What if the coronavirus lasts until the end of the year? Lawrence Yeo has a bleak forecast.

The pandemic is likely to hit the Middle East’s more fragile countries hardest.

The package for Mattel's 'Wicked' dolls has a shocking error.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Engaging Arctic Indigenous Communities Meaningfully in Decision-making Affecting Their Food Security Engaging Arctic Indigenous Communities Meaningfully in Decision-making Affecting Their Food Security

The Academic Staff Union of Universities on Tuesday raised an alarm over a plot to sabotage the interest of public universities in the country. ASUU’s National President, Prof Emmanuel Osodeke, at an event marking the 2024 ASUU’s Heroes Day in Abuja, also accused the World Bank and the International Monetary Fund of working relentlessly to

On December 9-10, 2024, The Jerusalem Post will host an inaugural summit in Miami, bringing forward the discussions about the "tomorrow" of our community.

Franz Wagner pumped in 32 points on Tuesday as the Orlando Magic cruised past the visiting Charlotte Hornets, 114-89, in NBA Cup action. Moritz Wagner scored 18 points off the bench and Jalen Suggs tallied all 17 of his points in the first half for Orlando, which has its first three-game winning streak of the season. Franz Wagner made 14 of 25 shots from the field as the Magic shot 46.2 percent overall. He also led Orlando with eight rebounds and five assists. READ: NBA Cup set to begin with eight group-play games LaMelo Ball’s 35 points and Grant Williams’ […]...

Keep on reading: NBA Cup: Franz Wagner scoring surge as Magic rout Hornets

Understanding the roots and complexities of fragility helps ADB meet the challenges facing many countries in Asia and the Pacific.

Case study on Singapore explains the country's resilience to swings in capital flows.

In a case study on Korea, a VAR model is used to investigate the effects of capital flows on asset prices.

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This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.

Dolphins in the Gulf of Mexico have tiny bits of plastic in their breath, and this is probably a worldwide problem

Could potassium fortification be the answer we're looking for when it comes to battling our unhealthy addiction to salt?

Taiwan’s first ever minister of digital affairs has transformed politics, using online platforms and AI to give power to the country’s citizens – with lessons for us all

Extreme weather and a growing population is driving a food security crisis. What can we do to break the vicious cycle of carbon emissions, climate change and soaring food costs – or is it already too late?

Researchers have used quantum light to create a magnetic field with a strength that is measured in imaginary numbers

Photographer Diane Tuft has documented how global warming is affecting bodies of water around the world

Extreme weather and a growing population is driving a food security crisis. What can we do to break the vicious cycle of carbon emissions, climate change and soaring food costs – or is it already too late?

Title: Too Much Radiation From Medical Imaging?
Category: Health News
Created: 8/27/2009 12:00:00 AM
Last Editorial Review: 8/27/2009 12:00:00 AM

Title: Slowed Reflexes in Aging Could Be Due to Brain Changes
Category: Health News
Created: 8/24/2010 2:10:00 PM
Last Editorial Review: 8/25/2010 12:00:00 AM

Title: Encouraging Your Baby's Babbling May Speed Language Development
Category: Health News
Created: 8/29/2014 9:36:00 AM
Last Editorial Review: 8/29/2014 12:00:00 AM

Title: Study Counters Critics of Plainer Cigarette Packaging
Category: Health News
Created: 8/29/2014 9:35:00 AM
Last Editorial Review: 8/29/2014 12:00:00 AM

Title: Too Few Female Urologists to Meet Aging Patients' Demand
Category: Health News
Created: 8/22/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: New Clues to Why Yawns Are Contagious
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: FDA Warns About Hand Sanitizers in Food-Like Packaging
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Space Travel Speeds Up Aging, Weakening of Bones
Category: Health News
Created: 8/4/2022 12:00:00 AM
Last Editorial Review: 8/4/2022 12:00:00 AM

Title: Is a Stye Contagious?
Category: Diseases and Conditions
Created: 7/15/2022 12:00:00 AM
Last Editorial Review: 7/15/2022 12:00:00 AM

Title: Exercise, Puzzles, Games: How Do They Help Aging Brains?
Category: Health News
Created: 7/21/2022 12:00:00 AM
Last Editorial Review: 7/21/2022 12:00:00 AM

Title: Magic Mushroom Hallucinogen May Treat Problem Drinking
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: Are Skin Rashes Contagious?
Category: Diseases and Conditions
Created: 8/10/2015 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM

Title: 9 Vitamins That May Help With Vaginal Dryness
Category: Health and Living
Created: 8/3/2022 12:00:00 AM
Last Editorial Review: 8/3/2022 12:00:00 AM

Title: Is Chlamydia Contagious?
Category: Diseases and Conditions
Created: 5/28/2015 12:00:00 AM
Last Editorial Review: 8/1/2022 12:00:00 AM

Title: Vaginal or C-Section, Method of Childbirth Won't Affect a Couple's Sex Life Later
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: AHA News: How You Feel About Aging Could Affect Health. Here's How to Keep the Right Attitude.
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Title: Is Laryngitis Contagious?
Category: Diseases and Conditions
Created: 9/10/2015 12:00:00 AM
Last Editorial Review: 7/22/2022 12:00:00 AM

A prefilled syringe (PFS) should be able to be adequately and consistently extruded during injection for optimal safe drug delivery and accurate dosing. To facilitate appropriate break-loose and gliding forces (BLGFs) required during injection, certain primary packaging materials (PPMs) such as the syringe barrel and plunger are usually coated with silicone oil, which acts as a lubricant. Due to its direct contact with drug, silicone oil can increase the number of particles in the syringe, which could lead to adverse interactions. Compliance with regulatory-defined silicone oil quantities in certain drug products, such as ophthalmics, presents a trade-off with the necessity for desirable low and consistent BLGF. In addition to its siliconization, the dimensional accuracy of the PPM has an important role in controlling the BLGF. The dimensions of the PPM are individualized depending on the product and its design and have certain tolerances that must be met during manufacturing. Most studies on ophthalmics focused on the adverse interactions between silicone oil and the drug. To the authors' knowledge, there have been no public studies so far that have investigated the impact of the dimensional variability of the PPM on the BLGF in ophthalmic PFSs. In this study, we applied advanced optical shaft and tactile measuring technologies to investigate this impact. The syringes investigated were first sampled during aseptic production and tested for the BLGF. Subsequently, defined dimensions of the PPM were measured individually. The results showed that the dimensional variability of the PPM can have a negative impact on the BLGF, despite their conformity to specifications, which indicates that the currently available market quality of PPMs is improvable for critical drug products such as ophthalmics. This study could serve as an approach to define product-specific requirements for primary packaging combinations and thus appropriate specifications based on data during the development stage of drug products.

Cellular plasticity in adult multicellular organisms is a protective mechanism that allows certain tissues to regenerate in response to injury. Considering that aging involves exposure to repeated injuries over a lifetime, it is conceivable that cell identity itself is more malleable—and potentially erroneous—with age. In this review, we summarize and critically discuss the available evidence that cells undergo age-related shifts in identity, with an emphasis on those that contribute to age-associated pathologies, including neurodegeneration and cancer. Specifically, we focus on reported instances of programs associated with dedifferentiation, biased differentiation, acquisition of features from alternative lineages, and entry into a preneoplastic state. As some of the most promising approaches to rejuvenate cells reportedly also elicit transient changes to cell identity, we further discuss whether cell state change and rejuvenation can be uncoupled to yield more tractable therapeutic strategies.

A STING (stimulator of interferon genes) agonist GSK3996915 under investigation in early discovery for hepatitis B was orally dosed to a mouse model for understanding the parent drug distribution in liver, the target organ. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to quantify the distribution of GSK3996915 in liver collected from mice administered a single oral dose at 90 mg/kg. GSK3996915 was detected with a zonal distribution localized in the portal triad and highly concentrated in the main bile ducts, indicating clearance through biliary excretion. High spatial resolution imaging showed the distribution of the parent drug localized to the cellular populations in the sinusoids, including the Kupffer cells. Additionally, a series of drug-related metabolites were observed to be localized in the central zones of the liver. These results exemplify the potential of utilizing MALDI IMS for measuring not only quantitative drug distribution and target exposure but also drug metabolism and elimination in a single suite of experiments.

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and α/β-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action and without intoxication. We review evidence on plant-derived cannabinoids for pain, with an emphasis on CBD and its multiple molecular targets expressed in pain pathways. We also discuss the function of eCB signaling in regulating pain responses and the therapeutic promises of inhibitors targeting ABHD6, a 2-arachidonoylglycerol (2-AG)-hydrolyzing enzyme. Finally, we discuss how the novel cannabinoid biosensor GRAB_eCB2.0 may be leveraged to enable the discovery of targets modulated by cannabinoids at a circuit-specific level.