal data show reports of student fights, bullying, and other forms of victimization have continued a decades-long decline.

Martha Caldwell, Oman Frame, Terry Roller, Dr. Kris Felicello, John Seborowski, Jessica Hannigan, John Hannigan and Kelly Wickham Hurst share their suggestions for combating bullying.

Virtual bullying can do real damage to students' educational and social progress, according to a new meta-analysis of research in the journal Review of Educational Research.

A Virginia study documents an increase in race-related bullying in middle schools in communities that voted for President Donald Trump, and a drop in those that favored Hilary Clinton.

The highly polarizing 2016 Presidential campaign blitzed the swing state of Virginia. And in the year that followed, a new study in the journal Educational Researcher suggests school bullying problems likewise split along political lines.

First lady Melania Trump unveiled her new "Be Best" initiative last week aimed at promoting emotional well-being, combating cyberbullying, and fighting the opioid crisis.