Hollywood is eager to get back to work after the coronavirus outbreak, but union officials, studio executives and others must first agree on new protocols to make filming safe again.

An ode to 1970s Southern California soft rock: Who needs musical aggression when there's a relentless, invisible enemy lurking outside your window?

California is the mecca of vacation attractions and excitement. It’s known for its beautiful scenery and infamous weather year-round. If you’re planning a family trip, you have your pick from Universal Studios Hollywood, Discovery Kingdom,...

The post Best Cities to Visit in Southern California appeared first on Geeky Traveller.

Unilever is recalling Wall’s Mini Calippo (Orange and Lemon-Lime) multi-packs because they may contain small pieces of metal. The presence of metal makes this product unsafe to eat.

On 29 July 2019, we published an article originally headlined "Islamic Caliphate in rural England: 35000 to pledge allegiance in mass conversion ceremony".

The $8,000 square foot, $8 million home sits atop a hill and features windows from floor to ceiling.

Watch Gary Varvel's time lapse video of his process of drawing heroes.

A great crisis produces great people and great courage

They say it takes three years to evaluate a draft class. How does the Colts 2017 class look three years later?

IU alum and Dallas Mavericks owner Mark Cuban pitches an idea to Kentucky basketball coach John Calipari as if he was a 'Shark Tank' contestant.

Newport Beach residents can use city beaches again for activities like walking, running, biking, swimming, surfing and fishing from 6 a.m. to 10 p.m.

The order streamlines workers' compensation claims and establishes that any essential worker infected with COVID-19 contracted the virus on the job.

Documents obtained from state Treasurer Fiona Ma's office through a records request include an invoice from a BYD subsidiary for 'N95 face masks.'

A trough off the West Coast is expected to bring a robust cooling trend to California next week.

With parts of the California economy poised to reopen Friday, cities will be taking it slow over concerns that COVID-19 remains a significant threat.

Desperate for coronavirus help, California spending billions on no-bid coronavirus contracts, little accountability

California says bars that reopen without state permission could lose alcohol license

California's state government faces a $54-billion budget deficit through next summer, according to an analysis released Thursday.

Across Southern California and in the Bay Area, communities are preparing to allow retailers to reopen, with restrictions.

Some 80% of state voters support employers providing full replacement wages to farmworkers to stay home when sick with COVID-19, poll finds.

California allows some retailers to open with curbside service, including bookstores, florists and toy stores. Many parks will reopen Saturday.

California's tepid reopening amid the coronavirus sparked a mix of excitement, confusion and uncertainty.

Tourist spots prepare to welcome visitors once coronavirus restrictions are lifted

More beaches, trials and parks opened as officials ease coronavirus restrictions

After nearly eight months of knowledge-gathering street tests and thousands of successful deliveries, Amazon has announced that its delivery robots have begun delivering packages to customers in Irvine, Calif.

As fires tear across California, a Silicon Valley technology company believes artificial intelligence could be the key to preventing them in the future.

• Elon Musk says Tesla may leave its Palo Alto headquarters and Fremont, California factory. 
• In a tweet Saturday morning, the chief executive continued his outrage against shelter-in-place orders that have forced most non-essential businesses to close. 
• Last week, Musk likened the rules to fascism, and urged leaders to "give people their goddamn freedom back." 
• Visit Business Insider's homepage for more stories.

After a week of decrying coronavirus shelter-in-place orders that have left Tesla's main factory shuttered and unable to produce vehicles, Elon Musk says the company may move its factory out of the state.

"Tesla is filing a lawsuit against Alameda County immediately," the chief executive said on Twitter Saturday morning. "The unelected & ignorant 'Interim Health Officer' of Alameda is acting contrary to the Governor, the President, our Constitutional freedoms & just plain common sense!"

That was followed up with a threat to move Tesla's headquarters outside the state.

"Frankly, this is the final straw," he replied. "Tesla will now move its HQ and future programs to Texas/Nevada immediately. If we even retain Fremont manufacturing activity at all, it will be dependent on how Tesla is treated in the future. Tesla is the last carmaker left in CA."

It wasn't immediately clear if a suit had yet been filed, or in which court Tesla will file the lawsuit. Most state and federal courts are closed on weekends and do not allow filing. In a subsequent Tweet, Musk alsourged shareholders to file a class action suit for damages caused by shutdown. 

Tesla's press relations department did not immediately respond to a request for comment. Alameda County did not immediately respond to a request for comment. 

Alameda County — the East Bay locale which includes Fremont, California, and Tesla's gigafactory about 30 miles southeast of San Francisco — extended its shelter-in-place order on April 29 "until further notice." Local authorities have not allowed Tesla to reopen the factory, and all manufacturing remains prohibited under the order.

The San Francisco Chronicle reported that Tesla was planning to resume some manufacturing operations at the factory as soon as last Wednesday, May 6. Local officials said it did not have permission to do so.

"Right now, the same health order is in place so nothing has changed," Fremont Police Department spokeswoman Geneva Bosques told Business Insider at the time. "Operating the assembly line was determined early on to be a violation."

Last week, following Tesla's first-quarter earnings announcement, Musk decried the shutdowns as a substantial risk to the company's financials.

"Frankly, I would call it forcible imprisoning of people in their homes against all of, their constitutional rights, in my opinion," he said on a conference call. "It's breaking people's freedoms in ways that are horrible and wrong and not why they came to America or built this country. What the f---. Excuse me. Outrage. Outrage."

"If somebody wants to stay in their house, that's great and they should be able to," he continued. "But to say they cannot leave their house and that they will be arrested if they do, that's fascist. That is not democratic — this is not freedom. Give people back their goddamn freedom."

Some states, including Texas, Georgia, and others, have begun to slowly allow certain businesses to re-open in recent weeks.

Musk praised counties neighboring Alameda, like San Joaquin for what he said were more "reasonable" responses. In a podcast released May 7, he told Joe Rogan that the company had learned from the coronavirus in China, where it briefly forced Tesla to close its Shanghai factory — a claim he repeated on Twitter Saturday. 

"Our castings foundry and other faculties in San Joaquin have been working 24/7 this entire time with no ill effects. Same with Giga Nevada," Musk said. "Tesla knows far more about what needs to be done to be safe through our Tesla China factory experience than an (unelected) interim junior official in Alameda County." 

As Musk began to complain about factory shutdowns in April, workers at Tesla's Fremont factory told Business Insider that the comments made them anxious.

"I'm for going back to work, but only if it is safe for me, my family, coworkers," said one production employee. "I don't feel like I'm being forced to stay home or that my freedom has been taken away. It's for the good of California."

Join the conversation about this story »

NOW WATCH: A cleaning expert reveals her 3-step method for cleaning your entire home quickly

Numéricable has selected the Calix E7-2 Ethernet Service Access Platform and gigabit passive optical network technology to upgrade its service delivery platform in Belgium and Luxembourg. Calix, along with optical specialist Arcadiz Telecom, will work closely to roll out Numéricable’s new high-speed broadband networks to deliver business services across the region. The new platform will enable Numéricable’s customers to take advantage of advanced voice, video, and data services at symmetrical speeds ranging from 30 megabits per second (30 Mbps) up to 1 gigabit per second (1 Gbps).

Numéricable serves over 150,000 customers in Brussels with triple-play services for residential subscribers. Owned by Coditel and with a close relationship to the French Numéricable organization, with whom it shares a range of resources, Numéricable Belgium is a long-established operator with a highly dispersed coax cable network. The company has traditionally delivered triple-play residential services over its hybrid fiber coax infrastructure, but in recent years has moved increasingly towards using its fiber to connect businesses and has developed a number of specific niche markets. The company is now looking at ways to maximize the potential of its fiber infrastructure in Belgium and Luxembourg and deliver revenue-generating advanced services to its business customers.

Tesla CEO Elon Musk said Saturday the company will file a lawsuit against Alameda County and threatened to move its headquarters and future programs to Texas or Nevada immediately, escalating a fight between the company and health officials over whether its factory in Fremont can reopen. Tesla had planned to bring back about 30% of […]

“Breathing would be delightful,” the director of products told me in our kickoff. His startup was growing fast. It had a bunch of new funding, the pressure was on to ship, and the team was underwater. I was there to help and take the pressure off so they could breathe. “Let’s begin to think strategically […]

The post Successful Scaling: How to Grow Without Tumbling Back Down appeared first on ReadWrite.

As a digital company, your business is not bound by conventional borders and has the freedom and opportunity to reach customers anywhere in the world. And just as you look outward for new markets, customers are also looking beyond their physical borders for their goods and services. As a study by KPMG shows, online buyers […]

San Diego, California

Baja California

The Amateur Traveler talks to Richard Miller of the SparkleTack podcast (about San Francisco history) about San Francisco. Richard guides us in a driving/walking tour from west to east. We start at lands end and end up near fisherman's wharf while talking about the sites and history of many of the places in between. This is a great companion episode with the 2 part soundseeing walking tour of San Francisco.

The Amateur Traveler talks to Carole Terwilliger Meyers the author of Weekend Adventures in San Francisco and Northern California. Carole comes on the show to talk about California’s traditional wine country of Napa and Sonoma Valleys. This episode focuses primarily on the Napa Valley and the many wineries that can be found there. We explore recreated castles, wine tasting , tours as well as other none wine related sites like mud baths, petrified forests, and the CIA (The Culinary Institute). We talk about restaurants and hotels, picnics and the wine train. Whether you are a connoisseur, a foodie or just a tourist, the Napa Valley has much to offer.

The Amateur Traveler talks to Eric Schwartzman (author, educator and podcaster) about his hometown of Los Angeles. Over a two part series of episodes Eric will give us sample itineraries for 4 days in the Los Angeles area. Be forewarned that no theme parks will be involved in Eric's tour but instead an insider's look at LA. So pack up your swim suit, a sport coat and nice shoes and get in your car to explore LA. Along the way Eric points out the cafes, coffee shops, restaurants, hotels and movie locations that he thinks you should know about.

Day 1: Eric starts us at the beach at Santa Monica. We visit the Santa Monica Pier, the rides and the aquarium and then head to Venice with its pier, canals, and famous muscle beach.

Day 2: We follow Eric to Beverly Hills and Westwood. We look over the valley from the Getty Center above the valley. We visit Century City which is now the home for high rises but one was where John Wayne shot westerns. We go shopping on world famous Rodeo Drive.

The Amateur Traveler talks to Eric Schwartzman (author, educator and podcaster) about his hometown of Los Angeles. In this second part of a two part series of episodes Eric will give us the last two days of his sample itineraries for 4 days in the Los Angeles area. In this insider’s look at LA Eric points out the cafes, coffee shops, restaurants, hotels and movie locations that he thinks you should know about.

Day 3: Hollywood – Sunset Strip, Grauman’s Chinese Theater, Roosevelt, L.A.’s best chili dog, Academy Awards theater, Sunset Grill, Hollywood Cemetary and more.

Day 4: Downtown – Chinatown for dim sum, Olvera St. for Mole, Union Station for breathtaking Mission Architecture, Santee Alley and Los Angeles St. for discount children’s formal wear, Disney Hall for magnificent modern architecture and Our Lady of Angels Catholic Church.

The Amateur Traveler talks to Bethany of the Nevada Tourism Bureau about Lake Tahoe. Lake Tahoe is a high elevation alpine lake on the border of California and Nevada. It is surrounded by 18 ski areas so it is a popular winter destination. In the winter it is also a great place for back country hiking, cross country skiing, snowshoeing, and snowmobiling. In the Summer, Tahoe is a popular area for hiking, fishing and outdoor activities. But, there is another side to Tahoe which is the casinos, restaurants, and entertainment of Nevada's South Tahoe.

The Amateur Traveler talks to Carrie from cruisebuzz.net about a popular vacation spot just off the coast of California, Catalina Island. 

Hear about travel to Lassen National Park in northern California as the Amateur Traveler talks to Dick Jordan about this spectacular if less visited destination. Lassen is in northeastern California. It is just as easy to get to from San Francisco as Yosemite National Park but with fewer tourists and one more volcano. The park centers around the dormant volcano Mt. Lassen and features other geothermal active areas.

Hear about travel to Santa Barbara, California as the Amateur Traveler talks to Heather Simon from wellplannedtravel.net about the "American Riviera".

Hear about travel to San Diego as the Amateur Traveler talks to Mike from MikesRoadTrip.com about this beautiful city in Southern California.

Hear about travel to California's premier wine region of Napa and Sonoma as the Amateur Traveler talks again to free lance journalist Jill Robinson about this area with more than just wine... but a lot of that

Hear about travel to San Francisco, California as the Amateur Traveler talks to Jill Robinson and Kimberley Levato authors of 100 Things to Do in San Francisco Before You Die.

los ángeles,hollywood,california,southern california,travel

Hear about the best of California's state parks as the Amateur Traveler talks to Jeff Ohlfs who has been to all the parks in the state park system.

An evangelical church network in California will ignore Democratic Gov. Gavin Newsom’s executive prohibitions this month, opening sanctuary doors for communal worship despite the ongoing coronavirus pandemic. According to Fox News, California Church United, representing roughly 3,000 churches and 2.5 million congregants statewide, announced Thursday that it will return to conducting in-person services by Pentecost…

The post Huge Group of California Churches Announces Plan To Defy Governor Newsom’s Order appeared first on The Western Journal.

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.