This Metasploit module exploits a stack overflow in the NetApi32 CanonicalizePathName() function using the NetpwPathCanonicalize RPC call in the Server Service. It is likely that other RPC calls could be used to exploit this service. This exploit will result in a denial of service on on Windows XP SP2 or Windows 2003 SP1. A failed exploit attempt will likely result in a complete reboot on Windows 2000 and the termination of all SMB-related services on Windows XP. The default target for this exploit should succeed on Windows NT 4.0, Windows 2000 SP0-SP4+, Windows XP SP0-SP1 and Windows 2003 SP0.

A tool only has value if it’s used. For example, you could be the sort of person who’s set a goal of wanting to exercise more. If someone gives you a nifty little Fitbit to help you do that, and you never open the box, how useful, then, is this little device? The same is true about smart energy management solutions: good tools exist, but whether it’s calories or energy use that you want to cut, at some point those helpful devices need to be unpacked.

Carbon emissions in 2014 remained at the previous year’s levels of 32.3 billion metric tons — a milestone that points to the impact worldwide renewable energy investment is having in the face of a 1.5 percent annual increase in global energy consumption, according to a new report from REN21. The tenth annual Renewables 2015 Global Status Report cites “increased penetration of renewable energy” and improvements in energy efficiency as the chief reasons for the noted emissions stabilization.

Papua New Guinea recently became the first country to formally submit the final version of its national climate action plan (called a “Nationally Determined Contribution,” or NDC) under the Paris Agreement. The small Pacific nation’s plan to transition to 100 percent renewable energy by 2030 is no longer just an “intended” nationally determined contribution (INDC) — it is now the country’s official climate plan.

Acting US director of national intelligence Richard Grenell says he spoke "with an influential Lebanese Shi'ite leader" who is "close" to coming out publicly in favor of decriminalizing homosexuality

Professor Ashutosh Varshney of Brown University analyzes the current state of India's democratic system as well as the strengths and challenges in this rapidly growing nation. Full interview.

- 5 MIN READ -

The post How Data-driven Personalized Learning is Propelling the Learning Industry Forward appeared first on e-Learning Feeds.

Watch A Week With Warnie, part of a week-long pop-up channel on Foxtel and Foxtel Now, from Monday 8pm (EST)!

Singer Janet Jackson has been admitted to hospital after she fell ill hours before her scheduled concert in Montreal, Canada. The 42-year-old singer got

Bags play an important role in our everyday life. Have a look around and you will see everyone with a bag of their own. Be it a student, a working women, a businessman, for that matter anyone, bags are inseparable.

In...

The purpose of this joint OECD/AFD initiative is to propose ways of thinking about new public policies that could better harness the skills of diasporas to foster development in the countries of origin.

This interactive chart, designed by Krisztina Szucs and Mate Cziner from Hungary, condenses highly complex data on the costs and benefits of education around the world. It clearly highlights important facts showing students, parents and policy makers where the real costs and benefits lie for them in relation to education

Equalities Minister Liz Truss ordered EqualiTeach to stop using the logo of the Government Equalities Office on its controversial guidelines stating teachers must allow trans pupils to use toilets of their choice.

Broadway star Ruthie Ann Miles, 37, has given birth to a baby girl and announced it on her Instagram. Hope Elizabeth was born last month to her and husband Jonathan Blumenstein.

Lizzo pulled out all the stops as she took to the stage for the Brit Awards at the O2 Arena on Tuesday night.

The singer, 31, ensured all eyes were on her as she arrived on the red carpet at the BRIT Awards at The 02 Arena in London on Thursday.

Lizzo, 31, looked sensational in a sheer dress over a racy corset for her afterparty look, emerging from The Box after a night of party hopping.

The Ferrari 250 spend six years in service chasing criminals through the streets of Rome, making it the most stylish paddy wagon to have patrolled roads.

There were 572 new hospitalizations due to coronavirus reported in New York on Friday, Gov. Andrew Cuomo said Saturday. This is the lowest number since the lockdown on March 20.

An Australian recruiter has listed the three biggest mistakes job candidates make on social media that could cost them a career.

While I was undergoing a life MOT, I realised there was one area I had overlooked - my hearing

The past week has got me wondering. Do we date men in order to have a plus one?

I decided not to invite David to my friend's wedding, partly because he was away at a party in France but also because I couldn't afford to have yet another expensive mini-break ruined

My boyfriend J can't understand why I keep in touch with former lovers when he isn't in touch with any of his. It's become something of a joke between us...

Believe it or not, it's a thing. But 'mermaiding' runs far deeper than simply dressing up in a silicone tail. So what's the big pull?

I'm in Los Angeles at the moment. I advise you to look away now if the casual smugness of that opening sentence was too much to bear

It wasn't my best couple of days. Having had my face-lift outed over pre-wedding drinks at the Saunton Sands Wellness Spa, I got back to my little hotel on Friday night to find...

He enjoyed a PDA-filled romance with UK actress Elizabeth Hurley between 2010 and 2013. 

October is domestic violence awareness month. Pushpa Achanta shares stories of victims of domestic violence to point out why the dilution of IPC Section 498A by the Supreme Court is a blow to the fight against domestic violence.

The Coronavirus crisis has left us all reevaluating our priorities in life. Bollywood celebrities too have had to pause their busy lives during the lockdown and spend time reflecting. Radhika Madan shared what has been the biggest learning from the crisis

A while ago, I was wondering how exactly one triggers HTML5’s XML mode — let’s call it XHTML5 from now on. You know, just out of curiosity. I’ll always prefer HTML over XHTML because it’s much less verbose and I like to keep things simple.

Co-morbidity, late hospitalization ailing Gujarat: AIIMS chief | Ahmedabad News - Times of India

Director of All India Institute of Medical Sciences, Delhi (AIIMS-D), Dr Randeep Guleria on Saturday said that late hospitalization of Covid-19 patients due to fear of stigma and higher prevalence of co-morbid conditions like diabetes, hypertension, heart and kidney disease were key reasons behind the high number of Civid-19 deaths in Gujarat.

Compact X-ray sources based on inverse Compton scattering provide brilliant and partially coherent X-rays in a laboratory environment. The cross section for inverse Compton scattering is very small, requiring high-power laser systems as well as small laser and electron beam sizes at the interaction point to generate sufficient flux. Therefore, these systems are very sensitive to distortions which change the overlap between the two beams. In order to monitor X-ray source position, size and flux in parallel to experiments, the beam-position monitor proposed here comprises a small knife edge whose image is acquired with an X-ray camera specifically designed to intercept only a very small fraction of the X-ray beam. Based on the source position drift recorded with the monitor, a closed-loop feedback stabilizes the X-ray source position by adjusting the laser beam trajectory. A decrease of long-term source position drifts by more than one order of magnitude is demonstrated with this device. Consequently, such a closed-loop feedback system which enables stabilization of source position drifts and flux of inverse Compton sources in parallel to experiments has a significant impact on the performance of these sources.

To investigate the effect of high-energy X-rays on site-specific radiation-damage, low-dose diffraction data were collected from radiation-sensitive crystals of the metal enzyme cytochrome c oxidase. Data were collected at the Structural Biology I beamline (BL41XU) at SPring-8, using 30 keV X-rays and a highly sensitive pixel array detector equipped with a cadmium telluride sensor. The experimental setup of continuous sample translation using multiple crystals allowed the average diffraction weighted dose per data set to be reduced to 58 kGy, and the resulting data revealed a ligand structure featuring an identical bond length to that in the damage-free structure determined using an X-ray free-electron laser. However, precise analysis of the residual density around the ligand structure refined with the synchrotron data showed the possibility of a small level of specific damage, which might have resulted from the accumulated dose of 58 kGy per data set. Further investigation of the photon-energy dependence of specific damage, as assessed by variations in UV-vis absorption spectra, was conducted using an on-line spectrometer at various energies ranging from 10 to 30 keV. No evidence was found for specific radiation damage being energy dependent.

The high temporal resolution in data acquisition, possible in the quick-scanning EXAFS (QEXAFS) mode of operation, provides new challenges in efficient data processing methods. Here a new approach is developed that combines an easy to use interactive graphical interface with highly optimized and fully parallelized Python-based routines for extracting, normalizing and interpolating oversampled time-resolved XAS spectra from a raw binary stream of data acquired during operando QEXAFS studies. The programs developed are freely available via a Github repository.

The redetermination of the crystal structure of barium oxidotellurate(IV) monohydrate allowed the localization of the hydrogen atoms that were not determined in the previous study [Nielsen, Hazell & Rasmussen (1971). Acta Chem. Scand. 25, 3037–3042], thus making an unambiguous assignment of the hydrogen-bonding scheme possible. The crystal structure shows a layered arrangement parallel to (001), consisting of edge-sharing [BaO6(H2O)] polyhedra and flanked by isolated [TeO3] trigonal pyramids on the top and bottom. O—H⋯O hydrogen bonds of medium strength link adjacent layers along [001].

Six reaction products of ZnII and NiII with pyridine-2,6-di­carb­oxy­lic acid (H2Lig1), 4-chloro­pyridine-2,6-di­carb­oxy­lic acid (H2Lig2) and 4-hy­droxy­pyridine-2,6-di­carb­oxy­lic acid (H2Lig3) are used to pinpoint the structural consequences of crystal field stabilization by an incomplete d shell. The pseudo-octa­hedral ZnII coordination sphere in bis­(6-carb­oxy­picolinato)zinc(II) trihydrate, [Zn(C7H4NO4)2]·3H2O or [Zn(HLig1)2]·3H2O, (1), is significantly less regular than that about NiII in the isostructural compound bis­(6-carb­oxy­picolinato)nickel(II) trihydrate, [Ni(C7H4NO4)2]·3H2O or [Ni(HLig1)2]·3H2O, (2). The ZnII complexes poly[(4-chloro­pyridine-2,6-di­carboxyl­ato)zinc(II)], [Zn(C7H2ClNO4)]n or [Zn(Lig2)]n, (3), and poly[[(4-hy­droxy­pyridine-2,6-di­carboxyl­ato)zinc(II)] monohydrate], {[Zn(C7H3NO5)]·H2O}n or {[Zn(Lig3)]·H2O}n, (4), represent two-dimensional coordination polymers with chelating and bridging pyridine-2,6-di­carboxyl­ate ligands in which the coordination polyhedra about the central cations cannot be associated with any regular shape; their coordination environments range between trigonal–bipyramidal and square-pyramidal geometries. In contrast, the corresponding adducts of the diprotonated ligands to NiII, namely tri­aqua­(4-chloro­pyridine-2,6-di­carboxyl­ato)nickel(II), [Ni(C7H2ClNO4)(H2O)3] or [NiLig2(OH2)3)], (5), and tri­aqua­(4-hy­droxy­pyridine-2,6-di­carboxyl­ato)nickel(II) 1.7-hydrate, [Ni(C7H3NO5)(H2O)3]·1.7H2O or [NiLig3(OH2)3)]·1.7H2O, (6), feature rather regular octa­hedral coordination spheres about the transition-metal cations, thus precluding the formation of analogous extended structures.

Highly Brønsted-acidic boron trifluoride monohydrate, a widely used `super acid-catalyst', is a colourless fuming liquid that releases BF3 at room temperature. Com­pared to the liquid com­ponents, i.e. boron trifluoride monohydrate and 1,4-dioxane, their 1:1 adduct, BF3H2O·C4H8O2, is a solid with pronounced thermal stability (m.p. 401–403 K). The crystal structure of the long-time-stable easy-to-handle and weighable com­pound is reported along with new preparative aspects and the results of 1H, 11B, 13C and 19F spectroscopic investigations, particularly documenting its high Brønsted acidity in aceto­nitrile solution. The remarkable stability of solid BF3H2O·C4H8O2 is attributed to the chain structure established by O—H⋯O hydrogen bonds of exceptional strength {O2⋯H1—O1 [O⋯O = 2.534 (3) Å] and O1—H1⋯O3i [2.539 (3) Å] in the concatenating unit >O2⋯H1—O1—H2⋯O3i<}, taking into account the mol­ecular (non-ionic) character of the structural moieties. Indirectly, this structural feature documents the outstanding acidification of the H2O mol­ecule bound to BF3 and reflects the super acid nature of BF3H2O. In detail, the C22(7) zigzag chain system of hydrogen bonding in the title structure is characterized by the double hydrogen-bond donor and double (κO,κO') hydrogen-bond acceptor functionality of the aqua ligand and dioxane molecule, respectively, the almost equal strength of both hydrogen bonds, the approximatety linear arrangement of the dioxane O atoms and the two neighbouring water O atoms. Furthermore, the approximately planar arrangement of B, F and O atoms in sheets perpendicular to the c axis of the ortho­rhom­bic unit cell is a characteristic structural feature.

The title compound [systematic name: (1R*, 8S)-2-acetamidoocta­hydro­pyrrol­izin-4-ium chloride–N-[(1R, 8S)-hexa­hydro-1H-pyrrolizin-2-yl)acetamide (1/1)], 2(C9H16N2O)·HCl or C9H17N2O+·Cl−·C9H16N2O, arose as an unexpected product when 1-exo-acetamido­pyrrolizidine (AcAP; C9H16N2O) was dissolved in CHCl3. Within the AcAP pyrrolizidine group, the unsubstituted five-membered ring is disordered over two orientations in a 0.897 (5):0.103 (5) ratio. Two AcAP mol­ecules related by a crystallographic twofold axis link to H+ and Cl− ions lying on the rotation axis, thereby forming N—H⋯N and N—H⋯Cl⋯H—N hydrogen bonds. The first of these has an unusually short N⋯N separation of 2.616 (2) Å: refinement of different models against the present data set could not distinguish between a symmetrical hydrogen bond (H atom lying on the twofold axis and equidistant from the N atoms) or static or dynamic disorder models (i.e. N—H⋯N + N⋯H—N). Computational studies suggest that the disorder model is slightly more stable, but the energy difference is very small.

The title compound, C24H18FNO3, crystallizes in the monoclinic centrosymmetric space group P21/n and its mol­ecular conformation is stabilized via C—H⋯O intra­molecular inter­actions. The supra­molecular network mainly comprises C—H⋯O, C—H⋯F and C—H⋯π inter­actions, which contribute towards the formation of the crystal structure. The different inter­molecular inter­actions have been further analysed via Hirshfeld surface analysis and fingerprint plots.

Five examples each of 3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-ones and the corresponding 1-(4-azido­phen­yl)-3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones have been synthesized in a highly efficient manner, starting from a common source precursor, and structures have been determined for three examples of each type. In each of 3-[5-(2-chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-one, C28H21ClN2O3, (Ib), the isomeric 3-[5-(2-chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn-1-yl­oxy)phen­yl]prop-2-en-1-one, (Ic), and 3-[3-methyl-5-(naphthalen-2-yl­oxy)-1-phenyl-1H-pyrazol-4-yl]-1-[4-(prop-2-yn­yloxy)phen­yl]prop-2-en-1-one, C32H24N2O3, (Ie), the mol­ecules are linked into chains of rings, formed by two independent C—H⋯O hydrogen bonds in (Ib) and by a combination of C—H⋯O and C—H⋯π(arene) hydrogen bonds in each of (Ic) and (Ie). There are no direction-specific inter­molecular inter­actions in the structure of 1-(4-azido­phen­yl)-3-[3-methyl-5-(2-methyl­phen­oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C26H21N5O2, (IIa). In 1-(4-azido­phen­yl)-3-[5-(2,4-di­chloro­phen­oxy)-3-methyl-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C25H17Cl2N5O2, (IId), the di­chloro­phenyl group is disordered over two sets of atomic sites having occupancies 0.55 (4) and 0.45 (4), and the mol­ecules are linked by a single C—H⋯O hydrogen bond to form cyclic, centrosymmetric R22(20) dimers. Similar dimers are formed in 1-(4-azido­phen­yl)-3-[3-methyl-5-(naphthalen-2-yl­oxy)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one, C29H21N5O2, (IIe), but here the dimers are linked into a chain of rings by two independent C—H..π(arene) hydrogen bonds. Comparisons are made between the mol­ecular conformations within both series of compounds.

SVAT4 is a computer program for interactive visualization of three-dimensional crystal structures, including chemical bonds and magnetic moments. A wide range of functions, e.g. revealing atomic layers and polyhedral clusters, are available for further structural analysis. Atomic sizes, colors, appearance, view directions and view modes (orthographic or perspective views) are adjustable. Customized work for the visualization and analysis can be saved and then reloaded. SVAT4 provides a template to simplify the process of preparation of a new data file. SVAT4 can generate high-quality images for publication and animations for presentations. The usability of SVAT4 is broadened by a software suite for simulation and analysis of electron diffraction patterns.

A rational way to find the appropriate conditions to grow crystal samples for bio-crystallography is to determine the crystallization phase diagram, which allows precise control of the parameters affecting the crystal growth process. First, the nucleation is induced at supersaturated conditions close to the solubility boundary between the nucleation and metastable regions. Then, crystal growth is further achieved in the metastable zone – which is the optimal location for slow and ordered crystal expansion – by modulation of specific physical parameters. Recently, a prototype of an integrated apparatus for the rational optimization of crystal growth by mapping and manipulating temperature–precipitant–concentration phase diagrams has been constructed. Here, it is demonstrated that a thorough knowledge of the phase diagram is vital in any crystallization experiment. The relevance of the selection of the starting position and the kinetic pathway undertaken in controlling most of the final properties of the synthesized crystals is shown. The rational crystallization optimization strategies developed and presented here allow tailoring of crystal size and diffraction quality, significantly reducing the time, effort and amount of expensive protein material required for structure determination.