Steve Dalkowski, a hard-throwing, wild left-hander whose minor league career inspired the creation of Nuke LaLoosh in 'Bull Durham,' died. He was 80.

Art, kids and wildlife bring harmony to a Long Beach garden. Plus 10 tips on what to do in the garden while quarantined.

London Ambulance Service and London Fire Brigade have announced a new partnership to boost the Covid-19 emergency response which will see firefighters helping with a number of roles across the ambulance service

Cinematographers Rodrigo Prieto and Lawrence Sher compare notes on their films, 'The Irishman' and 'Joker.'

Amber Havard and Rob Morgan co-star in "Bull," a drama about a troubled teen in a poor Houston neighborhood who comes under the tutelage of her neighbor.

Max Verstappen is keeping himself busy by taking part in esports races.

CELTIC will need to up their offer to David Turnbull if they want to salvage his £3million transfer.

CELTIC captain Scott Brown insists David Turnbull’s chances of joining the Hoops are not dead and urged the midfielder to re-think his transfer snub because they are “the right club” for him.

CELTIC have officially ended their pursuit of David Turnbull after being unable to agree personal terms with the Motherwell youngster.

STEPH MCGOVERN - who fronts her self-titled show The Steph Show on Channel 4 - made a cheeky admission on Twitter as her former BBC Breakfast co-star Bill Turnbull reacted to the presenter's "drunk" confession.

The victim, Nya Cope, was in a car with members of her family when she was shot, police said.

It was vintage Kamar Baldwin against Xavier

The Indianapolis Star is re-posting game stories from the 10-year anniversary of Butler's run to the 2010 NCAA championship game.

Ronald, not known as a shooter, breaks a long dry spell, and Willie Veasley follows with a 3 to push the Bulldogs over the Orange

Hayward scored eight of his 22 points in the closing six minutes, and Butler knocked off Kansas State 63-56 Saturday in the NCAA West Regional final.

The Bulldogs reached the title game with a 52-50 victory over Michigan State

Butler Bulldogs take Duke to the limit in the 2010 national championship game at Lucas Oil Stadium, capped but a famous missed shot

Brownsburg upended Plainfield on Dec. 7 but the Bulldogs will be missing a key player when the two teams meet in the Hendricks County finals.

DES MOINES-Iowa Firearms Coalition President Barry Snell shared their mission of protecting Second Amendment Rights for Iowans at the Bull Moose Club luncheon in Des Moines on Tuesday.  He explained how the IFC was formed and gave an update on their legislative achievements since their formation in 2010. “IFC got […]

Sabonis has two dance videos out, one in Pacers gear, the other shirtless.

The Bulldogs reached the title game with a 52-50 victory over Michigan State

Butler Bulldogs take Duke to the limit in the 2010 national championship game at Lucas Oil Stadium, capped but a famous missed shot

A chronology of key events

Key facts, figures and dates

How do you help millions of passengers navigate one of the world's largest airports? In Turkey, the answer is a fleet of humanoid robots.

The president and his team of unelected bureaucrats have siphoned power away from the legislature.

Istanbul Turkey

The Amateur Traveler talks to Vicente Perez about his home city of Pamplona, Spain. Pamplona is best known for the festival of San Fermin and of course for the running of the bulls. Vicente tells us more about that colorful festival, of which, the running of the bulls is actually a very small part. From the Txupinazo, the ceremonial firing of a rocket on July 6th until July 14th the population of Pamplona swells with celebrants. Processions of giant figures (the Comparsa), music, bull fights and lots and lots of partying fill the days and nights. But Vicente also tells of some of the other features of Pamplona and the Navarre region that can be enjoyed any time of year including wonderful food, beautiful mountains, castles, and the nearby cave of Zugarramurdi (Known for the Basque witch trials).

The Amateur Traveler talks to Craig Zabransky fro StayAdventurous.com about his recent trip to Bulgaria. He traveled with a Bulgarian friend and visited picturesque towns as well as the amazing blue waters of the Black Sea.

Hear about travel to Sofia, Bulgaria as the Amateur Traveler talks to Stephanie Craig from historyfangirl.com about her time in that country.

Hear about travel to Istanbul, Turkey as the Amateur Traveler talks to Christopher Mitchel from travelingmitch.com about the city where he lived for 3 years.

Hear about travel to Istanbul, Turkey as the Amateur Traveler talks to Christopher Mitchell from travelingmitch.com about the city where he lived for 3 years.

Hear about travel to Bulgaria as the Amateur Traveler talks to Tom and Patty Burkett about their road trip from Sofia to the Black Sea.

Everybody wanted to get to the shore last weekend when the state of Florida reopened its beaches. But one of the beachgoers who came in for some extra attention was a six-foot-long bull shark caught near Navarre Beach, according to WKRG-TV. Video shot by Shelley Goudy of Fort Walton showed several men gathered around the…

The post Florida Fishermen Nab 6-Foot Bull Shark During First Weekend of Reopened Beaches appeared first on The Western Journal.

The genial young administrator with a burgeoning reputation chuckles when it's pointed out to him that he can't seem to shake off 'working' for some of South Africa's biggest businessmen.

Kindlins are focal adhesion proteins that regulate integrin activation and outside-in signaling. The kindlin family consists of three members, kindlin-1, -2, and -3. Kindlin-2 is widely expressed in multiple cell types, except those from the hematopoietic lineage. A previous study has reported that the Drosophila Fit1 protein (an ortholog of kindlin-2) prevents abnormal spindle assembly; however, the mechanism remains unknown. Here, we show that kindlin-2 maintains spindle integrity in mitotic human cells. The human neuroblastoma SH-SY5Y cell line expresses only kindlin-2, and we found that when SH-SY5Y cells are depleted of kindlin-2, they exhibit pronounced spindle abnormalities and delayed mitosis. Of note, acetylation of α-tubulin, which maintains microtubule flexibility and stability, was diminished in the kindlin-2–depleted cells. Mechanistically, we found that kindlin-2 maintains α-tubulin acetylation by inhibiting the microtubule-associated deacetylase histone deacetylase 6 (HDAC6) via a signaling pathway involving AKT Ser/Thr kinase (AKT)/glycogen synthase kinase 3β (GSK3β) or paxillin. We also provide evidence that prolonged hypoxia down-regulates kindlin-2 expression, leading to spindle abnormalities not only in the SH-SY5Y cell line, but also cell lines derived from colon and breast tissues. The findings of our study highlight that kindlin-2 regulates mitotic spindle assembly and that this process is perturbed in cancer cells in a hypoxic environment.

31 July 2014 , Volume 70, Number 4

A long view of the problems of modern migration

7 May 2020 , Volume 96, Number 3

Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels.