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Enhancer–promoter interactions and transcription




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Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases




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HTML, CSS, and JavaScript code editing with Edge Code

Edge Code is an Adobe branded release of the Brackets project: a lightweight code editor with next-wave features.




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High-priced drugs in Medicare Part D: Diagnosis and prescription

Drug pricing in the U.S. is a persistently vexing policy problem. High drug prices stress consumers, payers, employers and “budgeteers”. At the same time the public demands new and better treatments, and the scientific advances that make such treatments possible. The pharmaceutical industry insists, with merit, that delivering new improved treatments, and in some cases…

       




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Health policy 101: How the Trans-Pacific Partnership will impact prescription drugs


For the last several years, the US government has been negotiating a free-trade agreement known as the Trans-Pacific Partnership (TPP) with 11 other countries across the Asia-Pacific and Latin American regions, which could have major impact on the pharmaceutical market.  When finalized it will be the largest free-trade agreement in history, impacting up to one-third of world trade and roughly 40 percent of the global gross domestic product. The deal has attracted a fair share of criticism from a wide range of groups, including concerns over proposed regulations for biologic drugs in participating countries. Specifically, critics are concerned about the length of data exclusivity granted to the companies that hold the patents on these drugs. Below is a primer on biologics and how they are being addressed in the TPP.


What are biologics and biosimilars?

Biologic drugs include any therapy derived from a biological source; a group which includes vaccines, anti-toxins, proteins, and monoclonal antibodies. Because they are typically much larger and more structurally complex than traditional ‘small-molecule’ drugs, they are also more difficult—and much more costly—to develop and manufacture. Biologics are also among the most expensive drugs on the market, costing an average of 22 times more than nonbiologic drugs. Avastin, a cancer drug, can cost more than $50,000 a year, while the rheumatoid arthritis drug Remicade can cost up to $2,500 per injection.

Given these high costs, there is substantial interest in encouraging the development of biosimilars, a term used to describe follow-on versions of an original biologic. Estimates of the potential cost savings vary substantially, but some have predicted that competition from biosimilars could reduce US spending on biologics by $44 to $66 billion over the next ten years.  In the European Union, biosimilars have been on the market since 2006, and a 2013 analysis found that, for the 14 biosimilars on the market, the average price discount was about 25 percent. By 2020, the overall cost savings are projected to total $16-$43 billion.

After the Affordable Care Act (ACA) was passed in 2010, the US Food and Drug Administration (FDA) developed an accelerated approval pathway for biosimilars, modeled after the pathway used for the approval of small-molecule generics. In order to meet the criteria for biosimilarity, the drug must share the same mechanism of action for the approved condition of use, and there must be no clinically significant differences between the two drugs in terms of purity, safety, or potency. FDA recently approved its first biosimilar, Zarxio, which is a copy of the oncology drug Neupogen.

What issues are being raised over data exclusivity in the US?

Under current FDA regulations, biologic drugs are granted 12 years of data exclusivity following approval. During this period of exclusivity, the FDA may not approve a biosimilar application that relies on the data submitted as part of the original biologic application. This form of temporary monopoly is distinct from patent protection, which is granted well before approval and is not related to clinical data.  Data exclusivity does not prevent another company from generating the data independently, but drug companies are unlikely to go to the considerable (and costly) effort of replicating a full course of clinical trials for a drug that is already on the market. (Though biosimilars may need to undergo some additional clinical testing under current FDA regulations, the amount of data required to support approval would certainly be less than what is required for an original biologic approval.)

The 12-year exclusivity period for biologics was established in the ACA following intense debate, and has continued to attract criticism. (By contrast, the period of data exclusivity is just five years for small-molecule drugs.) Supporters argue that given the greater cost and difficulty of bringing a biologic to market a longer period of exclusivity is necessary to incentivize innovation. Others argue that the resulting restrictions on competition keep drug prices unnecessarily high, inevitably putting a strain on the health system and keeping potentially life-saving drugs out of reach for many patients.

How would the TPP affect data exclusivity?

For the 11 countries besides the U.S. that are involved in the TPP, current data exclusivity protections range from zero (Brunei) to eight years (Japan). Under the Obama Administration’s current proposal, participating countries would increase those periods to match the US standard of 12 years. Curiously, this proposal directly contradicts the administration’s ongoing domestic efforts to lower the period of data exclusivity. Since the ACA passed, the Obama administration has repeatedly proposed reducing it to seven, arguing that this would save Medicare $4.4 billion over the next decade. Some have noted that, once the 12-year period is enshrined in the TPP, it will become significantly more difficult to change it through the US legislative process. Furthermore, imposing US standards on the 11 member countries would inevitably restrict competition at the global level, and many patient advocacy and international humanitarian organizations have argued that doing so would undermine the efforts of US global health initiatives like the Vaccine Alliance and the Global Fund to Fight AIDS, Tuberculosis and Malaria, which rely on price competition to manage program costs.

It is unclear whether the US will be successful in its efforts. There have been reports that the issue of data exclusivity has become a significant point of contention, and the US delegation may seek to compromise on its demands. It may, for example, negotiate exceptions for the poorer countries involved in the negotiation, as the Washington Post notes. However, the details of the negotiations are largely confidential, which makes it challenging to assess the possibilities, their relative advantages, or how the US Trade Representative (which is leading the US negotiations) is balancing the need to ensure adequate incentives for innovation with the need to control drug costs and facilitate patient access to potentially life-saving therapies.

Editor's note: Elizabeth Richardson, a research associate in the Center for Health Policy, contributed to the research and writing of this post. 

       




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Political Takeaways From the Federal Reserve Transcripts


The Federal Reserve last week released transcripts of Federal Open Market Committee (FOMC) meetings that took place in 2008 amidst a worsening global financial crisis. Sarah Binder describes what was found amongst the transcripts. Alongside financial and economic crises facing the Fed that year, the Fed faced a crisis as a political institution.  

      
 
 




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The medical marijuana mess: A prescription for fixing a broken policy

In 2013, Patrick and Beth Collins were desperate. Thirteen‐year‐old Jennifer, the younger of their two children, faced a life‐threatening situation. In response, the Collins family took extreme measures—sending Jennifer thousands of miles away in the company of her mother. Beth and Jennifer became refugees from a capricious government whose laws threatened Jennifer’s health, the family’s…

       




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Louisiana’s prescription drug experiment: A model for the nation?

The high cost of prescription drugs has become an increasingly pressing concern for policymakers, insurers, and families. New drugs—like those now available for hepatitis C— offer tremendous medical benefits, but at a cost that puts them out of reach for many patients. In an effort to address the affordability dilemma, the Louisiana Department of Health…

       




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Is it too late for sustainability? Not if we follow this prescription

Peter Rickaby says he has "never been more optimistic about the possibility of change," but it will require some radical action.




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Dear Globe and Mail editor: Cancel my subscription!

Margaret Wente trots out every 20-year-old trope spouted by tired old discredited climate change deniers.




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How a 14th century manuscript could solve our antibiotic crisis

Researchers are poring over an important medieval medical text with 360 recipes, many of which might have successfully fought infection long before modern science.




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Pilates, not pills: Doctors are writing exercise prescriptions

Family doctors are acknowledging that there's only so much medicine can do, and sometimes a walk in the park is just what a person needs.




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Product Service Systems are back with Fernish subscription furniture

This might be a model for how to live lightly in a circular economy.





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NBC UNIVERSO To Premiere Its First Original Scripted Series "El Vato" Starring Mexican Regional Star El Dasa Sunday, April 17 At 10pm/9c - “El Vato” :30 sec video promo

“El Vato” :30 sec video promo




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Eyeglass World Launches First Retail Collection of Prescription Lenses for Smart Glass Devices - Future of Eyewear

Eyeglass World launches first retail collection of smart glass technologies in the U.S., including specially designed prescription lens options and hardware for Recon, Vuzix and Epson wearable devices.





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New York Times expects ad revenue to plummet 50% in Q2, but broke its record for net new subscriptions in a quarter

The New York Times Company said it expects advertising revenue to fall between 50-55% year-over-year in the second quarter as impacts of the pandemic are hitting demand for advertisers. But the media company, which gets two-thirds of its revenue from subscriptions, said it added more than half a million net new digital subscriptions.




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Opinion: Hollywood couldn't script a plotline like what's happening in oil right now

Keeping up with all the recent twists and turns in the oil market is difficult. Here's where things stand as what could be a pivotal week gets underway.




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Xbox Game Pass subscriptions hit 10 million

Pay-monthly service sees huge surge in players and gaming time due to Coronavirus lockdown

Microsoft has announced that its Xbox Game Pass subscription service has passed 10 million members. The initiative, which adopts a similar model to Netflix and other streaming platforms, gives subscribers unlimited access to more than 100 Xbox and PC games for a monthly fee.

Commenting on the figure, Xbox chief Phil Spencer said that use of Game Pass, as well as the company’s online multiplayer gaming service Xbox Live, had increased substantially in recent weeks due to Covid-19. “Since March, Xbox Game Pass members have added over 23 million friends on Xbox Live, which is a 70% growth in friendship rate,” he said. “Game Pass members are also playing twice as much and engaging in more multiplayer gaming, which has increased by 130%.”

We saw record engagement in gaming this quarter:
• Xbox Live has nearly 90 million monthly active users
• Xbox Game Pass has more than 10 million subscribers
• Project xCloud has 100s of thousands of active users in preview across 7 countries, with more coming

Continue reading...




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Off script? The arts after Covid-19

Will the arts ever be the same again? The magic of digital technology has kept us connected to movies, music and TV shows during confinement, while distribution giants like Amazon have kept up supplies of books and CDs. But scrapped are the big summer music and theatre festivals. Can artists, producers and distributors hold out? Will Covid-19 finish off already struggling neighbourhood movie theatres? François Picard's panel reacts to the French president's promise of support for the industry and reflects on how confinement alters creativity.




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Pankaj Tripathi: Didn't have a script in mind

Over a month under lockdown and life has changed for many. While several have adopted new hobbies, some have taken to imparting wisdom through digital tutorials. In the time of online concerts, Pankaj Tripathi has found the ideal way to engage with his fans. The actor has started a series of Facebook live sessions, where he shares bitter-sweet experiences that changed his perspective of life. He says that the lockdown has "taught me priorities".

A source informs that Tripathi has been narrating stories from his childhood. "In one of the stories he recounted, Pankaj revealed how the train and its sound functioned as a clock for him. When he left his hometown, it was an image that reminded him of everything that mattered. It also evoked a sense of responsibility, inspiring him to work harder towards his goals. Now in isolation, separated from his parents by miles, at home with his wife and daughter, he admits that he has learned the value of their company."

"I didn't start it with a script in mind," says Tripathi, who wants to make it a series of conversations. He adds, "It's the simple things in life that we end up caring for the most. Locked down at home, waiting for these tough times to pass, it should remind people where their priorities lie."

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news




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WhatsApp facilitates group descriptions, admin controls

New Delhi: Instant messaging platform WhatsApp announced the rollout of a number of new features for group chats, in a bid to make the platform more interactive and engaging. Among the new features is group descriptions, wherein a short blurb will appear under the group info tab that allows users to set the purpose, guidelines, or topics for the group.

Furthermore, when a new member joins a group, the description will show up at the top of the chat.

In a move to give group administrators more authority, WhatsApp introduced a new control that will allow the former to restrict who can change the group's subject, icon, and description. Admins can also remove admin permissions of other group participants, while group creators can no longer be removed from the group they started.

Among other features, WhatsApp also introduced a 'group catch up' option, whereby a user, who has been away from a group chat, can quickly catch up on messages that mention or reply to them by tapping on a new @ button that appears at the bottom right corner of the chat.

Group participants can now search for anyone in a group by using the search option on the group info page. WhatsApp also introduced protection controls so users can't be repeatedly added to groups they've left. The new features are being rolled out for Android and iPhone users globally.





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Aamir Khan: Budding scriptwriters should continue writing with more enthusiasm

What started as a passion project for Aamir Khan in 2017, has grown into an initiative that is changing the landscape for budding writers in the Indian film industry. The second edition of Cinestaan India's Storytellers Script Contest, a nationwide hunt for scripts where the five winners take home a total cash prize of Rs 50 lakh, was launched this February. Over the past three months, the four-member jury — consisting of Khan, Anjum Rajabali, Juhi Chaturvedi and Rajkumar Hirani — sifted through numerous entries to choose five compelling stories that can be taken to the screen. While the on-ground event to announce the winners has been cancelled due to the current scenario, the superstar will unveil the new talent on social media today.

Excited to be part of an endeavour that celebrates screenwriting — an aspect he considers the backbone of every successful film — Khan urges budding writers to not let the prevailing situation dampen their creativity. "Budding scriptwriters should continue writing with more enthusiasm, especially during these times. Every filmmaker needs a good script," says the actor.

California-based NRI Sejal Pachisia has bagged the top prize of a whopping Rs 25 lakh for her story, On the Boundary. The second and third prizes have been won by Digant Patil and Soumil Shukla for Guilt and Laakh Maavla respectively. The prize is financed by Cinestaan Digital, an internet media firm focussed on building cinema-related products for Indian audiences. The chosen scripts will become part of its story incubator programme.


Screenwriters Anjum Rajabali and Juhi Chaturvedi

Rajabali, jury chairperson, says the contest was designed to provide a platform to new talent, thus helping deserving outsiders to gain a toehold in the industry.

"It's important that we raise the standard of our scriptwriting so that the quality of our cinema improves," he states.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news




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She-Hulk writer confirms the script of the upcoming series is ready

There have been reports that have suggested that the She-Hulk series at Disney + is in works! Now, the confirmation has come from the makers that the scripting is completed for Disney+ series is complete.

She-Hulk writer Dana Schwartz took to Twitter on May 6 and wrote, "The She-Hulk room ended so if you happen to be a showrunner looking for a writer who makes jokes and writes books and knows a lot of historical fun facts, hit me up!!!!"

Recently, Mark Ruffalo confirmed that he was in early talks with She-Hulk makers to return as Bruce Banner/The Hulk. “There’s nothing completely at a place where it’s a done deal,” the actor told Variety recently. “There’s some talk of having Banner/Hulk show up in [the Disney Plus series] ‘She–Hulk.’ If we come up with something good, that would be really interesting. Right now that’s about it. That’s all there is on the table.”

According to the comics, lawyer Jennifer Susan Walters developed Hulk-like abilities when she received a blood transfusion from her cousin Bruce Banner. Now, it seems like this might be a great segway for the actor to return to the Marvel universe. The character first appeared in the comics in the 1980s as a member of the Fantastic Four.

ALSO READ: Mark Ruffalo reveals he had turned down the role of Hulk in The Avengers, has an idea for standalone movie and speaks about She-Hulk series




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Sanjay Dutt says he is ready to foray into the digital space if he finds an exciting script

Sanjay Dutt is an actor who has appeared in a great many numbers of films spanning across genres, thus time and again proving his adaptability to wear the mask of different characters. The actor has been in the industry for a very long time and has even been part of the transformation and evolution of the Indian film industry.

Of late, Bollywood has been going through a paradigm shift as the world of content has been brought to digital platforms. OTT platforms have opened up new avenues and make any genre of series or films available, just a click away, which has been benignant for the viewers.

Actor Sanjay Dutt comments on how he feels OTT platform can be beneficial for artists, he says, "OTT platforms are flourishing and have brought about so much variety in terms of content. They also enable artists to experiment with material and characters. If I get a script that excites me, I would love to foray into digital entertainment."

Sanjay Dutt is an actor who is enriched with the experience of the various characters he has played on-screen and it would be thrilling to see him make a debut on OTT platform. The actor shows interest in foraying into the world of digital entertainment so the audience can just keep their fingers crossed and wait to see what happens!

2020 is an immensely packed year for Sanjay Dutt as the actor will be seen in five big banner films namely, KGF: Chapter 2, Shamshera, Bhuj: The Pride of India, Torbaaz and Sadak 2. The actor will certainly ace the characters as he can slip into any character given to him as he is rich with the experience of numerous characters he has played on -screen.




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Aamir Khan encourages budding scriptwriters to write more enthusiastically; will announce winners of script contest on social media 

In 2017, Aamir Khan started a project to boost budding writers in the Indian film industry. The second edition of Cinestaan India's Storyteller Script Contest, a nationwide hunt for scripts where the five winners take home a total cash prize of Rs. 50 lakh was launched this February. From the past few months, the four-member jury consisting of Aamir Khan, Anjum Rajabali, Juhi Chaturvedi and Rajkumar Hirani has gone through numerous entries to choose five compelling stories that can be taken to screen. 

However, this time instead of the on-ground event to announce the winners, Aamir Khan will unveil the winners on social media. Meanwhile, Khan is urging writers to not let the prevailing situation dampen their creativity. He said that budding writers should write with more enthusiasm, especially during these times. 

Says Rohit Khattar, Chairman of Cinestaan Digital, “I am grateful to our esteemed jury in working with us to bring Indian storytelling talent to the forefront especially during these surreal times. Thank you to the thousands of writers who had applied. The quality of the work was stellar and we would like to congratulate the winners who are truly deserving and wish them success.”

Speaking about the winners, Anjum Rajabali, the Jury Chairperson said, ‘We started this contest with the larger objective of attracting more people to write scripts. It’s very important that we improve the quality of our scriptwriting so that the quality of our cinema goes up. The caliber of scripts in this edition was better than last year and it’s heartening to see that the talent is developing. Thank you to the jury members for giving their valuable time in reading and assessing the scripts. Truly appreciate the Cinestaan team’s hard work. I have not seen this kind of unconditional support and generosity before, with the only reward being to encourage good writing in this country.’

Juhi Chaturvedi says, ‘As a writer, I understand the joy of being appreciated, especially on a big platform like this which motivates us to write more. Congratulations to the winners. I’m very happy that through this contest I was able to be a small part of your journey.’

Raju Hirani while congratulating the winners said, ‘I’m happy that the objective with which this contest was started, to inspire scriptwriters and give them a platform to send their scripts from all parts of the country - slowly and steadily we are moving towards our goal. The caliber of scripts this year has been better than last year.’

All the entries of the second edition of the contest went through a transparent and stringent process of evaluation at various levels. The shortlisted synopsis were asked to send in a complete script which were then assessed and then the winners selected by the jury. All scripts have been registered by the contestants with the Scriptwriters Association and other similar recognized bodies to ensure that the writers' content is completely protected.

‘Cinestaan India’s Storytellers Script Contest’ was launched by Cinestaan Digital Pvt. Ltd. and is India’s biggest Script Contest. The winners of the contest are awarded cash prizes worth Rs. 50 lakhs.

ALSO READ: Aamir Khan dismisses distributing money to the poor in wheat bag, says “Robin Hood doesn’t want to reveal himself”




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Kabir Khan reveals why it took him one and a half years to finalise the script of '83

The Ranveer Singh starrer '83 directed by Kabir Khan was supposed to release in theatres on April 10. However, owing to the lockdown the theatres have been shut down indefinitely. '83 narrates the story of Indian cricket team's historic World Cup win with Ranveer Singh playing the role of Kapil Dev who was leading Indian team back then.

Kabir Khan while talking to a tabloid revealed that the 1983 cricket world cup is the greatest underdog story ever. He said that one can replace cricket with kabbadi and it would still hold weight.

Kabir Khan after talking to the team of 1983 got to know of several stories related to the world cup that year and what went behind the scenes. However, he found it difficult to incorporate everything into the screenplay. He said that he could only pick 25 stories from the 100 stories he had. This is the reason that it took him one and a half years to finalize the script. The film is not just from the point of view of players but also that of commentators and the spectators.

Kabir Khan also revealed that cricketer Krishnamachari Srikant had got married three months before the world cup. When he got to know that they have been selected to play the world cup he booked tickets to go to the US with six other players. They were supposed to fly as soon as the group stage ended as they were confident that India would be knocked out of the competition. He said that no one believed that they would even make it to the semifinals, but once their winning streak started, the players started cancelling their tickets.

ALSO READ: Kabir Khan reveals Irrfan Khan was left in tears after watching Nawazuddin Siddiqui’s scene in New York




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Extraction Movie Review: Scriptless set-piece stunner!

Extraction
On: Netflix
Director: Sam Hargrave
Cast: Chris Hemsworth, Randeep Hooda
Rating: 

Takes a bit of an insider to know exactly how Bombay beat-cops randomly harass young adults milling around, minding their own business, outside clubs/bars past midnight — as if that's the biggest crime in town.

That scene, so representative of the city's dying night life, occurs rather early on in Extraction. By the look of it, it is shot in Bombay — set in a lane that could easily pass off for back-alley of what used to be Elbo (and is now Glass) Room in Bandra.

Only that this is a proper, hardcore Hollywood production, directed by a first-timer (Sam Hargrave) who, until this shoot, had probably never been to India. The hero, Australian-born Chris Hemsworth, tops the world's highest paid actors' lists, and is widely adjudged 'world's sexiest man alive' in the western press. The script — or rather the lack of it (sadly) — is written by Joe of the Russo Brothers — their last film as directors being Avengers: Endgame (naam toh suna hoga!).

Up until that point in the film I speak of (above), the dialogues in Extraction are mainly in Hindi. This carries on for long passages in the picture thereafter; including a whole lot of Bengali, as the action in the film altogether, ostensibly, shifts to Dhaka.

What's there not to be pleasantly gob-smacked by all this shudh 'desiness' going on in a thoroughbred global stunt-actioner? But I speak too soon. For, the moment those fellows in police uniform approach a few kids outside a Bombay bar, one of the boys in the group is abducted, others shot at. And the thriller cuts to such a frantic chase, that all there's left to it are a series of set-pieces, involving grenades, gun-fires and mortal combat.

No issues with that, of course. Just that this is so much of a (critic-proof) genre film, it seems the filmmakers couldn't care two hoots about every moment from thereon — flowing as generically as the audiences would ever imagine them to.

But for the setting, obviously. Which, truth be told, is essentially a white man's gaze at what a rat-hole the size of hell would look like, with the military and ragtag militias being one and the same thing. Guns going off on streets all day, people flocking and flopping like packs of sardines or lemmings off cliffs. This is supposed to be Bangladesh on any given day. Though, am told this was shot in Ahmedabad.

Watch the trailer of Extraction trailer here

Recalling how some Indians outraged over poverty-porn in Slumdog Millionaire, as if Danny Boyle had built a set to defame Bombay (he hadn't; it was what it was) — desis should take mass offence at the portrayal of Dhaka. Relax, that's a joke; suggesting no such thing! This is a frickin' movie. Watch it for that — just as others will.

What you'll appreciate then is the sort of fire-power and raw energy that laces this dusty stunner throughout. For its setting, this is probably a Rohit Shetty actioner to the power 10, in terms of gritty realism. And maybe there's a template in it somewhere for something desi in the Fast and Furious space.

Basically, Sam Hargrave has come into direction after a heavy body of work as stunt coordinator in Hollywood. A story-line may not artistically be his strongest point. But hell yeah, he knows a thing or two about action.

As does Hemsworth — a one-man army, running around here with a loaded arms factory, ensuring bang for the buck. Speaking of which, ideally, this Netflix film would've been best enjoyed in a theatre. This must also be said for the relatively under-rated, but much superior Netflix thriller, Triple Frontier (2019). That was about a huge robbery, involving a Colombian drug-lord, gone bizarre. This one involves Hemsworth's character being hired to 'extract' or rescue the abducted son of 'Bombay's Escobar', who's been kidnapped by 'Dhaka's Escobar' (accha!). Besides the entire city of Dhaka, along with all exit routes closed, Hemsworth has to also take on the Indian don's henchman — for reasons that should only be unlocked by viewers.

Randeep Hooda plays this feisty antagonist — full-on kicking ass, firing on all cylinders, opposite Hemsworth, no less — in Steven Seagal hairdo from the '80s. That's where this film deliberately belongs, too. Pankaj Tripathi is the Indian don, Ovi Mahajan Sr. His missing son is named, Ovi Mahajan Jr (kuch bhi!). Young Priyanshu Painyuli — the super-fine 'find' from the film Bhavesh Joshi Superhero — is the Bangladeshi don.

But for so much delightful desiness in this grand deadliness, would one have even watched this flick with such keen eyes? Let alone responded to it in so many words? Good question.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news




script

Sanjay Dutt says he is ready to foray into the digital space if he finds an exciting script

Sanjay Dutt is an actor who has appeared in a great many numbers of films spanning across genres, thus time and again proving his adaptability to wear the mask of different characters. The actor has been in the industry for a very long time and has even been part of the transformation and evolution of the Indian film industry.

Of late, Bollywood has been going through a paradigm shift as the world of content has been brought to digital platforms. OTT platforms have opened up new avenues and make any genre of series or films available, just a click away, which has been benignant for the viewers.

Actor Sanjay Dutt comments on how he feels OTT platform can be beneficial for artists, he says, "OTT platforms are flourishing and have brought about so much variety in terms of content. They also enable artists to experiment with material and characters. If I get a script that excites me, I would love to foray into digital entertainment."

Sanjay Dutt is an actor who is enriched with the experience of the various characters he has played on-screen and it would be thrilling to see him make a debut on OTT platform. The actor shows interest in foraying into the world of digital entertainment so the audience can just keep their fingers crossed and wait to see what happens!

2020 is an immensely packed year for Sanjay Dutt as the actor will be seen in five big banner films namely, KGF: Chapter 2, Shamshera, Bhuj: The Pride of India, Torbaaz and Sadak 2. The actor will certainly ace the characters as he can slip into any character given to him as he is rich with the experience of numerous characters he has played on -screen.




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Fan asks Sunil Chhetri for Netflix username, password; he gets him a subscription!

India's star footballer Sunil Chhetri has gone out of his way in order to help a fan who approached him online in order to get a free Netflix account.

Not only did Sunil Chhetri give the fan a Netflix subscription but also handed him a personally signed jersey.. This was after this fan had asked Sunil Chhetri to share his Netflix ID and password during coronavirus pandemic. The fan also stated that the football captain could change the password after the lockdown is done.

Taking to Twitter, Sunil Chhetri posted a screenshot of a message he received on Facebook and wrote: "Jersey X Autograph on a picture X Reply to the post X Video wishing the neighbour's son's pet dog X. Here's someone who has priorities straight and it's really making me want to consider the demand."

Netflix India's Twitter handle took note of this message from Chhetri and went on to reply: "While we on that topic, could we also get your autograph on a picture?"

Sunil Chhetri then proposed a 'barter' deal and asked for a two-month free subscription for the fan in return for an autographed jersey from him.

He wrote: "In the true spirit of a barter, how about you guys hand the kid a two-month subscription and I will send a signed shirt and a picture your way? Do we have a deal?"

In reply, Netflix India's Twitter handle posted: "How about we send him both the jersey and a subscription card? Let's make his day."

To this, Chhetri replied: "Sounds great guys, now that we've got this figured out. Subscription for the kid, Shirt for the kid, Shirt for you guys."

The boy had earlier sent a Twitter post to Sunil Chhetri. Take a look at the shared post by the footballer.

Earlier, in a series of tweets, Chhetri had announced that the members of the Indian team had come together and 'put on table a sum that has been sent to the PM-Cares Fund' to help in the fight against coronavirus.

Inputs from IANS

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This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever




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Issue with Subscription (EM Reserve) (krishnaati)

Hi, I have subscribed to EM Reserve and have paid for annual maintenance fee in Mar 2017. Now, my subscription is suspended and am asked to pay annual maintenance fee for Wealth Alliance. My understanding is that Reserve includes WA services as well. Is t..




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Hi, I have subscribed to EM Reserve and have paid for annual maintenance fee in Mar 2017. Now, my subscription is suspended and am asked to pay annual maintenance fee for Wealth Alliance. My understanding is that Reserve includes WA services as well. Is t..




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Opioid Prescriptions from Dentists Linked to Youth Addiction Risk

Dental painkillers put teens and young adults at increased risk for opioid addiction in the following year, a study from the Stanford University School of Medicine has found.




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Around Half of Dental Opioid Prescriptions Exceed Guidelines

Around half of the opioids prescribed by dentists in the United States exceed the three-day supply recommended by federal dental pain-management guidelines.




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Forecasting Proper Opioid Prescriptions After Cesarean

Knowing the dose of opioids taken after cesarean delivery and before discharge can inform individualized prescriptions and reduce unnecessary, leftover




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Sovereign Gold Bond 2020-21 - Issuance and Subscription-Series II




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Coffeeland by Augustine Sedgewick — the Java script

A history of coffee and its role in global capitalism is fact-filled and entertaining if occasionally over-caffeinated




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Diet autopilot Thistle raises $5M for health food subscriptions

What if it was easier to eat salad than junk food? Most diet routines take a ton of time, whether you’re cooking from scratch, making a meal kit or seeking a nutritious restaurant. But on-demand prepared food delivery companies like Sprig that tried to eliminate that work have gone bankrupt from poor unit economics. Thistle […]




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New Jersey man, 21, charged after woman, 19, dies from night of 'rough sex, prescription medication'

Michael T. Gaffney, 21 (left), of New Jersey, was charged with reckless manslaughter, following the death of a woman in the garage of the building (right) they'd attended a Halloween party at earlier.




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Justin Gatlin's win 'not the perfect script' - Seb Coe 

Lord Coe has admitted that athletics is losing the fight to ban drugs cheats for life after Justin Gatlin's 100 metres World Championship victory over Usain Bolt at the London Stadium.




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Why Roger Moore turned down 99 per cent of scripts he was offered

In the mid-Nineties I struck up a friendly relationship with Roger's PA, Doris Spriggs, while working at Pinewood Studios. When Doris retired in 2002, she recommended me for her job




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New Walmart service will try to RIVAL Amazon Prime with perks like discounted fuel and prescriptions

Walmart is rolling out a new subscription service to rival Amazon Prime that could include unique perks its online competitor does not already offer, like discounts on prescriptions and fuel.




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Former Bachelor stars reveal the truth about the 'scripted' reality series

Former Bachelor stars Rachael Gouvignon and Tiffany Scanlon have revealed some shocking secrets about the dating franchise on their new podcast, Keep It Real.




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JACI STEPHEN: The Nest is a compelling show with a tight script

I was all set to move to Loch Long, where The Nest is filmed, but unless I could live in Cape Cove, home to Dan (Martin Compston) and Emily (Sophie Rundle), I'll stay put




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If you want transcripts of Donald Trump's calls to Vladimir Putin you'll have to ask us: Kremlin

Asked about Democrats' push for the publication of Putin-Trump calls, Kremlin spokesman Dmitry Peskov responded that 'the publication is possible only on mutual accord.'




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Stunned Putin is stopped in public and quizzed by a woman in rare unscripted grilling

Russian President Vladimir Putin faced what appeared to be a rare unscripted grilling from a Russian woman who asked him how much he earns on Wednesday.




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Coronation Street forced to rewrite scripts as cast self-isolate as star reveals 'it's been tough'

Coronation Street have been forced to rewrite scripts as cast members self-isolate amid the Coronavirus crisis as star Andy Whyment revealed 'it's been a tough week'




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ZEE5 sees a 60% uptick in subscription globally due to the COVID-19 lockdown

As countries across the world continue to grapple with COVID-19, ZEE5 Global, which is present in 190 countries, sees a 60% surge in subscriptions and 20% growth in viewership in all markets. The platform’s focus this year is going to be on expanding across geographies, localization and strengthening its content strategy.Archana Anand, Chief Business Officer, ZEE5 Global further shares the growth plan, which are the key markets for ZEE5 global, and its retention strategy once the lockdown is lifted. As most countries across the globe continue being under lockdown, viewers are turning to OTT platforms to stay entertained and escape from the much scarier reality. ZEE5 Global has also seen a 60% uptick in the number of subscribers globally and a 20% growth in viewership in the past month due