If you feel up to it, please take a photo of something nice (anything that makes you feel good) and share it with all of us. It can be something on your desk. Something pretty you have hanging on the wall. Or maybe something interesting in your backyard, porch, stoop or balcony. Cute dog & cat photos are encouraged. I just want to look at something pleasant and nice. Stay safe and remember to be kind to yourself and to others.

Happy weekend, Mefites! This weekend jessamyn says: What's growing? Your garden? Your kids? Your hair? Your aggravation at your friends and neighbors? Your "What I'm gonna do when this is over" list? Your dream journal. Let's talk about growth!

As always this is a conversation starter, not limiter; feel free to let us know about non-growth things that're on your mind too. Just no politics please.

Just chat it up, fuzzballs!

Greetings, Sapients! You may have visited famed site "Metafilter" before - but did you know this: Metafilter also has "Metafilter Chat"! It does.

As this chat is associated with Metafilter proper, we chat about all kinds of things! Do you like cute animal GIFs? We chat those! Do you wish to ask a question? We answer! Do you fucking fuck the fucking thing? We fuck that!

As implied above, you may chat through the standard web interface. If you wish to use alternate methods of chatting, there are OPTIONS! We are very quite versatile, you know. [previously]

Prithee, come chat. We do not bite - unless you ask!

This is a Venture with Phil Quartararo former Warner Chairman/CEO and Co-founder of Virgin Records with Richard Branson and Linkin Park Manager, Grammy winning Producer Bob Cutarella and global industry veteran Chris Carlucci.

We are looking for management opportunities, consulting and production deals. We have worked with U2, Joss Stone, Linkin Park, The Coronas, and many more, we have the ability to walk acts into any Major or Indie label globally and set up your strategy and social media. Send us your music, we will listen and give you honest feedback, and who knows, we could open those doors you are looking to enter! We primarily seek artists that have built something and are ready to expose it globally, we work with label head on every continent as well as Booking Agents.

- Chris Carlucci-Partner-Licensing and Distribution and A&R
- Phil Quartararo-Partner-Former Warner Music CEO and Virgin Co-Founder
- Robert Cutarella-Partner-Grammy Winning Producer-Writer/Publishing
- Doreen D’Agostino-Publicist
- Mike Jackson-Partner/A&R Metal and Hard Rock
- Susan McCarthy-Partner/Business Manager
- Daniel Boehm-Managing Director-Europe
- Daniel Costa-A&R Manager-Los Angeles
- Dale Huxford-Managing Director UK and Legal
- Kai Yamata-Managing Director-Japan

Deal Type: Label/Management Signing
Decision Maker: I'm the final decision maker
Deal Structure: Negotiable
Compensation: Negotiable
Song Quality: Rough Mixes, Fully mastered, Broadcast ready
Similar Sounding Artists: Evanescence, Keith Urban, John Mayer, Foo Figters

Many times we use metaphors not only to illustrate what we are talking about but also to denote that we belong in a certain group. In this edition of Two Guys on Your Head, Dr. Art Markman and Dr. Bob Duke talk about the psychology of metaphors and framing discourse.

Years ago, when Fullmetal Alchemist (the first one) aired, someone released an mp3 of the seiyuu/voice actor for Roy Mustang either counting sheep or just plain counting in Japanese, probably from 1 to 100 or similar. It was extremely soothing. I have since lost my copy, and haven't had any luck finding it on the internet--does anyone know where to find this audio file?

The black hole is roughly 1,000 light-years from Earth — and more than 2,000 light-years closer than the next one known. What's more, scientists say, it may be just "the tip of an exciting iceberg."

In today's Alone Together series, Pam has suggested a track that is totally out there, so you have been warned! We'll be playing one of those songs each day on Life Matters as a way of lifting all our spirits. This one lifts the roof.

Andrew Forrest's Fortescue Metals Group loses its bid to overturn a Federal Court ruling granting native title to the Yindjibarndi people over a huge tract of iron-ore-rich Pilbara land.

A measles outbreak in Perth's south spreads to Western Australia's mining industry after a fly-in, fly-out worker for Fortescue Metals Group is diagnosed in the Pilbara.

The days of stubbing your toe on a chunk of gold may be over, but seasoned prospectors say there's still plenty to be found.

Two chemical leaks from metals processor Nyrstar have made their way into Port Pirie's groundwater and a waterway over the past two years, the ABC can reveal.

The owners of the mothballed Ravensthorpe nickel mine in WA's south-east, say they will move to re-open the site if surging demand for the metal continues.

Rutgers University-New Brunswick engineers have created flexible, lightweight 4D printed materials with potential applications in morphing airplane or drone wings, soft robotics and tiny implantable biomedical devices.

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties.

On March 27, 2019, the joint project IDAM held its kick-off meeting in Munich, which was intended to lead the way for furthering the use of AM processes in automotive series production.

An orthopaedic surgeon has identified the plate found in the corpse of 4.7-metre crocodile 'MJ' as a bone plate used to heal fractures in humans.

Check your public transport timetable before leaving the house this week in Sydney and NSW as more than 9,000 new weekly train, bus and ferry services launch for the Greater Sydney network.

After Justin Lampe's fencing business folded due to drought, he turned his hand to metal art sculptures and looked to his late father for inspiration.

(United States Seventh Circuit) - Affirmed. The district court's grant of summary judgment to defendants in a workplace injury case where the worker sued the manufacturer of a car crusher and the company it leased it to rather than his employer claiming defective design because his evidence did not comply with Federal Rule of Evidence 702.

(United States Fifth Circuit) - Held that a Houston law firm should be allowed to intervene in a lawsuit to protect its right to a contingent fee. The firm's client and the opposing party had allegedly conspired to cheat it out of its deserved attorney fee for work on a matter involving a foreign arbitral award. Remanded with directions to permit intervention and consider the law firm's claims on the merits.

(California Court of Appeal) - In a judgment enforcement action, arising out of a default judgment for plaintiff in a contracts dispute over defendant's failure to pay for sheet metal, the trial court's entry of amended default judgment is reversed in part and affirmed in part where: 1) Donald Koh was improperly added as a judgment debtor on an alter ego theory under Motores de Mexicali v. Superior Court, 51 Cal.2d 172 (1958); but 2) South Gate Steel was properly added as a judgment debtor on a corporate successor theory.

(California Court of Appeal) - Upheld an attorney fee award to a government contractor that defeated a municipality's claim brought under the California False Claims Act, even though the contractor did not prevail in the action as a whole.

(United States Seventh Circuit) - Affirmed. A lawsuit relating to who should pay for the cleanup of a contaminated site was dismissed because the limitations period had expired by the time the plaintiff filed suit.

(United States Seventh Circuit) - Affirmed. A lawsuit relating to who should pay for the cleanup of a contaminated site was dismissed because the limitations period had expired by the time the plaintiff filed suit.

NJ Rock Band Harvest Falls Debuts Video, Single, Charity Drive For New Song "MOMENT OF CONSEQUENCE"

Het is de maand van de meta-communicatie. Door het coronavirus vertellen we niet meer wat we doen, maar hoe we dat doen. Hoe moeten we thuiswerken met kinderen? Hoe kunnen we een online teammeeting inplannen? Hoe blijven we effectief in deze tijd? Deze vorm van communicatie heeft een naam: meta-communicatie. Wat is meta-communicatie precies? Wat […]

(United States Fifth Circuit) - Held that a Houston law firm should be allowed to intervene in a lawsuit to protect its right to a contingent fee. The firm's client and the opposing party had allegedly conspired to cheat it out of its deserved attorney fee for work on a matter involving a foreign arbitral award. Remanded with directions to permit intervention and consider the law firm's claims on the merits.

The Album Features Re-recordings Of 11 Classic TANK Songs Chosen From The First Four Albums And Given A New Lease Of Life With A Much More Up To Date Production And Renewed Energy.

New Standard Supports More Detailed Information On Compositions, Contributors, Artist Nicknames, Historic Chart Positions, Focus Track Data, Journalistic Material, And More

When it first made its debut fifteen years ago, this adorable Metallica "Master of Puppets" playset (made by Stevenson Entertainment...

The post Put on Your Own METALLICA Show During the Pandemic With This Mini-'Master of Puppets' Playset appeared first on Metal Injection.

Since 2016, Well of Night have been restlessly building their sound into a rare blend of riff-heavy, energetic and melodic...

The post WELL OF NIGHT Offer Seering, Melodic Black Metal Song "Doctrine of Futility and Human Extinction" appeared first on Metal Injection.

The word legend gets thrown around a lot, but Little Richard is undoubtedly a legend. He died earlier today at...

The post Rock & Metal Musicians Pay Tribute to Little Richard appeared first on Metal Injection.

Album Produced By Steve Evetts (The Dillinger Escape Plan, Suicide Silence, Poison The Well), And Mixed By Jamie King (Between The Buried And Me, The Contortionist)

New Album The Infinite Loop Out September 27th, Guest Performance By Derek Sherinian (Sons Of Apollo, Dream Theater)

SIFTING Reveal Emotional Music Video For Metal-ballad 'Enough', New Album Out September 27

Spencer Garrett, who portrayed Simon Tarses in The Next Generation: The Drumhead episode, spoke to StarTrek.com about getting the role, what the...

The production of formate from CO2 is considered an attractive strategy for the long-term storage of solar renewable energy in chemical form.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression.

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.

You read that right. Joanne and I visited a Masonic Cemetary. Alone. It was one of the most calming experiences of my life. We were kind of invited, by the town, and when we arrived, we were definitely welcomed by the residents. This all started when, in the brochure listing the “town attractions” that we received in St. Helens, were two cemeteries. The addresses as well as short descriptions were listed, as well as a short missive asking us to please be respectful and not make loud noises. It sounded really creepy and really interesting, so both of us jumped at the chance to drive out there right before sunset. They weren’t what I expected at all… Well, the first one was actually roped off with a “no trespassing” sign hanging from it, so we didn’t go inside. It was right alongside the highway in Oregon, across some old train tracks, visible from the road, and named and marked on a tourist map, yet they didn’t want visitors. I wonder what happened there. In any case, we headed for the other cemetery. This one was removed from the main road, and rumored to be a lot larger. It was also known to be haunted, but visitors were welcome as long as they were respectful. Off the map it was, but when we arrived, it was also gated off. A sad Joanne looks through the gate at the second destination that was cut off from us. Ah, but unlike the other cemetery, this one didn’t have a “no tresspassing” sign. There was a clear path around the sides of the gate, the ground bare of grass and obviously well-traversed. Apparently a lot of people walked around the gate. Maybe they just didn’t want us to drive. We decided to walk. There was even a sign. And a long, winding, steep road through the forest.  It was quite a hike to reach the top of the large hill where the cemetery was supposedly located, but the view was breathtaking. It took us a good ten or fifteen minutes to reach the top, and the road was quite steep. For some reason, to the immediate right of the trail, someone had been excavating land for quite some time, and there was a deep quarry. Why someone would dig a quarry next to a burial ground is beside me. I don’t doubt that the residents were unhappy about it. I wondered if maybe I would feel some spirits, but I didn’t expect what really happened to me. As soon as I stepped off of the road and onto the grass, a calm unlike anything I’ve ever felt descended upon me. It enveloped me in a warm cocoon, and Joanne and I immediately separated and wandered quietly alone between the gravestones. I know, 100%, that not only was I welcomed, but that the residents were happy to have me there. I talked a bit with some of the gravestones, but mostly wandered about, amazed at how much serenity I felt. We must have spent around a half hour wandering quietly alone, together, before we left in order to return to the festivities in town. But I’ll never forget the experience. It was something really, really special. I took some video footage too, but I’m not sure yet whether I want to use it. We’ll see! Someday, I’ll set up a tripod and get a shot of me walking like this. But for now, have Joanne instead. ???? <3

Барабанщик METALLICA Lars Ulrich считает, что его родная страна отлично справляется с мировой пандемией COVID-19.

Дания недавно начала медленно снимать ограничения для сдерживания распространения нового коронавируса. Вновь открылись школы для детей до 11 лет, а также малые предприятия, такие как парикмахерские и тату-салоны. Этот шаг был предпринят спустя чуть более месяца после того, как в Копенгагене были закрыты детские сады, начальные и средние школы, а также кафе, рестораны, бары, тренажёрные залы и парикмахерские. Кроме того, Дания расширила тестирование на коронавирус, включив в него людей со слабыми симптомами. Ранее тестировались только те, у кого симптомы были умеренными или тяжёлыми. Другие ограничения остаются в силе по крайней мере до 10 мая. Границы закрыты, а собрания ограничены 10 людьми.

Ulrich, родившийся в Дании и живший там до 16 лет, а затем переехавший в Лос-Анджелес, обсуждал пандемию коронавируса 28 апреля во разговора с Marc'ом Benioff'ом:

«Дания была одним из первых государств в мире, которое действительно пошло на полное закрытие страны, и там зарегистрировали самые низкие показатели заболеваемости во всей Западной Европе. Всего полторы недели назад они начали открывать детские сады и школы. И пока всё идёт хорошо. Но пока ещё рано говорить о полном успехе.

Я думаю, что мы все должны понимать, где бы мы ни были, по мере того, как мир снова открывается, это не произойдёт за один-два дня, как он был закрыт. Так что это будет очень постепенно. Как мы видим, даже в США есть места, которые начинают открываться, — есть они и в Европе, в Азии и так далее. У каждой страны будет свой набор средств и свои способы возвращения к новой жизни. Но Дания, за которой я ежедневно слежу, ведь я читаю датские газеты и общаюсь с моими друзьями в Дании, уже начала этот процесс. И я думаю, что они показывают весьма впечатляющий старт. Цифры, статистика и всё то, что не претерпело радикальных изменений, на самом деле, показатели продолжают снижаться. Как вы знаете, тут совсем не так, как было в некоторых азиатских странах, когда было дано небольшое послабление, и цифры вновь поползли вверх. Но в Дании пока это выглядит многообещающе.

Когда я думаю о Дании, я думаю только о слове "мы". В Дании всё всегда "мы" и "нас", и куда меньше про "я" и "меня". И поэтому, когда я думаю о том, что Дания пережила этот кризис, я очень горжусь тем, что называю себя датчанином. И я думаю, что прогресс, который там достигается, безусловно, воодушевляет и вдохновляет всех нас».

Когда ведущий спросил у Lars'a, не захочет ли он вернуться в Данию, если коронавирусный кризис в США усугубится, тот ответил, что у него всё ещё есть датский паспорт, и пошутил, что он спит, положив его под подушку:

«Мой датский паспорт находится рядом, если он вдруг понадобится!» #Metallica #ModernRock #Modern_Rock #AvantgardeRock #Avantgarde_Rock #HeavyMetal #Heavy_Metal #SymphonicMetal #Symphonic_Metal #ThrashMetal #Thrash_Metal