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East-West Center to Honor Distinguished Alumni at Okinawa Conference in September

HONOLULU (July 24, 2014) – The East-West Center has announced the names of EWC alumni, volunteers and a local alumni chapter that will be honored at the Center’s upcoming international alumni conference in Okinawa. The honorees are being recognized for their outstanding personal accomplishments and service toward the Center’s mission of helping to promote better relations and understanding among the peoples of Asia, the Pacific and the United States.

Distinguished Alumni Award




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Keethe Koyanagi, Shelley Wilson Selected as New Co-Chairs of East-West Center Foundation Board

Fundraising Board Also Welcomes Three New Members 

HONOLULU (Aug.19, 2014) – The Board of Directors of the East-West Center Foundation ­­- the Center’s community fundraising arm ­– has selected members Keethe Koyanagi and Shelley Wilson as the board’s new co-chairs. Koyanagi is senior vice president of the Credit Administration Division at First Hawaiian Bank, and Wilson is president of president of Wilson Homecare. Their one-year term as co-chairs began on Aug. 1.




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East-West Center Announces Scholarship Partnership with Okinawa Prefecture

NAHA, OKINAWA  (Sept. 20, 2014) – At the East-West Center’s 2014 international alumni conference that concluded yesterday  in Naha, Okinawa, Center officials announced a new partnership with the Okinawa Prefecture Government that will continue an established scholarship program that allows several Okinawan students each year to pursue graduate degree or leadership program study at EWC and the University of Hawai‘i.

From left: Hidemasu Goya, Robert Nakasone, EWC Adjunct Project Specialist, and Sayaka Sakuma

 




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Former Harvard Dean Paul Keenan Joins the East-West Center as Interim Development Director

HONOLULU (Sept. 26, 2014) – The East-West Center is pleased to announce that former Harvard Senior Associate Dean Paul Keenan has joined Center as Interim Director of Development. His part-time appointment is for an initial period of six months, beginning Sept. 23.

“Paul has proven relationship development skills, built over his 25 years of high-level experience in strategy development, marketing and organizational behavior and design,” said East-West Center President Charles E. Morrison. “We are greatly looking forward to his contributions to our strategic planning process and working with him to increase fundraising at the Center.”   




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East-West Center Welcomes New Diplomat-in-Residence, Nick Manring

HONOLULU (Sept. 25, 2014) – – Nicholas Manring, a 20-year veteran of the U.S. Foreign Service, has joined the East-West Center as Diplomat-in-Residence. He will be posted at the Center until June 2015.




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East-West Center Receives $750,000 NASA Grant to Study Changes in Mountain Forests of Nepal

HONOLULU (Jan. 15, 2015) -- The East-West Center has received a $750,000 grant from the U.S. National Aeronautics and Space Administration (NASA) to study changes in the mountain forests of Nepal over the past 25 years. Led by EWC Senior Fellow Jefferson Fox, the project will chart the previously unmapped mountain forests of Nepal’s Middle Hill region using data drawn from Landsat satellite imagery between 2000 and the present.

Investigators seek to document a suspected “forest transition” in Nepal, a country whose mountain forests have sustained the lives of much of its population for centuries. The forest transition refers to the recovery of trees and other plant growth in a previously deforested area.  




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East-West Center Awarded $267,000 Grant for U.S.-Japan Grassroots Exchange on Post-Disaster Community Building

Honolulu (Feb. 12, 2015) -- The East-West Center has been awarded a grant of  $267,186 from the Japan Foundation’s Center for Global Partnership for a three-year dialogue and travel-exchange program focusing on community participation in long-term recovery after a major disaster. 

Participants from the cities of Kobe and Kesennuma in Japan, and New Orleans and Galveston in the United States, will share experiences, perspectives, and best practices for increasing citizen input on post-disaster policy and decision-making. 




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East-West Center Announces 2015 Jefferson Fellows

International group of 15 accomplished journalists will travel together to China,
the Philippines, Singapore and Hawai‘i to study South China Sea conflicts

HONOLULU - (March 19, 2015) -- The East-West Center has announced the selection of 15 accomplished international journalists for its 2015 Jefferson Fellowships travel-study seminar. The journalists from 12 countries and territories will travel together in May to China, the Philippines, Singapore and Hawai‘i to study territorial conflicts, resource issues, environmental concerns and more in the South China Sea. Participants represent a range of top news organizations including the Associated Press, Washington Post, PBS NewsHour, Times of India, Straits Times, Kyodo News and others.




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East-West Center Community Responds to Nepal Quake

Photo by EWC Changing Faces Women's Leadership
Seminar alumna Luna K. C. Ghimire.




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East-West Center to Oversee $4 Million in NOAA Funding to Help Pacific Communities Cope with Climate Change

HONOLULU (May 5, 2015) -- The East-West Center has been awarded funding from the National Oceanic and Atmospheric Administration (NOAA) to continue to serve as the lead institution in the Pacific Regional Integrated Science and Assessment (RISA) program, which is designed to help island and coastal communities cope with the effects of climate change. This is the second full program award the Center has received from NOAA, and marks the program’s transition into a new phase.

The $4,099,785 NOAA grant will be shared over a five-year period by a variety of partners in the Pacific RISA program (see list below). The program was established in 2003 and is one of 11 regional RISA programs supported by NOAA across the U.S. The region covered by the Pacific program includes Hawai‘i, the Commonwealth of the Northern Mariana Islands, Guam, Federated States of Micronesia, Republic of the Marshall Islands, Republic of Palau and American Samoa.




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East-West Center Welcomes New Students From More Than 40 Countries and Territories

HONOLULU (August 13, 2015) – Nearly 100 student fellows from 40 countries and territories have arrived in Hawaii to participate in East-West Center programs this fall. The new graduate students and leadership program participants join a community of more than 110 continuing EWC participants in a diverse residential community on the East-West Center campus.

The new student fellows are participating in the EWC’s Community Building Institute, a two-week intensive activity that introduces the international students to Hawaii’s culture and major issues affecting the Asia Pacific region.




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Doris Duke Funding Adds U.S., Middle East Arts and Culture Reporters to East-West Center’s U.S.-Islamic Media Program

Doris Duke's Shangri La estate in Honolulu, now a center for Islamic arts and cultures. Photo: Reese Moriyama

HONOLULU (Aug. 18, 2015) – Thanks to more than $84,000 in funding from the Doris Duke Foundation for Islamic Art and the Doris Duke Charitable Foundation, the East-West Center’s 2015 Senior Journalists Seminar, which seeks to improve relations between the U.S. and Muslim regions, will include more Middle Eastern journalists and, for the first time, arts and culture reporters.




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East-West Center Researchers Receive National Science Foundation Grant for Trade and Innovation Workshop Series

HONOLULU (Sept. 3, 2015) – The East-West Center has received a $45,000 grant from the National Science Foundation to launch a series of agenda-setting workshops focusing on the impact of Asia Pacific trade agreements on trade and innovation in the region.

The East-West Center New Challenges for Trade and Innovation Workshop series, headed by EWC Senior Fellows Dieter Ernst and Michael Plummer, will bring together trade economists and experts on innovation, intellectual property rights, competition law, technical standards, and industrial development from the U.S., Asia and Europe.




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East-West Center Board Elects Richard Turbin as New Chairman

Honolulu Attorney Turbin chosen to head EWC’s Board of Governors;
Peter Ho and Ronald Moon appointed to board by Gov. Ige

HONOLULU (Feb 2, 2016) – Members of the East-West Center’s Board of Governors have elected Honolulu attorney Richard Turbin to serve as the board’s new chairman. At a meeting today, the board named Turbin, a member of the board since 2011, to succeed R. Brian Tsujimura, who had served his maximum term as chairman. Tsujimura will remain on the board as co-vice chair, along with re-appointed Vice Chair Margaret Carpenter, and as chair of the Development Committee.




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East-West Center Receives Largest Alumni Donation Ever

Longtime Taiwan IBM executive Gary S.H. Lin donates $300,000
to support EWC student scholarships and arts programs.

HONOLULU (March 14, 2016) – The East-West Center Foundation has received its largest single donation ever from a degree fellow alumnus. Longtime Taiwan IBM executive Gary S.H. Lin, who was a student at the Center in the 1960s, has donated $300,000 to support EWC student scholarships and arts programs. $250,000 of Lin’s gift will establish a scholarship fund to provide awards for one or more students from Taiwan who have an outstanding academic record and financial need, while the remaining $50,000 will provide support for Taiwan-related exhibitions or performances by the East-West Center Arts Program.




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New Supplemental Scholarship Established for Okinawan Students at the East-West Center

EWC Okinawan projects specialist Bob Nakasone
establishes $50,000 endowment in parents’ honor

 




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East-West Center Announces 2016 Jefferson Fellows

International group of 14 accomplished journalists will travel to China, Japan and Hawai‘i to explore the economic future of the Asia-Pacific region.

 

HONOLULU - (March 23, 2016) -- The East-West Center has announced the selection of 14 accomplished international journalists for its 2016 Jefferson Fellowships travel-study seminar. The print and broadcast journalists from 10 countries and territories will travel together in May to China, Japan and Hawai‘i to gain on-the-ground perspectives, deepen knowledge of regional issues and build a professional network of contacts. Participants represent a range of top news organizations including CNN International, National Public Radio, Times of India, Straits Times and others.

The selected Jefferson Fellows are:




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East-West Center Launches Asia Reacts ‘tracker’ of Asia’s Reactions to the U.S. Presidential Election and Foreign Policy

WASHINGTON, D.C.(May 11, 2016) - The Asia Matters for America initiative of the East-West Center today launched a new online resource, Asia Reacts, which tracks Asia’s reactions to important developments in U.S.–Asia relations during and after the 2016 U.S. presidential election. The effort will monitor responses of Asian governments, media, and experts.




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East-West Center Launches Revamped Pacific Islands Report Website

HONOLULU (June 16, 2016) – The Pacific Islands Development Program at the East-West Center has launched a new and improved version of its Pacific Islands Report news website, which provides readers with a free, curated roundup of current news, commentary and analysis from across the Pacific islands.




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Doris Duke Foundations Award East-West Center $300,000 Grant to Support U.S.-Islamic Journalist Exchange

HONOLULU (Aug. 8, 2016) – The East-West Center has been awarded a three-year grant totaling $300,000 from the Doris Duke Foundation for Islamic Art and the Doris Duke Charitable Foundation in support of the Center’s Senior Journalists Seminar media exchange program, which seeks to enhance media coverage and elevate the public debate regarding U.S. relations with Muslim majority regions.




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East-West Center Board of Governors Selects New President

HONOLULU (Aug. 26, 2016) -- The East-West Center Board of Governors announced that Dr. Richard R. Vuylsteke, an East-West Center alumnus with extensive experience throughout the Asia-Pacific region, has been selected as the next president of the East-West Center. The appointment of Dr. Vuylsteke concludes a year-long search involving several hundred potential candidates.




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East-West Center in Washington Kicks Off Inaugural Congressional Staff Program on Asia

WASHINGTON, D.C. (September 6, 2016) -- The East-West Center in Washington will hold the first session of the EWC-Sasakawa USA  Congressional Staff Program on Asia (CSPA), this week on Capitol Hill. This bipartisan educational certificate program for Congressional staff members will cover a range of contemporary, policy-relevant topics in U.S.-Asia relations over a series of weekly sessions, featuring speakers and discussions with U.S. officials and leading experts.




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East-West Center Welcomes New President

Dr. Richard R. Vuylsteke is an EWC alumnus who has run American Chambers of Commerce in Hong Kong and Taipei

HONOLULU (Jan. 5, 2017) – The East-West Center has welcomed its new President, Dr. Richard R. Vuylsteke, a former EWC grantee and staff member who rejoins the Center after several decades living in Asia and serving most recently as President of the American Chamber of Commerce in Hong Kong.




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East-West Center Board of Governors Elects Dr. James Scott as New Chairman

Former Punahou President is chosen by fellow board members to head EWC’s governing body; Bank of Hawai‘i’s Peter Ho named Vice Chair 

HONOLULU (Oct. 1, 2019) – Members of the East-West Center’s Board of Governors have elected board member and former Punahou School President Dr. James K. Scott to serve as the board’s new chairman. At a meeting Sept. 30, the board named Scott to succeed attorney Richard Turbin, who had served his maximum term as chairman but remains on the board as a member.




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East-West Center in Washington Concludes 2017 Congressional Staff Program on Asia

WASHINGTON, D.C. (August  9, 2017) –Congressional staff from Senate and House member offices and key committees wrapped up the 2017 EWC-Sasakawa USA  Congressional Staff Program on Asia (CSPA) last week on Capitol Hill. This bipartisan educational certificate program for Congressional staff members covered a range of contemporary, policy-relevant U.S.-Asia topics during weekly sessions between June and August.




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East-West Center Welcomes New Diplomat in Residence, Peggy Petrovich

HONOLULU (Sept. 7, 2017) –  Peggy Petrovich, a 17-year veteran of the U.S. Foreign Service, has joined the East-West Center as Diplomat-in-Residence. She will be posted at the Center until June 2018.




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East-West Center Board Re-Appoints Richard Turbin as Chairman

Former US Assistant Secretary of State Kurt Campbell and
Punahou School President James Scott Chosen as Vice Chairs

HONOLULU (Oct. 17, 2017) –Members of the East-West Center’s Board of Governors have re-appointed Honolulu attorney Richard Turbin as the board’s Chairman for another one-year term. Turbin, a member of the board since 2011, has served as its Chairman since February 2016. At a meeting on Oct. 6, the board also selected former US Assistant Secretary of State for East Asia and Pacific Kurt Campbell and Punahou School President James Scott as Vice-Chairs.




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East-West Center Receives $2.3 Million from Hawaii Pacific Rim Society

HONOLULU (Oct. 27, 2017) – The East-West Center has received one of the largest single donations in its history from longtime institutional supporter the Hawaii Pacific Rim Society. The $2.3 million gift will establish the Hideo Murakami Fund for Scholarships and the Arts to support EWC arts programming and scholarships for participants in the Center’s Asia Pacific Leadership Program.




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East-West Center Publishes Report on Inaugural Asia Pacific Dialogue of Women20 for the G20 Process

HONOLULU (January 19, 2018) – The East-West Center in Honolulu Hawai‘i has just published a report on the findings of the inaugural Women20 for the G20 Asia Pacific Dialogue, which was held at the Center in June. The 20-page report expands on initial policy recommendations that the participants released soon after the meeting to help the G20 address several of the most pressing areas of ongoing disparity in women’s economic status throughout the Asia Pacific region and the world.

Findings from the report will be highlighted at several upcoming international meetings on women’s empowerment:




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International Scholars, Officials and Business Leaders to Meet at East-West Center Alumni Conference in Seoul

HONOLULU (July 24, 2018) – Hundreds of scholars, officials, educators and business leaders from dozens of countries will be attending the East-West Center/EWC Association’s major international alumni conference, to be held August 23-25, 2018, at the Lotte Hotel Seoul.




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East-West Center Releases Updated Korea Matters for America/America Matters for Korea Publication and Website

WASHINGTON, DC (Aug. 27, 2018) -– The East-West Center and the Embassy of the Republic of Korea in the United States have now released the newest, updated versions of the Korea Matters for America/America Matters for Korea publication and website. The booklet and corresponding state and congressional district one-page connections summaries can be accessed and downloaded online at: https://AsiaMattersforAmerica.org/Korea.




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East-West Center Launches Updated 'Asia Matters for America' Publications and Website

Launch Event on Sidelines of Last Week's East Asia Summit in Singapore Marks 'Asia Matters' Data Initiative's 10th Anniversary

SINGAPORE (November 20, 2018) – At a conference on the sidelines of the East Asia Summit in Singapore last week, the East-West Center and the S. Rajaratnam School of International Studies at Nanyang Technological University, Singapore, with the support of the US Department of State, launched the East-West Center’s newly updated Asia Matters for America/America Matters for Asia publication, website, and one-page state summaries highlighting the mutual business, diplomatic, security, and cultural engagement between the US and the Indo-Pacific region.




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East-West Center Welcomes Ambassador Karena Lyons as New Vice President

HONOLULU (May 30, 2019) -- The East-West Center is pleased to welcome Ambassador Karena Lyons, the former New Zealand Ambassador to the nations of Micronesia and Consul General for Hawai‘i, as the Center’s new Vice President, Executive Director of Research, and Director (designate) of the Pacific Islands Development Program.




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East-West Center Alum David Stilwell Confirmed as Top U.S. Diplomat for Asia Pacific

HONOLULU (June 13, 2019) -- East-West Center alumnus David R. Stilwell was confirmed by 94-3 vote of the U.S. Senate today as the new U.S. Assistant Secretary of State for East Asian and Pacific Affairs. Stilwell, a retired Air Force Brigadier General, received his master’s degree in Asian studies as an EWC grantee in the 1980s and later was an Adjunct Senior Fellow with the Center.




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East-West Center Welcomes New Diplomat-in-Residence, Jay Avecilla

HONOLULU (Aug. 6, 2019) – Juan “Jay” Avecilla, a 16-year veteran of the U.S. Foreign Service, has joined the East-West Center as Diplomat-in-Residence. He will be posted at the Center until June 2020.

Prior to his arrival in Honolulu, Mr. Avecilla served as Management Officer in the U.S. Consulate General in Milan, Italy. Previously, he has served in various management positions at the U.S. Embassy in Islamabad, Pakistan and in the Bureau of European and Eurasian Affairs in Washington, D.C.  His other overseas assignments included tours as Consular/Management Officer in Fukuoka, Japan, Consular Officer in Buenos Aires, Argentina, and Economic Officer in Hanoi, Vietnam.    




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East-West Center Hosts Inaugural Micronesian Conference of Leaders

Delegations from the Federated States of Micronesia, Marshall Islands, and Palau
help chart course for a new era of the Pacific Islands Development Program




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Falklands' schools and Leisure Center will be reopening next Monday

Falkland Islands schools in Stanley are making final preparations for reopening on Monday, May 11. Camp Education, an integral part of the schooling system also re-opens on the same day.




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POSCO Completes Steel Wire Service Center in the U.S.

POSCO, Korea's largest steel maker, has completed on September 22 the construction of a steel wire service center in Jeffersonville, Indiana, with an annual capacity of 25,000 tons. The plant will supply steel wire goods to be used for bolts, nuts, and bearings to auto parts companies. Started in April last year, the service center cost the company US$20.9 million to build. The high-quality steel materials produced in the new plant will be supplied to companies like Simplex Korea, Taeyang M...




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Regency Centers Offers Compelling Value




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The Latest: Lack of food cited at India quarantine center

The Latest on the coronavirus pandemic. The new coronavirus causes mild or moderate symptoms for most people. For some, especially older adults and people with existing health problems, it can cause more severe illness or death. TOP OF THE HOUR: — Belarus hosts large military parade despite sharply rising coronavirus infections. — Germany says Europe must acknowledge it wasn’t well prepared for virus. — Seoul shuts down nightclubs, bars after spread of virus linked there. ___ PATNA, India — About 70 people fled from a quarantine center in the Indian state of Bihar’s Nawada district, alleging poor facilities and lack of food. They are among the tens of thousands of migrant workers who...




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Reimagining Japan Society New York: A beacon of hope at the epicenter of the pandemic

The U.S.-Japan relationship is going to come through this pandemic even stronger than before.




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HARMAN Opens New Software Center of Competence for Lifestyle Audio in India

BENGALURU, INDIA – HARMAN International Industries, Incorporated (NYSE: HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced that it has opened a new center of competence (CoC) for HARMAN’s...




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Open to the Public: Kennedy Center’s REACH Complex Welcomes Creativity, Music & Art

Sensuous and unique, the smooth white structures of the John F. Kennedy Center for the Performing Arts new, 21st century The REACH complex promises a different sort of experience than its more formal neighbor. Featuring innovative indoor and outdoor...




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Innovation Takes Center Stage at CES with HARMAN

It’s the most wonderful time of year again. That’s right, CES 2016 is upon us! This year in Las Vegas, you will experience firsthand a great suite of premium innovations from HARMAN - the premier connected technologies company for automotive, consumer and enterprise markets - featuring HARMAN’s unique approach to design and engineering. Can’t wait until January to see what’s new? Here’s a sneak peak of what to expect for CES and the year ahead. HARMAN will demonstrate the latest innovations and technologies in lifestyle audio and connected car to illustrate the future of connected lifestyle experiences.




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HARMAN to Establish New Global Development Center in Suzhou, China

AUTO CHINA 2014, BEIJING -- Harman International Industries, Inc. (NYSE:HAR), the global premium audio and infotainment group, said today that it will open a new global research and development center in Suzhou, China in mid 2015, initially adding about 100 new employees at the site. Construction of the new 10,000 sq. m. (100,000 sq. ft.) facility will begin in June. The announcement was made during the Beijing International Automotive Exhibition.




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HARMAN Ingenuity to take Center Stage at 2014 Audio Engineering Society Convention

LOS ANGELES, CA – HARMAN International Industries, Inc. (NYSE:HAR), the premium audio and infotainment group, will have a major presence at the 137th Audio Engineering Society Convention as it returns to the Los Angeles Convention Center Thursday, October 9 through Sunday, October 12 for the first time in twelve years. HARMAN, the premiere sponsor of both the annual AES President’s Reception and the AES Student Zone, will present several research papers, highlight new Professional audio equipment, and demonstrate the company’s latest innovative music restoration technology, Clari-Fi, throughout the week.




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Auto Show Season Kicks off with In-Car Audio Taking Center Stage in Detroit

At this year’s North American International Auto Show (NAIAS) in Detroit, HARMAN and its automotive partners brought the latest evolution of premium in-car experiences that reflect and seamlessly connect with your lifestyle. Ensuring users are...




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LeAnn Rimes Brings Battle With Psoriasis to Center Stage

Title: LeAnn Rimes Brings Battle With Psoriasis to Center Stage
Category: Health News
Created: 4/23/2010 10:10:00 AM
Last Editorial Review: 4/26/2010 12:00:00 AM




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Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers

ABSTRACT

Human adenoviruses (HAdVs) have developed mechanisms to manipulate cellular antiviral measures to ensure proper DNA replication, with detailed processes far from being understood. Host cells repress incoming viral genomes through a network of transcriptional regulators that normally control cellular homeostasis. The nuclear domains involved are promyelocytic leukemia protein nuclear bodies (PML-NBs), interferon-inducible, dot-like nuclear structures and hot spots of SUMO posttranslational modification (PTM). In HAdV-infected cells, such SUMO factories are found in close proximity to newly established viral replication centers (RCs) marked by the adenoviral DNA binding protein (DBP) E2A. Here, we show that E2A is a novel target of host SUMOylation, leading to PTMs supporting E2A function in promoting productive infection. Our data show that SUMOylated E2A interacts with PML. Decreasing SUMO-E2A protein levels by generating HAdV variants mutated in the three main SUMO conjugation motifs (SCMs) led to lower numbers of viral RCs and PML-NBs, and these two structures were no longer next to each other. Our data further indicate that SUMOylated E2A binds the host transcription factor Sp100A, promoting HAdV gene expression, and represents the molecular bridge between PML tracks and adjacent viral RCs. Consequently, E2A SCM mutations repressed late viral gene expression and progeny production. These data highlight a novel mechanism used by the virus to benefit from host antiviral responses by exploiting the cellular SUMO conjugation machinery.

IMPORTANCE PML nuclear bodies (PML-NBs) are implicated in general antiviral defense based on recruiting host restriction factors; however, it is not understood so far why viruses would establish viral replication centers (RCs) juxtaposed to such "antiviral" compartments. To understand this enigma, we investigate the cross talk between PML-NB components and viral RCs to find the missing link connecting both compartments to promote efficient viral replication and gene expression. Taken together, the current concept is more intricate than originally believed, since viruses apparently take advantage of several specific PML-NB-associated proteins to promote productive infection. Simultaneously, they efficiently inhibit antiviral measures to maintain the viral infectious program. Our data provide evidence that SUMOylation of the viral RC marker protein E2A represents the basis of this virus-host interface and regulates various downstream events to support HAdV productive infection. These results are the basis of our current attempts to generate and screen for specific E2A SUMOylation inhibitors to constitute novel therapeutic approaches to limit and prevent HAdV-mediated diseases and mortality of immunosuppressed patients.




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Ocrelizumab initiation in patients with MS: A multicenter observational study

Objective

To provide first real-world experience on patients with MS treated with the B cell–depleting antibody ocrelizumab.

Methods

We retrospectively collected data of patients who had received at least 1 treatment cycle (2 infusions) of ocrelizumab at 3 large neurology centers. Patients' characteristics including premedication, clinical disease course, and documented side effects were analyzed.

Results

We could identify 210 patients (125 women, mean age ± SD, 42.1 ± 11.4 years) who had received ocrelizumab with a mean disease duration of 7.3 years and a median Expanded Disability Status Scale score of 3.75 (interquartile range 2.5–5.5; range 0–8). Twenty-six percent of these patients had a primary progressive MS (PPMS), whereas 74% had a relapsing-remitting (RRMS) or active secondary progressive (aSPMS) disease course. Twenty-four percent of all patients were treatment naive, whereas 76% had received immune therapies before. After ocrelizumab initiation (median follow-up was 200 days, range 30–1,674 days), 13% of patients with RRMS/aSPMS experienced a relapse (accounting for an annualized relapse rate of 0.17, 95% CI 0.10–0.24), and 5% of all patients with MS experienced a 12-week confirmed disability progression. Treatment was generally well tolerated, albeit only short-term side effects were recorded, including direct infusion-related reactions and mild infections.

Conclusions

We provide class IV evidence that treatment with ocrelizumab can stabilize naive and pretreated patients, indicating that ocrelizumab is an option following potent MS drugs such as natalizumab and fingolimod. Further studies are warranted to confirm these findings and to reveal safety concerns in the longer-term follow-up.

Classification of evidence

This study provides Class IV evidence that for patients with MS, ocrelizumab can stabilize both treatment-naive and previously treated patients.