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[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00111

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[ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

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Published On :: Thu, 09 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00681

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[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00594

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[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00438

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[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00117

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[ASAP] Complete Regression of Carcinoma via Combined C-RAF and EGFR Targeted Therapy

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Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00159

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[ASAP] Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00661

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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00095

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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00106

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[ASAP] Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 d Inhibitors

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Published On :: Mon, 04 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00028

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[ASAP] Synthesis and Evaluation of <sup>11</sup>C- and <sup>18</sup>F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

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Published On :: Wed, 06 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00127

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[ASAP] Ligand Design for Cereblon Based Immunomodulatory Therapy

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00214

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Germany Facing Mass Blackouts Because The Wind And Solar Won’t Cooperate

By latestsolarnews.com
Published On :: Sat, 04 Mar 2017 19:59:09 +0000

Germany’s energy network nearly broken down in January because of poor execution from wind turbines and sun based boards, as indicated by information from a noteworthy exchange union. Wind and sunlight based power plants failed to meet expectations in January, 2017, as a result of shady climate with almost no wind, setting the phase for …

The post Germany Facing Mass Blackouts Because The Wind And Solar Won’t Cooperate appeared first on LatestSolarNews.

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Solar Trees Powering The Park Of South Florida

By latestsolarnews.com
Published On :: Sun, 23 Jul 2017 23:58:07 +0000

Joining South Florida’s lush, green canopy of real trees are a new crop of solar trees. These “trees” have blue trunks and bear no fruit, but supply clean energy to whoever needs it. If you’re at the beach and your phone starts to die, you can charge it right here using Solar Power. Here’s how …

The post Solar Trees Powering The Park Of South Florida appeared first on LatestSolarNews.

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Solar Powered Lights For The Yard

By latestsolarnews.com
Published On :: Wed, 26 Jul 2017 21:41:45 +0000

Reading about the various sofas reviews here and choosing amongst them to match your patio is not that difficult when compared to doing the entire electrical work of the patio. When you are lighting your patio the exact opposite thing you need to do is to be stumbling over electrical lines and attempting to put …

The post Solar Powered Lights For The Yard appeared first on LatestSolarNews.

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Sono Motors Introduces The SION Solar Powered Car

By latestsolarnews.com
Published On :: Sat, 23 Sep 2017 18:45:01 +0000

The fantasy of having the capacity to drive to work in a solar-powered car is at last turning into a reality. Sono Motors simply uncovered the SION solar-powered electric car gives you the ability to travel up to 18 miles utilizing only energy from the sun. Best of all, the SION isn’t only for the …

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Construction has started on the largest solar project in Nepal

By latestsolarnews.com
Published On :: Tue, 01 May 2018 18:55:50 +0000

The reports say that the constructions of a 25MW largest solar PV project in Nepal has begun. The foundation stone was laid last week at Devighat in Nuwakot by Minister for Energy, Water Resources and Irrigation, Barsha Man Pun. The government plans to finish the construction of the project in a year. As stated by …

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Back to the :roots

By simurai.com
Published On :: Wed, 09 Sep 2015 00:00:00 +0000

The cascade in CSS is a curse and blessing at the same time. It usually works quite well, but there are issues that let people get all worked up and ask the question Do We Even Need CSS Anymore. I can somewhat relate to that - but I also think it’s not the cascade alone and also about fighting specificity. Not running into issues with specificity is hard. Almost as hard as pronouncing that word.

In this post I’ll try to show a few ways how you can make the cascade be your friend and maybe reduce the need of overriding and thus encounter less fighting with specificity.

Tip 1:

For every CSS property that you write, try to move it up the tree as far as possible. In other words: Back to the :root.

For example, our site has a side bar and we want to add a short bio to it. The markup might look something like this:

<body>
	<main class=“Posts”>
	<aside class=“SideBar”>
		<nav class=“Nav”>
		<p class=“Bio”>

And the CSS:

.Bio {
	font-size: .8em;
	line-height: 1.5;
	color: #888;
}

That would work. But if we look at the Nav that is already in the SideBar, chances are good that some of the styles are the same. In our case it’s font-size and color. So let’s remove those properties from Nav and Bio and add it to the shared parent element, the SideBar.

.SideBar {
	font-size: .8em;
	color: #888;
}

And as it turns out, that line-height: 1.5; is already defined for our Posts. So since it seems that the whole page uses the same line-height, let’s remove it from the Bio and Post elements and move it all up to the root node.

:root {
	line-height: 1.5;
}

This probably sounds like common sense, but often it’s tempting to just style your new thing without even looking if some of the sibling elements define the same thing. This also happens when you copy&paste styles from another section or when pasting some snippets you found online. It might take a bit more time to refactor and seems scary, but it should keep our CSS in a healthier state.

Style the branches, not each leaf

Tip 2:

Style certain properties always as a combo.

A good example is the color and background-color combo. Unless you make only small tweaks, it’s probably a good idea to always change them together. When adding a background color to an element, it might not contain any text, but probably some child will. Therefore if we set foreground and background color together, we can always be sure we won’t run into any legibility and contrast issues. Also, next time we change a background color, we don’t have to hunt for all the text colors that need to be changed too, it’s right there in the same place.

Screenshot from Colorable

Tip 3:

Use “dynamic” values, such as currentColor and ems.

Sometimes it might make sense to use the text color for other properties. Like for border, box-shadow or for the fill of SVG icons. Instead of defining them directly you can use currentColor and it will be the same the color property. And since color inherits by default, you might can change it in only one place.

Similarly ems are mapped to font-size allowing you to scale everything by just changing the :root font size.

Here a few more details on currentColor and EMs.

Tip 4:

Override UA Styles to inherit from its parents.

Form controls like buttons, inputs get styled by the browser in a certain way. Overriding them with inherit makes them adapt to your own styles.

button,
input,
select,
textarea {
	color: inherit;
	font-family: inherit;
	font-style: inherit;
	font-weight: inherit;
}

The example above is taken from sanitize.css. normalize.css does the same, so if you use them, you’re already covered.

You can also try to restyle other inputs like a range slider, radio, checkbox etc. And as seen above, by using currentColor, make them automatically match the color property. And maybe move them from a light into a dark theme without changing anything.

Conclusion

That’s all nice stuff, but who is it for? Well, of course it can’t be forced upon every situation. I would say small and simple web sites benefit the most. But even when using a preprocessor, it might not hurt if it reduces the amount of CSS that gets output or when a few variables aren’t even needed.

Also it seems suited for the “single purpose class” approach like Tachyons. It might reduce complexity and the amount of classes that are needed.

Another interesting thing could be the upcoming custom properties a.k.a. CSS variables. Unlike variables in preprocessors, when overriding a custom property, it will only affect the current selector scope. So in a sense they will be “cascading variables”. But I still have to try that out and see how it works in practice.

ps. It is possible that this post is inspired by this tweet.

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DuoTone themes

By simurai.com
Published On :: Fri, 01 Jan 2016 00:00:00 +0000

Double-hue syntax themes for Atom.

DuoTone themes use only 2 hues (7 shades in total). It tones down less important parts (like punctuation and brackets) and highlights only the important ones. This leads to a more calm color scheme, but still lets you find the stuff you’re looking for.

A big thanks goes to @braver who did most of the initial language support.

Color variations

And here some more color variations created by other theme authors.

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Popular Design News of the Week: April 20, 2020 – April 26, 2020

By www.webdesignerdepot.com
Published On :: Sun, 26 Apr 2020 10:45:05 +0000

Every week users submit a lot of interesting stuff on our sister site Webdesigner News, highlighting great content from around the web that can be of interest to web designers. The best way to keep track of all the great stories and news being posted is simply to check out the Webdesigner News site, however, […]

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The Latest Research for Web Designers, April 2020

By www.webdesignerdepot.com
Published On :: Mon, 27 Apr 2020 10:45:10 +0000

Although life hasn’t returned to normal yet, the web design and marketing space doesn’t seem to have been too badly disrupted — at least not with all the new research and surveys floating around. And thank goodness for that. If we can maintain some semblance of normalcy, I think we’ll all get through this crisis in good shape.

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cybersecurity
design research
ecommerce marketing
technical seo
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Popular Design News of the Week: April 27, 2020 – May 3, 2020

By www.webdesignerdepot.com
Published On :: Sun, 03 May 2020 10:45:45 +0000

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8 of the Top WP Multipurpose Themes That You Can Use

By www.webdesignerdepot.com
Published On :: Tue, 05 May 2020 10:45:00 +0000

More than a few multipurpose WordPress themes have become big sellers in recent years, and for a reason. Actually, for several reasons. One reason is they serve as excellent toolkits for web designers who have large and varied clienteles. The best multipurpose themes, like those presented here, are popular for other reasons as well. They […]

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The matter of photography in the Americas / Natalia Brizuela and Jodi Roberts ; with contributions by Lisa Blackmore, Amy Sara Carroll, Marianela D'Aprile, María Fernanda Domínguez, Heloisa Espada, Rachel Price, Diana Ruiz, Tatiane Santa Ro

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - TR184.B75 2018

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Design: the key concepts / D.J. Huppatz

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Barker Library - NK1510.H87 2019

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The women of Atelier 17: modernist printmaking in midcentury New York / Christina Weyl

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - NE538.N5 W49 2019

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Legacy of the masters: painting and calligraphy of the Islamic world from the Shavleyan family collection / Will Kwiatkowski ; with contributions by John Seyller

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - N6260.K87 2019

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