Books played an important role in Aslan's salvation. Now he provides literature to other Central Asians.

A small team share stories and spread hope among least-reached Muslims in Central Asia.

Several civil society groups and student organisations of the Kuki tribes have condemned what they call "barbaric actions" of the Central Reserve Police Force (CRPF), a day after 10 men from the Kuki tribes were killed in Manipur's Jiribam district.

Radhakrishnan panel has submitted its report outlining reforms in the NTA and the authorities would need the state's cooperation to implement it.

Bharat Sanchar Nigam Limited (BSNL) has announced the launch of the first fibre-based intranet TV service in select regions in India. This service, dubbed IFTV, was first introduced last month alongside the unveiling of the state-owned telecommunications provider’s new logo and six other new facilities.

Dover, Del. (July 15, 2021) – The Delaware Division of Small Business and Office of Management and Budget (OMB) announced today the launch of a Market Pressure Relief Fund designed to assist state contractors facing increased costs for construction materials due to the pandemic. The fund will provide adjustment reimbursements for non-transportation construction materials purchased […]

DOJ-CLASI agreement covers most disputes with community owners Attorney General Kathy Jennings announced Monday that manufactured home owners in disputes with their community owners will be eligible for free legal representation by the non-profit Delaware Community Legal Aid Society, Inc. (CLASI), under a contract it entered with the Delaware Department of Justice. “Constituents in all three counties have […]

Attorney General Kathy Jennings’ Consumer Protection Unit promulgated final regulations that establish clear rules of the road for the Home Improvement Services industry in Delaware.  The regulations, issued pursuant to the Consumer Fraud Act, become effective today, November 1. The Regulation is based on hundreds of complaints received by the Department of Justice, and it requires a number […]

FOR IMMEDIATE RELEASE THURSDAY, OCTOBER 1, 2020   MEDIA CONTACT: Kenneth Briscoe Delaware Department of Labor Communications Coordinator kenneth.briscoe@delaware.gov   Thursday, October 1, 2020, The Delaware Department of Labor announced that the effective date of The Delaware Contractor Registration Act has been extended to July 1, 2021.    On September 28, 2020, Governor John Carney […]

The Delaware Department of Agriculture is administering the program and will be accepting applications until December 1, 2020.

Detecting illicit financial flows require much more than using traditional business methods. At this point, using centrality metrics in investigation and analytical models will provide wider detection approaches.

Using centrality metrics to detect illicit financial flows was published on SAS Users.

Dover, DE – The Delaware Department of Correction (DOC) announced today that it has signed three-year contracts with VitalCore Health Strategies to provide medical care, behavioral health care and substance use disorder treatment to individuals under DOC supervision. The DOC’s Bureau of Healthcare, Substance Abuse and Mental Health Services is responsible for contracting medical and behavioral health services in all […]

The Delaware Department of Natural Resources and Environmental Control announced that A-Del Construction of Newark has been awarded the contract for the replacement of the Bancroft Bridge in Alapocas Run State Park. Construction is tentatively scheduled to begin Oct. 1 and be completed in April 2025. Replacement of the existing Bancroft Bridge has been one of the DNREC Division of Parks and Recreation’s highest priorities since its emergency closure September 2021 when it was damaged beyond repair due to Hurricane Ida floodwaters.

OFFICE OF MANAGEMENT AND BUDGET: Division Of Facilities Management

THE Ministry of Commerce yesterday added two United States companies to the Unreliable Entity List over their involvement in arms sales to China’s Taiwan region. In a statement, the ministry said it

The Delimitation of the Extended Continental Shelves in the Central Arctic Ocean The Delimitation of the Extended Continental Shelves in the Central Arctic Ocean

Mexico City — Gunmen in a truck pulled up to a bar in central Mexico and opened fire, killing 10 people, authorities said, in an area that had been spared the worst of the country's raging criminal violence.  Security camera footage published by local media showed the perpetrators leaping from the vehicle and bursting into the venue as terrified customers fled or dived to the floor.   The attack late Saturday on Los Cantaritos bar in Queretaro's downtown district left 10 people dead and at least seven injured, according to the city's public security department chief Juan Luis Ferrusca.   "Emergency services arrived at the scene and confirmed that at least four people armed with long weapons had arrived on board a pickup truck," Ferrusca said in a video on social media.  One suspect was detained and the vehicle used in the attack was found abandoned and set on fire, he said.  The victims included three women, according to the Queretaro state prosecutor's office, which said forensic experts were examining the scene of the attack and the vehicle.  Queretaro, the capital of Queretaro state, is considered one of the safer cities in Mexico, which has been plagued by years of drug cartel-related violence.  "The entire security system of Queretaro is mobilized to find the criminals" behind the attack, state governor Mauricio Kuri said on social media platform X.  "We will continue to shield our borders and maintain the security of our state," he said, adding, "Those responsible for this brutal act will be punished."  Queretaro, a city known more for its colonial architecture than for its crime, is around 200 kilometers northwest of Mexico City.   Across Mexico, spiraling violence, much of it linked to drug trafficking and gangs, has seen more than 450,000 people murdered since 2006.   Tackling the murders and kidnappings that are a daily occurrence is among the major challenges facing President Claudia Sheinbaum.  The former Mexico City mayor, who became the country's first woman president on October 1, has ruled out declaring "war" on drug cartels.  Instead, she has pledged to continue her predecessor's strategy of using social policy to tackle crime at its roots, while also making better use of intelligence.   The northwestern cartel stronghold of Sinaloa has seen a surge in violence since the July arrest of drug lord Ismael Zambada in the United States unleashed a wave of gang infighting.   There has also been a spike in bloodshed in the southern state of Guerrero, the scene of long-running gang turf wars.   Authorities said Thursday that the bodies of 11 people, including two minors, were found abandoned in a pickup truck in the state capital Chilpancingo.  They were part of a group of 17 people -- reported to be traveling merchants -- who were declared missing last month.         

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

The town planning department on Tuesday signed a contract for the demolition of two apartment buildings in the government housing settlement of Platy in Aglandja, Nicosia, as part of the government’s Ktizo plan, which aims atimproving living conditions in refugee estates. According to a statement released by the interior ministry, the agreed cost for the […]

Construction company Aktor (formerly Intrakat) is now seeking over €35 million in damages through the courts after the public works department terminated the contract with regarding the Paphos-Polis road project, according to its CEO Alexandros Exarchou, who spoke at an online press conference. “We are compelled to pursue our legal rights in Cyprus and, if […]

The Paphos-Polis highway is the fourth public project this government has terminated because of major disputes with the contractor. Last year it pulled the plug on the waste treatment plant in Pentakomo, while earlier this year it ended the contract for the Larnaca port and marina with Kition Ocean Holdings followed by the termination of […]

A sovereign exposure exchange is a cost-effective risk management tool used by multilateral development banks (MDBs) to reduce sovereign portfolio concentration risks. It provides capital relief for MDBs by exchanging loan guarantees on credit exposure from borrowing countries where an MDB is highly concentrated for exposure to countries where the MBD’s exposure is lower or nonexistent.

Keynote address by Masatsugu Asakawa, President, Asian Development Bank, at the 23rd Ministerial Conference of the Central Asia Regional Economic Cooperation Program, 8 November 2024

This study finds contract farming in Lao PDR to be effective in raising incomes of small farmers, thus reducing poverty.

Long feted by fossil hunters and geologists, if UNESCO recognises the extraordinary rock formation at Madygen in Kyrgyzstan, it will soon be a player on the world stage

Title: 'Extended Cycle' Contraception Garners More Interest
Category: Health News
Created: 8/25/2008 2:00:00 AM
Last Editorial Review: 8/25/2008 12:00:00 AM

Title: Could Oral Contraceptives Help Ease Rheumatoid Arthritis?
Category: Health News
Created: 8/28/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM

Title: 6 in 10 of America's Single Guys 'Take Responsibility' for Contraception
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM

Title: Boom in Pot 'Concentrates' Could Pose Addiction Risk for Teens
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: FDA Mulling Over-the-Counter Sale of Contraceptive Pill
Category: Health News
Created: 7/11/2022 12:00:00 AM
Last Editorial Review: 7/11/2022 12:00:00 AM

Extract

We read with great interest the correspondence by T. Bitter and co-workers in the European Respiratory Review, about our recently published review entitled "Central sleep apnoea: not just one phenotype" [1]. We first want to express our gratefulness to the authors for their support and appreciation of our work, particularly regarding the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Mapping transcriptomic variations using either short- or long-read RNA sequencing is a staple of genomic research. Long reads are able to capture entire isoforms and overcome repetitive regions, whereas short reads still provide improved coverage and error rates. Yet, open questions remain, such as how to quantitatively compare the technologies, can we combine them, and what is the benefit of such a combined view? We tackle these questions by first creating a pipeline to assess matched long- and short-read data using a variety of transcriptome statistics. We find that across data sets, algorithms, and technologies, matched short-read data detects ~30% more splice junctions, such that ~10%–30% of the splice junctions included at ≥20% by short reads are missed by long reads. In contrast, long reads detect many more intron-retention events and can detect full isoforms, pointing to the benefit of combining the technologies. We introduce MAJIQ-L, an extension of the MAJIQ software, to enable a unified view of transcriptome variations from both technologies and demonstrate its benefits. Our software can be used to assess any future long-read technology or algorithm and can be combined with short-read data for improved transcriptome analysis.

Purpose Health care professionals (HCPs) working collaboratively can improve patient outcomes and also increase their understanding of each other’s professional roles. This descriptive study aimed to explore dental hygienists’ perceptions of collaboration with dentists and intraprofessional educational (IntraPE) experiences.Methods A convenience sampling method was used to assess DHs perceptions of collaboration with dentists using the Interprofessional Collaboration Scale (ICS), a validated scale that measures perceptions of communication, accommodation, and isolation among HCPs. One open-ended question was added to explore IntraPE. Demographics, work characteristics and responses from the ICS were analyzed using frequency, mean, standard deviation, Pearson’s correlation, t-test, ANOVA, and multivariable regression. Responses from the open-ended question were transcribed, organized, and coded. Themes were identified using the Delve Qualitative Analysis Tool.Results Of the 264 participants, the average age was 38.9, and most identified as female (98.9%). Data analysis revealed that DHs had positive perceptions of collaboration with dentists. Significant relationships were found between ICS factor accommodation and the average number of patients treated per day (rs = −0.242, p<0.001), dentists’ age (rs = −.145, p<0.05). Isolation showed a significant negative correlation with the average number of patients treated per day (rs = −0.156, p<0.05). Most reported having no opportunities for IntraPE education experiences with dentists. Five categories of themes were identified from the open-ended question: shared academic setting, clinic dentist, externships, desire for more shared learning, and shared patient experiences.Conclusion Dental hygienists in this study had an overall more positive than negative perception of collaboration with dentists. Dental and dental hygiene programs should focus on intraprofessional education experiences to continue to enhance collaboration.

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

ABSTRACTWe document the effort over the last 30 years to respond to the call by women advocates at the International Conference on Population and Development for more woman-initiated single or dual-purpose contraceptive methods by developing the Caya contoured diaphragm, an innovative diaphragm designed to meet the needs of women and their partners and expand options for nonhormonal barrier contraception. We describe the complex and interrelated set of activities undertaken to develop the product using a human-centered design process and how we are working to create a corollary sustainable market. This review includes the evidence generated around improved acceptability among couples in low- and middle-income countries and depicts challenges and practical actions on how to dispel misconceptions about diaphragm use. Importantly, we share programmatic lessons learned on increasing universal access to this new sexual and reproductive health technology. Following our new model for increasing access to new and underutilized methods, Caya is now registered and being marketed in nearly 40 countries worldwide.

ABSTRACTIntroduction:Emergency contraceptive pills (ECPs) are effective and can be used safely at any age repeatedly within the same cycle. They are often favored by youth yet are underutilized. Private facilities can increase ECP access but present barriers including cost. Identifying effective public-sector ECP distribution models can help ensure equitable access. The Malawi Ministry of Health developed a strategy to improve ECP access in 2020. We documented ECP provision through select public, youth-serving channels recommended by the strategy: general and youth-specific outreach, paid and unpaid community health workers (CHWs), and youth clubs.Methods:We conducted this mixed methods study from November 2022–March 2023 in 2 rural districts (Mchinji and Phalombe) implementing the strategy. We conducted qualitative interviews with 10 national stakeholders, 46 providers, and 24 clients aged 15–24 years about ECP service delivery. Additionally, 25 providers collected quantitative tally data about clients seeking ECPs. We analyzed qualitative data using grounded theory and quantitative data descriptively.Results:Stakeholders and providers reported ECP uptake increased in geographies where the strategy was implemented, especially among youth. Providers documented 3,988 client visits for ECPs over 3 months. Of these visits, 26% were from male clients, 36% were from clients aged younger than 20 years, and 64% received ECPs for the first time. Across channels, youth club leaders and unpaid CHWs reported the most client visits per provider and served the youngest clients. However, no ECPs were dispensed during 29% of visits due to stock-outs. While many providers were supportive of youth accessing ECPs, most held unfavorable attitudes toward repeat use.Conclusion:ECP access should be expanded through provision in the studied channels, especially youth clubs and CHWs. However, to meet demand, the supply chain must be strengthened. We recommend addressing providers’ attitudes about repeat use to ensure informed method choice.

ABSTRACTIntroduction:Health risks associated with short interpregnancy intervals, coupled with women’s desires to avoid pregnancy following childbirth, underscore the need for effective postpartum family planning programs. The antenatal period provides an opportunity to intervene; however, evidence is limited on the effectiveness of interventions aimed at reaching women in the antenatal period to increase voluntary postpartum family planning in low- and middle-income countries (LMICs). This systematic review aimed to identify and describe interventions in LMICs that attempted to increase postpartum contraceptive use via contacts with pregnant women in the antenatal period.Methods:Studies published from January 2012 to July 2022 were considered if they were conducted in LMICs, evaluated an intervention delivered during the antenatal period, were designed to affect postpartum contraceptive use, were experimental or quasi-experimental, and were published in French or English. The main outcome of interest was postpartum contraceptive use within 1 year after birth, defined as the use of any method of contraception at the time of data collection. We searched EMBASE, Global Health, and Medline and manually searched the reference lists from studies included in the full-text screening.Results:We double-screened 771 records and included 34 reports on 31 unique interventions in the review. Twenty-three studies were published from 2018 on, with 21 studies conducted in sub-Saharan Africa. Approximately half of the study designs (n=16) were randomized controlled trials, and half (n=15) were quasi-experimental. Interventions were heterogeneous. Among the 24 studies that reported on the main outcome of interest, 18 reported a positive intervention effect, with intervention recipients having greater contraceptive use in the first year postpartum.Conclusion:While the studies in this systematic review were heterogeneous, the findings suggest that interventions that included a multifaceted package of initiatives appeared to be most likely to have a positive effect.

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine the prevalence of IIH and RPT eligibility in mCRPC patients through a triple-tracer PET imaging strategy. Methods: This was a multisite prospective observational study in which mCRPC patients underwent both ¹⁸F-FDG and ⁶⁸Ga-prostate-specific membrane antigen (PSMA)–617 PET/CT scans. A third scan with ⁶⁸Ga-DOTATATE, a potential biomarker of neuroendocrine differentiation, was performed if an ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found. Per-tracer lesion positivity was defined as having an uptake at least 50% above that of the liver. IIH prevalence was defined as the percentage of participants having at least 2 lesions with discordant features on multitracer PET. Results: IIH was observed in 81 patients (82.7%), and at least 1 ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found in 45 patients (45.9%). Of the 37 participants who also underwent ⁶⁸Ga-DOTATATE PET/CT, 6 (16.2%) had at least 1 ⁶⁸Ga-DOTATATE–positive lesion. In total, 12 different combinations of lesion imaging phenotypes were observed. On the basis of our prespecified criteria, 52 (53.1%) participants were determined to be eligible for PSMA RPT, but none for DOTATATE RPT. Patients with IIH had a significantly shorter median overall survival than patients without IIH (9.5 mo vs. not reached; log-rank P = 0.03; hazard ratio, 2.7; 95% CI, 1.1–6.8). Conclusion: Most mCRPC patients showed IIH, which was associated with shorter overall survival. On the basis of a triple-tracer PET approach, multiple phenotypic combinations were found. Correlation of these imaging phenotypes with genomics and treatment response will be relevant for precision medicine.

BACKGROUND AND PURPOSE:

A cleftlike nonenhancing hypointensity was observed repeatedly in the pituitary gland at the adenohypophysis/neurohypophysis border on contrast-enhanced 3D fat-saturated T1-MPRAGE using clinical 7T MRI. Our primary goal was to assess the prevalence of this finding. The secondary goals were to evaluate the frequency of other incidental pituitary lesions, MRI artifacts, and their effect on pituitary imaging on the contrast-enhanced 3D fat-saturated T1 MPRAGE at 7T.