The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

The present invention relates to a novel method for synthesizing a composition of polymers, copolymers, terpolymers and tetrapolymers, and to the use thereof, said composition being made from: cyclodextrins, in particular α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, the derivatives or corresponding mixtures thereof, and/or calix[n]arene(s) and/or of calix[n]arene derivative(s) and/or a mixture of two or more different calix[n]arenes selected from calix[n]arenes (n=4-20) and/or the derivatives thereof, and to the uses thereof. A method was developed on the basis of direct-melt polycondensation. The invention can be used in the pharmaceutical, human medicine, veterinary medicine, chemistry, separation chemistry, environmental, electronics, biological, diagnostics, phytosanitation, medicinal food, agri-food, and cosmetics fields, and in the nutraceutical field and in the field of molecular imprints (MIP).

Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.

The present invention discloses metal (III) complex of a biuret-amide based macrocyclic ligand as green catalysts that exhibit both excellent reactivity for the activation of H2O2 and high stability at low pH and high ionic strength. The invention also provides macrocyclic biuret amide based ligand for designing of functional peroxidase mimics. Further, the present invention discloses synthesis of said metal (III) complex of a biuret-amide based macrocyclic ligand.

A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).

Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.

Cyclic CRF antagonist peptides having improved properties of “drugability”. The peptides are 33 residues in length with a lactam bond between the residues in position 22 and 25; however, they may be N-terminally shortened by up to 3 residues.

The present invention relates to a cyclosporine emulsion containing: i) a cyclosporine ii) a natural oil (long chain triglyceride) iii) a phosphatidylcholine, iv) glycerol, v) a pharmaceutically tolerable alkali salt of a free fatty acid, vi) a medium chain triglyceride-oil vii) optionally, hydrochloric acid or sodium hydroxide for pH adjustment viii) water.

Embodiments of the present invention are directed to heterocyclic compounds and organic light-emitting devices including the heterocyclic compounds. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high luminance and long lifespans.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

A grader blade mounted to a support frame has an auger-grinder mounted ahead of the grader blade. The auger-grinder has a first helical vane fixed to a rotatable axle with a plurality of teeth attached to and protruding outwardly from the auger. A shroud above and partially surrounding the auger-grinder has an inner shroud end wall, an outer shroud end wall and bearings in which the axle is journaled transverse to the direction of travel. A beater is fixed to the axle between an inner end of the helical vane and the inner wall. The beater has a plurality of paddles extending outwardly from the axle. An inner barrier wall is attached to the inner shroud wall and extends forward of the auger-grinder. A drive link is connected to the axle for connection to a prime mover for driving the axle in rotation.

A bicycle rack for arrangement on the rear end of a motor vehicle in an extendible fashion is provided. The bicycle rack includes a carrying frame, a slide-in element that is displaceably arranged in the carrying frame, and a carrier element that is pivotably arranged on the side-in element.

The present invention provides a method of making a flexible foaming member from recycled material. The present invention relates to a production method to recycling wastes containing rubber, plastic and metal materials and pulverize them into scraps under normal temperatures, then roughly separate the various materials contained in the waste scraps into different layers based on the difference of specific gravity, and further take out the scraps of rubber and plastic materials with lower specific gravity from the waste scraps, then conduct multiple heating and pulverizations under different temperatures to produce composite-material scraps, and then using some composite-material scraps to mix flexible materials and foaming agents, then pressing the mixture into a plate-like foaming material, and conduct vulcanization and foam forming for the plates of foam material to become a elastic foam.

A brake apparatus that can achieve front-rear distribution in accordance with a traveling environment variation. At an intermediate point from a start point of a second mode, first interval to an end point of a second mode, second interval, the increasing rate of braking force for a front wheel with respect to an operation amount is changed. The increasing rate of the operation amount prior to the intermediate point can be represented by a first inclination of a curve while the increasing rate of the operation amount after the intermediate point is represented by a second inclination of the curve. The first inclination is less than the second inclination. Setting the increasing rate after an intermediate point to be higher than the increasing rate before the intermediate point, the vehicle body generation deceleration can be caused to increase in a linear proportion to the operation amount.

A motorcycle with an ABS module disposed to make it hard to affect the layout of other components while suppressing the influence of vibration on the ABS module. A motorcycle includes rear frames joined to corresponding rear portions of the main frames and extending upwardly and rearwardly at a position below the corresponding seat frames. Front wheel braking members apply a braking force to a front wheel. An ABS module is connected to the front wheel braking means. A seat is supported on the upper portions of the seat frames. The ABS module has at least a portion disposed below the seat and between the seat frames and the rear frames as viewed from the side. The ABS module is suspended and supported by front and rear cross stays spanned between the pair of seat frames via a front elastic members and a rear elastic member.

The present invention relates to a synthesis method of metal cyclopentadienide by direct reaction of dicyclopentadiene with a group 1 metal in the presence of an aprotic solvent. Unlike the conventional method depending on retro Diels-Alder reaction of dicyclopentadiene to generate indirectly cyclopentadiene, the method of the present invention favors generation of cyclopentadiene and metal cyclopentadienide as well by adding dicyclopentadiene directly when the reaction temperature reaches to the boiling point of a reaction solvent.

In an embodiment, a processor-readable medium stores code representing instructions that when executed by a processor cause the processor to receive sheet length data for two paper sheets of a same standard dimension passing consecutively through a printing device. The processor calculates a length difference between the two paper sheets, and when the length difference exceeds a two-sheet threshold, it initiates an alignment correction cycle in a paper finishing device.

A bicycle saddle comprising: a supporting frame (2), set up for connecting the saddle to a seat post; a resting base (3), connected to the supporting frame (2) and intended for transmitting the weight of the cyclist to the supporting frame (2), which is provided with a front portion (31) and with a rear portion (32); a cover (4) that covers the resting base (3) and is intended for defining the surface of contact with the cyclist; a shock-absorbing anti-sliding insert (5), interposed between the resting base (3) and the cover (4), which protrudes at least partially from the cover (4) through an opening (41) made on the cover (4).

Shooters must presently take their firearms out of their hands to then manually actuate a new target into shooting position. This Target Apparatus will allow the shooter to shine his laser light, infrared light, flashlight, or multi-spectrum light onto a Target Apparatus-mounted sensor that engages a drive means mounted upon the target frame that then forwards a new target into position without removing the firearm from its' shooting position. The unit also uses a unique target backing material that does not require targets to be made of rolls of coated or heavy material stock. The system can utilize rolls of cash register paper, cut sections of gift wrapping paper, hand towel rolls, or even paper towels as target materials without snagging and preventing the next target from being presented.

The present invention relates to an organotemplate-free synthetic process for the production of a zeolitic material comprising YO2 and X2O3, wherein said process comprises the steps of (1) preparing a mixture comprising seed crystals, one or more sources for YO2, one or more sources for X2O3, and one or more solvents;(2) crystallizing the mixture obtained in step (1) to obtain a zeolitic material comprising YO2 and X2O3 as a crystallization product; wherein Y is a tetravalent element, and X is a trivalent element, and wherein at least a portion of the mother liquor obtained in step (2) is recycled to step (1) as a source for YO2, optionally after concentration of the mother liquor.

Provided are a method for post-treatment of a carbonaceous material using dehydrocyclization, a carbonaceous material post-treated by the method, and a polymer composite material including the carbonaceous material. More particularly, provided are a method for post-treatment of a carbonaceous material using dehydrocyclization, including subjecting the carbonaceous material to dehydrocyclization at room temperature to heal structural defects in the carbonaceous material, while increasing the effective conjugated length of the carbonaceous material to improve the electrical conductivity thereof, as well as a carbonaceous material post-treated by the method and a polymer composite material including the carbonaceous material.

A method for converting heat to electric energy is described which involves thermally cycling an electrically polarizable material sandwiched between electrodes. The material is heated by extracting thermal energy from a gas to condense the gas into a liquid and transferring the thermal energy to the electrically polarizable material. An apparatus is also described which includes an electrically polarizable material sandwiched between electrodes and a heat exchanger for heating the material in thermal communication with a heat source, wherein the heat source is a condenser. An apparatus is also described which comprises a chamber, one or more conduits inside the chamber for conveying a cooling fluid and an electrically polarizable material sandwiched between electrodes on an outer surface of the conduit. A gas introduced into the chamber condenses on the conduits and thermal energy is thereby transferred from the gas to the electrically polarizable material.

A self-excited alternator for generating electrical energy. The alternator includes a stator, a rotor, and an exciter. The rotor includes conductors which are integrated within the rotor via one of a casting process, a welding process, or a fastening process. The exciter includes a magnet producing a static magnetic field, and a rotatable conductive member coupled to the shaft and electrically coupled to the one or more conductors. The rotatable conductive member is operable to output the direct current to the one or more conductors upon rotation within the static magnetic field, thus exciting the alternator.

A method for converting heat to electric energy is described which involves thermally cycling an electrically polarizable material sandwiched between electrodes. The material is heated using thermal energy obtained from: a combustion reaction; solar energy; a nuclear reaction; ocean water; geothermal energy; or thermal energy recovered from an industrial process. An apparatus is also described which includes an electrically polarizable material sandwiched between electrodes and a heat exchanger for heating the material. The heat source used to heat the material can be: a combustion apparatus; a solar thermal collector; or a component of a furnace exhaust device. Alternatively, the heat exchanger can be a device for extracting thermal energy from the earth, the sun, ocean water, an industrial process, a combustion reaction or a nuclear reaction. A vehicle is also described which comprises an apparatus for converting heat to electrical energy connected to an electric motor.

An emissions recycling system is used on a vehicle towing an agricultural implement to enrich the fertility of the soil. The system includes an exhaust collector for collecting exhaust emissions from the internal combustion engine of the towing vehicle and an exhaust distribution system for injecting at least a portion of the exhaust emissions collected by the exhaust collector into the ground worked by the ground working tools of the agricultural implement. Fertility of the soil is enriched by bioactivity within the soil's micro flora which consumes the greenhouse gas and emissions.

A bicycle seatpost includes a first part and a second part. A curvature radius of the first part is r1, and an arc length of the first part is equal to or greater than πr1 and smaller than 2πr1, the first part is set toward a head of a bicycle. The second part is connected to the first part, wherein a curvature radius of the second part is greater than the curvature radius of the first part, the second part is set toward an end of the bicycle.

A foldable children's tricycle comprises a tricycle front, a link device and a positioning assembly. The tricycle can be folded by using the link device, which can save space and reduce transportation cost. In addition, an inserting rod of the positioning assembly can be engaged in first or second positioning grooves of the link device, so the tricycle can be fixed when expanding or folding, thus improving the structural strength of the tricycle.

An embodiment of the invention includes a three-component rear-wheel suspension system for interconnecting to a bicycle frame and a shock absorbing device. The three components are an upper stay pivotally attached to the frame, a lower stay having a rear wheel mount and pivotally connected to the upper stay at a location generally above the rear wheel mount, and a link pivotally connected to the frame at a location below where the upper stay is attached to the frame and pivotally coupled to the lower stay. The general arrangement of the linkages between the three components permit compression of the suspension system (i.e. relative upward movement of the rear wheel) with limited chainstay lengthening.

A foldable bicycle comprises a frame having a rear portion supporting a rear wheel about a rear axis of rotation, a front portion supporting a front wheel about a front axis of rotation and a hinge system. The hinge system comprises a first part arranged on the rear portion and provided with a first plane surface, and a second part arranged on the front portion and provided with a second plane surface. Inside the first and second parts an actuator mechanism is arranged for actuating a stud that locks or unlocks said parts. The first plane surface and the second plane surface are disposed in a plane that is slightly inclined relative to a horizontal plane, said inclined plane being configured to facilitate pivoting of the front portion relative to the rear portion towards a folded position, in which the rear and front axes of rotation are in alignment.

A modulator generates a baseband digital signal from an information-bearing digital signal. The baseband signal has time-varying phase and amplitude defined by a sequence of complex data words, each having an in-phase (I) component and a quadrature (Q) component. A noise-shaping modulator generates a noise-shaped digital signal from the baseband digital signal such that quantization noise in the noise-shaping modulator is attenuated by a spectral null of its noise transfer function. The spectral null is selected by a noise-shaping parameter corresponding to a selected one of a plurality of output frequencies. A signal converter generates an analog signal conveying the information of the information-bearing digital signal on an analog carrier signal having the selected output frequency.

Methods and apparatus for translating duty cycle information in duty-cycle-modulated signals to higher frequencies or higher data rates. An exemplary duty cycle translator includes a duty cycle evaluator, a high-speed digital counter, and a comparator. The duty cycle evaluator generates a first digital number representing a duty cycle of a low-frequency input duty-cycle-modulated (DCM) signal. The comparator compares the first digital number to a second digital number generated by the high-speed digital counter, and generates, based on the comparison, an output DCM signal having a higher frequency or data rate than the frequency or data rate of the low-frequency input DCM signal but a duty cycle that is substantially the same as the duty cycle of the low-frequency input DCM signal.

Methods of reclaiming plastic from plastic medical waste containers containing medical waste and manufacturing recycled medical devices are described. Recycled medical devices made from plastic medical waste containers containing medical waste are also described.

The present invention may be embodied as a compounding system having a chamber assembly defining a working chamber; a shaft, a sleeve assembly, and a plurality of arms. The sleeve assembly has first and second sleeve members each defining at least one arm opening and adapted to be arranged in a first configuration in which the first and second sleeve members are detached from each other and a second configuration in which the first and second sleeve members are secured together around the shaft to support the sleeve assembly on the shaft. Each of the arms is configured to be inserted partly through one of the arm openings when the sleeve assembly is in the first configuration and held in a desired configuration relative to one of the first and second sleeve members when the sleeve assembly is in the second configuration.

Cyclodextrin compositions including one or more radiation polymerizable monomers and a cyclodextrin inclusion complex, the cyclodextrin inclusion complex including a cyclodextrin compound and an olefinic inhibitor of an ethylene generation in produce, are coated onto packaging materials and cured. Treated containers and treated package inserts having the cured cyclodextrin compositions are useful in packaging of respiring plant materials.

Compounds of Formula I, including pharmaceutically acceptable salts, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

A document recycle box is provided to comprise: a housing 60, a cover 52 rotatably attached to housing 60, a convey belt device 51 of a recycle conveyor device 50 attached to one of housing 60 or cover 52 along one side of a recycle pathway 11 extending within housing 60, a plurality of rollers 53 of recycle conveyor device 50 attached to the other of housing 60 or cover 52 along the other side of recycle pathway 11 on the opposite side of conveyor belt device 51, and a drum device 43 rotatably disposed within housing 60. Cover 52 may be released from housing 60 to move recycle conveyor 50 away from rollers 53 to easily remove a jammed document within recycle pathway 11.

There is described a system and method for recycling carbon-containing material, in particular tires and plastics materials. The system includes a heating arrangement for anaerobically heating carbon containing material to produce carbon-containing gases. A condensing arrangement is also used to condense a proportion of the carbon-containing gases to provide condensed gases and non-condensed gases. In addition, a recirculating arrangement is provided for recirculating the non-condensed gases into the heating arrangement. Further systems and methods for pre- and post-processing of the carbon-containing material are also disclosed and products of the systems and methods are also described.

A disposal method for entirely recycling solid refuse includes the following steps: sorting, crushing, drying, pressing with high pressure to shaped articles, producing charcoal from combustible refuse in high temperature and firing incombustible refuse in high temperature, at last cooling high temperature articles to obtain solid fuel with various shapes and bricks or board used for building. The method achieves entirely recycling house refuse, especial solid refuse. The method recycles solid refuse to obtain fuel and building material with economic value. The method is simple and its processing cost is low.

A bicycle pump includes a pump body assembly, a handle assembly, a flexible hose assembly, and/or a magnet. The pump body assembly may include an outer tube, which defines an air chamber, and a head assembly with an air outlet opening. The handle assembly may slidably be associated with the body assembly, and include an inner tube and a piston, slidable inside the outer tube. The flexible hose assembly may be suitable to be stored inside the inner tube when the pump is not in use, and suitable to be connected to the air outlet opening during pumping. The magnet may connect the flexible hose assembly to the air outlet opening of the head assembly in a removable manner.

A highly alkalized humic and fulvic filter reagent for the removal of multiple contaminants from a gas is provided. The contaminants removed from the gas stream may include, but are not limited to, Carbon Dioxide, Sulfur Oxide, Nitrogen Oxides, Hydrogen Sulfides, radionuclides, mercaptans, ammonia, toxic metals, particulates, volatile vapors, and organics. The present invention further includes the disposal of the filter reagent by way of using the highly alkalized humic and fulvic filter for soil fertility, releasing the carbon dioxide from the filter reagent, converting the liquid filter reagent into a solid for disposal or for use as a contaminant removal filter for waters, wastes, and chemicals.

A gas separation process that utilizes ejector recycle with a membrane separation step in combination with a second separation step. The second separation step may be a second membrane separation, or may involve a different type of separation process. At least a portion of the non-product (i.e. residue) stream withdrawn from the second separation step is directed back to the ejector to form a processing loop. The ejector drives the gas flow in the loop and recycles the non-product stream to the first separation step.

The invention relates to a cyclonic fluid separator comprising a throat portion (4) which is arranged between a converging fluid inlet section and a diverging fluid outlet section. The cyclonic fluid separator is arranged to facilitate a cyclonic flow through the converging fluid inlet section and the throat portion towards the diverging fluid outlet section in a downstream direction. The diverging fluid outlet section comprises an inner primary outlet conduit (7) for condensable depleted fluid components and an outer secondary outlet conduit (6) for condensable enriched fluid components. The cyclonic fluid separator comprises a further outer secondary outlet conduit (16). The outer secondary outlet conduit (6) is positioned on a first position along a central axis (I) of the cyclonic fluid separator and the further outer secondary outlet conduit (16) is positioned on a second position along the central axis (I) of the cyclonic fluid separator.

A cyclone system for a gasifier having two or more cyclones arranged in series sharing a combined loop seal and dipleg is disclosed. Also disclosed is a method for capturing and recycling fines with the cyclone system.

A process for making bleached pulp comprises contacting an unbleached pulp mixture with a first recycled filtrate obtained from a first location (3) of a first recycled filtrate loop, to obtain a first pulp mixture having a first consistency; bleaching the first pulp mixture, to obtain a first bleached pulp mixture; pressing or dewatering the first bleached pulp mixture, to obtain a first pressed bleached pulp mixture and a second filtrate; sending at least a portion of the second filtrate to a second location (5) of the first recycled filtrate loop, wherein the second location (5) is downstream of and in fluid communication with the first location (3); contacting the first pressed bleached pulp mixture with a second recycled filtrate obtained from a third location (6) of the first recycled filtrate loop, to obtain a second pulp mixture having a second consistency, wherein the second consistency is greater than the first consistency, and wherein the third location (6) is downstream of and in fluid communication with the second location (5); bleaching the second pulp mixture, to obtain a second bleached pulp mixture; pressing or dewatering the second bleached pulp mixture, to obtain a second pressed bleached pulp mixture and a third filtrate; sending at least a portion of the third filtrate to a fourth location (8) of the first recycled filtrate loop, wherein the fourth location (8) is downstream of and in fluid communication with the third location (6); and recycling at least a portion of the third filtrate in the first recycled filtrate loop to the first location (3); to obtain the bleached pulp.

A motorcycle tire comprises a tread portion grooved so that twenty narrow annular zones thereof each have a land ratio of 70 to 90%, wherein the twenty narrow annular zones are defined by equally dividing the developed tread width along the tread face by twenty. On each side of the tire equator, main oblique grooves and auxiliary oblique grooves are arranged alternately in the tire circumferential direction and inclined to one tire circumferential direction. The main oblique grooves on each side of the tire equator extend beyond the tire equator to have axially inner ends located on the other side of the tire equator. The auxiliary oblique grooves on each side of the tire equator do not extend beyond the tire equator to have axially inner ends located on the same side of the tire equator.

Bicycle tires with at least one reinforcement layer that contains strength supports and that is arranged between carcass and tread rubber and/or between carcass layers below the tread rubber and/or within the tread rubber. For a high resistance to puncturing with low weight, the reinforcement layer contains multifilament threads of more than 30 polyester/polyarylate filaments, and the filaments are spun from molten liquid-crystal polymer.

One embodiment (100) collects air pressure created from forward motion of a motorcycle (300) in a reservoir assembly (1001) which stores a liquid lubricant, is attached to motorcycle frame (302), and comprises a containment chamber (102), cap (106), cap seal (104), air inlet port (107), lubricant outlet port (109), and an air inlet connector (108) and a lubricant outlet connector (110) to facilitate the external attachment of conduit. The air pressure is collected by and delivered to reservoir assembly (100-1) via an air collection conduit (118) attached to motorcycle front portion (306) by a mount (130) and urges liquid lubricant through a suction conduit (124), flow restrictor (112) and delivers lubricant via discharge conduit (114) to a chain applicator (116) attached to a motorcycle swing arm assembly (304) and to the inner circumference of drive chain (310). Lubricant flow ceases after motorcycle is stopped. Other embodiments are described and shown.

A high-pressure homogenizer including: a fixed body (7) housing a rotating crankshaft (10);a motor (3) for driving the crankshaft (10);a reduction gear unit (4) interconnected between the crankshaft and transmission elements (5, 6), characterized in that the reduction gear unit (4) is an epicyclic reduction gear unit. Preferably there is provided a lubricant feed line (15) which passes through the fixed body and reaches the epicyclic reduction gear unit (4). Preferably the epicyclic reduction gear unit (4) is constructed integrally with the fixed body (4).

A motorcycle boot comprises a sole or tread (22), a rigid shell (20) and an upper (52) associated with the rigid shell; the upper has furthermore a base insole (54) formed by a plurality of tubular channels (56) which extend over most of the bottom surface of the sole (54) and allow the air to pass at right angles to their axis; the shell has at the front an air intake communicating with the front end of the tubular channels.