CERN scientists have successfully tested a new method for transporting particles like protons, using the BASE-STEP system. This breakthrough opens the door to transporting antimatter safely across long distances, facilitating more precise experiments at laboratories such as Heinrich Heine University in Düsseldorf. The system, which uses vacuum chambers and superconducting magnets, promises to revolutionize antimatter research in the coming years.

Bharat Sanchar Nigam Limited (BSNL) has announced the launch of the first fibre-based intranet TV service in select regions in India. This service, dubbed IFTV, was first introduced last month alongside the unveiling of the state-owned telecommunications provider’s new logo and six other new facilities.

Experienced healthcare management strategist hired after lengthy national search Insurance Commissioner Trinidad Navarro welcomed Cristine Vogel to the Delaware Department of Insurance as its Director of Value-Based Health Care Delivery this week after a lengthy national search to fill the role. As the inaugural Director, Vogel will lead efforts that relate to value-based care, primary […]

Identifies Areas of Compliance and Opportunities to Continue Health Care Payment Transformation Early in March, Insurance Commissioner Trinidad Navarro and Cristine Vogel, the Director of the Department’s Office of Value-Based Health Care Delivery, issued the Annual Review of Carrier Progress Towards Meeting Affordability Standards. Vogel leads the Department’s efforts relating to value-based care, primary care, […]

For arts programming and projects taking place during fiscal year 2022 (September 2021 – August 2022) Wilmington, Del. (December 1, 2020) – The Delaware Division of the Arts has opened its annual online application process for grants for arts programming and projects taking place during fiscal year 2022 (September 2021 – August 2022). Applications will […]

For arts programming and projects taking place during fiscal year 2023 (September 2022 – August 2023) Wilmington, Del. (January 11, 2022) – The Delaware Division of the Arts has opened its annual online application process for grants for arts programming and projects taking place during fiscal year 2023 (September 2022 – August 2023). Applications will […]

For arts programming and projects taking place during fiscal year 2024 (September 2023 – August 2024)   Wilmington, Del. (December 2, 2022) – The Delaware Division of the Arts has opened its annual online application process for grants for arts programming and projects taking place during fiscal year 2024 (September 2023 – August 2024). Applications […]

The Delaware Division of the Arts has opened its annual online application process for grants for arts programming and projects taking place during fiscal year 2025 (September 2024 – August 2025). Applications will be submitted through the smARTDE online system and are due by 4:30 p.m. EST on Friday, March 1, 2024. New to smARTDE? […]

WILMINGTON, Del. – After reviewing customer feedback from three Community Conversations in Wilmington and Newark last week, DART will make a series of improvements. The recent Community Conversations offered DART riders, and the general public, the opportunity to provide feedback and share their experiences since DART’s service changes in mid-December. “The Community Conversations were intended […]

It is definitely in the fitness of things that the Supreme Court in a most learned, laudable, landmark, logical and latest judgment titled Ramji Lal Bairwa & Anr vs State of Rajasthan & Ors in Criminal Appeal No. 3403 of 2023 (@ SLP (Crl.) No. 12912 of 2022) and cited in Neutral Citation No.: 2024 I

NEW CASTLE (April 7, 2022) – The Department of Health and Social Services (DHSS) has launched a new website called CostAware to help Delawareans understand how their health care dollars are spent by comparing the variation of average costs for different episodes of care and medical services based on actual medical claims in Delaware. Hospital […]

The Delaware Division of Public Health (DPH), and Delaware Healthy Mother & Infant Consortium (DHMIC) are seeking applicants for Healthy Women, Healthy Babies (HWHB) Zones mini-grants to improve maternal and infant health outcomes in Delaware using community-based approaches.   It is anticipated that two new mini-grantees will be funded for the new grant cycle — each […]

DOVER, DE (Aug. 8, 2022) — The Delaware Division of Public Health’s (DPH) Physical Activity, Nutrition, and Obesity Prevention Program (PANO) is seeking mini-grant applications as part of the Advancing Healthy Lifestyles (AHL) initiative to improve community health and reduce chronic health conditions.   PANO expects to award five to eight mini-grants ranging from $5,000 to $15,000 in September.  All applications are due no later than August 17. The project period will run from October 2022 to May […]

Atlas Biomed's website is no longer active and the phone number listed is dead as well.

Owlet, a connected-baby care company raised a $24 million Series B investment from Trilogy Equity Partners, with participation from existing investors, including Eclipse Ventures, Broadway Angels, and Enfield Ventures, and the addition Pelion Venture Partners.

Owlet’s core product is a baby sock that contains a smart sensor. The sensor monitors pulse oximetry, a technology used in hospitals to measure an infant's heart rate and blood oxygen levels. The vital signs are communicated to parents’ smartphone via Bluetooth connection. The product retails for $299 and parents can also choose from monthly payment plans.

Other IoT-health startups using sensors to monitor vital signs include Aifloo, a company selling wrist-bands for elders and Air by Propeller, a smart health company that provides an API to predict local asthma conditions.

A complete product package of Owlet monitor includes three fabric socks, smart sock sensor, a base station (which rings an alarm if a baby’s vital signs are abnormal), and charging cords.

Before the company raised the latest round, it closed a $15 million Series B round in late 2016. The recent investment brought Owlet’s total equity funding to $46M. Owlet plans to use the growth capital to launch more baby care products.

Vesper, the maker of piezoelectric sensors used in microphone production and winner of CES Innovation Award 2018 raised a $23M Series B round. American Family Ventures led the investment with participation from Accomplice, Amazon Alexa Fund, Baidu, Bose Ventures, Hyperplane, Sands Capital, Shure, Synaptics, ZZ Capital and some undisclosed investors.

Vesper’s innovative sensors can be used in consumer electronics like TV remote controls, smart speakers, smartphones, intelligent sensor nodes, and hearables. The company will use the funding proceeds to scale-up its functions like mass production of its microphones and support expanded research and development, hiring, and establishing international sales offices.

The main product of Vesper is VM1000, a low noise, high range,single-ended analog output piezoelectric MEMS microphone. It consists of a piezoelectric sensor and circuitry to buffer and amplify the output.

The hot-selling product of Vesper is VM1010 with ZeroPower Listening which is the first MEMS microphone that enables voice activation to battery-powered consumer devices.

The unique selling point of Vesper’s products is they are built to operate in rugged environments that have dust and moisture.

"Vesper's ZeroPower Listening capabilities coupled with its ability to withstand water, dust, oil, and particulate contaminants enables users that have never before been possible," said Katelyn Johnson, principal of American Family Ventures. "We are excited about Vesper's quest to transform our connected world, including IoT devices."

Other recent funding news include $24 raised by sensor-based baby sock maker Owlet, IFTTT banks $24M from Salesforce to scale its IoT Enterprise offering, and Intel sells its Wind River Software to TPG.

In the rapidly evolving landscape of automotive electronics, traditional monolithic design approaches are giving way to something more flexible and powerful—chiplets. These modular microchips, which are themselves parts of a whole silicon system, offer unparalleled potential for improving system performance, reducing manufacturing costs, and accelerating time-to-market in the automotive sector. However, the transition to working with chiplets in automotive electronics is not without its challenges.

Designers must now grapple with a new set of considerations, such as die-to-die interconnect standards, complex processes, and the integration of diverse IPs. Advanced toolsets and standardized design approaches are required to meet these challenges head-on and elevate the potential of chiplets in automotive innovation. In the following discourse, we will explore in detail the significance of chiplets in the context of automotive electronics, the obstacles designers face when working with this paradigm, and how Cadence comprehensive suite of IPs, tools, and flows is pioneering solutions to streamline the chiplet design process.

Unveiling Chiplets in Automotive Electronics

For automotive electronics, chiplets offer a methodology to modularize complex functionalities, integrate different chiplets into a package, and significantly enhance scalability and manufacturability. By breaking down semiconductor designs into a collection of chiplets, each fulfilling specific functions, automotive manufacturers can mix and match chiplets to rapidly prototype new designs, update existing ones, and specialize for the myriad of use cases found in vehicles today.

The increasing significance of chiplets in automotive electronics comes as a response to several industry-impacting phenomena. The most obvious among these is the physical restriction of Moore's Law, as large die sizes lead to poor yields and escalating production costs. Chiplets with localized process specialization can offer superior functionality at a more digestible cost, maintaining a growth trajectory where monolithic designs cannot. Furthermore, chiplets support the assembly of disparate technologies onto a single subsystem, providing a comprehensive yet adaptive solution to the diverse demands present in modern vehicles, such as central computing units, advanced driver-assistance systems (ADAS), infotainment units, and in-vehicle networks. This chiplet-based approach to functional integration in automotive electronics necessitates intricate design, optimization, and validation strategies across multiple domains.

The Complexity Within Chiplets

Yet, with the promise of chiplets comes a series of intricate design challenges. Chiplets necessitate working across multiple substrates and technologies, rendering the once-familiar 2-dimensional design space into the complex reality of multi-layered, sometimes even three-dimensional domains. The intricacies embedded within this design modality mandate devoting considerable attention to partitioning trade-offs, signal integrity across multiple substrates, thermal behavior of stacked dies, and the emergence of new assembly design kits to complement process design kits (PDKs).

To effectively address these complexities, designers must wield sophisticated tools that facilitate co-design, co-analysis, and the creation of a robust virtual platform for architectural exploration. Standardizations like the Universal Chip Interconnect Express (UCIe) have been influential, providing a die-to-die interconnect foundation for chiplets that is both standardized and automotive-ready. The availability of UCIe PHY and controller IP from Cadence and other leading developers further eases the integration of chiplets in automotive designs.

The Role of Foundries and Packaging in Chiplets

Foundries have also pivoted their services to become a vital part of the chiplet process, providing specialized design kits that cater to the unique requirements of chiplets. In tandem, packaging has morphed from being a mere logistical afterthought to a value-added aspect of chiplets. Organizations now look to packaging to deliver enhanced performance, reduced power consumption, and the integrity required by the diverse range of technologies encompassed in a single chip or package. This shift requires advanced multiscale design and analysis strategies that resonate across a spectrum of design domains.

Tooling Up for Chiplets with Cadence

Cadence exemplifies the rise of comprehensive tooling and workflows to facilitate chiplet-based automotive electronics design. Their integrations address the challenges that chiplet-based SoCs present, ensuring a seamless design process from the initial concept to production. The Cadence suite of tools is tailored to work across design domains, ensuring coherence and efficiency at every step of the chiplet integration process.

For instance, Cadence Virtuoso RF subflows have become critical in navigating radio frequency (RF) challenges within the chiplets, while tools such as the Integrity 3D-IC Platform and the Allegro Advanced Multi-Die Package Design Solution have surfaced to enable comprehensive multi-die package designs. The Integrity Signal Planner extends its capabilities into the chiplet ecosystem, providing a centralized platform where system-wide signal integrity can be proactively managed. Sigrity and Celsius, on the other hand, offer universally applicable solutions that take on the challenges of chiplets in signal integrity and thermal considerations, irrespective of the design domain. Each of these integrated analysis solutions underscores the intricate symphony between technology, design, and packaging essential in unlocking the potential of chiplets for automotive electronics.

Cadence portfolio includes solutions for system analysis, optimization, and signoff to complement these domain-specific tools, ensuring that the challenges of chiplet designs don't halt progress toward innovative automotive electronics. Cadence enables designers to engage in power- and thermal-aware design practices through their toolset, a necessity as automotive systems become increasingly sophisticated and power-efficient.

A Standardized Approach to Success with Chiplets

Cadence’s support for UCIe underscores the criticality of standardized approaches for heterogeneous integration by conforming to UCIe standards, which numerous industry stakeholders back. By co-chairing the UCIe Automotive working group, Cadence ensures that automotive designs have a universal and standardized Die-to-Die (D2D) high-speed interface through which chiplets can intercommunicate, unleashing the true potential of modular design.

Furthermore, Cadence champions the utilization of virtual platforms by providing transaction-level models (TLMs) for their UCIe D2D IP to simulate the interaction between chiplets at a higher level of abstraction. Moreover, individual chiplets can be simulated within a chiplet-based SoC context leveraging virtual platforms. Utilizing UVM or SCE-MI methodologies, TLMs, and virtual platforms serve as first lines of defense in identifying and addressing issues early in the design process before physical silicon even enters the picture.

Navigating With the Right Tools

The road to chiplet-driven automotive electronics is one paved with complexity, but with a commitment to standards, it is a path that promises significant rewards. By leveraging Cadence UCIe Design and Verification IP, tools, and methodologies, automotive designers are empowered to chart a course toward chiplets and help to establish a chiplet ecosystem. With challenges ranging from die-to-die interconnect to standardization, heterogeneous integration, and advanced packaging, the need for a seamless integrated flow and highly automated design approaches has never been more apparent. Companies like Cadence are tackling these challenges, providing the key technology for automotive designers seeking to utilize chiplets for the next-generation E/E architecture of vehicular technology.

In summary, chiplets have the potential to revolutionize the automotive electronics industry, breathing new life into the way vehicles are designed, manufactured, and operated. By understanding the significance of chiplets and addressing the challenges they present, automotive electronics is poised for a paradigm shift—one that combines the art of human ingenuity with the power of modular and scalable microchips to shape a future that is not only efficient but truly intelligent.

Learn more about how Cadence can help to enable automakers and OEMs with various aspects of automotive design.

The automotive industry revolutionized the definition of a vehicle in terms of safety, comfort, enhanced autonomy, and internet connectivity. With this trend, the automotive industry rapidly adopted automotive Ethernet such as 10Base-T1, 100Base-T1, and in some cases, 1000Base-T1. 

Faster Speed (than CAN-FD), Scalability, embedded security protocols (like MacSec), cost and energy efficiency, and simple yet redundant network made Ethernet an obvious choice over CAN(FD) and FlexRay.  

Ethernet 10Base-T1 

10BASE-T1S is defined under IEEE with 802.3cg. The S in 10BASE-T1S stands for a short distance. 10BASE-T1S uses a multidrop topology, where each node connects to a single cable. Multidrop topology eliminates the need for switches and, as a result, fewer cables/less cost. The primary goal of 10BASE-T1S is a deterministic transmission on a collision-free multidrop network. 10BASE-T1S cables use a pair of twisted wires. As per IEEE, at least eight nodes can connect to each, but more connections are feasible.    

The Physical Layer Collision Avoidance [PLCA] protocol ensures that it uses the entire 10 Mbps bandwidth. In 10BaseTs, Reconciliation Sublayer provides optional Physical Layer Collision Avoidance (PLCA) capabilities among participating stations. Using PLCA-enabled Physical Layers in CSMA/CD half-duplex shared-medium networks can provide enhanced bandwidth and improved access latency under heavily loaded traffic conditions. The working principle of PLCA is that transmit opportunities on a mixing segment are granted in sequence based on a node ID unique to the local collision domain (set by the management entity). 10BASE-T1S also supports an arbitration scheme that guarantees consistent node access to the media within a predefined time.  

The 10BASE-T1S PHY is intended to cover the low-speed/low-cost applications in the industrial and automotive environment. A large number of pins (16) required by the MII interface is one of the significant cost factors that must be addressed to fulfill this objective. The 10BASE-T1S "Transceiver" solution is suited for embedded systems where the digital portion of the PHY is fully integrated, e.g., into an MCU or an Ethernet switch core, leaving only the analog portion (the transceiver) into a separate IC. 

Ethernet 100Base-T1/1000Base-T1 

100Base-T1 and 1000Base-T1 can be used for audio/video information. With Higher bandwidth capacity, 100Base-T1/ 1000Base-T1 paired with AVB (Audio video bridging) can be used for car infotainment systems. 100Base-T1/1000Base-T1 paired with time-sensitive networking [TSN] protocol can be used to fulfill the automotive industry's mission-critical, time-sensitive, and deterministic latency needs. 

 PTP Over MacSec  

With today's automotive network, all the Electronic Control Units connected require timing accuracy and network synchronization, Precision Time Protocol (PTP), defined in IEEE 1588, provides synchronized clocks throughout a network.  While maintaining the timing accuracy for mission-critical applications, protecting the vehicle network from vulnerable threats is mandatory, and PTP over MacSec provides the consolidated solution.  

With the availability of the Cadence Verification IP for 10/100/1000BaseT1 and TSN, adopters can start working with these specifications immediately, ensuring compliance with the standard and achieving the fastest path to IP and SoC verification closure. The 10/100/1000GBaseT1 and TSN provide a full-stack solution, including support to the PHY, MAC, and TSN layers with a comprehensive coverage model and protocol checkers. Ethernet BaseT1 and TSN VIP covers all features required for complete coverage verification closure. More details are available in the Ethernet Verification IP portfolio. 

Krunal 

The DBDoctor application checks the database for errors and other problems, and presents a report about them. DBDoctor supports .brd, .mcm, .mdd, .psm, .dra, .pad, .sav, and .scf databases.

DBDoctor can:

• Analyze and fix database problems.
• Eliminate duplicate vias.
• Perform batch design rule checking (DRC).
• Upgrade databases more than one revision old.

To verify the integrity of a drawing database at any time during the design cycle, run DBDoctor at regular intervals but make sure you always run it after completing a design.

You can run DBDoctor to verify work in progress, or from a terminal window outside the layout editor, perhaps to check multiple input designs in batch mode by using wildcards and various switches. You do not have to run the layout editor to use DBDoctor.

To run this from Allegro X APD and Allegro PCB Editor, go to Tools > Database Check.

You can also go to the Start menu and select Cadence PCB Utilities 2023 > PCB DB Doctor 2023.

You can also use the following command to run DBDoctor in batch mode in the system command prompt:

dbdoctor [-check_only] [-drc] [-drc_only] [-shapes][-no_backup] [-outfile <newboardname.brd>]>

Comment below if you want to know more about this command and its integration with SKILL programming!!

Hey, is it suitable to post here? I wanted a small yet robust amp for practicing while I travel. I wanted something that would fit in my pocket yet still be loud enough to hear.

Presented here is a amplifier based upon the LM386 Audio Amplifier.

There is a standard circuit in the data sheet that is an excellent place to start.

Materials needed:
1 - HM359 project box
1 - 668-1237 speaker
1 - BS6I battery conn
1 - CP1-3515 stereo jack
1 - SC1316 stereo jack
2 - 450-1742 knob
1 - 679-1856 switch
1- 3mm LED
1 - 10 ohm 1/4W resistor
1 - 10uF ceramic cap
1 - .05 uF ceramic cap
1 - 420 uF electrolytic cap
1 - 8 ohm resistor
2 - 51AADB24 10K pot
1 - HM1252 circuit board
1 - LM386N-4 amplifier

Wire and Solder
Step 1: Prep the enclosure

Careful planning is required the first time you free build a circuit. The circuit board has solder pads but not traces. You will have to use thin wire to make the connections for the circuit to work.

Begin by laying out the components on the circuit board that will need to pass through the enclosure. This enclosure has a removable top panel which will be used for the volume, gain and 1/4 inch stereo jack.

Space is limited to check for fit before drilling.

All drilling of the plastic should be done with a step drill bit. This will make the cleanest holes without breaking the plastic.

Lay out the pots a few spaces back but still in line with the desired position. mark the center of each pot shaft then drill with a step drill tot he tightest fitting hole size. Make a center mark between the pot holes then drill for the stereo jack

On the inside of the top cover position and mark where the speaker will go.

Make a template on grid paper the same size as the speaker.

Tape the template to the inside of the cover as shown then use a step bit to drill holes on the center of every square in the grid. This will form the speaker grille. clean up the holes.

Step 2: place the major components

Solder the pots to the circuit board as shown. then place the stereo jack(note in order to get the final fit I had to trim and modify the stereo jack housing a little)

Next, position and solder the switch on the circuit board and mark a space on the top cover that will need to be cut for the switch opening. Use a small file to cut the opening.

Use a sharp knife to bevel the edges of the switch hole to allow for easier operation.

Drill a hole in the side of the upper case for the headphone jack and fasten it in place. ( I had to recess the hole a bit for the retaining nut to grab)

Step 3: Build the circuit

The speaker is held in place by using 2 small brackets that come with the serial cable connector hood. ( I had a bunch around that would never be used)

Refer the the circuit shown from the datasheet and the datasheet for the LM386. The basic circuit only has the volume control while the datasheet shows how to add a gain control across pins 1 and 8 of the amplifier.

The speaker is wired in series with the headphone jack. The headphone jack has internal switches that shut the speaker off when the phones are plugged in.

I chose to use a chip socket for the amplifier which make prototyping easier since you do not have to worry about solder heating as much.

Carefully lay the circuit out on the board and begin wiring components together. I added a second pot and cap in series between pins 1 and 8 of the amp to be able to manually set the gain in addition to volume.

Check you connections with a multimeter before adding the amplifier.

I chose to add a LED indicator for power. This was done by using one side of switch contacts from the battery. The LED is in series with a 220 ohm resistor.

Assemble the case and insert the battery.

Step 4: Final notes

If the speaker is noisy while the headphones work normally, try reversing the speaker connections. If it does not correct the issue, connect a 8 ohm resistor across the speaker contacts.

You may have to place an insulating layer between the speaker and the place where the stereo jack comes through to prevent contact. This will be noted by a loud buzz.

You may have to add some foam in the battery compartment to stop the battery from banging around.

For reference, I've also read an article about amplifiers: http://www.apogeeweb.net/article/60.html

Thanks for reading!
​

At a bustling Cadence event, we met Adrian, an intern at a startup who immerses himself in Cadence tools for his research and work.

Adrian was enthusiastic about the innovative technologies at his disposal but faced a significant challenge: internet access was limited to a single machine for new joiners, forcing interns to wait in line for their turn to use online resources.

Adrian's excitement soared when he discovered a game-changing solution: Doc Assistant. The cloud-based help viewer, Doc Assistant, ships with all Cadence tools, enabling Adrian to access help resources offline from any machine equipped with the software. This meant Adrian could continue his research and work seamlessly, irrespective of internet availability!

Meeting Cadence users and customers at such events has given us the opportunity to showcase how they can benefit from the diverse features that Doc Assistant offers.

With that note, welcome back to our Doc Assistant A-Z blog series! In Part 1, we explored key features and benefits that our innovative viewer brings to the table. Today, in Part 2, we'll dive deeper into the advanced functionalities and customization options that make Doc Assistant indispensable for its users.

Whether you're looking to streamline your workflow or enhance your user experience, this blog will provide the insights you need to fully leverage the capabilities of our documentation viewer. Let’s get started!

What Makes Doc Assistant Stand Out?

Here are a few (more) cool features of Doc Assistant!

That's not all. We have more coming your way. Until next time, take care and stay tuned for our next edition!

Want to Know More?

For any questions or general feedback, write to docassistant.support@cadence.com.

Subscribe to receive email notifications about our latest Custom IC Design blog posts.

Happy reading!

-Priya Sriram, on behalf of the Doc Assistant Team

Welcome back to the Doc Assistant A-Z blog series!

Since the launch of Doc Assistant, we've been gathering feedback and input from our customers regarding their experiences with our latest documentation viewer. My interaction with Ralf was particularly useful and interesting.

Ralf is a design engineer who works on complex schematics and intricate layouts. For each release, he is challenged with the task of verifying the tool and feature changes across multiple releases. He shared with me that he has been using Doc Assistant’s capabilities to help him achieve this.

Ralf explained that he utilizes Doc Assistant to open and compare documents from different releases side-by-side, seamlessly tracking updates across multiple releases and verifying those updates in his Cadence tools. Additionally, in Doc Assistant’s online mode, he compares documents across previous tool versions, ensuring a thorough review of any changes. Finally, he was happy to share with me that Doc Assistant features have helped him significantly reduce the time he spends on identifying such changes.

You, of course, can also achieve such productivity gains using several Doc Assistant features designed to help simplify such tasks!

In previous editions of this blog series, we looked at some key features and benefits of Doc Assistant. If you've missed these editions, I would highly recommend that you read them:

• Doc Assistant A-Z: Making the Most of the Cadence Cloud-Based Help Viewer: Part 1
• Doc Assistant A-Z: Making the Most of the Cadence Cloud-Based Help Viewer: Part 2
  

In this third installment, we're diving into some more of Doc Assistant's key capabilities.

To learn more about how to use the above features, check out the Doc Assistant User Guide.

These are just a few of the productivity gain features in Doc Assistant. We’ll cover more in the next blog in the series.

Want to Know More?

If you have any feedback on Doc Assistant or would like to request more information or a demo, please contact docassistant.support@cadence.com.

Subscribe to receive email notifications about our latest Custom IC Design blog posts.

Happy reading!

- Priya Sriram, on behalf of the Doc Assistant Team

An intercepted missile fired from Yemen sparked blazes near Jerusalem Monday, and later the Houthi rebels said they carried out a successful attack on central Israel. The Iran-backed militant group said it executed a "military operation targeting the Nahal Sorek military base" southeast of Jaffa, and that the "hit was accurate and led to a fire." Meanwhile, the main television news outlet operated by the Houthis said U.S. and British forces carried out a series of airstrikes targeting the Amran and Saada governorates in Yemen. The Israeli military told Agence France-Presse a projectile from Yemen was intercepted in the Bet Shemesh area west of Jerusalem, and debris from that interception caused fires. In a statement to the AFP, it said: "Following the sirens that sounded in the Shfelat Yehuda, Yehuda, and Lakhish areas of central Israel, the IAF (Israeli Air Force) intercepted one projectile that approached Israel from the direction of Yemen. "The projectile did not cross into Israeli territory. Sirens were sounded in accordance with protocol." An Iran-backed coalition, the Islamic Resistance in Iraq, claimed to have carried out four drone attacks on “vital targets” in Israel Monday, but did not disclose details about the targets in a series of Telegram posts. Strikes in Gaza, Lebanon At least three people were killed Sunday when an Israeli strike hit a tent sheltering a displaced family in the central Gaza Strip, Palestinian health officials reported. Palestinians reported heavy bombing late Sunday in the western areas of Nuseirat camp, and least 24 people were wounded and taken to the Awda hospital in Nuseirat, the head of the hospital’s ambulance service told the Associated Press. Earlier Sunday in northern Gaza, an Israeli strike on a home sheltering displaced people in the urban refugee camp of Jabaliya killed at least 17 people including nine women, according to Dr. Fadel Naim, director of Al-Ahly Hospital in Gaza City. An Israeli airstrike killed at least 23 people, including seven children, in Aalmat village north of Beirut, far from the areas in the east and south where Hezbollah militants have a major presence. Lebanon's health ministry said another six people were wounded. There was no Israeli evacuation warning and no immediate Israeli comment on the attack. The United Nations children’s agency says the war between Israel and Hezbollah has killed more than 200 children in Lebanon.   Lebanon’s Health Ministry said at least 3,189 people have been killed and over 14,000 wounded in Lebanon in more than a year of conflict between Israel and the Hezbollah militant group. Some 1.2 million people have been displaced. The war in Gaza was triggered when Hamas-led militants stormed into southern Israel on Oct. 7, 2023, killing about 1,200 people, mostly civilians, and abducting about 250. Some 100 hostages are still inside Gaza, although about one-third of them are believed to be dead. Israel's counteroffensive has killed more than 43,000 Palestinians, more than half of them women and children, according to local health authorities. The Israeli military says the death toll includes thousands of Hamas militants. Hamas has been designated as a terrorist organization by the United States, the United Kingdom, European Union and others. Israeli President Isaac Herzog is scheduled to meet with outgoing U.S. President Joe Biden on Tuesday in Washington as the mid-month deadline approaches for Israel to meet a Biden administration ultimatum that it allow more humanitarian aid into Gaza to assist Palestinians or risk possible restrictions on U.S. military funding. Information from The Associated Press, Agence France-Presse and Reuters was included in this report.

The newly sworn-in governor of Edo State, Monday Okpebholo,  is set to probe the administration of his predecessor, Godwin Obaseki. Okpebholo announced he will set up a panel of inquiry to investigate the past administration’s refusal to inaugurate 14 elected lawmakers of the State House of Assembly in 2019. The 14 lawmakers elected on the […]

The post Edo: Okpebholo to probe Obaseki’s govt first appeared on Business Hallmark.

Extreme heat is an invisible but increasingly tangible climate risk. It varies by time and place and has wide-reaching but unequal impacts, particularly to women and vulnerable people. As global temperatures rise, extreme heat events (heat waves) are becoming more frequent and severe.

to write a good document based essay

This brochure outlines how nature is being rapidly degraded and shows how ADB-designed nature-based solutions (NBS) can help protect vulnerable communities and ecosystems to make countries in Asia and the Pacific more climate resilient.

The proposed project will support the Royal Government of Cambodia in its commitment to reduce Gender-based Violence (GBV) line with Sustainable Development Goal (SDG) 5 on gender equality, specifically to eliminate all forms of violence against all women and girls in the public and private spheres, through proven and novel approaches across the continuum of prevention, mitigation, and response.

Extract

Living with a respiratory illness requires patients to manage a wide range of symptoms, many of which will worsen as a disease progresses. Breathlessness is a hallmark feature of respiratory conditions, occurring in almost all individuals with COPD and interstitial lung disease (ILD) [1, 2]. Cough is present in 78% of people with ILD and is frequently distressing, with physical, social and emotional impacts [1, 3].

PWAS (proteome-wide association study) is an innovative genetic association approach that complements widely used methods like GWAS (genome-wide association study). The PWAS approach involves consecutive phases. Initially, machine learning modeling and probabilistic considerations quantify the impact of genetic variants on protein-coding genes’ biochemical functions. Secondly, for each individual, aggregating the variants per gene determines a gene-damaging score. Finally, standard statistical tests are activated in the case-control setting to yield statistically significant genes per phenotype. The PWAS Hub offers a user-friendly interface for an in-depth exploration of gene–disease associations from the UK Biobank (UKB). Results from PWAS cover 99 common diseases and conditions, each with over 10,000 diagnosed individuals per phenotype. Users can explore genes associated with these diseases, with separate analyses conducted for males and females. For each phenotype, the analyses account for sex-based genetic effects, inheritance modes (dominant and recessive), and the pleiotropic nature of associated genes. The PWAS Hub showcases its usefulness for asthma by navigating through proteomic-genetic analyses. Inspecting PWAS asthma-listed genes (a total of 27) provide insights into the underlying cellular and molecular mechanisms. Comparison of PWAS-statistically significant genes for common diseases to the Open Targets benchmark shows partial but significant overlap in gene associations for most phenotypes. Graphical tools facilitate comparing genetic effects between PWAS and coding GWAS results, aiding in understanding the sex-specific genetic impact on common diseases. This adaptable platform is attractive to clinicians, researchers, and individuals interested in delving into gene–disease associations and sex-specific genetic effects.

Background:

Higher trust in healthcare providers has been linked to better health outcomes and satisfaction. Lower trust has been associated with healthcare-based discrimination.

BACKGROUND:Training in mechanical ventilation is a key goal in critical care fellowship education. Web-based simulators offer a cost-effective and readily available alternative to traditional on-site simulators. However, it is unclear how effective they are as teaching tools. In this study, we evaluated the test scores of fellows who underwent mechanical ventilation training by using a web-based simulator compared with fellows who used an on-site simulator during a mechanical ventilation course.METHODS:This was a nonrandomized controlled trial conducted as part of a mechanical ventilation course that involved 70 first-year critical care fellows. The course was identical except for the simulation technology used. One group of instructors used a traditional on-site simulator, the ASL 5000 Lung Solution (n = 39). The second group was instructed in using a web-based simulator, VentSim (n = 31). Each fellow completed a pre-course test and a post-course test by using a validated, case-based ventilator waveform examination that consisted of 5 questions with a total possible score of 100. The primary outcome was a comparison of the mean scores on the posttest between the 2 groups. The study was designed as a non-inferiority trial with a predetermined margin of 10 points.RESULTS:There was no significant difference in the mean ± SD pretest scores between the web-based and the on-site groups (21.1 ± 12.6 and 26.9 ± 13.6 respectively; P = .11). The mean ± SD posttest scores were 45.6 ± 25.0 for the web-based simulator and 43.4 ± 16.5 for on-site simulator (mean difference 2.2; one-sided 95% CI –7.0 to ∞; Pnon-inferiority = .02 [non-inferiority confirmed]). Changes in mean ± SD scores (posttest – pretest) were 25.9 ± 20.9 for the web-based simulator and 16.5 ± 15.9 for the on-site simulator (mean difference 9.4, one-sided 95% CI 0.9 to ∞; Pnon-inferiority < .001 [non-inferiority confirmed]).CONCLUSIONS:In the education of first-year critical care fellows on mechanical ventilation waveform analysis, a web-based mechanical ventilation simulator was non-inferior to a traditional on-site mechanical ventilation simulator.

Background

The real-world consequences of a Philips Respironics recall for positive airway pressure (PAP) devices distributed between 2009 and 2021 are unknown.

Exercise significantly alters human physiological functions, such as increasing cardiac output and muscle blood flow and decreasing glomerular filtration rate (GFR) and liver blood flow, thereby altering the absorption, distribution, metabolism, and excretion of drugs. In this study, we aimed to establish a database of human physiological parameters during exercise and to construct equations for the relationship between changes in each physiological parameter and exercise intensity, including cardiac output, organ blood flow (e.g., muscle blood flow and kidney blood flow), oxygen uptake, plasma pH and GFR, etc. The polynomial equation P = a_iHRⁱ was used for illustrating the relationship between the physiological parameters (P) and heart rate (HR), which served as an index of exercise intensity. The pharmacokinetics of midazolam, quinidine, digoxin, and lidocaine during exercise were predicted by a whole-body physiologically based pharmacokinetic (WB-PBPK) model and the developed database of physiological parameters following administration to 100 virtual subjects. The WB-PBPK model simulation results showed that most of the observed plasma drug concentrations fell within the 5^th–95^th percentiles of the simulations, and the estimated peak concentrations (C_max) and area under the curve (AUC) of drugs were also within 0.5–2.0 folds of observations. Sensitivity analysis showed that exercise intensity, exercise duration, medication time, and alterations in physiological parameters significantly affected drug pharmacokinetics and the net effect depending on drug characteristics and exercise conditions. In conclusion, the pharmacokinetics of drugs during exercise could be quantitatively predicted using the developed WB-PBPK model and database of physiological parameters.

Pregnane X receptor (PXR) belongs to the nuclear receptor superfamily that plays a crucial role in hepatic physiologic and pathologic conditions. Phase separation is a process in which biomacromolecules aggregate and condense into a dense phase as liquid condensates and coexist with a dilute phase, contributing to various cellular and biologic functions. Until now, whether PXR could undergo phase separation remains unclear. This study aimed to investigate whether PXR undergoes phase separation. Analysis of the intrinsically disordered regions (IDRs) using algorithm tools indicated a low propensity of PXR to undergo phase separation. Experimental assays such as hyperosmotic stress, agonist treatment, and optoDroplets assay demonstrated the absence of phase separation for PXR. OptoDroplets assay revealed the inability of the fusion protein of Cry2 with PXR to form condensates upon blue light stimulation. Moreover, phase separation of PXR did not occur even though the mRNA and protein expression levels of PXR target, cytochrome P450 3A4, changed after sorbitol treatment. In conclusion, for the first time, these findings suggested that exogenous PXR does not undergo phase separation following activation or under hyperosmotic stress in nucleus of cells.

ABSTRACTToxicological emergencies present a significant health challenge in Nepal. Despite the high burden, the country has inadequate formal toxicology training, medical toxicology expertise, and adequate poison control infrastructure. In recognition of this need, the Nepal Poison Information Center (PIC) was established as a collaborative effort involving local and international partners. Through a comprehensive partnership framework, the Nepal PIC provides 24 hours a day, 7 days a week expert guidance to health care workers, conducts educational webinars, and engages in research. Initial data from the pilot phase indicate successful consultation delivery. Challenges include bureaucratic hurdles and the need for sustainable funding. Despite these challenges, the Nepal PIC demonstrates early feasibility and potential for expansion into a comprehensive toxicology center, contributing to the advancement of clinical toxicology in Nepal. Long-term sustainability relies on governmental support and continued advocacy efforts.

The aim of this study was to validate a previously developed deep learning model in 5 independent clinical trials. The predictive performance of this model was compared with the international prognostic index (IPI) and 2 models incorporating radiomic PET/CT features (clinical PET and PET models). Methods: In total, 1,132 diffuse large B-cell lymphoma patients were included: 296 for training and 836 for external validation. The primary outcome was 2-y time to progression. The deep learning model was trained on maximum-intensity projections from PET/CT scans. The clinical PET model included metabolic tumor volume, maximum distance from the bulkiest lesion to another lesion, SUV_peak, age, and performance status. The PET model included metabolic tumor volume, maximum distance from the bulkiest lesion to another lesion, and SUV_peak. Model performance was assessed using the area under the curve (AUC) and Kaplan–Meier curves. Results: The IPI yielded an AUC of 0.60 on all external data. The deep learning model yielded a significantly higher AUC of 0.66 (P < 0.01). For each individual clinical trial, the model was consistently better than IPI. Radiomic model AUCs remained higher for all clinical trials. The deep learning and clinical PET models showed equivalent performance (AUC, 0.69; P > 0.05). The PET model yielded the highest AUC of all models (AUC, 0.71; P < 0.05). Conclusion: The deep learning model predicted outcome in all trials with a higher performance than IPI and better survival curve separation. This model can predict treatment outcome in diffuse large B-cell lymphoma without tumor delineation but at the cost of a lower prognostic performance than with radiomics.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

Sleep is a fundamental feature of life for virtually all multicellular animals, but many questions remain about how sleep is regulated by circadian rhythms, homeostatic sleep drive that builds up with wakefulness, and modifying factors such as hunger or social interactions, as well as about the biological functions of sleep. Substantial headway has been made in the study of both circadian rhythms and sleep in the fruit fly Drosophila melanogaster, much of it through studies of individual fly activity using Drosophila activity monitors (DAMs). Here, we describe approaches for the activation of specific neurons of interest using optogenetics (involving genetic modifications that allow for light-based neuronal activation) and thermogenetics (involving genetic modifications that allow for temperature-based neuronal activation) so that researchers can evaluate the roles of those neurons in controlling rest and activity behavior. In this protocol, we describe how to set up a rig for simultaneous optogenetic or thermogenetic stimulation and activity monitoring for analysis of sleep and circadian rhythms in Drosophila, how to raise appropriate flies, and how to perform the experiment. This protocol will allow researchers to assess the causative role in the regulation of sleep and activity rhythms of any genetically tractable subset of cells.

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.