Серхио Перес продолжит выступать за Red Bull Racing в 2025 году, – об этом пишет испанская газета Marca, ссылаясь на свои источники...

На прошлой неделе сотрудники FIA побывали на базе Red Bull в Милтон-Кинсе для детального изучения внутренней системы регулировки высоты подвески.

Мексиканец признался, что отказался от предложений двух других команд ради продления контракта с Red Bull.

1. Melania Trump's 'I am the most bullied person' video viral as she 'rejects' Jill Biden's tea invite  The Times of India
2. Melania Trump declines invite to meet Jill Biden over Mar-a-Lago raids when FBI ’snooped through her wardrobe’  Mint
3. Jimmy Kimmel again mocks Donald Trump for Melania's ‘interesting’ decision to…  Hindustan Times
4. Biden Invites Trump To White House, But Why Is Melania Refusing To Go?  News18
5. Melania Trump To Skip White House Meeting With Jill Biden: Report  NDTV

Every year I try to keep an eye out for any children's book that gives ample attention to photographs in some way. Thanks to advances in technology and printing, it's never been easier to make books with photographic images. Yet despite this, few come out. Today's list is a small one, but I'm grateful that each and every single one of these books exists.

Bulgarian President Rumen Radev spoke about the threat of climate change at the COP29 climate summit in Baku on Tuesday, where he backed a net zero target, admitting that just 10 years ago, he would have thought the goal was incompatible with competitiveness. The UN summit in Baku runs from 11 to…

When he wrote this letter to his mother in 1944, Roald Dahl was working at the British Embassy in Washington, D.C.—one of hundreds of undercover agents employed by Britain’s MI6 foreign intelligence service to spy on the United States. Dahl’s debut novel, The Gremlins, had been published the year before, and it would be another

Last week, I briefly mentioned the shaded metallic thread sets from Au Ver a Soie that I’m so happy to …

An optical illusion. These circles are concentric. (Baingio Pinna and Richard L. Gregory, “Shifts of Edges and Deformations of Patterns,” Perception 31:12 [December 2002], 1503-1508.)

We’ve all been there – the frustration of searching high and low for that elusive piece of furniture to turn our home decorating vision into reality. For Sabrina, her search was for the ideal console table. “Unfortunately, I could not find the perfect console, so my husband had to believe in it again and build one himself!” she shared on her Instagram post. After realizing that the perfect entryway console was nowhere to be found, the couple decided to take […]

The post Failed Furniture Hunt Inspires Couple’s Fabulous Entryway Console Hack appeared first on IKEA Hackers.

Cybersecurity researchers are calling attention to a new sophisticated tool called GoIssue that can be used to send phishing messages at scale targeting GitHub users. The program, first marketed by a threat actor named cyberdluffy (aka Cyber D' Luffy) on the Runion forum earlier this August, is advertised as a tool that allows criminal actors to extract email addresses from public GitHub

Crews say they faced crucial delays trying to save dying patients because of the time it took to put on equipment.

Teachers can use evidence-based strategies for delivering vocabulary instruction to improve reading comprehension and vice versa by integrating literacy across content areas. These should engage students in active processing, which is essential to student learning and retention.

Children from backgrounds of poverty often lag behind more advantaged peers in early language skills, including breadth and depth of vocabulary knowledge. We report the results of a pilot study of an explicit and elaborated vocabulary intervention in preschool classrooms serving children from lower-income backgrounds. The intervention used multimodal instruction, including segments from public television children's programs and interactive games, to build children's knowledge of and semantic connections for 128 words across 18 weeks of daily lessons.

Sure, some airlines let you work in a free stopover. But Turkish Airlines goes one step further and offers up a free city tour on a stopover as short as six hours. Maybe getting into a shuttle bus and tooling around Istanbul after seven hours on an Airbus isn’t your cup of tea, but if […]

Take a good look at the people melting down on social media because their team didn't win an election. That's what it looks likes when your politics becomes your faith.

The post We Dodged A Demonic Political Bullet appeared first on Clash Daily.

Canan Moodie used his start against Scotland to show that he is about far more than just pace out wide and aerial ability.

By SADF – Nov. 30, 2022 Online conversation on The West, a New Haven for the ‘Muslim Brotherhood’s Planetary Nebula’? On November the 29th at 16H.00 (CET), SADF promoted an online conversation in the web platform StreamYard titled ‘The West, a New Haven for the ‘Muslim Brotherhood’s Planetary Nebula’?’ The conversation included the Member of the European Parliament (EPP, […]

Accumulation of the microtubule-associated protein tau is associated with Alzheimer's disease (AD). In AD brain, tau is abnormally phosphorylated at many sites, and phosphorylation at Ser-262 and Ser-356 plays critical roles in tau accumulation and toxicity. Microtubule affinity–regulating kinase 4 (MARK4) phosphorylates tau at those sites, and a double de novo mutation in the linker region of MARK4, ΔG316E317D, is associated with an elevated risk of AD. However, it remains unclear how this mutation affects phosphorylation, aggregation, and accumulation of tau and tau-induced neurodegeneration. Here, we report that MARK4ΔG316E317D increases the abundance of highly phosphorylated, insoluble tau species and exacerbates neurodegeneration via Ser-262/356–dependent and –independent mechanisms. Using transgenic Drosophila expressing human MARK4 (MARK4wt) or a mutant version of MARK4 (MARK4ΔG316E317D), we found that coexpression of MARK4wt and MARK4ΔG316E317D increased total tau levels and enhanced tau-induced neurodegeneration and that MARK4ΔG316E317D had more potent effects than MARK4wt. Interestingly, the in vitro kinase activities of MARK4wt and MARK4ΔG316E317D were similar. When tau phosphorylation at Ser-262 and Ser-356 was blocked by alanine substitutions, MARK4wt did not promote tau accumulation or exacerbate neurodegeneration, whereas coexpression of MARK4ΔG316E317D did. Both MARK4wt and MARK4ΔG316E317D increased the levels of oligomeric forms of tau; however, only MARK4ΔG316E317D further increased the detergent insolubility of tau in vivo. Together, these findings suggest that MARK4ΔG316E317D increases tau levels and exacerbates tau toxicity via a novel gain-of-function mechanism and that modification in this region of MARK4 may affect disease pathogenesis.

NEW YORK (AP): The Rockefeller Center Christmas tree arrived in New York City on Saturday, signalling the start of the holiday season in the Big Apple. The 74-foot Norway spruce was driven into Manhattan's Center Plaza, where it was hoisted in...

Proteins in the α-macroglobulin (αM) superfamily use thiol esters to form covalent conjugation products upon their proteolytic activation. αM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas those of αM complement components C3 and C4B have an increased hydroxyl reactivity that is conveyed by a conserved histidine residue and allows conjugation to cell surface glycans. Human α2-macroglobulin–like protein 1 (A2ML1) is a monomeric protease inhibitor but has the hydroxyl reactivity–conveying histidine residue. Here, we have investigated the role of hydroxyl reactivity in a protease inhibitor by comparing recombinant WT A2ML1 and the A2ML1 H1084N mutant in which this histidine is removed. Both of A2ML1s' thiol esters were reactive toward the amine substrate glycine, but only WT A2ML1 reacted with the hydroxyl substrate glycerol, demonstrating that His-1084 increases the hydroxyl reactivity of A2ML1's thiol ester. Although both A2ML1s conjugated and inhibited thermolysin, His-1084 was required for the conjugation and inhibition of acetylated thermolysin, which lacks primary amines. Using MS, we identified an ester bond formed between a thermolysin serine residue and the A2ML1 thiol ester. These results demonstrate that a histidine-enhanced hydroxyl reactivity can contribute to protease inhibition by an αM protein. His-1084 did not improve A2ML1's protease inhibition at pH 5, indicating that A2ML1's hydroxyl reactivity is not an adaption to its acidic epidermal environment.