There would not be sufficient benefit to updating estimates of the social cost of carbon (SCC) within a year based only on the revision of a specific climate parameter in the existing framework used by the government’s interagency group to measure the SCC, says a new interim report from the National Academies of Sciences, Engineering, and Medicine.

Although more than $500 million in federally funded research on Persian Gulf War veterans between 1994 and 2014 has produced many findings, there has been little substantial progress in the overall understanding of the health effects, particularly Gulf War illness, resulting from military service in the war, says a new report from the Institute of Medicine (IOM) of the National Academies of Sciences, Engineering, and Medicine.

Ovarian cancer should not be categorized as a single disease, but rather as a constellation of different cancers involving the ovary, yet questions remain on how and where various ovarian cancers arise, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Although individual anglers – people who fish recreationally – generally take small numbers of fish, collectively, a large number of them can have a substantial impact on the overall stock.

The U.S. Environmental Protection Agency (EPA) carries out experiments in which volunteer participants agree to be intentionally exposed by inhalation to specific pollutants at restricted concentrations over short periods to obtain important information about the effects of outdoor air pollution on human health.

While the Federal Motor Carrier Safety Administration’s (FMCSA) Safety Measurement System (SMS) used to identify commercial motor vehicle carriers at high risk for future crashes is conceptually sound, several features of its implementation need improvement, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

A new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine takes a comprehensive look at evidence on the human health effects of e-cigarettes.

A new report from the National Academies of Sciences, Engineering, and Medicine finds K-12 teachers face new expectations and more demands from policymakers, parents, students, and schools, including addressing changes in curriculum standards, the emergence of more explicit teaching goals, and shifts in what it means to support all students in their development.

This tutorial will explain how to find the version number for Windows Defender in Windows 10. [...]

While the broader markets have seen sharp declines, Frank Holmes, CEO and chief investment officer of U.S. Global Investors, homes in on gold, gold stocks and bitcoin, and gives his prognosis for the...

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Julio Osorio stands in the Valhalla Memorial Park Cemetery near his mother's grave. (Emily Elena Dugdale/KPCC); Credit: Emily Elena Dugdale

The devastating Woolsey fire broke out one year ago. In Malibu, it wreaked havoc not only on hundreds of homeowners but also on the day laborers, housekeepers and gardeners who traveled to the city to work in its affluent neighborhoods.

This content is from Southern California Public Radio. View the original story at SCPR.org.

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A new study shows that the West Antarctic Peninsula is experiencing some of the most rapid climate change on Earth, featuring dramatic increases in temperatures, retreats in glaciers and declines in sea ice. The Southern Ocean absorbs nearly half of the carbon dioxide -- the key greenhouse gas linked to climate change -- that is absorbed by all the world's oceans. The study tapped an unprecedented 25 years of oceanographic measurements in the Southern Ocean and highlights the need for more monitoring in the region. The research revealed that carbon dioxide absorption by surface waters off the West Antarctic Peninsula is linked to the stability of the upper ocean, along with the amount and type of algae present. A stable upper ocean provides algae with ideal growing conditions. During photosynthesis, algae remove carbon dioxide from the surface ocean, which in turn draws carbon dioxide out of the atmosphere. From 1993 to 2017, changes in sea ice dynamics off the West Antarctic Peninsula stabilized the upper ocean, resulting in greater algal concentrations and a shift in the mix of algal species. That's led to a nearly five-fold increase in carbon dioxide absorption during the summertime. The research also found a strong north-south difference in the trend of carbon dioxide absorption. The southern portion of the peninsula, which to date has been less impacted by climate change, experienced the most dramatic increase in carbon dioxide absorption, demonstrating the poleward progression of climate change in the region.

Image credit: Drew Spacht/The Ohio State University

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Many people turn to the Internet to find a Mr. or Ms. Right. But lemurs just give their potential partners a sniff. A study of lemur scents has found that an individual’s distinctive body odor reflects genetic differences in their immune system, and that other lemurs can detect these differences by smell. From just one whiff, these primates can tell which prospective partners have immune genes different from their own. The ability to sniff out mates with different immune genes could make their offspring’s immune systems more diverse and able to fight more pathogens. Shown here: Fritz the ring-tailed lemur sniffs a tree for traces of other lemurs’ scents.

Image credit: David Haring/Duke Lemur Center

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On August 17, 2017, scientists made history with the first direct observation of a merger between two neutron stars. It was the first cosmic event detected in both gravitational waves and the entire spectrum of light, from gamma rays to radio emissions. The impact also created a kilonova -- a turbocharged explosion that instantly forged several hundred planets’ worth of gold and platinum. The observations provided the first compelling evidence that kilonovae produce large quantities of heavy metals, a finding long predicted by theory. Astronomers suspect that all of the gold and platinum on Earth formed as a result of ancient kilonovae created during neutron star collisions. Based on data from the 2017 event, first spotted by the Laser Interferometer Gravitational-wave Observatory (LIGO), astronomers began to adjust their assumptions of how a kilonova should appear to Earth-bound observers. A team of scientists reexamined data from a gamma-ray burst spotted in August 2016 and found new evidence for a kilonova that went unnoticed during the initial observations.

Image credit: NASA/ESA/E. Troja

Source: Streetwise Reports   04/27/2020

Avadel Pharmaceuticals Plc (AVDL:NASDAQ) today announced "positive topline data from its pivotal Phase 3 REST-ON trial assessing the safety and efficacy of FT218, an investigational, once-nightly formulation of sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy." The firm pointed out that it met all three of the co-primary efficacy endpoints in the study for each of three dosage levels which it claims demonstrates "highly significant, clinically meaningful improvements on the Maintenance of Wakefulness Test, Clinical Global Impression-Improvement and mean weekly cataplexy attacks."

The company's Chief Medical Officer Jordan Dubow, M.D., commented, "We are excited to see these positive topline data from the REST-ON study, where all three dose levels of once-nightly FT218 demonstrated a statistically significant and clinically meaningful improvement on the measures of the two prominent symptoms of narcolepsy, as well as an improvement in overall functioning compared to placebo...Once-nightly FT218 delivered a clinically meaningful response within three weeks of treatment initiation, which was sustained through each treatment period...We think once-nightly FT218, if approved, has the potential to be a meaningful contributor to patient care."

Avadel Pharma's CEO Greg Divis remarked, "The successful outcome of the REST-ON study strengthens our belief that, if approved, once-nightly FT218 has the potential to be a significant advancement for patients in the estimated $1.7 billion twice-nightly sodium oxybate market. Our proprietary market research with physicians and patients informs us that there is a strong interest in a once-nightly sodium oxybate formulation. We look forward to sharing the results from the REST-ON study with the FDA and progressing toward a potential approval that would allow us to bring this important treatment to the patients who need it most. If approved, FT218 would be the first once-nightly therapy to address both excessive daytime sleepiness and cataplexy in patients with narcolepsy."

The REST-ON study is a double-blind, randomized, placebo-controlled Phase 3 trial to assess the efficacy and safety of once-nightly FT218, a formulation of sodium oxybate using Avadel's proprietary Micropump technology for extended-release oral suspension in the treatment of excessive daytime sleepiness and cataplexy in patients suffering from narcolepsy. The company stated that 212 patients were enrolled in the study and result "showed that the 9 g dose of once-nightly FT218 demonstrated a highly significant and clinically meaningful improvement compared to placebo across all three co-primary endpoints."

The company advised that FT218 has been granted Orphan Drug Designation from the U.S. FDA for the treatment of narcolepsy. The firm added that the designation was granted on basis that FT218 may be clinically superior to a formulation of sodium oxybate that is already approved by the FDA for the same indication.

Avadel Pharmaceuticals is biopharmaceutical company headquartered in Dublin, Ireland. The company's primary focus is on the development and potential FDA approval for FT218, which just completed its Phase 3 REST-ON clinical trial for the treatment of narcolepsy patients suffering from excessive daytime sleepiness and cataplexy. The firm also develops and markets sterile injectable drugs for use in hospital settings.

Avadel started off the day with a market capitalization of around $456.2 million with approximately 46.4 million shares outstanding and a short interest of about 14.00%. AVDL shares opened more than 34% higher today at $13.30 (+$3.37, +34.28%) over Friday's $9.83 closing price and reached a new 52-week high price this morning of $13.49. The stock has traded today between $11.90 and $13.49 per share and is currently trading at $12.27 (+$2.44 +24.82%).

Disclosure:
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( Companies Mentioned: AVDL:NASDAQ, )

Parts of Africa and the Asia-Pacific region may be vulnerable to outbreaks of the Zika virus, including some of the world's most populous countries and many with limited resources to identify and respond to the mosquito-borne disease, a new study says.

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Using electric fans to relieve high levels of heat and humidity may, surprisingly, have the opposite effect for seniors, a study by UT Southwestern Medical Center heart specialists suggests.

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Soccer is an increasingly popular sport in the United States, both professionally and recreationally, with over 3 million registered soccer players under 19 years of age playing in leagues every year. A new study conducted by the Center for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital found that with the increase in the number of players there has been a rise in the number and rate of injuries.

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A new tool for minimising offshore wind energy's impacts on other activities in the North Sea has been developed. The tool identifies space for wind farms based on their priority compared to other marine activities, such as sand extraction or fishing.

Astronomers using the Atacama Large Millimeter/submillimeter Array (ALMA) surveyed dozens of young stars -- some Sun-like and others approximately double that size -- and discovered that the larger variety have surprisingly rich reservoirs of carbon monoxide gas in their debris disks. In contrast, the lower-mass, Sun-like stars have debris disks that are virtually gas-free.

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A team of Carnegie scientists has discovered three giant planets in a binary star system composed of stellar ''twins'' that are also effectively siblings of our Sun. One star hosts two planets and the other hosts the third. The system represents the smallest-separation binary in which both stars host planets that has ever been observed. The findings, which may help explain the influence that giant planets like Jupiter have over a solar system's architecture, have been accepted for publication in The Astronomical Journal.

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Additional funding mechanisms are required to finance adaptation to climate change in developing countries, according to a new study. The study predicts how relationships between costs associated with adapting to and mitigating against climate change, and costs associated with damages caused by climate change, will progress over the next century.

One of the most common causes of water quality impairment is suspended particulate matter (SPM). A study by a team of UK researchers suggests that standards for SPM set by EU member states to help achieve the WFD should reflect the natural differences in the levels of this pollutant that are expected in contrasting environments. Their study provides hints as to how a potential alternative system for regulating SPM concentrations might be devised.

Inderpal Singh Kalra, ED-IT and Digital Banking & Emerging Payments at IDBI Bank throws light on three crucial solutions that leverage ML to manage risk.

To estimate the losses of wild pollinators across Great Britain, a study mapped records of 353 wild bee and hoverfly species, collected across the country from 1980 to 2013. It found that a third of species decreased, while a tenth increased. On average, the geographic range of bee and hoverfly species declined by a quarter, which equates to a net loss of 11 species from each 1km grid square (with uncommon species more harshly affected), highlighting a significant risk to biodiversity, pollinators, and their ecosystems.

The EU would not be breaking World Trade Organization (WTO) rules if it chose to extend REACH’s authorisation scheme on substances of very high concern (SVHC) to products imported to Europe, a recent legal analysis concludes. At present, the scheme — which is effectively a ban on SVHC, with some exceptions — applies only to products made within the European Economic Area (EEA).

Innovatively designed batteries offer a way for vehicles to move away from their dependence on fossil fuels. There has been little mass-market uptake of new battery design, however. In the last century, only four types of battery have been used: manganese oxide; lead acid; nickel; and lithium ion, which is a relative newcomer, introduced in 1991. To understand how innovation moves from research and development (R&D) to application and the mass market, scientists perform technology lifecycle (TLC) analyses, often focusing on R&D and basic research. This study adds an additional indicator — start-up companies — to explore the early phases of how batteries transition from science into industry.

Contamination of the aquatic environment by pharmaceutical drugs used in human and veterinary medicine is an emerging issue, as it can cause toxic effects in biological systems. This study explored how the marine organism Hediste diversicolor, a polychaete worm, responded to exposure to salicylic acid, a key component of aspirin. They found the species to adapt and respond in a way that minimised the effects of metabolising the contaminating compound, suggesting that the acid does not currently pose a threat to marine polychaetes.

Living near busy roads is associated with an increased risk of childhood leukaemia, according to French researchers. The study found that children living within 500 metres of major roads were more likely to develop leukaemia than those who lived far from such roads. It is possible that high levels of traffic pollution from the roads are responsible for the higher rates of the illness.

A new study aimed at increasing knowledge of indoor air quality (IAQ) in recently built or refurbished office buildings has found that levels of pollutants are mostly within World Health Organization (WHO) air-quality guidelines, however they vary between seasons. In addition, some levels of particulate matter were found to exceed WHO guideline values. The OFFICAIR project was funded by the European Union's Seventh Framework Programme.

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Best Friends Animal Society shares 14 reasons why 'the one' for you might have four legs.

Observations of next month's historic Venus transit may eventually help astronomers spot and study alien planets circling faraway stars, one prominent researche

For many children, realism isn't really the objective, so we should probably stop looking for that in their art.

The holidays have plenty of hustle and bustle, and it can overwhelm children on the autism spectrum. Sensitive Santas can help bring seasonal joy.

Research suggests that long-distance relationships encourage more communication and that couples try harder.

The popularity of weird beards and mustaches among young men living in Brooklyn, N.Y., may be more than just a hipster fad.

From the researcher who discovered peacock spiders, a new Australian spider species engages in a complex game to determine if a potential mate is a virgin.

New research explains why babies lose interest when they see something that seems simple.

After exhausting other price-sensible real estate options, a watercraft-loving Portland family settles on a 43-foot boat found on Craigslist for $14,000.

The R.W. Lindholm Residence is the newest, but certainly not the first, Wright-designed structure to be relocated in its entirety.

Video: Below the surface, thousands of marine creatures are still in danger from the Gulf oil disaster.