act Factors affecting female bear harvest rates By feedproxy.google.com Published On :: Wed, 29 Jan 2020 17:00:40 EST Examining the factors that affect the number of females being harvested during the bear hunting season will help Pennsylvania wildlife officials manage population. Full Article
act Secret Service Sends FOIA Requester A Redacted Version Of A Public DOJ Press Release By www.techdirt.com Published On :: Thu, 7 May 2020 03:35:56 PDT The government loves its secrets. It loves them so much it does stupid things to, say, "secure the nation..." or "protect the integrity of deliberative processes" or whatever the fuck. We should not trust the government's reasoning when it chooses to redact information from documents it releases to FOIA requesters. These assertions should always be challenged because the government's track record on redactions is objectively awful. Here's the latest case-in-point: Emma Best -- someone the government feels is a "vexatious" FOIA filer -- just received a completely stupid set of redactions from the Secret Service. Best requested documents mentioning darknet market Hansa, which was shut down (along with Alpha Bay) following an investigation by US and Dutch law enforcement agencies. The documents returned to Best contained redactions. This is unsurprising given the nature of the investigation. What's surprising is what the Secret Service decided to redact. As Best pointed out on Twitter, the Secret Service decided public press releases by the DOJ were too sensitive to be released to the general public. Secret Service is now redacting press releases under b5 (deliberative process). Compare the redacted press releases from @SecretService with the unredacted versions posted to @TheJusticeDept's website. https://t.co/qsfoS9q6o7 Reform b5 now. #FOIA pic.twitter.com/57CKvW5R8Y — Emma Best ????️???? ???? (Mx. Yzptlk) (@NatSecGeek) April 27, 2020 Here's one of the redactions [PDF] the Secret Service applied to a press release that can be found unaltered and unedited at the Justice Department's publicly-accessible website: And here's what the Secret Service excised, under the bullshit theory that a publicly-released press statement is somehow an "inter-agency or intra-agency memorandums or letter which would not be available by law to a party other than an agency in litigation with the agency." “This is likely one of the most important criminal investigations of the year – taking down the largest dark net marketplace in history,” said Attorney General Jeff Sessions. “Make no mistake, the forces of law and justice face a new challenge from the criminals and transnational criminal organizations who think they can commit their crimes with impunity using the dark net. The dark net is not a place to hide. The Department will continue to find, arrest, prosecute, convict, and incarcerate criminals, drug traffickers and their enablers wherever they are. We will use every tool we have to stop criminals from exploiting vulnerable people and sending so many Americans to an early grave. I believe that because of this operation, the American people are safer – safer from the threat of identity fraud and malware, and safer from deadly drugs.” Um. Is Jeff Sessions being Yezhoved by the Secret Service? Does the agency consider him to be enough of a persona non grata after his firing by Trump to be excised from the Secret Services' official recollection of this dark web takedown? This insane conspiracy theory I just made up makes as much sense as anything the Secret Service could offer in explanation for this redaction. The redaction removed nothing but the sort of swaggering statement Attorney Generals always make after a huge bust. Needless to say, Emma Best is challenging the Secret Service's redactions. Pithily. I am appealing the integrity of the redactions, as you withheld public press releases under b5, which is grossly inappropriate. Yeah. That's an understatement. The Secret Service has no business redacting publicly-available info. Even if this was a clerical error, it's so bad it's insulting. And that's why you can't trust the government on things like this: when it's not being malicious, it's being stupid. Full Article
act Utah Pulls Plug On Surveillance Contractor After CEO's Past As A White Supremacist Surfaces By www.techdirt.com Published On :: Thu, 7 May 2020 13:53:02 PDT A couple of months ago, a records request revealed a private surveillance contractor had access to nearly every piece of surveillance equipment owned and operated by the state of Utah. Banjo was the company with its pens in all of the state's ink. Banjo's algorithm ran on top of Utah's surveillance gear: CCTV systems, 911 services, location data for government vehicles, and thousands of traffic cameras. All of this was run through Banjo's servers, which are conveniently located in Utah government buildings. Banjo's offering is of the predictive policing variety. The CEO claims its software can "find crime" without any collateral damage to privacy. This claim is based on the "anonymization" of harvested data -- a term that is essentially meaningless once enough data is collected. This partnership is now on the rocks, thanks to an investigation by Matt Stroud and OneZero. Banjo's CEO, Damien Patton, apparently spent a lot of his formative years hanging around with white supremacists while committing crimes. In grand jury testimony that ultimately led to the conviction of two of his associates, Patton revealed that, as a 17-year-old, he was involved with the Dixie Knights of the Ku Klux Klan. On the evening of June 9, 1990 — a month before Patton turned 18 — Patton and a Klan leader took a semi-automatic TEC-9 pistol and drove to a synagogue in a Nashville suburb. With Patton at the wheel, the Ku Klux Klan member fired onto the synagogue, destroying a street-facing window and spraying bullets and shattered glass near the building’s administrative offices, which were next to that of the congregation’s rabbi. No one was struck or killed in the shooting. Afterward, Patton hid on the grounds of a white supremacist paramilitary training camp under construction before fleeing the state with the help of a second Klan member. If you're wondering where the state of Utah's due diligence is in all of this, there's a partial explanation for this lapse: the feds, who brought Patton in, screwed up on their paperwork. Because Patton’s name was misspelled in the initial affidavit of probable cause filed in Brown’s case — an FBI agent apparently spelled Damien with an “o” rather than an “e” — any search of a federal criminal court database for “Damien Patton” would not have surfaced the affidavit. Now that his past has been exposed, the state of Utah has announced it won't be working with Banjo. The Utah attorney general’s office will suspend use of a massive surveillance system after a news report showed that the founder of the company behind the effort was once an active participant in a white supremacist group and was involved in the shooting of a synagogue. The AG's office can only shut down so much of Banjo's surveillance software. Other government agencies not directly controlled by the state AG are making their own judgment calls. The University of Utah is suspending its contract with Banjo, but the state's Department of Public Safety has only gone so far as to "launch a review" of its partnership with the company. City agencies and a number of police departments who have contracts with Banjo have yet to state whether they will be terminating theirs. And the AG's reaction isn't a ban. The office appears to believe it might be able to work through this. “While we believe Mr. Patton’s remorse is sincere and believe people can change, we feel it’s best to suspend use of Banjo technology by the Utah attorney general’s office while we implement a third-party audit and advisory committee to address issues like data privacy and possible bias,” Piatt said. “We recommend other state agencies do the same.” It's refreshing to hear a prosecutor state that it's possible for former criminals to turn their lives around and become positive additions to their communities, but one gets the feeling this sort of forgiveness is only extended to ex-cons who have something to offer law enforcement agencies. Everyone else is just their rap sheet for forever, no matter how many years it's been since their last arrest. The other problem here is the DA's office's tacit admission it did not take data privacy or possible bias into account before granting Banjo access to the state's surveillance equipment, allowing it to set up servers in government buildings, and giving it free rein to dust everything with its unaudited AI pixie dust. These are all steps that should have taken place before any of this was implemented, even if the state had chosen to do business with a company with a less controversial CEO. This immediate reaction is the right step to take, but a little proactivity now and then would be a welcome change. Full Article
act The EARN IT Act Also Threatens Journalists And Their Sources By www.techdirt.com Published On :: Fri, 8 May 2020 09:34:27 PDT The EARN IT Act is dangerous. It threatens speech on the internet and tech companies' ability to provide secure communications for their users. There may not be anything about encryption in the dry text of the bill, but the threat is there all the same. No one knows what "best practices" the law will demand from online services, but the bill's focus on child porn strongly suggests any platform that "allows" this information to be transmitted using encrypted communications will be targeted by the government. Bill Barr and Chris Wray have made it clear encryption is the enemy. Both have advocated for encryption backdoors, even if they're both too cowardly to use that term. No one thinks the government and service providers shouldn't do all they can to prevent the sharing of child porn, but undermining encryption isn't the solution. It may shield some child porn producers and consumers from detection, but the government's efforts in this area show encryption hasn't posed much of a problem to investigators and prosecutors. Encryption protects people who aren't criminals. As Runa Sundvik explains for TechCrunch, targeting encryption via the EARN IT Act also threatens some of the foremost beneficiaries of the First Amendment: journalists. [T]echnology experts warn the bill not only fails to meet the challenge, it creates new problems of its own. My job is to enable journalists to do their work securely — to communicate with others, research sensitive stories and publish hard-hitting news. This bill introduces significant harm to journalists’ ability to protect their sources. Strip communications platforms of their encryption and you make it that much easier to expose journalists' sources and snoop on their communications. This isn't an existential threat. It's an actual threat. The FBI has spied on journalists and several successive presidential administrations have made rooting out leakers a priority. But it does more than harm journalists. It also harms the people they're trying to reach: readers. Encryption protects readers who visit news sites utilizing HTTPS. That's almost all of them at this point. This ensures their connection is shielded from people trying to snoop on their web activity. More importantly, it ensures the sites they reach are legit and the content originating from the journalists the site says it is. If EARN IT becomes law, whistleblowers and other sources will see their secure options disappear. Tor, Signal, etc. will be considered nothing more than aiders and abettors of criminal activity. Anything secured by encryption will be treated as a virtual dead drop for criminal content. Protecting children from exploitation is important. But the tradeoff legislators are demanding isn't actually a tradeoff. The American public will receive no net benefit from this tangential attack on encryption. Very often we're first informed about serious government misconduct by journalists. Destroying this outlet works out well for the government so often exposed as untrustworthy, but it does nothing for the governed. Full Article
act What does the Book of Acts teach about Forgiveness? By redeeminggod.com Published On :: 2020-02-27T16:00:57Z Lots of people are very confused about the topic of Forgiveness in the Bible. This study looks at what the book of Acts teaches about forgiveness, and in this way, we see a glimpse of what the Bible teaches about forgiveness. This study is an excerpt from from my Gospel Dictionary online course. Full Article One Verse Redeeming Scripture Redeeming Theology z Acts 10:43 Acts 13:38 Acts 2:38 Acts 26:18 Acts 5:31 forgiven forgiveness forgiveness of sins
act From Playing Games to Committing Crimes: A Multi-Technique Approach to Predicting Key Actors on an Online Gaming Forum By www.lightbluetouchpaper.org Published On :: Mon, 27 Jan 2020 15:01:00 +0000 I recently travelled to Pittsburgh, USA, to present the paper “From Playing Games to Committing Crimes: A Multi-Technique Approach to Predicting Key Actors on an Online Gaming Forum” at eCrime 2019, co-authored with Ben Collier and Alice Hutchings. The accepted version of the paper can be accessed here. The structure and content of various underground … Continue reading From Playing Games to Committing Crimes: A Multi-Technique Approach to Predicting Key Actors on an Online Gaming Forum → Full Article Academic papers Cybercrime
act Contact Tracing in the Real World By www.lightbluetouchpaper.org Published On :: Sun, 12 Apr 2020 10:34:03 +0000 There have recently been several proposals for pseudonymous contact tracing, including from Apple and Google. To both cryptographers and privacy advocates, this might seem the obvious way to protect public health and privacy at the same time. Meanwhile other cryptographers have been pointing out some of the flaws. There are also real systems being built … Continue reading Contact Tracing in the Real World → Full Article Academic papers Cryptology News coverage Politics Privacy technology Security economics Security psychology coronavirus private contact tracing public health
act Three Paper Thursday: Exploring the Impact of Online Crime Victimization By www.lightbluetouchpaper.org Published On :: Thu, 30 Apr 2020 13:26:03 +0000 Just as in other types of victimization, victims of cybercrime can experience serious consequences, emotional or not. First of all, a repeat victim of a cyber-attack might face serious financial or emotional hardship. These victims are also more likely to require medical attention as a consequence of online fraud victimization. This means repeat victims have a … Continue reading Three Paper Thursday: Exploring the Impact of Online Crime Victimization → Full Article Academic papers Cybercrime Security psychology Three Paper Thursday
act Australian contact-tracing app sent no data to contact-tracers for at least ten days after hurried launch By go.theregister.co.uk Published On :: Thu, 07 May 2020 06:02:06 GMT Doesn't play well on iPhones, but bureaucrats rushed it out rather than wait months for perfection. Meanwhile serious bug reports have emerged Australia’s “COVIDSafe” contact-tracing app was rushed to market in the knowledge it would perform poorly on some devices and without agreements in place to let actual contact-tracers use the data it collects. As a result, no collected data has been used in at least 10 days since its launch.… Full Article
act Microsoft claims AWS has used new JEDI mind trick with secret contract objection filing By go.theregister.co.uk Published On :: Fri, 08 May 2020 09:01:10 GMT It's over, Amazon, we have the high ground (and all you had was a high price) says Redmond Updated Amazon.com has filed a second, secret, appeal against the decision to award Microsoft the Pentagon's $10bn Joint Enterprise Defense Infrastructure (JEDI) cloud contract.… Full Article
act Need some weekend reading? How about the source code for UK, Australia's coronavirus contact-tracing apps By go.theregister.co.uk Published On :: Sat, 09 May 2020 01:29:41 GMT Problems aside, no one is sure how useful phone-based tracking will be The NHSX, a technology group within the UK government's National Health Service, has released the source code for its Android and iOS COVID-19 coronavirus contact-tracing apps in an effort to allay privacy concerns and improve the code.… Full Article
act 01/08/17 - They hide the fact By www.tinyghosts.com Published On :: Monday, 09 Jan 2017 Full Article
act Featured - How Products are Born: What exactly is going on in research and development anyway? By www.labspaces.net Published On :: Wed, 16 Feb 2011 14:18:06 -0600 OK, let’s pick up our discussion where we left off last week, at feasibility. You did it. You successfully convinced a room full of vice presidents and directors, or maybe even the CEO that they should take your fabulous product idea to the next level. You’ve got marketing on board, excited to promote it and now it’s time for the work to begin.You are the lead scientist s; (read more) Source: Suzy - Discipline: BioTech Full Article
act It’s Not Too Late — Free Printable Mother’s Day Cards / Cool Activities By www.freerangekids.com Published On :: Wed, 06 May 2020 17:30:24 +0000 These “cards” are really an excuse for kids to interview their moms and shower them with the ultimate gifts: attention to mom’s quirky uniqueness, gratitude, and offers of help! Here you go — click here! (Mother’s Day is SUNDAY!) Full Article Miscellaneous
act The Angler’s Code: What are the Best Practices for a Better Fishing Future? By www.oceanbluefishing.com Published On :: Thu, 30 Apr 2020 05:08:02 +0000 The Angler’s Code: What are the Best Practices for a Better Fishing Future? The post The Angler’s Code: What are the Best Practices for a Better Fishing Future? appeared first on Ocean Blue Fishing Adventures. Full Article Featured Post How To anglers code anglers practice best fishing practices fishing practices fishing tips Ocean Blue Fishing Vanuatu Fishing
act Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis By www.jci.org Published On :: Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of CD68+ macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor β (TCRβ) repertoire in the CP and control groups. TCRβ sequencing revealed a significant increase in TCRβ repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vβ-Jβ gene family usage between hereditary and idiopathic CP and a positive correlation of TCRβ rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP. Full Article
act TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation By www.jci.org Published On :: Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis. Full Article
act Retrograde nerve growth factor signaling abnormalities in familial dysautonomia By www.jci.org Published On :: Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD. Full Article
act (H)Elping nerve growth factor: Elp1 inhibits TrkA’s phosphatase to maintain retrograde signaling By www.jci.org Published On :: Nerve growth factor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons to the targets of those axons. How this occurs when axons contain a plethora of proteins that can silence those signals has long perplexed the neurotrophin field. In this issue of the JCI, Li et al. suggest an answer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonomia (FD) causes peripheral neuropathy. They describe a distinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off those signals. This finding helps explain the innervation deficits prominent in FD and reveals a unique role for Elp1 in the regulation of NGF-dependent TrkA activity. Full Article
act The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5 By www.jci.org Published On :: IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity. Full Article
act Helicobacter pylori: preying on SIVA for survival in the stomach By www.jci.org Published On :: Infection with the Gram-negative bacterium Helicobacter pylori remains the most important modifiable risk factor for the development of gastric cancer, a leading cause of cancer-related deaths worldwide. How the interactions between H. pylori and its host shape the gastric environment during chronic infection warrants further investigation. In this issue of the JCI, Palrasu et al. used human cell lines and mouse models to provide mechanistic insight into H. pylori’s ability to delay apoptosis in gastric epithelial cells by actively driving the degradation of a proapoptotic factor, SIVA1. Their findings suggest that promoting the survival of gastric epithelial cells has implications not only for H. pylori pathogenesis but for host tumorigenesis. Full Article
act Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells By www.jci.org Published On :: Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor. Full Article
act Local microvascular leakage promotes trafficking of activated neutrophils to remote organs By www.jci.org Published On :: Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs. Full Article
act Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα–mediated lipid metabolism By www.jci.org Published On :: Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases. Full Article
act Apple Faces Class Action Lawsuit Over 'Flexgate' Issue With MacBook Pro Displays By www.macrumors.com Published On :: Fri, 08 May 2020 08:43:43 PDT A nationwide class action lawsuit filed against Apple in Northern California court this week accuses the company of knowingly concealing a defect with a display-related flex cable on recent 13-inch and 15-inch MacBook Pro models. As discovered by repair website iFixit last year, some MacBook Pro models released in 2016 and 2017 have experienced issues with uneven backlighting caused by a delicate flex cable that can wear out and break after repeated opening and closing of the display. Impacted notebooks can exhibit uneven lighting at the bottom of the screen, which has been described as a "stage light" effect, and the backlighting system can eventually fail entirely. Since the issue often takes time to manifest, the affected MacBook Pro units can be outside of Apple's one-year warranty period when they start exhibiting symptoms, resulting in an out-of-warranty repair fee of up to $850. "Imagine spending more than $2,500 on a laptop only for it to fail shortly after the manufacturer's warranty expires," said PARRIS Law Firm attorney R. Rex Parris. "What's even more appalling is Apple requiring customers to spend an additional $600 to $850 to replace the screen." Apple seemingly fixed the issue by extending the length of the flex cable by 2mm in the 2018 MacBook Pro. It also launched a free repair program in May 2019, but the program only applies to 13-inch MacBook Pro models released in 2016. iFixit found the 2018 MacBook Pro flex cable on the left to be 2mm longer The class action lawsuit seeks restitution for all costs attributable to replacing or replacing the affected MacBook Pro units, and calls for Apple to expand its repair program to cover the 15-inch MacBook Pro. The proposed class is defined as all persons within the United States who purchased a 2016 or newer MacBook Pro. Related Guide: "Flexgate" Display Issues Affecting 2016 MacBook Pro and LaterRelated Roundup: MacBook ProTags: lawsuit, FlexgateBuyer's Guide: MacBook Pro (Caution)This article, "Apple Faces Class Action Lawsuit Over 'Flexgate' Issue With MacBook Pro Displays" first appeared on MacRumors.comDiscuss this article in our forums Full Article Retina MacBook Pro lawsuit Flexgate
act Oh, God, it's happening: Disney announces live action (...ish?) 'Robin Hood' remake By www.flayrah.com Published On :: Sun, 12 Apr 2020 03:21:18 +0000 Disney has announced that it will be producing a new Robin Hood movie. Yes, that Robin Hood. read more Full Article Disney movies Robin Hood
act 'Life and Death. One Awareness.', by Sashas Keeper (Cacti - T. pachanoi) By erowid.org Published On :: Wed, 06 May 2020 17:10:01 GMT Erowid Exp101191 Full Article Erowid : Experience :
act College for ALL Act presented by Senator Bernie Sanders on May 19 2015 By www.cpa-connecticut.com Published On :: Wed, 20 May 2015 03:27:56 +0000 Read the text of Senator Bernie Sanders bill to make college tuition free for students and to be financed by a tax on Wall Street speculation. WASHINGTON, May 19 – Sen. Bernie Sanders (I-Vt.) today introduced legislation to make 4-year public colleges and universities tuition free. “We live in a highly competitive global economy. If our economy is to be strong, we need the best educated work force in the world. That will not happen if every year hundreds of thousands of bright young people cannot afford to go to college and if millions more leave school deeply in debt,” Sanders said. Under the legislation, $70 billion a year in assistance – two-thirds from the federal government and one-third from states – would replace what public colleges and universities now charge in tuition and fees. The federal share of the cost would be offset by imposing a tax on Wall Street transactions by investment houses, hedge funds and other speculators. The legislation also would overhaul student loan programs so students and their parents could reduce crushing debt loads which now exceed Americans’ credit card debt. Federal profits on loans would be eliminated, work-study programs expanded and incentives offered for colleges and universities to keep costs down. “We once led the world in the percentage of our people with a college degree, now we are in 12th place.” Sanders said. “Countries like Germany, Denmark, Sweden and many more are providing free or inexpensive higher education for their young people. They understand how important it is to be investing in their youth. We should be doing the same,” he added. Tuition at 4-year public colleges and universities rose by 50 percent in the United States during the past decade. As state governments have cut support for higher education, the burden has shifted to students and their parents. With this spring’s college commencement season underway, the class of 2015 is the most indebted class in American history, according to Mark Kantrowitz, publisher of Edvisors, a website on college costs and financial aid. Continue reading → Full Article Accountants CPA Hartford Articles College for All Act free tuition bill of Senator Bernie Sanders Robin Hood tax on Wall Street Summary of Senator Sanders' College for All Act text of Senator Bernie Sanders bill transcript video
act Our intelligence agencies have issued disclaimers stating that their reports of Russian hacking of the election lack any proof of facts By www.cpa-connecticut.com Published On :: Thu, 12 Jan 2017 08:09:28 +0000 Jimmy Dore: The intelligence agencies have been releasing the reports to convince us that we should be upset at Russia because they hacked our election. First of all, who gives a shit if they did? The United States tapped Angela Merkel’s … Continue reading → Full Article Accountants CPA Hartford Articles American Conservative Assessing Russian Activities and Intentions in Recent US Elections CIA CNN disclaimers FBI intelligence reports Russia hacking James Clapper January 11 2017 Jimmy Dore John Harwood MSNBC NCCIC New York Times Our intelligence agencies have issued disclaimers stating that their reports of Russian hacking of the election lack any proof of facts Philip Giraldi Russia Hacking Absolutely NOT Confirmed By Intelligence Agencies Stef Azmorano The Jimmy Dore Show transcript video
act The SEBAC agreement is the mother of all can-kicks a sweetheart deal protected by contract for a full decade By www.cpa-connecticut.com Published On :: Mon, 02 Oct 2017 19:34:00 +0000 The sweetheart deal that Governor Malloy and his fellow Democrats in the General Assembly cut with state employee unions, the so-called SEBAC agreement, is protected by contract for a full decade —leaving meaningful reforms waaay down the road. The contract is the mother of all can-kicks. Continue reading → Full Article Accountants CPA Hartford Articles Connecticut union concession bill Democrat GOP budget Governor Malloy Joe Aresimowicz kicking the can down the road Republican SEBAC agreement spiking state employee unions The SEBAC agreement is the mother of all can-kicks The SEBAC agreement is the mother of all can-kicks a sweetheart deal protected by contract for a full decade
act Not Just the End of IT, the End of IT Contractors By www.cringely.com Published On :: Mon, 30 Mar 2020 20:10:12 +0000 Earlier this week I predicted the demise of conventional IT caused by the wide adoption of SD-WAN and SASE, accelerated by the emergency demands of everyone working from home. Now that Congress has passed a $2.2 trillion COVID-19 bail-out, let’s throw-in the implications of that legislation to see what effect it is all likely to have on what used to be IT. The short version is to expect an even bigger bloodbath as IT employees at all levels are let go forever. Please understand that some version of this bloodbath was going to happen anyway. What matters right now is how we respond to it. While my previous column was generally about turning lower-level IT nerds into Uber drivers, this one goes a little further […] Digital Branding Web Design Marketing Full Article 2020 cloud computing computer networks Predictions strategy COVID-19 economics IBM recession SASE SD-WAN
act U.S. Chamber Foundation and IBM Issue New Report on Impact of Corporate Social Responsibility on Public Sentiment, Brand Reputation By www.ibm.com Published On :: Thu, 20 Apr 2017 03:35:21 GMT The U.S. Chamber Foundation’s Corporate Citizenship Center and IBM today issued a new report that explores how efforts by businesses to be a positive force in communities – commonly referred to as corporate social responsibility (CSR) – influences public perception of those companies. Full Article IBM Watson Analytics
act IBM Vice President Supply Chain Joanne Wright to Speak at Supply Chain Leaders in Action Business Forum By www.ibm.com Published On :: Tue, 09 May 2017 04:45:47 GMT IBM today announced that Joanne Wright, Vice President Supply Chain has been selected to speak at the upcoming Supply Chain Leaders in Action Business Forum, which takes place in Naples, Florida on June 5-7. Full Article IBM Commerce
act IBM lidera iniciativa Global ‘Call for Code’ para utilizar Cloud, Data, IA y Blockchain para mitigar el impacto de desastres naturales By www.ibm.com Published On :: jue, 24 may 2018 04:22:04 GMT IBM y organizaciones aliadas lanzaron la iniciativa global 'Call for Code', el esfuerzo más grande y ambicioso para reunir a desarrolladores del sector académico y empresarial, para resolver uno de los problemas más acuciantes de la sociedad de nuestro tiempo: prevenir, responder y recuperarse de desastres naturales. Full Article Cloud Computing
act BP lanza la primera App para facturar consumos en sus estaciones de servicio en México, desarrollada con tecnología de IBM By www.ibm.com Published On :: vie, 24 ago 2018 04:53:02 GMT La compañía energética BP anunció el lanzamiento de su aplicación móvil BPme, desarrollada con capacidades de inteligencia artificial (IA) de IBM Watson, buscando mejorar constantemente la experiencia de los usuarios de las estaciones de servicio de BP en México. Full Article IBM Watson
act Auckland University of Technology Re-signs IBM for Five Year IT Network Services Contract By www.ibm.com Published On :: Fri, 25 May 2012 02:47:50 GMT IBM has replaced Auckland University of Technology (AUT)’s core IT network as part of a new five year services contract. The new network, which went live in March, gives AUT great flexibility for deploying equipment to meet the changing needs of the university and enables it to capitalise on future enhancements in technology, such as video and data centres. Full Article Education
act Dona IBM servicios de consultoría a organizaciones mexicanas para proyectos de impacto social By www.ibm.com Published On :: lun, 20 feb 2017 07:59:19 GMT Con la finalidad de apoyar el desarrollo de proyectos de alto impacto en la Ciudad de México, la Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología e IBM, ponen en marcha el día de hoy el programa de consultoría Corporate Service Corps (CSC), en su edición Ciudad de México. Full Article Corporate
act Organizaciones beneficiadas e IBM, comparten resultados de servicios de consultoría en proyectos de impacto social By www.ibm.com Published On :: mar, 21 mar 2017 05:07:43 GMT Después de un mes de haber iniciado la consultoria pro-bono de IBM denominada Corporate Service Corps (CSC), el día de hoy se hizo la entrega del resumen ejecutivo de cada uno de los proyectos de las organizaciones receptoras de este apoyo: Asociación Mexiana de Ayuda a Niños con Cáncer (AMANC), Fondo Unido México, Fundación Carlos Slim, el Patronato del Museo Nacional de Antropología. Full Article Corporate
act Dona IBM Servicios de Consultoría a Organizaciones Queretanas para Proyectos de Impacto Social By www.ibm.com Published On :: mar, 03 oct 2017 08:50:58 GMT IBM, Peace Corps y cuatro instituciones locales dieron inicio el día de hoy al programa de consultoría Corporate Service Corps (CSC), en su edición Cd. de Querétaro; con la finalidad de apoyar el desarrollo de proyectos de alto impacto en esta localidad. IBM y Peace Corps (PC) trabajarán en conjunto con la Secretaría de Desarrollo Social del Estado de Querétaro, el Instituto Queretano de las Mujeres, el Municipio de Querétaro - Delegación Santa Rosa Jáuregui, y la Universidad Politécnica de Santa Rosa Jáuregui (UPSRJ). Full Article Corporate
act IBM Announces Smart Analytics and Transactional Systems to Draw Key Insights from Vast Amounts of Data By www.ibm.com Published On :: Wed, 07 Apr 2010 11:43:40 GMT IBM today announced new systems highly-tuned and optimised to help clients more quickly draw insights from vast amounts of data to anticipate emerging business trends, capture new opportunities and avoid risks. These new optimised systems support all environments in a data center, enabling clients to handle higher volumes of transactions and analyse data where it resides. Full Article Global Financing
act IBM and the City of Melbourne launch a personalised, interactive online experience for fashionistas at Melbourne Spring Fashion Week Opening Night By www.ibm.com Published On :: Tue, 02 Sep 2014 07:21:56 GMT Melbourne, Australia - 18 August 2014: IBM (NYSE: IBM) and the City of Melbourne today launched a new interactive online experience for this year’s Melbourne Spring Fashion Week (MSFW) to enhance the iconic event and help shoppers hunt down the best retail bargains. The launch of the experience signifies the beginning of a three-year partnership between the City of Melbourne and IBM as the Official Innovation and Technology Partner for MSFW. Full Article Retail
act IBM serves real time interactive data to fans at the Australian Open By www.ibm.com Published On :: Mon, 19 Jan 2015 07:12:32 GMT IBM (NYSE: IBM) and Tennis Australia today announced new and expanded data driven experiences that will enhance Australian Open 2015 for fans on site and around the world. IBM SlamTracker has been redesigned with new point-by-point data visualisations, commentary and statistics that include player and ball movement data for the first time ever at the Australian Open. IBM CrowdTracker, new for 2015, will provide fans with live match, venue and social information via ausopen.com and the official Australian Open apps. Full Article Media & Entertainment
act Westpac selects IBM as lead technology services provider under five-year contract By www.ibm.com Published On :: Sun, 21 Nov 2010 10:10:06 GMT IBM today announced the signing of a new five-year infrastructure services agreement with The Westpac Group, which marks a key step in Westpac’s technology transformation program. Full Article Banking and Financial Services
act 【記事まとめ4件】三井住友VISAカード 永久輝せあコーナー2020年2月更新/+act 風間柚乃/Marisol 礼 真琴/ウィズたからづか 諏訪さき By takarazuka.okashi.pupu.jp Published On :: 2020-02-10T19:43:48+09:00 【記事まとめ4件】 三井住友VISAカード 特別コーナーに永久輝せあ舞台レビュー・中編をアップ 宝塚歌劇団・花組 永久輝せあコーナー 永久輝せあコーナー[今月のメッセージ][ステージフォトレビュー]更新 特別コーナー【永久輝せあ舞台レビュー・中編... Full Article
act Innovation activity slows in Australia according to Innovation Index By www.ibm.com Published On :: Thu, 31 Jul 2008 04:14:11 GMT IBM Australia and the Melbourne Institute of Applied Economic and Social Research, University of Melbourne, today announced the launch of the IBM-Melbourne Institute 'Innovation Index of Australian Industry’ second edition. The Study revealed that the annual increase in the rate of innovative activity in Australia in 2006 was only 0.7 percent, with only four industries experiencing an increase in the annual rate of innovation in that period: communication services; mining; finance; and the insurance industry. Full Article Energy & Utilities
act Lisa Gerrard in Action By stuckincustoms.com Published On :: Thu, 30 Apr 2020 13:01:00 +0000 Stuck at a Music Festival in Panama Here’s a crazy Covid story for you! From Paradise to Hell: Trapped at a Music Festival Because of COVID-19 (2020) Festival Goers are stuck on a Panaman Island due to the outbreak of the COVID-19. from Documentaries Daily Photo – Lisa Gerrard in Action This was the second […] Full Article Camera Gear Frankfurt Germany Sony A7R 2 Travel concert performance stage
act Telstra wins Best Practice Excellence Award By www.ibm.com Published On :: Wed, 21 May 2008 11:27:39 GMT Telstra Corporation Limited (Telstra) was awarded the 2008 Excellence Award in the ‘Best Practices - Service Provider’ category by the TeleManagement Forum (TM Forum). Full Article Business partners
act Board Game Review > Middara: Unintentional Malum Act 1 By www.thatswhatjennisaid.com Published On :: Sat, 02 Nov 2019 20:04:00 +0000 I don't keep my finger on the pulse of all the independent Kickstarter campaigns running at any given time. There's just too much unique content being produced month after month for me to sift through everything. I leave that to those who write previews and reviews for a living (I am an IT Consultant for a living; I write reviews as a hobby because I'm passionate about board gaming). The only way an independent Kickstarter campaign is going to be on my radar is if the designer/publisher reaches out to me to let me know the campaign is running or if it's created a bit of buzz already in the key circles that I frequent. I definitely wasn't closely monitoring Kickstarter campaigns four years ago when the original edition of Middara was initially funded. It was an adventurous dungeon crawl that promised to be so much more than an ordinary dungeon crawl. With options to run in campaign mode for an ongoing narrative or crawl mode for one off gameplay, it could work as a long term project for committed game groups as well as a fun game for casual players. It was a long road from its 2015 campaign to its 2019 fulfillment with a lot of unhappy backers along the way who voiced frustration at the late fulfillment of the game. In early summer 2019, a few months after delivery of the original Middara game was completed, Succubus Publishing launched their Middara: Unintentional Malum Triology Kickstarter campaign. This offered a reprint of the original game (retitled Middara: Unintentional Malum Act 1), expanding it to over 80 hours of content, as well as two new adventure expansions (Acts 2 and 3) and a host of other Kickstarter exclusive add-on and stretch goal content. It also promised a faster turnaround on delivery to backers. Suddenly Middara and its designers (Clayton Helme, Brooklynn Lundberg, Brenna Moncur, and Ian Tate) were the talk of the town and my husband Chris and I had an intense discussion about backing the second campaign. We were torn - yes the game sounded really cool, but we already own one behemoth campaign dungeon crawl (I’m looking at you Gloomhaven). Did we really need another? We hemmed and hawed and let the decision hang in the air. And then then publisher decided for us, by sending us a review copy of Middara: Unintentional Malum Act 1 (M:UMA1). As soon as the box arrived at the end of June, I poured over all the components. So much stuff! Such a huge box! The artwork (conceived and illustrated by Stephanie Gustafsson, Alex Hansen, Hector Sevilla Lujan, Rhett Mason, and Jon Troy Nickel) is absolutely beautiful. The illustrations are well drawn, well detailed, and bursting with color.The game could have an audience in the tween set if the drawings were a little less risqué, but as marketed to older teens and adults, everything is within decency standards. The minis are of good quality; well sculpted. I do wish that at least the starting adventurer minis came pre-painted (I always wish that because I have no painting skills or supplies) especially when M:UMA1 is priced at $150. The components are sturdy and should hold up to regular usage. We haven’t sleeved our cards yet and because of the sheer quantity of them (hundreds) they’ll likely remain unsleeved. I especially enjoy the custom dice, separated by color to indicate which dice should be used during dice rolls. After examining all the game contents, my interest was definitely on the upswing and Chris and I set about assembling a crew to play the game in adventure mode. It’s daunting to find others willing to commit to 80+ hours of gameplay, but soon enough we had a happy foursome. One of the players, Craig, actually owned the original edition of Middara but hadn’t found the time to assemble a group and get it on the table. Our other player was his coworker and friend Matt. Craig showed up for our first night of gameplay with a sweet surprise – he had ordered the fancy game mats and was happy to share them with us for our adventure. In M:UMA1 adventure mode, players begin the first game by taking on the roles of young students preparing for their Magical Aptitude and Skill Test (MAST). We spent that first evening getting to know the four starting characters (called adventurers) and deciding who would role play each one. Every adventurer has their own unique backstory, motivations, starting equipment (armor, weapons, relics, consumables, etc.), and vivid personality. I chose Nightingale because I saw myself in her and thought I would really enjoy playing her. Chris chose Rook, Craig took Remi, and Matt selected Zeke. M:UMA1 adventure mode breaks down the overall campaign (called the adventure) into many sessions called encounters. We typically play one or two encounters each evening we get together, with each encounter lasting anywhere from one to two hours. To start an encounter, all players gather round the table and lay out their adventurer cards and equipment. The narrative is read from the Adventure book, or alternatively listened to on the Middara app. We all really love the app. It’s available on the Apple App store or Google Play store and allows players to hear the narrative bits of the story without requiring one of them to do the reading aloud. The voice actor Succubus Publishing hired is fantastic; she is an expressive reader who brings the characters alive. While the entire adventure in M:UMA1 is narrative driven and so every encounter advances the plot at least a little bit, there are some encounters that have several pages of story so using the app is really nice. After the narration is finished, the location boards are set up for the encounter, forming the terrain, similar to any other dungeon crawl. Directions for setup are given in the Adventure book with modifications in the Diagram book. Some elements of the terrain may have their details partially hidden, such as loot tokens (which hide the exact reward until a character performs an encounter adjacent to the token) and totem tokens (which hide what they represent until an adventurer comes within line of sight of the token). The starting spaces on the board for each adventurer and the monsters (called combatants) are specified in the Adventure book. Once everything is setup, the game begins; turn order for adventurers and monsters is driven by initiative cards that were shuffled and randomly laid out in a row during setup. During the encounter, players spend their turns moving their adventurers around the terrain, following movement rules, as they work to complete the encounter goals. Usually this involves reaching the exit token, but other goals are possible. Since players typically get rewards (gold, equipment, experience points, etc.) each time their adventurer slays a monster, most will want to prioritize battling the monsters over making a quick run for the exit token. There isn’t a lot of analysis paralysis during game play as the best options for next steps on a player’s turn are usually fairly obvious. Combatants spend their turns completing actions as specified on their description cards. Those that are designated as adventurer opponents are called intelligent combatants and have intelligent combatant cards, while the ones that players control and that fight on behalf of adventurers are called command combatants. Exploring the terrain and battling intelligent combatants are governed by an extensive set of rules (60+ pages!) provided in the rulebook. It took us at least three encounters before we really understood most of the basic rules and even now, we find ourselves frequently checking the summary poster we printed out as a giant player aid. There’s just too much information to memorize it all, especially when the information is subject to change due to errata. Which brings me to one of the few complaints I have about this game -the large volume of errata. You either have to remember to frequently check the long list of corrections and changes (to the 1.0 rulebook and to the text printed on various components such as equipment cards, combatant cards, etc) and update gameplay as you go along, or dedicate a session to reviewing all the changes and corrections and marking up the components with the correct text in one sitting. We started off trying to do the former but it was so frustrating that we switched to the latter and it took me at least an hour. For the rulebook errata, you can take a shortcut to getting the updates in place (if you don’t mind the ink and paper expense) by printing out the updated 1.08 rulebook from the Succubus website. Another note on the rules- deciding which rule set to play under has become a complicated issue that players will need to come to agreement on as Succubus has compiled and released an entirely new version of the rules (v1.1) that changes several of the fundamental aspects of the game. This was done in response to the feedback from players who have extensively played through the game using the original 1.0 rulebook with errata corrections. The major overhaul is meant to strengthen aspects of the game that felt too weak and weaken aspects that seemed overpowered, but not all players agree on the changes. Also, the 1.1 changes are still in Beta release and so they are subject to change as they continue to be finalized. Our little group likes to keep things simple, so we opted to stick to the 1.08 rule set, at least for now. Theme is really important to me, so I was very happy to discover that Middara’s theme is well implemented across all components and the gameplay thus far in M:UMA1 . This is where the game really shines over its competitors. Its narrative is extremely detailed and offers so much depth in the characters. More so than Gloomhaven. More so than any other board game I’ve played. An experienced screenwriter could easily adapt the storyline into a fantastic adventure film for the big screen and I’d go see it. My two year stint playing through the Pathfinder Skull and Shackles Adventure Card Game is a distant second in plot development, and even then, that game only had such a rich narrative track because we employed a user written storyline that we found on BGG (the publisher offered little in the way of quality narrative for the game). I come back to the table each week to play M:UMA1 , not just for the fun of fighting monsters and gaining rewards, but also to find out what happens next in the story. Bonus: as the plot unfolds, adventurers grow in skill and discipline and new content becomes available. At the time of this writing, we've played through all of Chapter 1 and are partway through Chapter 2 (about 10 distinct sessions). Once we are finished with M:UMA1 in adventure mode (we estimate it will take us over a year, meeting weekly) there are plenty of scenarios and special content for us to replay M:UMA1 in crawl mode. In fact, a large portion of the Kickstarter promo box is content exclusively for use with crawl mode and I’m excited about eventually digging into that. Based on my experience with M:UMA1 so far, I highly recommend the game. Not only is the game worthwhile on its own merits, but the friendship building that comes from playing a year+ long adventure with others is wonderful. You can make a full afternoon or evening out of each session, sharing a meal together before sitting down to play the game. Although I was given a review copy of Act 1, I like Middara so much that I’ll be purchasing Acts 2 and 3 myself (or putting them on my Christmas list). You can pre-order the entire trilogy or any part of it on the Succubus Publishing website once the publisher reopens wave 2 pre-orders.-------------------------------------------------Publisher: Succubus PublishingPlayers: 2-4 (We played with 4)Actual Playing Time (vs the guideline on the box): About 1 - 3 hours per encounterGame type: narrative driven, dungeon crawl, campaign, action points, role playing, cooperative, dice rolling, grid movementRating:Jenni’s rating scale:OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.OUI OUI: I would play this game again; this game is good. I would buy this game.OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.NON: I would not play this game again. I would return this game or give it away if it was given to me. Full Article action points games campaign games cooperative games dice rolling games dungeon crawl games grid movement games Kickstarter role playing games Succubus Publishing