Despite once again being denied seeing Tony Ferguson do battle with Khabib Nurmagomedov, the UFC has served up the next best thing as the fiercely exciting Justin Gaethje steps in to face Ferguson for the interim title at UFC 249.
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  Introduction Android* applications may require a peer-to-peer connection between two or more Android* devices without a Wi-Fi access point or Internet access. Two examples of this are file sharing...

After not being able to fly during the nationwide lockdown, Airline companies entertain Twitteratis with an interesting word play on Twitter.

To Dick Costolo, there’s gold in them thar tweets, and Twitter has just begun to mine it.

For the next four days, a sprawling conference centre here will become the global hub for the telecommunications and technology industries.

It refers to the difficulty of the direction that takes the small hole around its partner-a difficulty that the research team has now integrated into a highly sophisticated model.

AN NRI WANTS TO SELL HIS PROPERTY IN INDIA. UNDER I. TAX PROVISIONS THE BUYER IS SUPPOSED TO DEDUCT TDS @ 20% . WHETHER A LOWER RATE IS THERE UNDER THE data BETWEEN UAE AND INDIA?

IN MY PREVIOUS QUERY THE WORD SHOULD BE DTAA AND NOT DATA.. THANKS.

Five persons were killed in a clash between two groups at Moti Hamirpar village in Kutch district of Gujarat on Saturday afternoon, police said.

Are they basically the same thing? I am trying to get as much experience with Allegro since a lot of jobs I am looking at right now are asking for Cadence Allegro experience (I wish they asked for Altium experience...). I currently have access to PCB Editor, but I don't want to commit to learning Editor if Allegro is completely different. Also walmart one, are the Cadence Allegro courses worth it? I won't be paying for it and if it's worth it, I figure I might as well use the opportunity to say I know how to use two complex CAD tools.

Hello,

I created a floorplan view in Virtuoso ( it contains pins and blockages). I am trying to run PnR in Innovus for floorplan created in Virtuoso. I used  set vars(oa_fp)    "Library_name cell_name view_name"   to read view from virtuoso. I am able to see pins in Innovus but not the blockages. Can i know how do i get the blockages created in virtuoso to Innovus.

Regards,
Amuu 

For a netlist vs. netlist LEC flow we have to solve the following problem:

- in the RTL code we replicate a large array of N x M all-identical hard-macros, let call them MACRO_A

- MACRO_A is pre-assembled in Innovus and contains digital parts and analog parts (bottom-up hierarchical flow)

- at top-level (full-chip) we instantiate this array of all-identical macros

- in the top-level place-and-route flow we perform ecoChangeCell to remaster the top row of this array with MACRO_B

- MACRO_B is just a copy of the original MACRO_A cell containing same pins position, same internal digital functionality and also same digital layout, only slight differences in one analog block inside the macro

- MACRO_A and MACRO_B have the same .lib file generated with the do_extract_model command at the end of the Innovus flow, they only differ in the name of the macro

- when performing post-synthesis netlist vs post-place-and-route we load .lib files of both macros in Conformal LEC

- the LEC flow fails because Conformal LEC sees only MACRO_A instantiated in the post-synthesis netlist and both MACRO_A and MACRO_B in the post-palce-and-route netlist

Since both digital functionality and STD cells layout are the same between MACRO_A and MACRO_B we don't want to keep track of this difference already at RTL stage, we just want to perform this ECO change in place-and-route and force Conformal to assume equivalence between MACRO_A and MACRO_B .

Basically what I'm searching for is something similar to the add_instance_equivalences Conformal command but that works between Golden and Revised designs on cell primitives/black-boxes .

Is this flow supported ?

Thanks in advance

Luca

For a project, we depend on capturing warnings. This works fine in Virtuoso but behaves differently in Allegro.

In our observations

Virtuoso:

>>> warn("Hello")

*WARNING* Hello

Allegro:

>>> warn("Hello")

*WARNING* Hello

But when we capture the warning:

Virtuoso:

>>> warn("Hello") getWarn()

"Hello"

Allegro:

>>> warn("Hello") getWarn()

"*WARNING* Hello"

This is a Problem for because we put an empty String in the warn and depend on the fact that no Warning results in an empty String but on Allegro the output always begins with *WARNING*

Is there a way to make the behavior consistent in both versions?

I'm in the process of weeding a regression test list. I have a coverage database from the full regression list and would like to diff it with the coverage database from the new reduced regression test list. If possible I would than like to trace back any buckets covered with the full list, but not with the partial list, into the original tests that covered them.

Is that possible using IMC? if not, is it possible to do from Specman itself?

(Note that we're not using vManager)

Thanks,

Avidan

Hi,

I am currently struggling with measuring the delay between two clocks with a sufficient accuracy. The reference one is a fixed-phase clock, and the other one is a squared clock resulting of a circuit (kind of PLL) synthesis.
As I need to run a large amount of Monte-Carlo simulations in transient noise, I need to improve the simulation speed, while keeping a satisfactory delay measurement accuracy (<0.1ps), more specifically at 0V-crossings of the differential clocks. So I cannot simply set a max timestep <0.1ps as it would be far too long to simulate.
To sum up, I would need a very relaxed timestep on clock up and down levels, and a very short timestep only at rise/fall transitions.

For this purpose, I wrote a Verilog-A script
- using a timmer function to accurately emulate the reference clock 0V-crossing times (and get the related times with $abstime)
- using @(cross to get the 0V-crossing times of the synthesized clock: but this is not accurate enough (I see simulation noise around 3ps in Conservative). Indeed, the "cross" event occures at the simulation time following the effective 0V-crossing time; this could be sometimes >3ps, far not enough accurate for my purpose.
- I have tried to replace the cross with the "above" function, but it hasn't changed anything, whatever the time_tol value I put (<0.1ps for instance), the result is the same as with the "cross" function and the points are larger than >>0.1ps, weirdly.

So I have decided to give up Verilog-A to measure the delay between my two clocks.
I am currently trying to use the "delay" function of the Cadence Calculator as I guess it will "extrapolate" the time between two simulation points and therefore give a more accurate measurement of the 0V-crossing events, but when I try to compute the delay difference between the synthesized clock and the reference clock, it returns "0".

...

Could you please give me hints to dramatically improve my 0V-crossing time measurements while relaxing the simulation time?
- either by helping me in writing a more suitable Verilog-A script
- or by helping me in using the "delay" function of the calculator
- or maybe by providing me a "magic" Skill function?
Using AMS+Multithread simulator...

Thanks a lot in advance for your help and best regards.

ગુજરાત સ્થાપના દિવસ અંગે PM Modi એ Tweet કરીને ગુજરાતની જનતાને આપી શુભેચ્છાઓ

Kansai Electric Power Co. Inc. announces that the 290-MW Nam Ngiep 1 hydropower plant has begun commercial operations.

Austrade has partnered with the NSW Government to deliver one of the largest business missions from Guangdong Province ever to visit Australia.

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Today's lesson in Cooking as a Grown-Ass adult: Blenders are used for more than frozen margs in summer and collecting dust in winter.

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...

By James H. Spencer, Sumeet Saksena, and Jefferson Fox HONOLULU (1 April 2020)—The current COVID-19 pandemic, which started in Wuhan, China, underscores what the public health community has warned about for more than two decades—the risk of viral diseases capable of spreading from animal to human hosts. The first outbreaks of “bird flu” (highly pathogenic avian influenza―HPAI, subtype H5N1) raised similar concerns 20 years ago―concerns that have persisted with the outbreak of SARS in 2002–2004 and COVID-19 today. New outbreaks of avian influenza are also still occurring in poultry and humans, primarily in Asia but also in other parts of the world.

This is a summary only. Click the title for the full article, or visit www.EastWestCenter.org/Research-Wire for more.

EU appears open-minded about pay between assignment contracts Having inherited the Agency Workers Regulations 2010 on taking office, the UK Government had p...

A horror crash involving a truck and a tanker carrying a flammable substance has led to the closure of the N2, near the Mtunzini Toll Plaza on the KwaZulu-Natal north coast. ......

European Commission aims to level the playing field between suppliers and large customers by introducing recommendations on unfair trade practices The European Commission recently adopted a Communication encouraging EU Member States to look at ways ...

The French Competition Authority (FCA) is entitled to give advisory opinions on any competition matter, in particular for the attention  of the French Government and the Parliament. The FCA has been recently asked to give its opinion on coopera...

The novel coronavirus has destroyed lives and livelihoods in both the United States and China. But instead of bonding the two nations together to fight the pandemic, it has sent their already strained relations on a rapid downward spiral — and fanned the flames of a potentially dangerous strain of nationalism. China has been criticized at home and abroad over its handling of the virus, especially during the initial outbreak. Pushing back such criticism with increasingly fierce rhetoric, Beijing says it is merely “responding” to false accusations, particularly from the US. In March, as the pandemic raged across the globe, Chinese Foreign Ministry spokesman Zhao Lijian...

A daily commute of two-and-a-half hours each way would take a toll on anyone, but for Özkan, a construction worker in Istanbul, the hardest part of his long journey is coping with his fears about what might happen after he gets home. “The conditions on our job site are deplorable, and I feel psychologically broken […]

The post Across the World, Construction Workers are Caught Between Coronavirus Risk and Joblessness appeared first on Inter Press Service.

The partnership will ensure farmers get the input not only at the correct price but also at the right time.

The COVID-19 pandemic has exacerbated inequalities and revealed to what extent current economic models are not sustainable. It has also shown that most countries are not equipped to cope with a health crisis. The World Food Program is warning that the lives and livelihoods of 265 million people in low and middle-income countries will be […]

The post The Unseen Link Between Clean Cooking and the COVID-19 Pandemic appeared first on Inter Press Service.

1

To level the playing field in Asia and the Pacific, women-owned companies need financial backing to support their importing and exporting needs.

Rawalpindi : Merchants while lauding decision of the government for relaxing coronavirus lockdown took a sigh of relief as Eid season is around the corner. For the last few weeks specifically following the advent of the holy month of Ramazan, there were reports that merchants were treating...

A language reclamation activist confronts linguistic imperialism and the dehumanisation of two South African first languages through digital inclusion advocacy.

Title: Leprosy May Pass Between Armadillos and People
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: Study Finds Direct Link Between Obesity, Heart Disease
Category: Health News
Created: 5/2/2012 10:05:00 AM
Last Editorial Review: 5/2/2012 12:00:00 AM

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Category: Health News
Created: 4/28/2014 4:36:00 PM
Last Editorial Review: 4/29/2014 12:00:00 AM

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Title: AHA News: The Often-Overlooked Connection Between Sleep Troubles and Stroke
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Dr Harpreet Bajaj summarizes the known and unknown links between diabetes and COVID-19, focusing on three clinical questions.

Purpose: Oral and craniofacial conditions or diseases can impact an individual's health and quality of life. The purpose of this study was to assess the perceived oral health related quality of life (OHRQoL) of children, and evaluate the reported level of agreement between caregivers and their children.Methods: Purposive sampling was used to recruit children ages 8-15, and their caregivers from a dental clinic in a pediatric hospital for this descriptive, cross-sectional study. A modified version of a validated measure, Child Oral Health Impact Profile-Short Form (COHIP-SF), was used for a 22-item questionnaire encompassing three subscales: oral health, functional well-being, and social emotional well-being. Two additional items were included to assess child/caregiver's level of agreement. A dental chart review was also conducted to assess the child's overbite, overjet, and decayed surfaces. Data were analyzed through descriptive statistics and examined for assumptions of normality and linearity.Results: Sixty child/caregiver pairs (n=120) participated in this study. Overbite, overjet and decayed surfaces were not found to be related to any OHRQoL variable, including child/caregiver ratings and overall agreement (p>.05). Average OHRQoL scores for caregivers found to be more positive those of their children (p=.02). Agreement between caregivers and the child's gender was shown to be significant (p=.01). Female child scores differed significantly from males with respect to their caregiver responses (p=.02). Caregivers rated a higher OHRQoL for female children, thus overestimating their female child's reported OHRQoL.Conclusions: The moderate level of agreement found between children and caregivers reinforces the importance of including the child, as well as the caregiver, when assessing OHRQoL.

ABSTRACT

Many HIV prevention strategies are currently under consideration where it is highly informative to know the study participants’ times of infection. These can be estimated using viral sequence data sampled early in infection. However, there are several scenarios that, if not addressed, can skew timing estimates. These include multiple transmitted/founder (TF) viruses, APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like)-mediated mutational enrichment, and recombination. Here, we suggest a pipeline to identify these problems and resolve the biases that they introduce. We then compare two modeling strategies to obtain timing estimates from sequence data. The first, Poisson Fitter (PF), is based on a Poisson model of random accumulation of mutations relative to the TF virus (or viruses) that established the infection. The second uses a coalescence-based phylogenetic strategy as implemented in BEAST. The comparison is based on timing predictions using plasma viral RNA (cDNA) sequence data from 28 simian-human immunodeficiency virus (SHIV)-infected animals for which the exact day of infection is known. In this particular setting, based on nucleotide sequences from samples obtained in early infection, the Poisson method yielded more accurate, more precise, and unbiased estimates for the time of infection than did the explored implementations of BEAST.

IMPORTANCE The inference of the time of infection is a critical parameter in testing the efficacy of clinical interventions in protecting against HIV-1 infection. For example, in clinical trials evaluating the efficacy of passively delivered antibodies (Abs) for preventing infections, accurate time of infection data are essential for discerning levels of the Abs required to confer protection, given the natural Ab decay rate in the human body. In such trials, genetic sequences from early in the infection are regularly sampled from study participants, generally prior to immune selection, when the viral population is still expanding and genetic diversity is low. In this particular setting of early viral growth, the Poisson method is superior to the alternative approach based on coalescent methods. This approach can also be applied in human vaccine trials, where accurate estimates of infection times help ascertain if vaccine-elicited immune protection wanes over time.

ABSTRACT

Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is known, how they interact to promote pathogenesis is rarely understood. The zoonotic bacterium Brucella abortus, the causative agent of brucellosis, delivers effector proteins via its VirB type IV secretion system (T4SS) which mediate biogenesis of the endoplasmic reticulum (ER)-derived replicative Brucella-containing vacuole (rBCV). Here, we show that T4SS effectors BspB and RicA display epistatic interactions in Brucella replication. Defects in rBCV biogenesis and Brucella replication caused by deletion of bspB were dependent on the host GTPase Rab2a and suppressed by the deletion of ricA, indicating a role of Rab2-binding effector RicA in these phenotypic defects. Rab2a requirements for rBCV biogenesis and Brucella intracellular replication were abolished upon deletion of both bspB and ricA, demonstrating that the functional interaction of these effectors engages Rab2-dependent transport in the Brucella intracellular cycle. Expression of RicA impaired host secretion and caused Golgi fragmentation. While BspB-mediated changes in ER-to-Golgi transport were independent of RicA and Rab2a, BspB-driven alterations in Golgi vesicular traffic also involved RicA and Rab2a, defining BspB and RicA’s functional interplay at the Golgi interface. Altogether, these findings support a model where RicA modulation of Rab2a functions impairs Brucella replication but is compensated by BspB-mediated remodeling of Golgi apparatus-associated vesicular transport, revealing an epistatic interaction between these T4SS effectors.

IMPORTANCE Bacterial pathogens with an intracellular lifestyle modulate many host cellular processes to promote their infectious cycle. They do so by delivering effector proteins into host cells via dedicated secretion systems that target specific host functions. While the roles of many individual effectors are known, how their modes of action are coordinated is rarely understood. Here, we show that the zoonotic bacterium Brucella abortus delivers the BspB effector that mitigates the negative effect on bacterial replication that the RicA effector exerts via modulation of the host small GTPase Rab2. These findings provide an example of functional integration between bacterial effectors that promotes proliferation of pathogens.

ABSTRACT

The human gut microbiota (HGM) has far-reaching impacts on human health and nutrition, which are fueled primarily by the metabolism of otherwise indigestible complex carbohydrates commonly known as dietary fiber. However, the molecular basis of the ability of individual taxa of the HGM to address specific dietary glycan structures remains largely unclear. In particular, the utilization of β(1,3)-glucans, which are widespread in the human diet as yeast, seaweed, and plant cell walls, had not previously been resolved. Through a systems-based approach, here we show that the symbiont Bacteroides uniformis deploys a single, exemplar polysaccharide utilization locus (PUL) to access yeast β(1,3)-glucan, brown seaweed β(1,3)-glucan (laminarin), and cereal mixed-linkage β(1,3)/β(1,4)-glucan. Combined biochemical, enzymatic, and structural analysis of PUL-encoded glycoside hydrolases (GHs) and surface glycan-binding proteins (SGBPs) illuminates a concerted molecular system by which B. uniformis recognizes and saccharifies these distinct β-glucans. Strikingly, the functional characterization of homologous β(1,3)-glucan utilization loci (1,3GUL) in other Bacteroides further demonstrated that the ability of individual taxa to utilize β(1,3)-glucan variants and/or β(1,3)/β(1,4)-glucans arises combinatorially from the individual specificities of SGBPs and GHs at the cell surface, which feed corresponding signals to periplasmic hybrid two-component sensors (HTCSs) via TonB-dependent transporters (TBDTs). These data reveal the importance of cooperativity in the adaptive evolution of GH and SGBP cohorts to address individual polysaccharide structures. We anticipate that this fine-grained knowledge of PUL function will inform metabolic network analysis and proactive manipulation of the HGM. Indeed, a survey of 2,441 public human metagenomes revealed the international, yet individual-specific, distribution of each 1,3GUL.

IMPORTANCE Bacteroidetes are a dominant phylum of the human gut microbiota (HGM) that target otherwise indigestible dietary fiber with an arsenal of polysaccharide utilization loci (PULs), each of which is dedicated to the utilization of a specific complex carbohydrate. Here, we provide novel insight into this paradigm through functional characterization of homologous PULs from three autochthonous Bacteroides species, which target the family of dietary β(1,3)-glucans. Through detailed biochemical and protein structural analysis, we observed an unexpected diversity in the substrate specificity of PUL glycosidases and glycan-binding proteins with regard to β(1,3)-glucan linkage and branching patterns. In combination, these individual enzyme and protein specificities support taxon-specific growth on individual β(1,3)-glucans. This detailed metabolic insight, together with a comprehensive survey of individual 1,3GULs across human populations, further expands the fundamental roadmap of the HGM, with potential application to the future development of microbial intervention therapies.

Finding common ground and building trust between local stakeholders could help prevent violent encounters between police and young black men, new research finds.

BACKGROUND Pregnant patients from rural counties of Western North Carolina face additional barriers when accessing comprehensive perinatal substance use disorders care at Project CARA as compared to patients local to the program in Buncombe County. We hypothesized regional patients would be less engaged in care.

METHOD Using a retrospective cohort design, univariate analyses (², t-test; P < .05) compared patients' characteristics, engagement in care, and delivery outcomes. Engagement in care, the primary outcome, was operationalized as: attendance at expected, program-specific prenatal and postpartum visits, utilization of in-house counseling, community-based and/or inpatient substance use disorders treatment, and maternal urine drug screen at delivery negative for illicit substances.

RESULTS Regional patients (n = 324) were more likely than Buncombe County patients (n = 284) to have opioid [209 (64.5%) versus 162 (57.0%)] or amphetamine/methamphetamine use disorders (25 [7.7%] versus 13 [4.6%]), but less likely to have cannabis use (19 [5.9%] versus 38 [13.4%]; P = .009) and concurrent psychiatric disorders (214 [66.0%] versus 220 [77.5%]; P = .002). Engagement at postpartum visits was the significantly different outcome between patients (110/221 [49.8%] versus 146/226 [64.6%]; P = .002).

LIMITATIONS Outcomes were available for 66.8% of regional and 79.6% of Buncombe County patients of one program in one predominately white, non-Hispanic region of the state.

CONCLUSION Contrary to our hypothesis, regional and Buncombe County women engaged in prenatal care equally. However, a more formal transition into the postpartum period is needed, especially for regional women. A "hub-and-spokes" model that extends delivery of perinatal substance use disorders care into rural communities may be more effective for engagement retention.

Background

Plasma cardiac troponin (cTn) elevation occurs in acute ischemic stroke and intracranial hemorrhage and can suggest a poor prognosis. Because acute cerebral venous thrombosis (CVT) might lead to venous stasis, which could result in cardiac stress, it is important to evaluate whether cTn elevation occurs in patients with CVT.